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The osteogenic niche-targeted arsenic nanoparticles prevent colonization of disseminated breast tumor cells in the bone

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Acta Pharmaceutica Sinica B 2022年第1期12卷 364-377页

作者： Cong Liu Anzhi Hu Huijuan Chen Jing Liang Mancang Gu Yang Xiong Chao-feng mu School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Center for Synthetic Biochemistry Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou Institute of Biomaterials and EngineeringWenzhou 325011China

Up to 70% of patients with late-stage breast cancer have bone metastasis. Current treatment regimens for breast cancer bone metastasis are palliative with no therapeutic cure. Disseminated tumor cells(DTCs) colonize inside the osteogenic niches in the early stage of bone metastasis. Drug delivery into osteogenic niches to inhibit DTC colonization can prevent bone metastasis from entering its late stage and therefore cure bone metastasis. Here, we constructed a 50% DSS6 peptide conjugated nanoparticle to target the osteogenic niche. The osteogenic niche was always located at the endosteum with immature hydroxyapatite. Arsenic-manganese nanocrystals(around 14 nm) were loaded in osteogenic niche-targeted PEG-PLGA nanoparticles with an acidic environment-triggered arsenic release. Arsenic formulations greatly reduced 4 T1 cell adhesion to mesenchymal stem cells(MSCs)/preosteoblasts(pre-OBs) and osteogenic differentiation of osteoblastic cells. Arsenic formulations also prevented tumor cell colonization and dormancy via altering the direct interaction between 4 T1 cells and MSCs/*** chemotactic migration of 4 T1 cells toward osteogenic cells was blocked by arsenic in mimic 3 D osteogenic niche. Systemic administration of osteogenic niche-targeted arsenic nanoparticles significantly extended the survival of mice with 4 T1 syngeneic bone metastasis. Our findings provide an effective approach for osteogenic niche-specific drug delivery and suggest that bone metastasis can be effectively inhibited by blockage of tumor cell colonization in the bone microenvironment.

关键词： Bone metastasis Osteogenic niche Breast cancer Arsenic trioxide Bone marrow Bone colonization Arsenic-manganese nanocrystal Immature hydroxyapatite

Comparison Between the Effects of 2-Selenium Bridged β-Cyclodextrin and Ebselen on Treating SHRsp Stroke

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Chemical Research in Chinese Universities 2008年第3期24卷 322-329页

作者： JIA Zhi-dan LIN feng LIU Lei mu Ying YAN Gang-lin LUO Gui-min Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education Jilin University Changchun 130021 P R. China

A glutathione peroxidase（GPX） mimic, 2-selenium bridged β-cyclodextrin（2-SeCD）, was synthesized. In order to examine its role and mechanism in treating stroke we chose stroke-prone spontaneously hypertensive rats（SHRsp） as animal model. 56 SHRsps of 8-week olds were randomly divided into several groups： test groups （low, moderate, high dose of 2-SeCD） and control groups（positive and negative）. After onset of the stroke, the rats in test groups were orally administrated with different amounts of 2-SeCD, the positive control group with ebselen, and the negative control group with drinking water. The treatment lasted two weeks, followed by observation of the rats for 10 days, meanwhile blood pressure, biochemical parameters of plasma, and the contents of nitric oxide（NO） and malondialdehyde（MDA） in plasma and brain were determined. The results show that there were significant differences in contents of NO and MDA in plasma and brain between the test groups（high, moderate dose of 2-SeCD） and negative control group. The NO contents of the test groups were obviously higher than that of the negative control group （P〈0.01）. The MDA contents of the test groups（high, moderate dose of 2-SeCD） were obviously lower than that of the negative control group（P〈0.01）. The mechanism of 2-SeCD in treating stroke was discussed, which maybe related to the increase of NO and the decrease of MDA in plasma and brain tissue, but the exact mechanism should be further studied. Moreover, the tendencies of changes in systolic blood pressure, contents of NO and MDA, and other physiological parameters for the test groups were shown to be much better than the corresponding parameters for the positive group（the group with ebselen）（P〈0.05）, indicating that the treatment effect of 2-SeCD is better than that of ebselen.

关键词： 2-Selenium bridged β-cyclodextrin Glutathione peroxidase Enzyme mimic Stroke Stroke-prone spontaneously hypertensive rat Nitric oxide Malondialdehyde

Relative peripheral refraction in school children with different refractive errors using a novel multispectral refraction topographer

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1477-1482页

作者： Hui-Ling Hu Serena Zhe-Chuang Li Ai-Ying feng Hao-Xi Zhong Jing-feng mu Mei-Zhou Liu Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina NIMO Ophthalmology Research Institute Beijing 100176China

