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构建新发展格局:时代背景、实践意义和实践路径

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中国商论 2024年第1期 29-32页

作者：冯昊王建辉沈阳工业大学辽宁沈阳110870

构建以国内大循环为主体、国内国际双循环相互促进的新发展格局,是以习近平同志为核心的党中央立足我国发展实际作出的重大决策,这一决策将长期指导我国宏观经济实现高质量增长。高质量发展是全面建设社会主义现代化国家的首要任务,推... 详细信息

构建以国内大循环为主体、国内国际双循环相互促进的新发展格局,是以习近平同志为核心的党中央立足我国发展实际作出的重大决策,这一决策将长期指导我国宏观经济实现高质量增长。高质量发展是全面建设社会主义现代化国家的首要任务,推动高质量发展必须以构建新发展格局为基础,深刻认识和把握新发展格局的科学内涵,构建新发展格局的实践意义及积极探索其实现路径,对努力实现高质量发展具有十分重要的指导意义。

关键词：新发展格局高质量发展双循环创新型国家社会主义现代化

Multi-objective reentry trajectory optimization method via GVD for hypersonic vehicles

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Journal of Systems Engineering and Electronics 2017年第4期28卷 732-744页

作者： Chaofang Hu Yue Xin hao feng School of Electrical Engineering and Automation Tianjin University Tianjin 300072 China

In the constrained reentry trajectory design of hypersonic vehicles, multiple objectives with priorities bring about more difficulties to find the optimal solution. Therefore, a multi-objective reentry trajectory optimization (MORTO) approach via generalized varying domain (GVD) is proposed. Using the direct collocation approach, the trajectory optimization problem involving multiple objectives is discretized into a nonlinear multi-objective programming with priorities. In terms of fuzzy sets, the objectives are fuzzified into three types of fuzzy goals, and their constant tolerances are substituted by the varying domains. According to the principle that the objective with higher priority has higher satisfactory degree, the priority requirement is modeled as the order constraints of the varying domains. The corresponding two-side, single-side, and hybrid-side varying domain models are formulated for three fuzzy relations respectively. By regulating the parameter, the optimal reentry trajectory satisfying priorities can be achieved. Moreover, the performance about the parameter is analyzed, and the algorithm to find its specific value for maximum priority difference is proposed. The simulations demonstrate the effectiveness of the proposed method for hypersonic vehicles, and the comparisons with the traditional methods and sensitivity analysis are presented.

关键词： hypersonic vehicle reentry trajectory design multi-objective optimization generalized varying domain direct collocation method

铁死亡相关基因作为皮肤黑色素瘤预后因素的多组学分析

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中南大学学报（医学版） 2024年第2期49卷 159-174页

作者：吴猛李可廖阳英李蓝肖潇陈勇健郭俊玮辰胡丰曲靖汪政冯浩湖南省人民医院皮肤科长沙410002 湖南省中医药研究院附属医院(湖南省中西医结合医院)皮肤科长沙410006 湖南第一师范学院计算机学院长沙410205

目的:黑色素瘤具有高度恶性和异质性。开发特定的黑色素瘤预后预测模型对提高患者的生存率和选择治疗策略至关重要。最近,铁死亡已被证明是一种由过度脂质过氧化诱导的铁依赖性程序性细胞死亡形式。然而,铁死亡相关基因(ferroptosis-rel... 详细信息

目的:黑色素瘤具有高度恶性和异质性。开发特定的黑色素瘤预后预测模型对提高患者的生存率和选择治疗策略至关重要。最近,铁死亡已被证明是一种由过度脂质过氧化诱导的铁依赖性程序性细胞死亡形式。然而,铁死亡相关基因(ferroptosis-related genes,FRGs)与黑色素瘤预后的相关性仍不清晰。本研究评估FRGs在黑色素瘤中的作用,开发一种新的预后模型,旨在为黑色素瘤的个性化治疗及疗效改善提供新思路。方法:首先通过系统地表征癌症基因组图谱(The Cancer Genome Atlas,TCGA)-皮肤黑色素瘤(skin cutaneous melanoma,SKCM)中73个FRGs的遗传改变和mRNA表达。同时通过反转录聚合酶链反应和蛋白质印迹法验证筛选的特定靶基因。随后使用TCGASKCM队列构建多基因特征模型。根据特征模型将黑色素瘤患者分为高风险和低风险组,对铁死亡相关的特征模型与免疫特征、免疫治疗的疗效或药物反应进行相关分析。结果:通过分析TCGA-SKCM数据集中的黑色素瘤样本,发现FRGs在基因变异和拷贝数变异方面表现出高频率,这些变化显著影响了基因的表达。此外,与正常皮肤组织相比,在黑色素瘤组织中发现了30个显著差异表达的基因。随后使用LASSO Cox回归方法构建的FRGs相关预后模型成功识别了13个与患者总体生存预后相关的FRGs,并通过外部数据集验证了该模型的有效性。最后,功能富集和免疫响应结果分析进一步表明高风险和低风险组之间存在免疫细胞浸润、突变负担和低氧状态的显著差异,且该模型能有效预测免疫治疗响应和药物敏感性。结论:本研究建立了一种强预后预测模型,可为黑色素瘤患者的靶向治疗和免疫治疗提供新的方向。

