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Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

International Journal of Extreme Manufacturing 2024年第1期6卷 296-311页

作者： Cijun Shuai Xiaoxin Shi feng Yang Haifeng Tian pei feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017People’s Republic of China

Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe *** this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser *** results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant *** accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative *** antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(***)and Gram-positive Staphylococcus aureus(***).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

关键词： bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties

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Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity

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Bio-Design and Manufacturing 2024年第2期7卷 105-120页

作者： Cijun Shuai Xiaoxin Shi Kai Wang Yulong Gu feng Yang pei feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017China

Bacterial infection is a major problem following bone implant ***,poly-l-lactic acid/carbon nanotube/hydroxyapatite(PLLA/CNT/HAP)bone scaffolds possess enhanced mechanical properties and show good ***,wesynthesizedsilver(Ag)-dopedCNT/HAP(CNT/Ag-HAP)nanohybrids via the partial replacing of calcium ions(Ca2+)in the HAP lattice with silver ions(Ag+)using an ion doping technique under hydrothermal ***ﬁcally,the doping process was induced using the special lattice structure of HAP and the abundant surface oxygenic functional groups of CNT,and involved the partial replacement of Ca2+in the HAP lattice by doped Ag+as well as the in situ synthesis of Ag-HAP nanoparticles on CNT in a hydrothermal *** result-ing CNT/Ag-HAP nanohybrids were then introduced into a PLLA matrix via laser-based powder bed fusion(PBF-LB)to fabricate PLLA/CNT/Ag-HAP scaffolds that showed sustained antibacterial *** then found that Ag+,which pos-sesses broad-spectrum antibacterial activity,endowed PLLA/CNT/Ag-HAP scaffolds with this activity,with an antibacterial effectiveness of 92.65%.This antibacterial effect is due to the powerful effect of Ag+against bacterial structure and genetic material,as well as the physical destruction of bacterial structures due to the sharp edge structure of *** addition,the scaffold possessed enhanced mechanical properties,showing tensile and compressive strengths of 8.49 MPa and 19.72 MPa,***,the scaffold also exhibited good bioactivity and cytocompatibility,including the ability to form apatite layers and to promote the adhesion and proliferation of human osteoblast-like cells(MG63 cells).

关键词： Ag-doped Carbon nanotube/hydroxyapatite(CNT/HAP) Antibacterial properties Bone scaffold

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Integrating Bimetallic Nanoparticles with Covalent Organic Frameworks as Multifunctional Nanozyme for Colorimetric Detection of Hydrogen Peroxide and Glutathione

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Journal of Analysis and Testing 2024年第3期8卷 278-287页

作者： Yuying Yuan Xiaoxue Xi Ting Bao Pingguan Bian feng pei Xiuhua Zhang Shengfu Wang Wei Wen Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei University Hubei Yihua Chemical Co. Ltd

The controllable growth of metal nanoparticles on nanomaterials is becoming an effective strategy for developing nanocomposites with designated performance. Herein, a simple and mild strategy for the in situ growth of Pt–Pd bimetallic nanoparticles on covalent organic frameworks（COFs） to regulate the nanozyme activity was designed for colorimetric detection of hydrogen peroxide（H2O2） and glutathione（GSH）. The COFs not only offer sufficient loading sites for the uniform dispersion of Pt–Pd bimetallic nanoparticles, but also increase the adsorption of substrate to promote the catalytic reaction. With the bimetallic synergistic effect of Pt–Pd nanoparticles, the prepared multifunctional nanozyme（Pt–Pd/COFs nanozyme） simultaneously exhibited superior peroxidase（POD）-like activity and oxidase（OXD）-like activity. Using the multifunctional nanozyme, a colorimetric sensing system was constructed for sensitive detection of H2O2and GSH, with the wide linear ranges of 5–1000 μmol/L and 1–40 μmol/L, and the detection limits were 1.14 μmol/L and 0.43 μmol/L, respectively. It was successfully used for the detection of real samples in environmental water and serum, providing a simple method for disease diagnosis and environmental monitoring.

