检索结果-南通市图书馆

Higher-order topology induced by structural buckling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第8期9卷 55-61页

作者： Huaqing Huang Feng Liu School of Physics Peking University Collaborative Innovation Center of Quantum Matter Center for High Energy Physics Peking University Department of Materials Science and Engineering University of Utah

Higher-order topological insulator(HOTI) states, such as two-dimension(2D) HOTI featured with topologically protected corner modes at the intersection of two gapped crystalline boundaries, have attracted much recent interest. However, the physical mechanism underlying the formation of HOTI states is not fully understood, which has hindered our fundamental understanding and discovery of HOTI materials. Here we propose a mechanistic approach to induce higher-order topological phases via structural buckling of 2D topological crystalline insulators(TCIs). While in-plane mirror symmetry is broken by structural buckling, which destroys the TCI state, the combination of mirror and rotation symmetry is preserved in the buckled system, which gives rise to the HOTI state. We demonstrate that this approach is generally applicable to various 2D lattices with different symmetries and buckling patterns, opening a horizon of possible materials to realize 2D HOTIs. The HOTIs so generated are also shown to be robust against buckling height fluctuation and in-plane displacement. A concrete example is given for the buckledβ-Sb monolayer from first-principles calculations. Our finding not only enriches our fundamental understanding of higher-order topology, but also opens a new route to discovering HOTI materials.

关键词： higher-order topological insulators structural buckling rotation-reflection symmetry buckled honeycomb antimony monolayer

Nuclear cGAS: sequestration and beyond

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2022年第2期13卷 90-101页

作者： Juli Bai Feng Liu Departments of Pharmacology University of Texas Health at San AntonioSan AntonioTXUSA National Clinical Research Center for Metabolic Diseases Metabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangsha 410011China

The cyclic GMP-AMP(cGAMP)synthase(cGAS)has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway.In the past several years,a growing body of evidence has revealed that cGAS is also localized in the nucleus where it is associated with distinct nuclear substructures such as nucleosomes,DNA replication forks,the double-stranded breaks,and centromeres,suggesting that cGAS may have other functions in addition to its role in DNA sensing.However,while the innate immune function of cGAS is well established,the non-canonical nuclear function of cGAS remains poorly understood.Here,we review our current understanding of the complex nature of nuclear cGAS and point to open questions on the novel roles and the mechanisms of action of this protein as a key regulator of cell nuclear function,beyond its well-established role in dsDNA sensing and innate immune response.

关键词： cGAS STING innate immunity nuclear translocation DNA damage repair micronuclei

因为坚持所以幸运——中国建研院中建研科技股份有限公司总裁刘枫

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工程建设标准化 2023年第2期 66-78页

作者：刘枫中国建研院中建研科技股份有限公司中国工程建设标准化协会空间结构专委会中国钢结构协会中国钢结构协会空间结构分会专家组

我是一个地道的理科生,一路语文成绩平平,却一直很喜欢码字,闺女小时候,我还给她记了五六年的blog,洋洋洒洒写了一百多篇,“读书少”所以文章中从来没有华丽词藻,全靠质朴情感取胜。这些年因为懒而荒了笔,接到关于“结构师灵魂N问”的邀... 详细信息

我是一个地道的理科生,一路语文成绩平平,却一直很喜欢码字,闺女小时候,我还给她记了五六年的blog,洋洋洒洒写了一百多篇,“读书少”所以文章中从来没有华丽词藻,全靠质朴情感取胜。这些年因为懒而荒了笔,接到关于“结构师灵魂N问”的邀约,欣欣然接受。

关键词：理科生语文成绩文章

维普期刊数据库

Optimizing mechanical properties of magnesium alloys by philosophy of thermo-kinetic synergy:Review and outlook

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第2期10卷 346-383页

作者： Tianle Wang Feng Liu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’anShaanxi 710072China Analytical&Testing Center Northwestern Polytechnical UniversityXi’anShaanxi 710072China

Although several strategies(including grain refinement,texture adjustment,precipitation hardening,etc.)have been verified to effectively improve the mechanical properties of lightweight magnesium(Mg)alloys,considerable efforts are still needed to be made to comprehensively understand the potential mechanisms controlling complex microstructures and deformation behaviors exhibited by the hexagonal close-packed host lattice of Mg,thus assisting the rational design of materials at a more physical level.As the cornerstone of this review,a universal rule,the so-called synergy of thermodynamics and kinetics(i.e.,thermo-kinetic diversity,correlation and connectivity),including a recently proposed theory of generalized stability(GS),is introduced to deepen our understanding on common behaviors in Mg alloys(i.e.,deformations(slip and twining modes),phase transformations(especially for precipitations)and interactions in between)at a new perspective.Guided by the GS theory,typical cases for Mg alloys design are qualitatively evaluated to reemphasize the traditional strengthening and toughening strategies mentioned above and to illuminate their exquisite coordination for breaking through the trade-off relationship between strength and ductility,corresponding to a typical thermo-kinetic pair(i.e.,high driving force(ΔG)-high GS).To produce the Mg alloys with superior strength-ductility balances,the potential capacity of this GS theory for guiding processing path design is discussed,finally。

关键词： Magnesium alloys Synergy of thermodynamics and kinetics Generalized stability Superior strength-ductility balance

维普期刊数据库

Prediction of giant and ideal Rashba-type splitting in ordered alloy monolayers grown on a polar surface

在线全文

学校读者我要写书评

暂无评论

National Science Review 2021年第4期8卷 100-106页

作者： Mingxing Chen Feng Liu Key Laboratory for Matter Microstructure and Function of Hunan Province Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Synergetic Innovation Center for Quantum Effects and Applications(SICQEA)School of Physics and Electronics Hunan Normal University Department of Materials Science and Engineering University of Utah

A large and ideal Rashba-type spin-orbit splitting is desired for the applications of materials in spintronic devices and the detection of Majorana fermions in solids. Here, we propose an approach to achieve giant and ideal spin-orbit splittings through a combination of ordered surface alloying and interface engineering,that is, growing alloy monolayers on an insulating polar surface. We illustrate this unique strategy by means of first-principle calculations of buckled hexagonal monolayers of Sb Bi and Pb Bi supported on Al2O3(0001). Both systems display ideal Rashba-type states with giant spin-orbit splittings, characterized with energy offsets over 600 meV and momentum offsets over 0.3 ?-1, respectively. Our study thus points to an effective way of tuning spin-orbit splitting in low-dimensional materials to draw immediate experimental interest.

