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Journal of Iron and Steel Research International 2024年第5期31卷 1127-1138页

作者： Hao Li Hong-mei Chen Xu Zhang Qian-hao Zang Jing Zhang di feng Yan-xin Qiao Yu-hang Guo School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina School of Metallurgy and Materials Engineering Jiangsu University of Science and TechnologySuzhou215600JiangsuChina

The solidification methods of electromagnetic stirring(EMS)and non-electromagnetic stirring were employed to prepare Mg–6Gd–3Y–xZn–0.6Zr(x=1,1.5,2,3)*** evolution of alloy microstructures and the changes in properties were analyzed for different Zn *** has been observed that in alloys without electromagnetic stirring,as the Zn content increases,the alloy structure gradually *** primary second phase transitions from Mg5RE phase to long-period stacking ordered(LPSO)phase,resulting in improved hardness and *** alloys subjected to electromagnetic stirring,there is a relatively higher content of the second phase,primarily consisting of LPSO *** applying electromagnetic stirring,the quantity and the type of LPSO phase in the alloy *** alloy structure becomes more uniform with electromagnetic stirring,resulting in increased hardness and reduced hardness gradients within the *** mechanical properties of alloys with electromagnetic stirring are superior to those without electromagnetic stirring.

关键词： Rare earth magnesium alloy LPSO phase Electromagnetic stirring Casting Property

Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

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Genes & diseases 2024年第2期11卷 1066-1081页

作者： Junyan Yan Lu Xiao di feng Baolin Chen Ting Yang Bei Tong Ruifang Luo Yuting Wang Jie Chen Children Nutrition Research Center Children's Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Child Nutrition and HealthMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing 401122China Department of Gastroenterology Children's Hospital of Chongqing Medical UniversityChongqing 401122China

Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier ***-chain fatty acids (SCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is ***,there is an urgent need to understand how and which SCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAN),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of SCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAN groups were enriched by RNA *** the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were ***,the above changes in the VAD groups were rescued by VA supplementation in the early postnatal *** study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its *** findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely postnatal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy.

关键词： CEACAM1 Colonic epithelial barrier HDAC3 Short-chain fatty acids Vitamin A deficiency

Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome

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World Journal of Gastroenterology 2024年第6期30卷 527-541页

作者： Xin Li Li-Jiang Ji Kai-di feng Hua Huang Mei-Rou Liang Shi-Jin Cheng Xiu-Dong Meng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Department of Anorectal Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu 215500Jiangsu ProvinceChina College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel *** ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with *** are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and *** NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or *** evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of ***,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in ***,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are ***,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关键词： Ulcerative colitis Exosomes Inflammasome Evidence Therapeutics

Cytochrome P450 CitCYP97B modulates carotenoid accumulation diversity by hydroxylating b-cryptoxanthin in Citrus

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Plant Communications 2024年第6期5卷 57-72页

作者： Yingzi Zhang Jiajing Jin Nan Wang Quan Sun di feng Shenchao Zhu Zexin Wang Shunxin Li Junli Ye Lijun Chai Zongzhou Xie Xiuxin Deng National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Carotenoids in plant foods provide health benefits by functioning as provitamin *** ofthe vital provitamin A carotenoids,b-cryptoxanthin,is typically plentiful in citrus ***,little is known about the genetic basis of b-cryptoxanthin accumulation in ***,we performed a widely targeted metabolomic analysis of 65 major carotenoids and carotenoid derivatives to characterize carotenoid accumulation in Citrus and determine the taxonomic profile of *** used data from 81 newly sequenced representative accessions and 69 previously sequenced Citrus cultivars to reveal the genetic basis of b-cryptoxanthin accumulation through a genome-wide association *** identified a causal gene,CitCYP97B,which encodes a cytochrome P450 protein whose substrate and metabolic pathways in land plants were *** subsequently demonstrated that CitCYP97B functions as a novel monooxygenase that specifically hydroxylates the b-ring of b-cryptoxanthin in a heterologous expression *** planta experiments provided further evidence that CitCYP97B negatively regulates b-cryptoxanthin *** the sequenced Citrus accessions,we found that two critical structural cis-element variations contribute to increased expression of CitCYP97B,thereby altering b-cryptoxanthin accumulation in ***/introgression appear to have contributed to the prevalence of two cis-element variations in different Citrus types during citrus ***,these findings extend our understanding of the regulation and diversity of carotenoid metabolism in fruit crops and provide a genetic target for production of b-cryptoxanthin-biofortified products.

