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Audio Mixing Inversion via Embodied Self-supervised Learning

Machine Intelligence Research 2024年第1期21卷 55-62页

作者： Haotian Zhou feng yu Xihong Wu Department of AI Music and Music Information Technology Central Conservatory of MusicBeijing 100031China Laboratory of Music Artificial Intelligence Laboratory of Philosophy and Social SciencesMinistry of EducationBeijing 100031China School of Intelligence Science and Technology Peking UniversityBeijing 100871China

Audio mixing is a crucial part of music production.For analyzing or recreating audio mixing,it is of great importance to conduct research on estimating mixing parameters used to create mixdowns from music recordings,i.e.,audio mixing inversion.However,approaches of audio mixing inversion are rarely explored.A method of estimating mixing parameters from raw tracks and a stereo mixdown via embodied self-supervised learning is presented.In this work,several commonly used audio effects including gain,pan,equalization,reverb,and compression,are taken into consideration.This method is able to learn an inference neural network that takes a stereo mixdown and the raw audio sources as input and estimate mixing parameters used to create the mixdown by iteratively sampling and training.During the sampling step,the inference network predicts a set of mixing parameters,which is sampled and fed to an audio-processing framework to generate audio data for the training step.During the training step,the same network used in the sampling step is optimized with the sampled data generated from the sampling step.This method is able to explicitly model the mixing process in an interpretable way instead of using a black-box neural network model.A set of objective measures are used for evaluation.The experimental results show that this method has better performance than current state-of-the-art methods.

关键词： Audio mixing inversion intelligent audio mixing self-supervised learning audio signal processing deep learning

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Phase separation of GRP7 facilitated by FERONIAmediated phosphorylation inhibits mRNA translation to modulate plant temperature resilience

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Molecular Plant 2024年第3期17卷 460-477页

作者： Fan Xu Long Wang Yingbin Li Junfeng Shi Dorothee Staiger feng yu state Key Laboratory of Chemo/Biosensing and Chemometrics College of Biologyand Hunan Key Laboratory of Plant Functional Genomics and Developmental RegulationHunanUniversityChangsha 410082P.R.China State Key Laboratory of Hybrid Rice Hunan Agricultural Biotechnology Research InstituteHunan Academy of Agricultural SciencesChangsha 410125P.R.China RNA Biology and Molecular Physiology Faculty of BiologyBielefeld University33615 BielefeldGermany

Changes in ambient temperature profoundly affect plant growth and performance.Therefore,the molecu-larbasis of plant acclimation to temperature fluctuation is of great interest.In this study,we discovered that GLYCINE-RICH RNA-BINDING PROTEIN 7(GRP7)contributes to cold and heat tolerance in Arabidopsis thaliana.We found that exposure to a warm temperature rapidly induces GRP7 condensates in planta,which can be reversed by transfer to a lower temperature.Cell biology and biochemical assays revealed that GRP7 undergoes liquid-liquid phase separation(LLPS)in vivo and in vitro.LLPS of GRP7 in the cyto-plasm contributes to the formation of stress granules that recruit RNA,along with the translation machinery component eukaryotic initiation factor 4E1(elF4E1)and the mRNA chaperones COLD SHOCK PROTEIN 1(CSP1)and CSP3,to inhibit translation.Moreover,natural variations in GRP7 affecting the residue phos-phorylated by the receptorkinase FERONIA alter its capacity to undergo LLPS and correlate with the adap-tation of some Arabidopsis accessions to a widertemperature range.Taken together,ourfindings illustrate the role of translational control mediated by GRP7 LLPS to confer plants with temperature resilience.

