检索结果-南通市图书馆

Cellular & Molecular Immunology 2021年第1期18卷 171-181页

作者： Ruo Chen Ke Wang zhuan feng Ming-Yang Zhang Jiao Wu Jie-Jie Geng Zhi-Nan Chen Department of Cell Biology College of Life Science and TechnologyJinan UniversityGuangdongChina National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityShaanxiChina

Thymic involution during aging is a major cause of decreased T-cell production and reduced ***,we show that the loss of CD147 on T cells prevents thymic senescence,resulting in slowed shrinkage of the thymus with age and increased production of naive T *** phenotype is the result of slowing of the epithelial-mesenchymal transition(EMT)process in thymic epithelial cells(TECs),which eventually leads to reduced adipocyte *** an in vitro coculture system,we found that TGFβ is an important factor in the EMT process in TECs and that it can reduce the expression of E-cadherin through p-5mad2/FoxC2 ***,CD147 on T cells can accelerate the decline in E-cadherin expression by interacting with Annexin A2 on *** the presence of TGFβ,Annexin A2 and E-cadherin colocalize on ***,CD147 on T cells competitively binds to Annexin A2 on TECs,leading to the isolation of ***,the isolated E-cadherin is easily phosphorylated by phosphorylated Src kinase,the phosphorylation of which was induced by TGFβ,and finally,p-E-cadherin is ***,in the thymus,the interaction between T ceils and TECs contributes to thymic involution with *** this study,we illuminate the mechanism underlying the triggering of the EMT process in TECs and show that inhibiting TGFβ and/or CD147 may serve as a strategy to hinder age-related thymic involution.

关键词： CD147 TGFβ thymic involution EMT

Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rheumatoid Arthritis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rh...

CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis

第十二届全国免疫学学术大会

作者： feng zhuan the Fourth Military Medical University

Objective:To study the role of A20 in mesenchymal stem cells(MSC) as a potential therapeutic target for Rheumatoid Arthritis(RA).Methods:A20 and pro-inflammatory cytokines levels of bone marrow MSCs(BM-MSCs) of 11 RA patients and 8 health controls(HCs) were analyzed by Real-Time quantitative PCR(RT-qPCR).After co-culture with A20 interfered or overexpressed umbilical cord MSCs(UC-MSCs),the differentiation of T cells were detected by flow cytometer *** therapeutic effect of MSCs adoptive transfer were confirmed in collagen II-induced arthritis(CIA) model of DBA mice according to joint swelling ***:A20 decreased in RA patients’ BM-MSCs,together with up-regulation of pro-inflammatory cytokine,*** co-culture results of BM-MSCs with peripheral blood mononuclear cell(PBMC)-derived T cells demonstrated that decreased expression of A20 in MSCs which lead to the over expression of IL-6 could disturb Th17/Treg balance by promoting the differentiation of Th17 cells but repressing Treg *** expression of A20 in MSCs could reverse such disequilibrium which may be a main anti-inflammatory factor for *** model showed that adoptive transfer of MSCs attenuated joint swelling and reduce the production of ***:The regulatory role of A20 in pro-inflammatory IL-6 production could be a potential target for the transfer of MSCs in RA adoptive therapy.

关键词： A20 mesenchymal stem cell rheumatoid arthritis adoptive therapy

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第12期18卷 2618-2631页

作者： JieJie Geng Ruo Chen feng-fan Yang Peng Lin Yu-meng Zhu Xianghui Fu Ke Wang zhuan feng Jiao Wu Hai Zhang Qi-jing Li Zhi-Nan Chen Ping Zhu Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi’anP.R.China National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’anP.R.China Department of Immunology Duke University Medical CenterDurhamNCUSA

Regulatory T cell(Treg)stability is necessary for the proper control of immune activity and tissue ***,it remains unclear whether Treg stability must be continually reinforced or is established during development under physiological ***3 has been characterized as a central mediator of the genetic program that governs Treg ***,we demonstrate that to maintain Foxp3 protein expression,Tregs require cell-to-cell contact,which is mediated by the CD147-CD98 *** Tregs are produced,CD147,which is expressed on their surface,is stimulated by CD98,which is widely expressed in the physiological *** a result,CD147’s intracellular domain binds to CDK2 and retains it near the membrane,leading to Foxp3 dephosphorylation and the prevention of Foxp3 *** addition,the optimal distribution of Foxp3+Tregs under both pathological and physiological conditions depends on CD98 ***,our study provides direct evidence that Foxp3-dependent Treg stability is reinforced in the periphery by the interaction between CD147 and CD98 in the surrounding *** importantly,Tregs with high CD147 expression effectively inhibit inflammatory responses and maintain Foxp3 stability,which has guiding significance for the application of Tregs in immunotherapy.