关键词： Rashba effect interface spin-orbit coupling

cGAS-STING signaling and function in metabolism and kidney diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2021年第10期13卷 728-738页

作者： Juli Bai Feng Liu Department of Pharmacology University of Texas Health at San AntonioSan AntonioTX 78229USA National Clinical Research Center for Metabolic Diseases Metabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangsha 410011China

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway senses the presence of cytosolic DNA and,in turn,triggers downstream signaling to induce the expression of inflammatory and type I interferon genes in immune cells.Whereas the innate immune function of the cGAS-STING pathway is well studied over the past years,emerging evidence suggests that this signaling pathway may have additional functions beyond innate immune surveillance.Consistent with this notion,dysregulation of the cGAS-STING signaling pathway in adipocytes,hepatocytes,and renal proximal tubule epithelial cells are associated with metabolic dysfunction,impaired energy homeostasis,and kidney diseases.In this review,we summarize current understanding of the cGAS-STING pathway in several metabolic diseases such as obesity,insulin resistance,alcoholic and nonalcoholic fatty liver diseases,as well as acute kidney injury and chronic kidney disease.We also review the interaction between the cGAS-STING pathway and lipid metabolism.Lastly,we discuss potential mechanisms by which cGAS-STING signaling regulates metabolism and point toward future avenues of research targeting the cGAS-STING pathway as possible means to treat common metabolic disorders.

关键词： cGAS STING obesity NAFLD NASH AKI CDK

COVID-19 and cardiovascular diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2021年第3期13卷 161-167页

作者： Fan liu Feng Liu Lu Wang State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The coronavirus disease 2019(COVID-19)remains a global public health emergency.Despite being caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),besides the lung,this infectious disease also has severe implications in the cardiovascular system.In this review,we summarize diverse clinical complications of the heart and vascular system,as well as the relevant high mortality,in COVID-19 patients.Systemic inflammation and angiotensin-converting enzyme 2-involved signaling networking in SARS-CoV-2 infection and the cardiovascular system may contribute to the manifestations of cardiovascular diseases.Therefore,integration of clinical observations and experimental findings can promote our understanding of the underlying mechanisms,which would aid in identifying and treating cardiovascular injury in patients with COVID-19 appropriately.

关键词： COVID-19 cardiovascular diseases SARS-CoV-2 ACE2 systemic inflammation

Three-dimensional structure of the antennal lobe in the Southern house mosquito Culex quinquefasciatus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2021年第1期28卷 93-102页

作者： Zi Ye Feng Liu Nannan liu Department of Biological Sciences Vanderbilt UniversityNashvilleTennesseeUSA Department of Entomology and Plant Pathology Auburn UniversityAuburnAlabamaUSA

The Southern house mosquito Culex quinquefasciatus relies on its olfactory system to locate the human hosts for blood meals,by which several deadly diseases are transmitted.Olfactory sensory neurons(OSNs)housed in the sensilla on the olfactory appendages send their axons into the antennal lobes(ALs),the primary olfactory center in the brain,where the OSNs expressing the same olfactory receptors converge upon the same spherical structures known as glomeruli in the AL.The structure of the antennal lobe,that is,the spatial organization of the glomeruli,governs the insect's odor identification and discrimination.Drosophila studies have demonstrated the specific connections between receptors and glomeruli based on the 3D structure of the antennal lobe,deepening our understanding of the relationships between glomerular activities and behaviors,but as yet the structure of the Cx.quinquefasciatus antennal lobe remains unknown.We therefore constructed a 3D model of the Cx.quinquefasciatus antennal lobe using nc82 antibody staining,identifying 62 and 44 glomeruli in the female and male mosquito antennal lobe,respectively,with a significant sexual dimorphism in terms of the antennal lobe volume and glomerulus number.These results demonstrate the structural basis of mosquito odor coding and provide a platform for future studies of the mosquito olfactory signal processing mechanism.

关键词： 3D-reconstruction antennal lobe Culex quinquefasciatus glomerulus olfaction

T cell metabolism in obesity and beyond:comments on‘DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-y production’

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2021年第5期13卷 389-391页

作者： Haiyan Zhou Feng Liu National Clinical Research Center for Metabolic Diseases Metabolic Syndrome Research Centerand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangsha 410011China Department of Pharmacology University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA

T cells have long been known as the core of adaptive immunity and play piv-otal roles in host defense(Zhu et al.,2010).There are two main types of T cells in our body,cytotoxic T cells(CD8^(+))and helper T(Th)cells(CD4^(+)),the latter comprised of Th1,Th2,Th17,and Treg subsets.Increasing evidence supports that metabolic reprogramming of T cells leads to dramatic changes in tissue microenvironments,which may alter whole-body energy homeostasis and metabolism,beyond their roles in adaptive immunity(Varanasi et al.,2020).

关键词： metabolism immunity