关键词： fluctuating temperature glycine-rich RNA-binding protein phase separation cold shock proteins translation

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Curation,nomenclature,and topological classification of receptor-like kinases from 528 plant species for novel domain discovery and functional inference

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Molecular Plant 2024年第4期17卷 658-671页

作者： Qian Liu Qiong Fu yujie Yan Qian Jiang Longfei Mao Long Wang feng yu Heping Zheng State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University College of BiologyChangshaHunan 410082China Bioinformatics Center Hunan University College of BiologyChangshaHunan 410082China

Receptor-like kinases(RLKs)are the most numerous signal transduction components in plants and play important roles in determining how different plants adapt to their ecological environments.Research on RLKs has focused mainly on a small number of typical RLK members in a few model plants.There is an urgent need to study the composition,distribution,and evolution of RLKs at the holistic level to increase our understanding of how RLKs assist in the ecological adaptations of different plant species.In this study,we collected the genome assemblies of 528 plant species and constructed an RLK dataset.Using this dataset,we identified and characterized 524948 RLK family members.Each member underwent systematic topological classification and was assigned a gene ID based on a unified nomenclature system.Furthermore,we identified two novel extracellular domains in some RLKs,designated Xiao and Xiang.Evolutionary analysis of the RLK family revealed that the RLCK-XVII and RLCK-XII-2 classes were present exclusively in dicots,suggesting that diversification of RLKs between monocots and dicots may have led to differences in downstream cytoplasmic responses.We also used an interaction proteome to help empower data mining for inference of new RLK functions from a global perspective,with the ultimate goal of understanding how RLKs shape the adaptation of different plants to the environments/ecosystems.The assembled RLK dataset,together with annotations and analytical tools,forms an integrated foundation of multiomics data that is publicly accessible via the metaRLK web portal(http://metaRLK.biocloud.top).

关键词： RLK RLCK domain signaling pathway receptor-protein interactions

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Intelligent 3D garment system of the human body based on deep spiking neural network

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虚拟现实与智能硬件（中英文） 2024年第1期6卷 43-55页

作者： Minghua JIANG Zhangyuan TIAN Chenyu yu Yankang SHI Li LIU Tao PENG Xinrong HU feng yu School of Computer and Artificial Intelligence Wuhan Textile UniversityWuhan 430200China Engineering Research Center of Hubei Province for Clothing Information Wuhan 430200China

Background Intelligent garments,a burgeoning class of wearable devices,have extensive applications in domains such as sports training and medical rehabilitation.Nonetheless,existing research in the smart wearables domain predominantly emphasizes sensor functionality and quantity,often skipping crucial aspects related to user experience and interaction.Methods To address this gap,this study introduces a novel real-time 3D interactive system based on intelligent garments.The system utilizes lightweight sensor modules to collect human motion data and introduces a dual-stream fusion network based on pulsed neural units to classify and recognize human movements,thereby achieving real-time interaction between users and sensors.Additionally,the system incorporates 3D human visualization functionality,which visualizes sensor data and recognizes human actions as 3D models in real time,providing accurate and comprehensive visual feedback to help users better understand and analyze the details and features of human motion.This system has significant potential for applications in motion detection,medical monitoring,virtual reality,and other fields.The accurate classification of human actions contributes to the development of personalized training plans and injury prevention strategies.Conclusions This study has substantial implications in the domains of intelligent garments,human motion monitoring,and digital twin visualization.The advancement of this system is expected to propel the progress of wearable technology and foster a deeper comprehension of human motion.

关键词： Intelligent garment system Internet of things Human action recognition Deep learning 3D visualization

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TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer's disease

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Science China Chemistry 2024年第4期67卷 1360-1372页

作者： Meiru Lu Changlong Hao Liguang Xu feng yu Jiwei Jiang Yanli Wang Jun Xu Hua Kuang Chuanlai Xu Maozhong Sun International Joint Research Laboratory for Biointerface and Biodetection State Key Laboratory of Food Science and ResourcesSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Institute of Life Sciences Jiangsu UniversityZhenjiang 212013China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China National Clinical Research Center for Neurological Diseases Beijing 100070China

