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Association of autoimmune thyroid disease with type 1 diabetes mellitus and its ultrasonic diagnosis and management

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World Journal of Diabetes 2024年第3期15卷 348-360页

作者： Jin Wang Ke Wan Xin Chang rui-feng Mao Department of Ultrasound Medicine Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina Faculty of Medicine and Health The University of SydneyCamperdown NSW 2050Australia School of Life Science Huaiyin Normal UniversityHuai'an 223300Jiangsu ProvinceChina

As a common hyperglycemic disease,type 1 diabetes mellitus(T1DM)is a complicated disorder that requires a lifelong insulin supply due to the immunemediated destruction of pancreaticβ*** it is an organ-specific autoimmune disorder,T1DM is often associated with multiple other autoimmune *** most prevalent concomitant autoimmune disorder occurring in T1DM is autoimmune thyroid disease(AITD),which mainly exhibits two extremes of phenotypes:hyperthyroidism[Graves'disease(GD)]and hypothyroidism[Hashimoto's thyroiditis,(HT)].However,the presence of comorbid AITD may negatively affect metabolic management in T1DM patients and thereby may increase the risk for potential diabetes-related ***,routine screening of thyroid function has been recommended when T1DM is ***,first,we summarize current knowledge regarding the etiology and pathogenesis mechanisms of both ***,an updated review of the association between T1DM and AITD is ***,we provide a relatively detailed review focusing on the application of thyroid ultrasonography in diagnosing and managing HT and GD,suggesting its critical role in the timely and accurate diagnosis of AITD in T1DM.

关键词： Type 1 diabetes mellitus Autoimmunity Autoimmune thyroid disease Ultrasonography Diagnosis

Dynamic characteristics of coal specimens with varying static preloading levels under low-frequency disturbance load

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Journal of Central South University 2024年第8期31卷 2644-2657页

作者： Wen, Xiao-ze feng, Guo-rui Guo, Jun Yu, Lu-yang Qian, rui-peng Zhang, Jie Zhang, Peng-fei feng, Wen-ming College of Mining Engineering Taiyuan University of Technology Taiyuan China Key Laboratory of Shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of Technology Taiyuan China State Key Laboratory of Hydroelectric and Engineering Tsinghua University Beijing China

The mechanical properties of residual coal pillars under the influence of upward mining disturbances significantly affect the safety of residual mining activities on working faces. This study conducted low-frequency disturbance dynamic uniaxial compression tests on coal specimens using a self-developed dynamic-static load coupling electro-hydraulic servo system, and studied the strength evolutions, surface deformations, acoustic emission (AE) characteristic parameters, and the failure modes of coal specimens with different static preloading levels were studied. The disturbance damage is positively correlated with the coal specimen static preload level. Specifically, the cumulative AE count rates of the initial accelerated damage stage for the coal specimens with static preloading level of 60% and 70% of the uniaxial compressive strength (UCS) were 2.66 and 3.19 times that of the 50% UCS specimens, respectively. Macroscopically, this behaviour manifested as a decrease in the compressive strength, and the mean strengths of the disturbance-damaged coal specimens with 60% and 70% of UCS static preloading decreased by 8.53% and 9.32%, respectively, compared to those of the specimens under pure static loading. The crack sources, such as the primary fissures, strongly control the dynamic response of the coal specimen. The difference between the dynamic responses of the coal specimens and that of dense rocks is significant.

关键词： low-frequency disturbance dynamic response coal specimens static preloading level

Sedimentary architecture of submarine channel-lobe systems under different seafloor topography:Insights from the Rovuma Basin offshore East Africa

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Petroleum Science 2024年第1期21卷 125-142页

作者： Mei Chen Sheng-He Wu rui-feng Wang Jia-Jia Zhang Peng-Fei Xie Min Wang Xiao-feng Wang Ji-Tao Yu Qi-Cong Xiong State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Faculty of Geosciences University of BremenBremen28359Germany MARUM-Center for Marine and Environmental Sciences University of BremenBremen28359Germany Research institute of Petroleum Exploration and Development PetroChinaBeijing10083China School of Geosciences Yangtze UniversityWuhan 100083HubeiChina CNODC Mozambique Ltd. Beijing 100034China