关键词： Bimetallic synergistic effect H2O2 and GSH detection Oxidase-like activity Peroxidase-like activity Pt–Pd/COFs nanozyme

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Cardiac remodeling in patients with atrial fibrillation reversing bradycardia-induced cardiomyopathy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1339-1345页

作者： De-Kui Gao Xiang-Lin Ye Zhen Duan Hong-Yang Zhang Tao Xiong Zheng-Hong Li Hai-feng pei Department of Cardiology Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina Department of Cardiology The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina Department of Clinical Medicine Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Special Inspection Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina

BACKGROUND Bradycardia-induced cardiomyopathy(BIC),which is a disease resulting from bradycardia,is characterized by cardiac chamber enlargement and diminished cardiac *** correction of bradycardia can allow for significant improvements in both cardiac function and structure;however,this disease has been infrequently *** this case,we conducted a longitudinal followup of a patient who had been enduring BIC for more than 40 years to heighten awareness and prompt timely diagnosis and rational *** SUMMARY A woman who presented with postactivity fatigue and dyspnea was diagnosed with bradycardia at the age of *** she had no obvious symptoms,she did not receive any treatment to improve her bradycardia during the 42-year follow-up,except for the implantation of a temporary pacemaker during labor induction *** time progressed,the patient's heart gradually expanded due to her low ventricular rate,and she was diagnosed with *** 2014,the patient developed atrial fibrillation,her ventricular rate gradually increased,and her heart shape gradually returned to *** report describes the cardiac morphological changes caused by the heart rate changes in BIC patients older than 40 years,introduces another possible outcome of BIC,and emphasizes the importance of early intervention in treating *** BIC can induce atrial fibrillation,causing an increased ventricular rate and leading to positive cardiac remodeling.

关键词： Bradycardia cardiomyopathy Heart rate Atrial fibrillation Cardiac dilatation Case report

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基于教育数字化演进之路的青年思想政治教育探究

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马克思主义理论学科研究 2024年第3期10卷 108-116页

作者：冯培首都经济贸易大学马克思主义学院北京100070

中国教育数字化在互联网的飞速发展中一路走来,经历了文本化1.0时代、图像化2.0时代、智能化3.0时代。国家设立思想政治教育学科40年来,在数字技术形态演进中的“变”中之“常”,为青年思想政治教育提供了三个规律性的启迪,即秉持内容... 详细信息

中国教育数字化在互联网的飞速发展中一路走来,经历了文本化1.0时代、图像化2.0时代、智能化3.0时代。国家设立思想政治教育学科40年来,在数字技术形态演进中的“变”中之“常”,为青年思想政治教育提供了三个规律性的启迪,即秉持内容为王是核心,契合个性需求是根本,形成联通共振是要义。基于此,面对教育数字化转型升级之际学生的“常”中之“新”,青年思想政治教育应把握有效性引领的三个向度:把握导向为魂之“常”,引领需求变化之“新”,强化教育的敏感度和契合度;把握内容为王之“常”,构建传播供给之“新”,优化传导的精准度和鲜活度;把握贯通为要之“常”,营造生态场景之“新”,深化工作的关联度和共享度。

关键词：思想文化传播教育数字化青年思想政治教育

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喷水推进船舶骑浪横甩薄弱性衡准校核方法

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船舶力学 2024年第8期28卷 1133-1140页

作者：封培元蔡佑林范佘明喷水推进技术重点实验室上海201100 上海市船舶工程重点实验室上海200011 中国船舶及海洋工程设计研究院上海200011

当前国际海事组织(IMO)二代稳性规范中骑浪/横甩稳性失效模式的第二层薄弱性衡准校核方法仅适用于采用常规螺旋桨推进方式的船舶。然而,采用喷水推进方式的船舶同样属于该稳性失效模式的敏感船型,因此有必要建立此类船舶的规范校核方法... 详细信息