Tripartite motif 21(TRIM21)is an E3 ubiquitin ligase that shows great promise for protein degradation through ubiquitination.Here,ultrasmall chiral gold nanoparticles(D-or L-NPs)modified by D-or L-glutathione ligands were fabricated.After conjugated with an NLR family pyrin domain-containing protein 3(NLRP3)antibody(D-NP-a NLRP3 or L-NP-a NLRP3),DNP-a NLRP3 showed effective delivery efficiency of the antibody into microglia and prevented Aβ-mediated microglia senescence,and p16^(ink4a),a marker of senescence,in the microglia was reduced by 90.3%±7.8% while L-NP-a NLRP3 decreased by 48.01%±3.1%.Mechanistic investigations revealed that the D-NP-a NLRP3((1.5±0.3)×10^(7)M^(-1))exhibited sixteen-fold larger binding affinity to transmembrane glycoprotein SLC3A2 than L-type((9.5±2.7)×10^(5)M^(-1)),which led to a high efficiency of antibody delivery and TRIM21-dependent NLRP3 degradation.Notably,the blood-brain barrier(BBB)-crossing ability of chiral NP-a NLRP3 as well as NLRP3 degradation was demonstrated in vivo.The APP/PS1 Alzheimer's disease(AD)model mice experiments exhibited a reduction of 89.7%±6.8% for the NLRP3 protein and 84.2±7.5% for p16^(ink4a)following the intravenous administration of D-NP-a NLRP3 once a week for 60 days.Furthermore,the levels of the AD markers Aβ and phosphorylatedTau in the brains were reduced by 86.2%±8.2% and 81.6%±9.1%;these were 2.1-fold and 1.9-fold higher than those treated with L-NP-a NLRP3,respectively.The studies provide a method to rescue AD-like pathologies and prevent senescence.

关键词： chiral gold nanoparticles amyloid-β NLRP3 TRIM21 senescence Alzheimer's disease

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Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy

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Chinese Chemical Letters 2024年第4期35卷 420-425页

作者： Hao Cai Xiaoyan Wu Lei Jiang feng yu yuxiang Yang Yan Li Xian Zhang Jian Liu Zijian Li Hong Bi School of Materials Science and Engineering Anhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China

The reactive oxygen species(ROS) generation efficiency is always limited by the extreme tumor microenvironment(TME), leading to unsatisfactory antitumor effects in photodynamic therapy(PDT). As a promising gas therapy molecule, nitric oxide(NO) is independent of oxygen and could even synergize ROS to enhance the therapeutic effect. However, the short half-life, instability, and uncontrollable release of exogenous NO limited the application of tumor synergistic therapy. Herein, we reported a novel kind of red-emissive carbon dots(CDs) that was capable of lysosome-targeted and light-controlled NO delivery. The CDs were synthesized by using metformin and methylene blue(MB) via a hydrothermal method.The obtained metformin-MB CDs(MMCDs) exhibited a higher1O2quantum yield and NO generation efficiency under light emitting diode(LED) light irradiation. Noteworthily, the1O2could further in situ oxidize NO into peroxynitrite anions(ONOO-), which own the higher cytotoxicity against cancer cells.Cell experiments indicate that MMCDs could destruct lysosome membrane integrity and kill almost 80%of Hep G2 cells under light irradiation while very low cytotoxicity in the dark. Moreover, MMCDs significantly decreased tumor volume and weight after phototherapy in hepatoma Hep G2-bearing mice. Our study provides a new strategy for light-controlled NO generation as well as precise lysosome-targeting for enhancement of PDT efficiency.

关键词： Carbon dots Nitric oxide Lysosome-targeting Photodynamic therapy Cancer

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Effects of Crosswise Appendage Plate Flexibility on the Drag Reduction Characteristics of Cylinder

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Journal of Applied Mathematics and Physics 2024年第6期12卷 2032-2040页

作者： Jiyao Yang Xiaomei Ye Guoyi He feng yu The School of Aircraft Engineering Nanchang Hangkong University Nanchang China The School of Foreign Languages Nanchang Hangkong University Nanchang China