关键词： Treg Stability CD147 CD98 CDK2 Immune therapy

Against all odds:The road to success in the development of human immune reconstitution mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第4期7卷 460-470页

作者： Yixiao Bin Jing Ren Haowei Zhang Tianjiao Zhang Peijuan Liu Zhiqian Xin Haijiao Yang zhuan feng Zhinan Chen Hai Zhang School of Basic Medical Sciences Shaanxi University of Chinese MedicineXianyangChina Department of Cell Biology National Translational Science Center for Molecular MedicineFourth Military Medical UniversityXi'anChina State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical UniversityXi'anChina Department of Occupational&Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public HealthFourth Military Medical UniversityXi'anChina

The mouse genome has a high degree of homology with the human genome,and its physiological,biochemical,and developmental regulation mechanisms are similar to those of humans;therefore,mice are widely used as experimental ***,it is undeniable that interspecies differences between humans and mice can lead to experimental *** differences in the immune system have become an impor-tant factor limiting current immunological *** application of immunodefi-cient mice provides a possible solution to these *** transplanting human immune cells or tissues,such as peripheral blood mononuclear cells or hematopoietic stem cells,into immunodeficient mice,a human immune system can be reconstituted in the mouse body,and the engrafted immune cells can elicit human-specific immune *** have been actively exploring the development and differen-tiation conditions of host recipient animals and grafts in order to achieve better im-mune *** genetic engineering methods,immunodeficient mice can be further modified to provide a favorable developmental and differentiation microenvironment for the *** initially only being able to reconstruct single T lymphocyte lineages,it is now possible to reconstruct lymphoid and myeloid cells,providing important research tools for immunology-related *** this review,we compare the differences in immune systems of humans and mice,describe the devel-opment history of human immune reconstitution from the perspectives of immuno-deficient mice and grafts,and discuss the latest advances in enhancing the efficiency of human immune cell reconstitution,aiming to provide important references for im-munological related researches.

关键词： hematopoietic stem cell human immune reconstitution immune response immunodeficient mice peripheral blood mononuclear cell transplantation

Relationship Between Lodging Resistance and Chemical Contents in Culms and Sheaths of Japonica Rice During Grain Filling

在线全文

学校读者我要写书评

暂无评论

Rice science 2010年第4期17卷 311-318页

作者： ZHANG feng-zhuan JIN Zheng-xun MA Guo-hui SHANG Wen-nan LIU Hai-ying Xu Mei-lan LIU Yan Agricultural College Northeast Agricultural University Harbin 150030 China China National Hybrid Rice R ＆ D Center Changsha 41 O125 China Jilin Province Ping＇an Seeds Company Changchun 133000 China

To understand the relationship between lodging resistance and chemical component contents in culms and leaf sheaths of rice, the physical strength and maximum bearing capacity of culm, and the contents and amounts of potassium （K） silicon （Si） and soluble sugars in culms and leaf sheaths were investigated using four japonica rice varieties with different lodging resistance characteristics during grain filling. There were significant differences in the total amounts of K, Si and soluble sugars in culms and leaf sheaths among the tested rice varieties. The difference in the total amount of Si was greater than that of K or soluble sugars. The physical strength and maximum bearing capacity of culm continuously decreased from heading to ripening, with a rapid decrease at the dough stage. However, the contents and total amounts of K and Si in culms and the Si content in leaf sheaths gradually increased and an accumulation of K and Si in culms was exhibited, whereas the content and total amount of K and the total amount of Si in leaf sheaths gradually decreased and an exportation of K and Si in leaf sheaths was presented. The physical strength was positively and significantly correlated with the total amounts of K and Si in culms during grain filling except that at the heading stage, the total amount of soluble sugars in culms at the heading and milky stages, the total amounts of Si and soluble sugars in leaf sheaths at the heading stage, the total amount of K in leaf sheaths at the heading and milky stages, and the maximum bearing capacity during grain filling. It is suggested that the lodging resistance of japonica rice would be improved by increasing the amount of soluble sugars in plants at the early filling stage, and enhancing the amount of Si in plants during grain filling through topdressing Si fertilizer at the early filling stage.

关键词： japonica rice grain filling lodging resistance chemical component content dynamic change

Transforming growth factor-β1 in invasion and metastasis in colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2002年第4期8卷 674-678页

作者： Bin Xiong Hong-Yin Yuan Ming-Bo Hu feng Zhang Zheng-zhuan Wei Ling-Ling Gong Guo-Liang Yang Department of Oncology,Affiliated Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,China Department of Oncology Affiliated Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina. xbxh@***