Seafloor topography plays an important role in the evolution of submarine ***,it is still not so clear how the shape of slope affects the three-dimensional(3-D)architecture of submarine *** this study,we analyze the effect of topography factors on different hierarchical lobe architectures that formed during Pliocene to Quaternary in the Rovuma Basin offshore East *** characterize the shape,size and growth pattern of different hierarchical lobe architectures using 3-D seismic *** find that the relief of the topographic slope determines the location of preferential deposition of lobe complexes and single *** the topography is irregular and presents topographic lows,lobe complexes first infill these *** lobes are deposited preferentially at positions with higher longitudinal(***-slope)slope *** the longitudinal slope becomes higher,the aspect ratio of the single lobes ***(***-slope)topography does not seem to have a strong influence on the shape of single lobe,but it seems to affect the overlap of single *** the lateral slope gradient is relatively high,the single lobes tend to have a larger overlap ***,as the average of lateral slope and longitudinal slope gets greater,the width/thickness ratio of the single lobe is smaller,*** tend to accumulate *** results demonstrate that the shape of slopes more comprehensively influences the 3-D architecture of lobes in natural deep-sea systems than previously other lobe deposits and analogue experiments,which helps us better understand the development and evolution of the distal parts of turbidite systems.

关键词： Submarine fan Seafloor topography Sedimentary architecture Slope system SW Indian ocean

Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys

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Zoological Research 2024年第5期45卷 1013-1026页

作者： Ling Wang Wei-Qiang Liu Juan Du Meng Li rui-feng Wu Ming Li Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

DNA methylation plays a crucial role in environmental ***,using whole-genome bisulfite sequencing,we generated comprehensive genome-wide DNA methylation profiles for the high-altitude Yunnan snub-nosed monkey(Rhinopithecus bieti)and the closely related golden snub-nosed monkey(***).Our findings indicated a slight increase in overall DNA methylation levels in golden snub-nosed monkeys compared to Yunnan snub-nosed monkeys,suggesting a higher prevalence of hypermethylated genomic regions in the *** genomic methylation analysis demonstrated that genes associated with differentially methylated regions were involved in membrane fusion,vesicular formation and trafficking,hemoglobin function,cell cycle regulation,and neuronal *** results suggest that the high-altitude-related epigenetic modifications are extensive,involving a complete adaptation process from the inhibition of single Ca^(2+)channel proteins to multiple proteins collaboratively enhancing vesicular function or inhibiting cell differentiation and *** assays demonstrated that overexpression or down-regulation of candidate genes,such as SNX10,TIMELESS,and CACYBP,influenced cell viability under stress ***,this research suggests that comparing DNA methylation across closely related species can identify novel candidate genomic regions and genes associated with local adaptations,thereby deepening our understanding of the mechanisms underlying environmental adaptations.

关键词： Snub-nosed monkeys Whole-genome bisulfite sequencing DNA methylation High-altitude adaptation

Homologous heterostructure of MoS_(2) and MoO_(2) coupled with carbon layers as cathode catalyst for rechargeable lithium-oxygen batteries

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Rare Metals 2024年第7期43卷 3383-3390页

作者： Yi-Ming Zhang Zhao-rui Zhou Lan-Ling Zhao Ye-Bing Li rui-feng Li Ya Zhou Sana Shoukat Abulgasim-Ahmed-Abbaker Adam Jun Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China Shenzhen Research Institute of Shandong University Shenzhen 518063China School of Physics Shandong UniversityShenzhen 518063China

Lithium-oxygen batteries tend to experience high overpotentials because of the sluggish oxygen reduction reaction and oxygen evolution reaction during cycling.A potential solution to address this issue is to develop a... 详细信息

关键词： lithium process. kinetics

Variations in Column Concentration of Greenhouse Gases in China and Their Response to the 2015-2016 El Niño Event

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Journal of Meteorological Research 2024年第3期38卷 608-619页