In engineering applications (Like an ocean riser), fluid flow around bluff bodies generates substantial resistance, which can jeopardize structural integrity, lifespan, and escalate resource consumption. Therefore, employing drag reduction measures becomes particularly crucial. This paper employs the immersed boundary method to investigate the impact of transversely oriented appendage plate flexibility on the drag of cylinders under different Reynolds numbers and distances. The results indicate that flexible appendage plate exerts drag reduction effects on the downstream cylinder, with this effect gradually diminishing as Reynolds numbers increase. At identical Reynolds numbers, the drag reduction effect initially increases and then decreases with distance, with the optimal drag reduction distance observed at D = 2.5. Compared to cylinders without appendage plate, the maximum drag reduction achieved is 30.551%. Addressing the drag reduction issue in cylinders holds significant importance for ensuring engineering structural integrity, enhancing engineering efficiency, and developing novel underwater towing systems.

关键词： Appendage Plate Flexibility Cylinder Flow Drag Reduction

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Current Situation and Progress of Pig Model in Otology Research

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Journal of Biosciences and Medicines 2024年第2期12卷 326-339页

作者： Xiaoping Liu Maomao Ai[] Ying Lin[] feng yu Institute of Otolaryngology Head and Neck Surgery Affiliated to Jinan University Guangzhou Red Cross Hospital Affiliated to Jinan University Guangzhou China

Pig models are widely used in otological research. The establishment of common pig and miniature pig animal models has opened up new fields in otological research and is also an ideal large otological animal model. This article introduces the applications, current status, progress, advantages, and issues of using pigs as otologic animal models. It summarizes current research on pigs in the fields of hearing disorders, otitis, vertigo, cochlea, gene editing, and tissue engineering, among other otologic and audiological areas. These models are valuable for translating basic medical science into clinical applications. Based on this, platforms have been established for studying deafness and vertigo, cochlear implantation experiments, stem cell and gene therapy, and tissue engineering. These serve as ideal experimental models for the prevention and treatment of ear diseases, pointing toward new directions. This will bolster the promotion and application of pig models in the fields of tissue engineering and gene editing in the future.

关键词： Pig Miniature Pig Animal Model

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Derivation of Expanded Isospectral-Nonisospectral Integrable Hierarchies via the Column-vector Loop Algebra

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 778-800页

作者： Hai-feng WANG yu-feng ZHANG School of Science Jimei UniversityXiamen 361021China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A scheme for generating nonisospectral integrable hierarchies is introduced.Based on the method,we deduce a nonisospectral hierarchy of soliton equations by considering a linear spectral problem.It follows that the corresponding expanded isospectral and nonisospectral integrable hierarchies are deduced based on a 6 dimensional complex linear space ■.By reducing these integrable hierarchies,we obtain the expanded isospectral and nonisospectral derivative nonlinear Schr?dinger equation.By using the trace identity,the biHamiltonian structure of these two hierarchies are also obtained.Moreover,some symmetries and conserved quantities of the resulting hierarchy are discussed.

关键词： expanded isospectral-nonisospectral integrable hierarchies column-vector loop algebra bi-Hamiltonian structure symmetry

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Mechanism of selective laser trabeculoplasty:a systemic review

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 963-968页

作者： yu-feng Chen Wen Zeng Department of Ophthalmology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

Although selective laser trabeculoplasty(SLT)is a recognized method for the treatment of glaucoma,the exact changes in the target tissue and mechanism for its intraocular pressure lowing effect are still unclear.The purpose of this review is to summarize the potential mechanisms of SLT on trabecular meshwork both in vivo and in vitro,so as to reveal the potential mechanism of SLT.SLT may induce immune or inflammatory response in trabecular meshwork(TM)induced by possible oxidative damage etc,and remodel extracellular matrix.It may also induce monocytes to aggregate in TM tissue,increase Schlemm’s canal(SC)cell conductivity,disintegrate cell junction and promote permeability through autocrine and paracrine forms.This provides a theoretical basis for SLT treatment in glaucoma.

关键词： mechanisms selective laser trabeculoplasty glaucoma trabecular meshwork

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