AIM:To compare relative peripheral refraction(RPR)in Chinese school children with different refractive errors using multispectral refraction topography(MRT).METHODS:A total of 713 eyes of primary school children[172 emmetropia(E),429 low myopia(LM),80 moderate myopia(MM),and 32 low hypermetropia(LH)]aged 10 to 13y were *** were measured using MRT without *** results showed RPR at 0-15°(RPR 0-15),15°-30°(RPR 15-30),and 30°-45°(RPR 30-45)annular in the inferior(RPR-I),superior(RPR-S),nasal(RPR-N),and temporal(RPR-T)*** equivalent(SE)was detected and calculated using an ***:There were significant differences of RPR 15-30 between groups MM[0.02(-0.12;0.18)]and LH[-0.13(-0.36;0.12)](P<0.05),MM and E[-0.06(-0.20;0.10)](P<0.05),and LM[-0.02(-0.15;0.15)]and E(P<0.05).There were also significant differences of RPR 30-45 between groups MM[0.45(0.18;0.74)]and E[0.29(-0.09;0.67)](P<0.05),and LM[0.44(0.14;0.76)]and E(P<0.001).RPR values increased from the hyperopic to medium myopic group in each *** were significant differences of RPR-S between groups MM[-0.02(-0.60;0.30)]and E[-0.44(-0.89;-0.04)](P<0.001),and LM[-0.28(-0.71;0.12)]and E(P<0.05).There were also significant differences of RPR-T between groups MM[0.37(0.21;0.78)]and LH[0.14(-0.52;0.50)](P<0.05),LM[0.41(0.06;0.84)]and LH(P<0.05),and LM and E[0.29(-0.10;0.68),P<0.05].A Spearman’s correlation analysis showed a negative correlation between RPR and SE in the 15°-30°(P=0.005),30°-45°(P<0.05)annular(P=0.002),superior(P<0.001),and temporal(P=0.001)***:Without pupil dilation,values for RPR 15-30,30-45,RPR-S,and T shows significant differences between myopic eyes and emmetropia,and the differences are negatively correlated with SE.

关键词： relative peripheral refraction myopia school children multispectral refraction topography

Extreme Ultraviolet Frequency Comb with More than 100μW Average Power below 100nm

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Chinese Physics Letters 2020年第12期37卷 48-51页

作者： Jin Zhang Lin-Qiang Hua Zhong Chen mu-feng Zhu Cheng Gong Xiao-Jun Liu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Extreme ultraviolet(XUV)frequency comb is a powerful tool in precision *** also brings many new opportunities to the field of strong field physics since high harmonic generation related phenomena can be studied with high repetition *** demonstrate the generation of an XUV frequency comb with the aid of intra-cavity high harmonic generation *** setup is driven by a high power infrared frequency comb,and an average power of 4.5 kW is reached in the femtosecond enhancement *** Xe gas as the working media,harmonics up to the 19th order are *** measurement indicates that as much as 115.9μW(1.3 mW)are generated at^94 nm(~148 nm).The shortest wavelength we can reach is^55 *** coherence of the generated light is tested with an optical-heterodyne-based measurement of the third *** resulted line width is^3 *** addition,with this system,we also observe a strong suppression of below threshold harmonics from O2 compared to that from *** results suggest that the current system is ready for precision spectroscopic measurements with few-electron atomic and molecular systems in XUV region as well as the study of strong field physics with an unprecedented 100 MHz repetition rate.

关键词： process. harmonic harmonics

Effect of impurity scattering on superconductivity in K2Cr3As3

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Science China(Physics,Mechanics & Astronomy) 2016年第5期59卷 2-6页

作者： Yi Liu Jin-Ke Bao Hao-Kun Zuo Abduweli Ablimit Zhang-Tu Tang Chun-mu feng Zeng-Wei Zhu Guang-Han Cao Department of Physics Zhejiang University Hangzhou 310027 China Collaborative Innovation Centre of Advanced Microstructures Nanjing 210093 China Wuhan National High Magnetic Field Center School of Physics Huazhong University of Science and Technology Wuhan 430074 China State Key Lab of Silicon Materials Zhejiang University Hangzhou 310027 China

Impurity scattering in a superconductor may serve as an important probe for the nature of superconducting pairing state. Here we re- port the impurity effect on superconducting transition temperature Te in the newly discovered Cr-based superconductor K2Cr3As3. The resistivity measurements show that the crystals prepared using high-purity Cr metal （≥99.99%） have an electron mean free path much larger than the superconducting coherence length. For the crystals prepared using impure Cr that contains various non- magnetic impurities, however, the Tc decreases significantly, in accordance with the generalized Abrikosov-Gor＇kov pair-breaking theory. This finding supports a non-s-wave superconductivity in K2Cr3As3.

