检索结果-南通市图书馆

The development and application of silicon Neutron Transmutation Doping (NTD) technology in China

在线全文

学校读者我要写书评

暂无评论

Engineering Sciences 2009年第4期7卷 95-100页

作者： Qiao Chenyang Sun Zhiyong Ke Guotu Lu Cungang Shen feng Chen huiqiang China Institute of Atomic Energy Beijing 102413 China

The research and development history of silicon Neutron Transmutation Doping (NTD) technology and its applications at home and abroad are introduced in this *** advantages of NTD,compared with conventional technology of doping,are *** principle of NTD as well as the implementation of the main procedures related to Si NTD is *** market demand tendency is prospected,and the advanced measures on NTD quality control are described.

关键词： monocrystal silicon Neutron Transmutation Doing (NTD) uniformity doping accuracy application design

在线全文

学校读者我要写书评

暂无评论

岩土中的附加应力和实质应力

辽宁工程技术大学学报（自然科学版） 2016年第4期35卷 371-375页

作者：尚军冯慧强伊尧国李琳天津城建大学土木工程学院天津300384 天津城建大学地质与测绘学院天津300384

为分析岩土中的附加应力和实质应力,建立科学合理的强度准则和本构模型,根据土结构性形成的条件,给出适用于土的应力状态变量.在既有总应力和附加应力概念的基础上,给出了实质应力的概念.认为控制土强度和本构关系的应力变量不是所谓总... 详细信息

为分析岩土中的附加应力和实质应力,建立科学合理的强度准则和本构模型,根据土结构性形成的条件,给出适用于土的应力状态变量.在既有总应力和附加应力概念的基础上,给出了实质应力的概念.认为控制土强度和本构关系的应力变量不是所谓总应力和附加应力,而是实质应力.在此基础上,分析了三轴实验中的实质应力状态演变和基坑开挖过程中三种应力的变化过程,从而进一步印证了实质应力的合理性.

关键词：应力表示总应力附加应力实质应力本构关系

以K_0固结线为基准的修正Lade-Duncan模型

在线全文

学校读者我要写书评

暂无评论

辽宁工程技术大学学报（自然科学版） 2016年第3期35卷 289-293页

作者：冯慧强高凌霞王冲于珊天津城建大学土木工程学院天津300384 大连民族大学土木建筑工程学院辽宁大连116650 中国地质大学工程学院湖北武汉430074

针对传统塑性力学中土的屈服曲面是以等倾线为轴的各向同性曲面,无法考虑原状土的K0固结这一常规初始状态以及各向异性等结构性属性,在描述原状土的屈服、破坏等力学性能时不能很好地拟合试验的问题,类似等倾线与π平面,以K0固结线为轴... 详细信息

针对传统塑性力学中土的屈服曲面是以等倾线为轴的各向同性曲面,无法考虑原状土的K0固结这一常规初始状态以及各向异性等结构性属性,在描述原状土的屈服、破坏等力学性能时不能很好地拟合试验的问题,类似等倾线与π平面,以K0固结线为轴线,建立了可以反映土的各向异性的χ平面.并在此基础上构造了适用于原状土的修正Lade-Duncan模型.对既有π平面上真三轴试验数据的数学分析表明,修正Lade-Duncan模型能更客观的描述原状土的屈服、破坏、各向异性等结构性属性.

关键词：各向异性屈服面等倾线 K0固结线 χ平面 Lade-Duncan破坏准则

Microstructural characterization of electron beam welded joints of TiAl-based in-termetallic compound

在线全文

学校读者我要写书评

暂无评论

工程科学学报 2005年第2期 221-221页

作者： WU huiqiang, feng Jicai, HE Jingshan, ZHOU Li National Key Laboratory of Advanced Welding Production Technology, Harbin Institute of Technology, Harbin 150001, China

The feasibility to use electron beam welding to join the nominal composition Ti-48Al-2Cr-2Nb alloy was assessed. The microstructure characterization and cracking susceptibility of the joints were evaluated by means of OM, SEM, XRD, and microhardness. It was found that the welded microstructure exhibited columnar and dendritic structures. Microstructural constituents in the fusion zone were a massive gamma structure and some amount of lamellar structure consisting of alternating platelets of α2 and γ. The major contributing factor to the susceptibility to solidification cracking was microsturctural change in this study for the suppression of α phase decomposition leading to produce more retained α2 brittle phase. Compared with transgranular cleavage fracture in the base metal, the weld metal exhibited mainly translamellar fracture.