关键词：皮肤黑色素瘤铁死亡风险评分免疫疗法靶向治疗肿瘤微环境

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基于SEM模型的热环境时空特征及影响因素分析:以西安都市圈为例

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环境科学 2024年第6期45卷 3734-3745页

作者：张颖王旭红冯子豪苑嘉欣余孟千禧西北大学城市与环境学院西安710127 陕西省地表系统与环境承载力重点实验室西安710127

城市热环境是评价城市生态环境的重要指标之一,直接关系到居民健康及城市经济可持续发展,但目前研究缺乏自然和人文多维因子对热环境的影响路径分析.基于西安都市圈2020年MODISMYD11A2地表温度数据,辅以气象、地表因子和人类活动等数据... 详细信息

城市热环境是评价城市生态环境的重要指标之一,直接关系到居民健康及城市经济可持续发展,但目前研究缺乏自然和人文多维因子对热环境的影响路径分析.基于西安都市圈2020年MODISMYD11A2地表温度数据,辅以气象、地表因子和人类活动等数据,综合利用ArcGIS空间地统计分析、冗余分析(RDA)和结构方程模型(SEM),研究城市热环境在不同季节的时空分布特征,揭示城市热环境的主要影响因素并量化其直接和间接效应.结果表明:①西安都市圈的地表温度呈现北高南低,自城市中心向四周递减的空间格局,夏季热环境污染最严重.②冗余分析表明影响热环境的主要因素为:气温、不透水地表、植被和降水.③SEM结果显示,气象、地表和人类活动因子对城市热环境的直接影响显著并占主导地位,气温、不透水面和兴趣点密度对热环境有显著的直接正效应(0.10~0.33),水体、降水和植被对热环境有显著的直接负效应(-0.29~-0.25).人类活动对夜晚地表温度的直接影响力高于地表因子和气象因子,提高经济效益有利于缓解城市热环境效应.以上结果可为城市热岛局地气候变化研究和绿色生态宜居城市环境建设提供科学参考.

关键词：城市热环境地表温度(LST) 冗余分析(RDA) 结构方程模型(SEM) 西安都市圈

基于非期望产出SBM模型和重心模型的重庆市农业生态效率测评

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湖北农业科学 2024年第3期63卷 177-182页

作者：冯浩夏国峰尤显平重庆三峡学院重庆404100

使用非期望产出SBM模型、相关性分析模型和重心模型等研究方法,测评2010—2018年重庆市农业生态效率、各年份重庆市农业生态效率空间分布的相关性和农业生态效率重心时空演化轨迹。结果表明,2010—2018年重庆市各年份农业生态效率呈波... 详细信息

使用非期望产出SBM模型、相关性分析模型和重心模型等研究方法,测评2010—2018年重庆市农业生态效率、各年份重庆市农业生态效率空间分布的相关性和农业生态效率重心时空演化轨迹。结果表明,2010—2018年重庆市各年份农业生态效率呈波动上升趋势,农业生态效率空间分布由负相关性转变为正相关性,农业生态效率的重心偏移呈螺旋状均散落在重庆市长寿区。

关键词：农业生态效率非期望产出SBM模型重心模型相关性分析重庆市

Intermittent Fault Diagnosability of Interconnection Networks

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Journal of Computer Science & Technology 2017年第6期32卷 1279-1287页

作者： Jia-Rong Liang hao feng Xiaojiang Du School of Computer and Electronic Information Guangxi University Nanning 530004 China Department of Computer and Information Sciences Temple University Philadelphia PA 19122 U.S.A.

An interconnection network＇s diagnosability is an important metric for measuring its self-diagnostic capability. Permanent fault and intermittent fault are two different fault models that exist in an interconnection network. In this paper, we focus on the problem pertaining to the diagnosability of interconnection networks in an intermittent fault situation. First, we study a class of interconnection networks called crisp three-cycle networks, in which the Chin-number （the number of common vertices each pair of vertices share） is no more than one. Necessary and sufficient conditions are derived for the diagnosability of crisp three-cycle networks under the PMC （Preparata, Metze, and Chien） model. A simple check can show that many well-known intereonnection networks are crisp three-cycle networks. Second, we prove that an intereonnection network S is a ti-fault diagnosable system without repair if and only if its minimum in-degree is greater than ti under the BGM （Barsi, Grandoni, and Masetrini） model. Finally, we extend the necessary and sufficient conditions to determine whether an interconnection network S is ti-fault diagnosable without repair under the MM （Maeng and Malek） model from the permanent fault situation to the intermittent fault situation.