关键词： superconductivity impurity effect K2Cr3As3

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

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World Journal of Clinical Cases 2019年第15期7卷 2065-2074页

作者： Ji-Bing Chen Zhong-Bao Pan Duan-Ming Du Wei Qian Yang-Yang Ma feng mu Ke-Cheng Xu Central Laboratory Fuda Cancer Hospital of Jinan UniversityGuangzhou 510665Guangdong ProvinceChina Intervention Department of Shenzhen Second People’s Hospital Shenzhen 518035Guangdong ProvinceChina

BACKGROUND We present the case of a 72-year-old female patient with gallbladder cancer(GBC)who developed in situ recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur(a fluoropyrimidine derivative)chemotherapy,which failed to control the progression of the *** patient further developed metastases in the lymph nodes around the head of the *** patient had severe anemia,requiring weekly blood *** gallbladder tumor invaded the descending part of the duodenum,causing intestinal leakage and hepatic colonic *** SUMMARY The patient refused other treatments and began daily hydrogen inhalation *** 1 mo of treatment,the gallbladder and liver tumors continued to progress,and intestinal obstruction *** continuous hydrogen therapy and symptomatic treatments including gastrointestinal decompression and intravenous nutrition support,the intestinal obstruction was gradually *** months after hydrogen therapy,the metastases in the abdominal cavity gradually reduced in size,her anemia and hypoalbuminemia were corrected,lymphocyte and tumor marker levels returned to normal,and the patient was able to resume normal *** This is the first report of an efficacy and safety study about hydrogen therapy in patient with metastatic GBC and a critical general condition,who has remained stable for more than 4 months.

关键词： Hydrogen gas Metastatic gallbladder cancer Case report

Automated optical inspection of FAST’s reflector surface using drones and computer vision

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Light(Advanced Manufacturing) 2023年第1期4卷 1-11页

作者： Jianan Li Shenwang Jiang Liqiang Song Peiran Peng feng mu Hui Li Peng Jiang Tingfa Xu Beijing Institute of Technology Beijing 100081China National Astronomical Observatories of China Beijing 100107China Beijing Institute of Technology Chongqing Innovation Center Chongqing401135China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)is the world’s largest single-dish radio *** large reflecting surface achieves unprecedented sensitivity but is prone to damage,such as dents and holes,caused by naturally-occurring falling ***,the timely and accurate detection of surface defects is crucial for FAST’s stable *** manual inspection involves human inspectors climbing up and examining the large surface visually,a time-consuming and potentially unreliable *** accelerate the inspection process and increase its accuracy,this work makes the first step towards automating the inspection of FAST by integrating deep-learning techniques with drone ***,a drone flies over the surface along a predetermined *** surface defects significantly vary in scale and show high inter-class similarity,directly applying existing deep detectors to detect defects on the drone imagery is highly prone to missing and misidentifying *** a remedy,we introduce cross-fusion,a dedicated plug-in operation for deep detectors that enables the adaptive fusion of multi-level features in a point-wise selective fashion,depending on local defect ***,strong semantics and fine-grained details are dynamically fused at different positions to support the accurate detection of defects of various scales and *** AI-powered drone-based automated inspection is time-efficient,reliable,and has good accessibility,which guarantees the long-term and stable operation of FAST.

关键词： FAST Drone Deep learning Feature fusion

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铁路车站取送车作业问题的一般模型

中国铁道科学 2011年第5期32卷 114-119页

作者：牟峰王慈光薛锋西华大学交通与汽车工程学院四川成都610039 西南交通大学交通运输学院四川成都610031

在各种装卸地点布置形式、各种到发车流、各种取送车作业组织方式条件下,将合理取送顺序、合理取送批次数和合理取送时机作为一个整体,研究铁路车站取送车作业问题。以取送车作业顺序偏序关系、装卸区容车能力、相异放射枝不能同批、调... 详细信息

在各种装卸地点布置形式、各种到发车流、各种取送车作业组织方式条件下,将合理取送顺序、合理取送批次数和合理取送时机作为一个整体,研究铁路车站取送车作业问题。以取送车作业顺序偏序关系、装卸区容车能力、相异放射枝不能同批、调机牵引能力、交货时间窗为约束条件,以站内货车处于取送车作业状态的时间最少为优化目标,建立取送车作业问题的一般模型。模型的每个解都对应1个完整的取送车作业方案,设计了解的编码型式。利用排列组合理论和方法分析取送车作业问题解的结构关系,证明取送车作业问题是具有取送车作业批次和顺序2个优化维度的调度问题。

关键词：车站作业取送车作业二维组合优化建模

Total hip arthroplasty （THA） for the treatment of end-stage osteochondritis dissecans （OD） of the femoral head

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复旦学报（医学版） 2013年第4期40卷 501-504页

作者： YUAN Heng-feng YANG mu-yi XU Wei-dong Department of Orthopedic Changhai Hospital Second Military Medical University Shanghai 200433 China

Osteochondritis dissecans(OD)is an idiopathic,localized disorder where articular cartilage and subchondral bone become separated and fragmentized from the articular surface[1-2]This unusual disease usually affects the distal part of the femur,humerus and ankle[3].However,OD of the femoral head is rarely seen which was generally and typically reported as a complication of Perthes' disease or congenital dislocation of the hip[4-5].

关键词：软骨骨炎症状治疗方法