当前国际海事组织(IMO)二代稳性规范中骑浪/横甩稳性失效模式的第二层薄弱性衡准校核方法仅适用于采用常规螺旋桨推进方式的船舶。然而,采用喷水推进方式的船舶同样属于该稳性失效模式的敏感船型,因此有必要建立此类船舶的规范校核方法。本研究通过类比螺旋桨推力模型,建立喷水推进系统的力学模型,在不改变当前骑浪/横甩第二层薄弱性衡准校核理论方法和框架的前提下,通过最少的流程变动实现适用于喷水推进船舶的第二层薄弱性衡准校核,并基于实泵数据和样船算例证明所提出方法的有效性。基于研究成果形成专门针对喷水推进船舶的规范校核方法,突破当前规范在船舶推进方式方面的局限性,不但使规范变得更为完备,而且能为喷水推进船舶的稳性安全评估提供有利的技术支撑。

关键词：二代稳性骑浪/横甩喷水推进薄弱性衡准校核流程

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Rapid detection and risk assessment of soil contamination at lead smelting site based on machine learning

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 3054-3068页

作者： Sheng-guo XUE Jing-pei feng Wen-shun KE Mu LI Kun-yan QIU Chu-xuan LI Chuan WU Lin GUO School of Metallurgy and Environment Central South UniversityChangsha 410083China Henan Key Laboratory of Monitoring and Remediation in Heavy Metal Polluted Soil Jiyuan 454650China Henan Academy of Geology Zhengzhou 450000China

A general prediction model for seven heavy metals was established using the heavy metal contents of 207soil samples measured by a portable X-ray fluorescence spectrometer(XRF)and six environmental factors as model correction *** eXtreme Gradient Boosting(XGBoost)model was used to fit the relationship between the content of heavy metals and environment characteristics to evaluate the soil ecological risk of the smelting *** results demonstrated that the generalized prediction model developed for Pb,Cd,and As was highly accurate with fitted coefficients(R~2)values of 0.911,0.950,and 0.835,*** presented the highest ecological risk,and there existed high potential ecological risk at some positions with different depths due to high mobility of ***,the application of machine learning significantly increased the accuracy of pXRF measurements,and identified key environmental *** adapted potential ecological risk assessment emphasized the need to focus on Pb,Cd,and As in future site remediation efforts.

关键词： smelting site potentially toxic elements X-ray fluorescence potential ecological risk machine learning

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含粗粒滑带土剪切带演化及空间展布规律研究

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岩土力学 2024年第4期45卷 1067-1080页

作者：李泽闯张昊程培峰王艳丽东北林业大学土木与交通学院黑龙江哈尔滨150040 华汇工程设计集团股份有限公司浙江绍兴312000

对含不同强度粗颗粒的滑带土进行了可视化中型直剪试验,通过竖直置入铝丝观察剪切后铝丝变形情况获取剪切破坏带的空间信息,并建立了剪切带空间曲面方程。通过粒子图像测速(particle image velocimetry,PIV)技术对可视面处二维剪切带信... 详细信息

对含不同强度粗颗粒的滑带土进行了可视化中型直剪试验,通过竖直置入铝丝观察剪切后铝丝变形情况获取剪切破坏带的空间信息,并建立了剪切带空间曲面方程。通过粒子图像测速(particle image velocimetry,PIV)技术对可视面处二维剪切带信息进行提取,并与剪切试验得到的空间曲面方程的边界外推值进行对比,证明了空间曲面方程与PIV技术能够描述剪切带特征。然后通过PIV技术对不同剪切总位移与某一剪切位移下短时间内相对位移规律进行了分析。最后分析了预制损伤与粗颗粒强度对剪切带特征的影响。研究结果表明,剪切带形状为两端薄中间厚的带状,可采用高斯曲面方程对剪切带轮廓进行拟合。剪切带在发展过程中经历压密、自由损伤、损伤沿固定路径发展与剪切带贯通4个阶段,损伤使得剪切带发展各阶段前移,粗颗粒强度会对局部剪切带变形产生较大影响而对整体剪切带的变形影响较小。该研究成果对于揭示滑坡剪切带形成与演变规律从而设计合理的边坡防治方案具有重要意义。