关键词： electron beam welding titanium aluminide microstructure crack

Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu Ru feng Wenyu Li Yin Xiao Xinxiu Liu Yu Chen Xiaoxiao Wang Bing Bai Huijing Wu Qingqing Cai Zhiming Li Jibin Li Suxia Lin Yanxia He Liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian Zhao huiqiang Huang State Key Laboratory of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

Histone demethylase Bcjarl regulating pathogenic development and virulence of the gray mold fungus Botrytis cinerea

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Histone demethylase Bcjarl regulating pathogenic development...

中国植物病理学会2019年学术年会

作者： Hou Jie feng huiqiang Chang Haowu Liu Yue Li Guihua Yang Song Sun Chenhao Zhang Mingzhe Yuan Ye Sun Jiao Zhang Hao Qin Qingming College of Plant Sciences Jilin University College of Forestry BeiHua University College of Computer Science and Technology Jilin University

Histone 3 Lysine 4（H3K4） demethylation is ubiquitous in organisms;however,the roles of H3K4 demethylase JARID1（Jar1）/KDM5 in the development and pathogenesis of fungal pathogens remain largely ***,we demonstrate that Jar1/KDM5 in Botrytis cinerea,the gray mold fungus,plays crucial roles in these *** BcJAR1 gene was deleted in *** wild-type strain B05.10 and was reintroduced into the BcJAR1 deletion mutant to generate the complemented strains via Agrobacterium tumefaciens-mediated transformation（ATMT） *** roles of BcJAR1 in the fungus development and pathogenesis were investigated using approaches of genetics,molecular/cell biology,pathogenicity and transcriptomic *** findings demonstrate that Bcjar1 is a H3K4 demethylase and is functionally equivalent to ScJhd2,the sole H3K4 demethylase in Saccharomyces cerevisiae that belongs to the ***1 regulates H3K4 me3 and H3K4 me2/me3 methylation levels during vegetative and pathogenic development,*** of BcJAR1 impairs conidiation,appressorium formation and stress adaptation;abolishes infection cushion（IC） formation and virulence,but promotes sclerotium production,of the △BcJar1 ***1 mediates reactive oxygen species（ROS） production and proper accumulation and assembly of Sep4,a virulence determinant that initiates infection structure（IFS） formation and host *** cAMP partially restored the ability of appressorium formation,but failed to rescue IC formation of the △Bcjar1 mutants,suggesting that cAMP can trigger processes that bypass the defect resulting from the absence of the histone ***1 orchestrates global expression of genes related to ROS production,stress response,carbohydrate transmembrane transport,secondary metabolites,etc.,which are required for conidiation,IFS formation,host penetration,and virulence of the gray mold *** work systematically elucidates BcJar1 functions and provides novel insights

关键词： Botrytis cinerea H3K4 demethylase JARID1(Jar1)/KDM5 stress adaptation infection structures development and pathogenesis septin protein Sep4 reactive oxygen species cAMP signaling

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

象山港海域细菌的分布特征及其环境影响因素

生态学报 2011年第14期31卷 4007-4018页

作者：杨季芳王海丽陈福生屠霄霞陈吉刚冯辉强华中农业大学食品科学技术学院湖北武汉430070 宁波市微生物与环境工程重点实验室宁波315100 浙江万里学院生物与环境学院宁波315100 宁波市象山港海洋环境监测站宁波315141