作者： Ningwei LIU Lingjun XIA Youjun DOU Shaorou DONG Jing WEN Ying WANG rui feng Ruonan WANG Yuhe LI Institute of Atmospheric Environment China Meteorological AdministrationShenyang110166China Jiangxi Ecological Meteorology Centre Nanchang330096China Beijing Xiangyuan Academy of Meteorological Observing Technology Beijing100081China Climate Centre of Guangdong Province Guangzhou510641China Guangdong Meteorological Service Guangzhou510062China Liaoning Provincial Meteorological Equipment Support Centre Shenyang110166China Meteorological Centre of Northeast Air Traffic Administration of Civil Aviation of China Shenyang110161China

Since the industrial revolution,enhancement of atmospheric greenhouse gas concentrations as a result of human activities has been the primary cause of global *** monitoring and evaluation of greenhouse gases are significant prerequisites for carbon emission *** monthly data of global atmospheric carbon dioxide(CO_(2))and methane(CH4)column concentrations(hereinafter XCO_(2) and XCH_(4),respectively)retrieved by the Greenhouse Gas Observation Satellite(GOSAT),we analyzed the variations in XCO_(2)and XCH_(4)in China during 2010-2022 after confirming the reliability of the ***,the influence of a strong El Niño event in 2015-2016 on XCO_(2) and XCH_(4) variations in China was further *** results show that the retrieved XCO_(2) and XCH_(4) from GOSAT have similar temporal variation trends and significant correlations with the ground observation and emission inventory data of an atmospheric background station,which could be used to assess the variations in XCO_(2) and XCH_(4) in ***_(2) is high in spring and winter while XCH_(4) is high in *** XCO_(2) and XCH_(4) gradually declined from Southeast China to Northwest and Northeast China,with variation ranges of 401-406 and 1.81-1.88 ppmv,respectively;and the high value areas are located in the middle-lower Yangtze River ***_(2) and XCH_(4) in China increased as a whole during 2010-2022,with rapid enhancement and high levels of XCO_(2) and XCH_(4) in several *** significant increases in XCO_(2) and XCH_(4) over China in 2016 might be closely related to the strong El Niño-Southern Oscillation(ENSO)event during *** a global warming background in 2015,XCO_(2) and XCH_(4) increased by 0.768%and 0.657%in 2016 in *** analysis reveals that both the XCO_(2) and XCH_(4) variations might reflect the significant impact of the ENSO event on glacier melting in the Tibetan Plateau.

关键词： greenhouse gases column concentration CO_(2) CH4 El Niño-Southern Oscillation(ENSO) El Niño

Clinical efficacy of endovascular revascularization combined with vacuum-assisted closure for the treatment of diabetic foot

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World Journal of Diabetes 2024年第7期15卷 1499-1508页

作者： feng-rui Lei Xiao-Fei Shen Chuang Zhang Xin-Qing Li Hao Zhuang Hong-Fei Sang Department of Vascular Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BACKGROUND The diabetic foot is a common cause of disability and death,and comorbid foot infections usually lead to prolonged hospitalization,high healthcare costs,and a significant increase in amputation *** most diabetic foot trauma is complicated by lower extremity arteriopathy,which becomes an independent risk factor for major amputation in diabetic foot *** To establish the efficacy and safety of endovascular revascularization(ER)combined with vacuum-assisted closure(VAC)for the treatment of diabetic *** Clinical data were collected from 40 patients with diabetic foot admitted to the Second Affiliated Hospital of Soochow University from April 2018 to April *** foot lesions were graded according to Wagner’s classification,and blood flow to the lower extremity was evaluated using the ankle-brachial index test and computerized tomography angiography of the lower extremity *** subcutaneous insulin infusion pumps were used to achieve glycemic *** limb revascularization was facilitated by percutaneous transluminal balloon angioplasty(BA)or *** were cleaned by nibbling *** granulation tissue growth was induced by VAC,and wound repair was performed by skin grafting or skin flap *** Of the 35 cases treated with lower limb revascularization,34 were successful with a revascularization success rate of 97%.Of these,6 cases underwent stenting after BA of the superficial femoral artery,and 1 received popliteal artery stent *** the 25 cases treated with infrapopliteal artery revascularization,39 arteries were reconstructed,7 of which were treated by drug-coated BA and the remaining 32 with plain old *** was performed in 32 ***-four cases of skin grafting and 2 cases of skin flap transplantation were *** patients underwent major amputations,whereas 17 had minor amputations,accounting for a success limb salvage rate of 95%.CONCLUSION ER in