关键词： diagnosability intermittent fault PMC(Preparata,Metze,and Chien)model BGM(Barsi,Grandoni,and Masetrini)model MM(Maeng and Malek)model

Differential methylation analysis for bisulfite sequencing using DSS

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Quantitative Biology 2019年第4期7卷 327-334页

作者： hao feng hao Wu Department of Population and Quantitative Health Sciences Case Western Reserve UniversityClevelandOH 44106USA Department of Biostatistics and Bioinformatics Emory University Rollins School of Public HealthAtlantaGA 30322USA

Bisulfite sequencing(BS-seq)technology measures DNA methylation at single nucleotide resolution.A key task in BSseq data analysis is to identify differentially methylation(DM)under different *** we provide a tutorial for BS-seq DM analysis using Bioconductor package *** uses a beta-binomial model to characterize the sequence counts from BS-seq,and implements rigorous statistical method for hypothesis *** provides flexible functionalities for a variety of DM analyses.

关键词： epigenetics DNA methylation bisulfite sequencing differential methylation

Unsupervised change detection of man-made objects using coherent and incoherent features of multi-temporal SAR images

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Journal of Systems Engineering and Electronics 2022年第4期33卷 896-906页

作者： feng hao WU Jianzhong ZHANG Lu LIAO Mingsheng State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China Key Laboratory of Land Subsidence Monitoring and Prevention Ministry of Land and ResourcesShanghai 200072China Shanghai Engineering Research Center of Land Subsidence Shanghai 200072China Shanghai Institute of Geological Survey Shanghai 200072China

Constrained by complex imaging mechanism and extraordinary visual appearance,change detection with synthetic aperture radar(SAR)images has been a difficult research topic,especially in urban *** existing studies have extended from bi-temporal data pair to multi-temporal datasets to derive more plentiful information,there are still two problems to be solved in practical ***,change indicators constructed from incoherent feature only cannot characterize the change objects ***,the results of pixel-level methods are usually presented in the form of the noisy binary map,making the spatial change not intuitive and the temporal change of a single pixel *** this study,we propose an unsupervised man-made objects change detection framework using both coherent and incoherent features derived from multi-temporal SAR *** coefficients of variation in timeseries incoherent features and the man-made object index(MOI)defined with coherent features are first combined to identify the initial change ***,an improved spatiotemporal clustering algorithm is developed based on density-based spatial clustering of applications with noise(DBSCAN)and dynamic time warping(DTW),which can transform the initial results into noiseless object-level patches,and take the cluster center as a representative of the man-made object to determine the change pattern of each *** experiment with a stack of 10 TerraSAR-X images in Stripmap mode demonstrated that this method is effective in urban scenes and has the potential applicability to wide area change detection.

关键词： change detection multi-temporal synthetic aperture radar(SAR)data coherent and incoherent features clustering

Atomic-scale simulations for lithium dendrite growth driven by strain gradient

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Applied Mathematics and Mechanics(English Edition) 2020年第4期41卷 533-542页

作者： Gao XU feng hao Jiawang HONG Daining FANG State Key Laboratory for Turbulence and Complex Systems&Center for Applied Physics and Technology College of EngineeringPeking UniversityBeijing 100871China Department of Engineering Mechanics Shandong UniversityJinan 250100China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China

Dendrite formation is a major obstacle, e.g., capacity loss and short circuit,to the next-generation high-energy-density lithium(Li)-metal batteries. The development of successful Li dendrite mitigation strategies is impeded by an insu?cient understanding in Li dendrite growth mechanisms. The Li-plating-induced internal stress in Li-metal and its e?ects on dendrite growth have been widely studied, but the underlying microcosmic mechanism is elusive. In the present study, the role of the plating-induced stress in dendrite formation is analyzed through ?rst-principles calculations and ab initio molecular dynamic(AIMD) simulations. It is shown that the deposited Li forms a stable atomic nano?lm structure on the copper(Cu) substrate, and the adsorption energy of Li atoms increases from the Li-Cu interface to the deposited Li surface, leading to more aggregated Li atoms at the interface. Compared with the pristine Li-metal, the deposited Li in the early stage becomes compacted and su?ers the in-plane compressive stress. Interestingly,there is a giant strain gradient distribution from the Li-Cu interface to the deposited Li surface, making the deposited atoms adjacent to the Cu surface tend to press upwards with perturbation and causing the dendrite growth. This provides an insight into the atomicscale origin of Li dendrite growth, and may be useful for suppressing the Li dendrite in Li-metal-based rechargeable batteries.

关键词： lithium(Li)-metal-based battery Li dendrite strain gradient depositing