关键词：含粗粒滑带土剪切带中型直剪试验可视化 PIV技术

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不同险态情景下共驾型智能车辆接管行为特征分析

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吉林大学学报（工学版） 2024年第3期54卷 683-691页

作者：严利鑫冯进培郭军华龚毅轲华东交通大学交通运输工程学院南昌330013

为提高驾驶人在不同险态交通情景下接管智能车辆的安全性,在模拟驾驶平台上分别研究了高速公路、山区道路和城市道路3类典型险态环境下驾驶人接管行为的特征和差异性。试验采集并分析了16名驾驶人在3类典型险态环境下的驾驶行为数据。... 详细信息

为提高驾驶人在不同险态交通情景下接管智能车辆的安全性,在模拟驾驶平台上分别研究了高速公路、山区道路和城市道路3类典型险态环境下驾驶人接管行为的特征和差异性。试验采集并分析了16名驾驶人在3类典型险态环境下的驾驶行为数据。结果表明:①驾驶人在接管车辆时采取的应急操作包括制动、转向、同时转向制动3种,各行为占比分别为71.4%、16.7%和11.9%。②不同险态交通情景下驾驶人接管反应时间无显著差异(P>0.05);在高速-城市险态情景下车辆最大纵向减速度存在显著差异(P=0.002<0.05),在山区-城市险态情景下车辆最大纵向减速度存在显著差异(P=0.048<0.05);在城市-山区险态情景下车辆最大转向盘转角存在显著差异(P=0.015<0.05);在山区-高速险态情景下车辆最大转向盘转角存在显著差异(P=0.000<0.05)。说明在不同险态交通情景下应采用不同的接管措施以提升接管的安全性和有效性。本文研究结果可为不同险态环境下的智能车辆接管系统研发提供参考。

关键词：交通运输系统工程智能车辆接管行为险态场景警报方式

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宫腔镜电切术在宫颈管赘生物治疗中的应用效果观察

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中国实用医药 2024年第6期19卷 25-28页

作者：吴培凤沂水县人民医院 276400

目的探究宫腔镜电切术在宫颈管赘生物治疗中的应用效果。方法 160例宫颈管赘生物患者,随机分为观察组与对照组,各80例。对照组接受经阴道宫颈管赘生物摘除术治疗,观察组采取宫腔镜下宫颈管赘生物电切术治疗。对比两组临床相关指标,术... 详细信息

目的探究宫腔镜电切术在宫颈管赘生物治疗中的应用效果。方法 160例宫颈管赘生物患者,随机分为观察组与对照组,各80例。对照组接受经阴道宫颈管赘生物摘除术治疗,观察组采取宫腔镜下宫颈管赘生物电切术治疗。对比两组临床相关指标,术后月经正常、粘连、复发情况,术后疼痛评分,术后并发症发生情况。结果观察组手术时间(45.42±5.54)min、下床活动时间(3.37±0.53)d、住院时间(5.25±1.67)d均较对照组的(65.72±8.58)min、(5.17±0.79)d、(10.48±1.89)d更短(P<0.05)。观察组术中出血量(20.46±4.25)ml较对照组的(37.82±5.57)ml更少(P<0.05)。观察组术后月经正常率为93.75%,较对照组的73.75%更高(P<0.05)。观察组术后粘连及术后复发率分别为0、0,较对照组的13.75%、12.50%更低(P<0.05)。观察组术后1、3、5 d疼痛评分分别为(3.48±0.43)、(1.35±0.24)、(0.56±0.12)分,均较对照组的(6.34±1.06)、(3.28±0.68)、(2.21±0.47)分低(P<0.05)。观察组并发症发生率6.25%低于对照组的20.00%(P<0.05)。结论针对宫颈管赘生物患者采取宫腔镜电切术可缩短手术时间,降低术中出血量,加速患者术后康复进程,住院时间更短,可有效提升术后月经正常率,降低术后粘连率及复发率,并缓解患者术后疼痛,降低术后并发症发生风险。

关键词：宫颈管赘生物宫腔镜电切术月经正常复发率

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