关键词： Diabetic foot Revascularization Vacuum-assisted closure Balloon angioplasty Wound repair

Compressive performance of innovative reinforced pillars in closed/abandoned mines

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Journal of Central South University 2024年第8期31卷 2780-2793页

作者： Li, Jian Bai, Jin-wen feng, Guo-rui Wang, Shan-yong Zhao, Hong-chao Mi, Jia-chen Pan, rui-kai Shi, Xu-dong Ma, Jun-biao College of Mining Engineering Taiyuan University of Technology Taiyuan China Key Laboratory of Shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of Technology Taiyuan China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan China Priority Research Centre for Geotechnical Science and Engineering School of Engineering The University of Newcastle Callaghan Australia School of Geology and Mining Engineering Xinjiang University Urumqi China Department of Mining Engineering Shanxi Institute of Energy Jinzhong China

Pillar is closely related to the stability and reliability of underground spaces in closed/abandoned mines. The present research introduced a new technique to strengthen square cement mortar columns via fiber-reinforced polymer (FRP) strips to verify the strengthening effect of FRP on pillars. Compared to a fully wrapped FRP jacket, the advantages of FRP strip are cost-effective and easy-to-construct. A series of compression tests as well as theoretical analysis were carried out to explore the mechanical behavior of square cement mortar specimens partially strengthened with FRP strips. The results verified the effectiveness of FRP strips in enhancing the stress and strain of cement mortar. Different from unconfined cement mortar specimens, these FRP-strengthened cement mortar specimens are featured with the double-peaked behaviors, mainly attributed to the stress state transformation from a one-dimensional to a three-dimensional stress state. It also indicated that the enhancement of stress increased with the FRP strip width. Moreover, the brittle-ductile transition ductile failure characteristics were also observed in FRP-confined cement mortar specimens. The ultimate ductility of the cement mortar specimen decreases gradually with the growth of the FRP strip width. The main contribution of this research is to enrich the strengthening techniques for residual pillars.

关键词： brittle-ductile transition double-peaked behaviors fiber-reinforced polymer partially strengthening uniaxial compression

基于半监督学习的驾驶路怒情绪低侵入度分级辨识方法

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中国公路学报 2024年第8期37卷 231-247页

作者：柴晨冯蕊同济大学道路与交通工程教育部重点实验室

为实时监控驾驶过程中的路怒情绪，及时进行有效的干预和调整，提出一种准确高效的驾驶路怒情绪分级辨识方法。基于侵入度较低的驾驶行为及语音特征展开，并采用半监督学习方法建立模型，以减少对数据标签的依赖，提高小样本低标注条件... 详细信息

为实时监控驾驶过程中的路怒情绪，及时进行有效的干预和调整，提出一种准确高效的驾驶路怒情绪分级辨识方法。基于侵入度较低的驾驶行为及语音特征展开，并采用半监督学习方法建立模型，以减少对数据标签的依赖，提高小样本低标注条件下路怒辨识的准确性。通过开展由30人参与的高仿真驾驶模拟试验采集驾驶数据，利用滑动时间窗截取路怒事件后，提取特征形成路怒驾驶数据集。在此基础上，将半监督学习(Semi-supervised Learning, SSL)的伪标签融合于梯度提升机算法(Gradient Boosting Machine, GBM)建立SSL-GBM模型，充分发掘数据内部信息以降低对人工标注的依赖，并在自动机器学习框架中自动化完成数据处理、特征工程、模型搜索、参数优化等流程，从而实现驾驶路怒水平的分类判别。研究结果表明：路怒驾驶情绪辨识模型在预测路怒5级评分中，准确率能够达到90.3%,相较于已有模型中表现最好者提高了3.7%;特别对于2～5级路怒的识别准确度均有2.5%以上的提升，检测失效的比例大幅降低。在驾驶全程路怒水平的预测中，模型表现出应用于实时路怒检测的优秀表征能力和泛化性能，由此验证了方法的有效性和合理性。研究结果可为驾驶辅助系统提升危险驾驶监测能力提供技术支撑，在路怒驾驶状态判别方面具有重要的实际应用价值。

关键词：交通工程路怒识别半监督学习自动机器学习驾驶模拟器交通安全驾驶人