AIM：To investigate the role of TGFβ1 in invasion and metastasis in colorectal cancer by analysing TGFβ1 correlated wity depth of tumor invasion,stage and ***:Serum TGFβ1levels were determined in50patients with colorectal cancer and 30healthy volunteers using a TGFβ1 enzyme-linked immunosorbent ***β1 expression in primary and lymph node metastatic lesions were detected in 98cases of colorectal cancer by immunohistochemical staining and in situ ***:Serum levels of TGFβ1 in patients with colorectal cancer(40±18μg·L^-1)were significantly higher than those in the healthy control group(19±8μg·L^-1),P<*** levels of serum TGFβ1were found in 60%of patients with colorectal cancer when the mean+2s was used as the upper limit of the normal range(35.1μg·L^-1).Increases in serum TGFβ1 levels were significantly asociated with Dukei's stage(P<0.05),but there was no significant difference between,Duki's stage Bpatients and Dukei's stage *** the cytoplasm of cancer cells,TGFβ1 was immunostained in37.8%(37/98)of colorectal cancer,and this expression was confirmed by in situ hybridization,Among35cases of colorectal cancer with lymph node metastatic lesions,TGFβ1 positive staining was found in18(51.4%)cases of primary tumor,and 25(71.4%)cases with lymph node metastatic lesions,respectively,Of17cases with no staining in the primary lesion.7(41.2%)casesshowed TGFβ1 staining in the metastatic *** TGFβ1 levels and TGFβ1 expression in colorectal cancer tissues were correlated significantly with depth of tumor invasion,stage and metastasis,Patients in stage C-D,T3-T4and with metastasis had significantly higher TGFβ1 levels than patients in stage A-B,T1-T2and without metastasis(P<0.05).CONCLUSION:These results suggest that transforming growth factor-β1 is closely related to the invasion and metastasis of colorectal *** increased the invasive and metastatic potential of tumor by altering a tumor ***β1 ma

关键词：结直肠癌转化生长因子β1 肿瘤侵袭肿瘤转移作用机制

Changes in Activities of Key Enzymes for Starch Synthesis and Glutamine Synthetase in Grains of Progenies from a Rice Cross During Grain Filling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice science 2010年第3期17卷 243-246页

作者： LI Xiao-guang LIU Hai-ying JIN Zheng-xun LIU Hong-liang HUANG Xing XU Mei-lan ZHANG feng-zhuan College of Agriculture Northeast Agricultural University Harbin 150030 China Tonghua Academy of Agricultural Sciences Hailong 135007 China Jilin Province Ping ＇an Seeds Company Changchun 133000 China

The progenies differed in amylose and protein contents in grains, which derived from a rice cross, Dongnong 423×Toukei 180, were used to study changes in the activities of ADP-glucose pyrophosphorylase （AGPP）, soluble starch synthetase （SSS）, starch branching enzyme （SBE） and glutamine synthetase （GS） in rice grains during grain filling. The activities of AGPP, SSS and SBE gradually increased and then declined as a single-peak curve with the process of grain filling in the progenies with high and low amylose contents in grains. The progenies with high amylose content peaked earlier in the AGPP, SSS and SBE activities and had higher AGPP, SSS and SBE activities at the early grain filling stage than those with low amylose content. The GS activity peaked earlier and was higher at the late stage of grain filling in the progenies with high protein content than in those with low protein content. It is suggested that the activities of key enzymes for starch synthesis and glutamine synthetase could be changed in oriented breeding for amylose and protein contents in grains.

关键词： rice hybrid progeny grain filling enzyme activity

Effects of Grain Protein Content Selection on Protein Content and Key Enzyme Activity Involved in Nitrogen Metabolism in Progenies Derived from a Rice Cross

在线全文

学校读者我要写书评

暂无评论

Rice science 2010年第2期17卷 156-160页

作者： HUANG Xing JIN Zheng-xun LI Xiao-guang LIU Hong-liang Xu Mei-lan ZHANG feng-zhuan ZHANG Zhong-chen Agricultural College Northeast Agricultural University Harbin 150030 China

Two japonica rice parents （Tong 769 and Xixuan 1） and their progenies, significantly different in protein content of grains, were investigated to reveal the activities of proteinase in leaves and glutamine synthetase in grains, as well as the dynamic changes of soluble protein content in grains during rice grain filling. The results showed that the parents were very similar in protein content, however, advanced lines with different protein contents in grains and varied activities of proteinase and glutamine synthetase were acquired by consecutively directional selection of the grain protein content in their progenies. Moreover, the enzyme activity and the protein content in grains exceeded their parents during grain filling. The protein content in grains was positively related with the proteinase activity, and the soluble protein content was negatively related with the glutamine synthetase activity in grains to some extent.

关键词： rice hybrid progeny protein content nitrogen metabolism enzyme activity

Autolysosome dysfunction regulates inflammatory response in ankylosing spondylitis monocytes

在线全文

学校读者我要写书评

暂无评论

Autolysosome dysfunction regulates inflammatory response in ...

第十二届全国免疫学学术大会

作者： Zhai Yue Lin Peng feng zhuan Han Qing Luo Xing Chen Zhinan Zhu Ping Department of Clinical Immunology PLA Specialized Research Institute of Rheumatology &ImmunologyXijing HospitalFourth Military Medical University National Translational Science Center for Molecular Medicine Department of Cell Biology Fourth Military Medical University

Background:Autolysosome is a stage of autophagy,which includes the fusion of a autophagosome and a *** dysfunction of autolysosome will facilitate the infection of ***,the role of autolysosome in autoimmune diseases i... 详细信息

关键词： Autolysosome Autophagy Ankylosing spondylitis A20 IL-1

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

降低通信铁塔耗钢量的技术措施

福建建设科技 1999年第2期 16-17页

作者：庄峰福建省电力勘测设计院 350003

通过对福建联通GSM二期工程的通信塔的设计实践，分析影响通信塔耗钢指标的主要因素，并提出有效的控制措施。

关键词：通信塔结构布局耗钢量铁塔设计