于2007年的7月(夏季)、11月(秋季)与2008年的1月(冬季)、4月(春季)用高保真、无扰动重力柱状取样器替代常规抓斗式采样,首次系统研究了象山港海域的水样(表层海水和上覆水)及沉积物中细菌丰度的时空分布特征,并采用主成分分析及多元逐... 详细信息

于2007年的7月(夏季)、11月(秋季)与2008年的1月(冬季)、4月(春季)用高保真、无扰动重力柱状取样器替代常规抓斗式采样,首次系统研究了象山港海域的水样(表层海水和上覆水)及沉积物中细菌丰度的时空分布特征,并采用主成分分析及多元逐步回归分析方法研究了影响细菌丰度时空分布的主要环境因素,结果表明:调查期间象山港海域的细菌的丰度较高,象山港海域的富营养化较严重。调查期间象山港海域水样及沉积物样品中细菌丰度实测值的变化范围为1.50×105?9.78×1010个/mL(个/g),总均值为2.76×109个/mL(个/g);季节分布特征为夏季(7月)极显著高于其他季节,赤潮的暴发导致春季(4月)的调查结果最低。浮游细菌丰度表现为底层均大于表层的垂直分布特征;平面分布特征均为从港顶到港口递减、养殖区高于非养殖区、电厂附近海域出现较高值的趋势,近岸人类的工农业活动造成的陆源污染及海水增养殖活动造成的养殖污染是造成此分布特征的主要原因。多元统计结果表明:溶解氧、水温、营养盐(N、P)、pH以及有机质污染等是影响该海域细菌丰度的最主要因素。

关键词：象山港海洋细菌丰度环境因素

在线全文

学校读者我要写书评

暂无评论

广东省三级综合医院辐射防护安全现状调查

护理学杂志 2016年第15期31卷 59-61页

作者：赖敏华张容冯惠强广东省医学科学院/广东省人民医院护理部广东广州510080 广东省卫生与计划生育委员会

目的调查广东省三级综合医院辐射防护安全现状。方法采用自行设计的医院辐射防护安全问卷对广东省5所三级综合医院的302名介入放射医务人员进行调查。结果医院辐射防护安全得分为(95.32±14.30)分(满分112分),其中得分最高的维度是机器... 详细信息

目的调查广东省三级综合医院辐射防护安全现状。方法采用自行设计的医院辐射防护安全问卷对广东省5所三级综合医院的302名介入放射医务人员进行调查。结果医院辐射防护安全得分为(95.32±14.30)分(满分112分),其中得分最高的维度是机器维护(3.76±0.80)分;最低为个人防护设备(3.02±0.92)分。不同工作类别、学历及介入放射科工龄的医务人员得分差异有统计学意义(P<0.05,P<0.01)。结论广东省5所三级综合医院在辐射防护设备建设方面有待加强,培训体系有待健全,配套管理体系有待进一步完善。

关键词：综合医院介入放射学辐射防护安全

在线全文

学校读者我要写书评

暂无评论

基于多网络融合的船舶寻迹和导航终端开发

全球定位系统 2015年第2期40卷 76-80页

作者：沈光冯辉强田增山杨进超宁波市海洋与渔业信息监测中心浙江宁波315000 重庆邮电大学移动通信技术重庆市重点实验室重庆400065

随着船舶营运和作业范围的越来越大,自然环境和国际环境的变化,船舶面临的风险逐年升高,对船舶寻迹和导航系统越来越迫切。针对船舶营运的特性及无线网络特性,设计了北斗短信/移动蜂窝网/Zigbee多网融合的船舶寻迹和导航终端,对终端进... 详细信息

随着船舶营运和作业范围的越来越大,自然环境和国际环境的变化,船舶面临的风险逐年升高,对船舶寻迹和导航系统越来越迫切。针对船舶营运的特性及无线网络特性,设计了北斗短信/移动蜂窝网/Zigbee多网融合的船舶寻迹和导航终端,对终端进行设计和开发,测试验证该终端可以有效保证对船舶的定位和导航。

关键词：多网络融合船舶寻迹北斗定位北斗短信