关键词： carotenoids b-cryptoxanthin cytochrome P450 CYP97B hydroxylation

Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 251-254页

作者： Mo-Wei Kong feng-di Sun Zhen-Ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-Qing Tang Ting-Fang Yang Guo-Xiang He Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the article published in World J Gastrointest Oncol 2019,11:*** specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal *** significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors,the incidence and mortality rates of treatment-related car-diotoxicity have been increasing,severely impacting the survival and prognosis of cancer *** drugs are widely used as antimetabolites in the treatment of malignant tumors,including gastrointestinal tumors,and they represent the second largest class of drugs associated with ***,there is often a lack of awareness or understanding regarding their cardiotoxic effects and associated risks.

关键词： Cardiotoxicity Gastrointestinal tumors Risk factors Fluoropyrimidine Chest pain

The causes of adverse reactions in traditional Chinese medicine

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Toxicology Advances 2024年第1期6卷 1-2页

作者： Kai-di feng Yu-Jie Zeng Xiao-Hui Yang Xin-Ju Li College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Integrated Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

With the increasingly widespread application of traditional Chinese medicine in clinical practice,the safety of traditional Chinese medicine has been given more *** occurrence of adverse drug reactions of traditional Chinese medicine will harm the health of patients,leading to a certain incidence rate and mortality rate,and serious adverse drug reactions of traditional Chinese medicine will lead to increased treatment costs of patients,bringing huge economic burden to patients and society[1-3].

关键词： mortality clinical bringing

基于电场传感器阵列的输电线路电压非接触式测量方法

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高电压技术 2024年第1期50卷 292-301页

作者：冯迪刘灏李嘉贤毕天姝华北电力大学新能源电力系统国家重点实验室北京102206 国网冀北电力有限公司电力科学研究院北京100054

电压作为表征线路运行状态的重要参量,实现其灵活准确的测量对保证电力系统稳定运行至关重要。传统的接触式电压测量方法,因电压互感器体积较大、会产生电磁谐振和高频振荡、额外测量需断电安装等问题,对于海量化测量并不便利。相比较而... 详细信息

电压作为表征线路运行状态的重要参量,实现其灵活准确的测量对保证电力系统稳定运行至关重要。传统的接触式电压测量方法,因电压互感器体积较大、会产生电磁谐振和高频振荡、额外测量需断电安装等问题,对于海量化测量并不便利。相比较而言,非接触式测量不接触导线,更加安全和便捷,将成为未来电压测量的发展方向。文中提出了基于电场传感器阵列的输电线路电压非接触式测量方法,该方法为了解决导线位置信息未知的问题,设计了与导线方向垂直排列的电场传感器阵列;求解了含导线未知信息量的方程组;构建了比例系数矩阵,反推出导线电压瞬时值;分析了电场传感器对测量的影响;最后,进行了10 kV电压等级电压瞬时值仿真验证,结果显示最大测量误差为2.219%。

关键词：非接触式电压测量电压瞬时值模拟电荷法电场传感器阵列比例系数矩阵

直面地形的思考——山地民居与山地建筑设计体系关联研究

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建筑学报 2024年第6期 90-95页

作者：冯棣滕文皓陈科重庆大学建筑城规学院重庆400030 山地城镇建设与新技术教育部重点实验室重庆400030

探讨了重庆建筑工程学院建筑史学者如何从地形出发,总结了山地民居的"六法、十二法、十八法"法则,并在各个历史时期用以指导具体的山地建筑设计,最终构建出富有地域特色的山地建筑学科体系,且以此为传统,作为对抗当代山地建筑设计均质... 详细信息

探讨了重庆建筑工程学院建筑史学者如何从地形出发,总结了山地民居的"六法、十二法、十八法"法则,并在各个历史时期用以指导具体的山地建筑设计,最终构建出富有地域特色的山地建筑学科体系,且以此为传统,作为对抗当代山地建筑设计均质化的策略.

关键词：山地民居山地地形民居手法山地建筑设计

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基于多目标函数的避洪转移安置方案优化

人民长江 2024年第2期55卷 35-40页

作者：邓卓王媛冯迪河海大学水利水电学院江苏南京210024 河海大学土木与交通学院江苏南京210024

针对目前避洪转移方案仅考虑时间或距离成本最优导致部分安置点人数分配不合理的问题,从“安全第一、就近就便、平灾结合、利于管理”的避洪转移安置方案基本要求出发,首先对安置点的适用性、分布合理性及容量大小3个方面进行分析,依据... 详细信息

针对目前避洪转移方案仅考虑时间或距离成本最优导致部分安置点人数分配不合理的问题,从“安全第一、就近就便、平灾结合、利于管理”的避洪转移安置方案基本要求出发,首先对安置点的适用性、分布合理性及容量大小3个方面进行分析,依据“时间、距离、适宜度和安置容量”四因素初步筛选合适的安置点。然后通过路权函数建立避洪转移时间成本矩阵,以转移时间成本和安置点的优化分配为多目标函数确定避洪转移安置点的最优分配方案。最后以TOPSIS评价方法对避洪转移安置点分配的单目标方案与多目标方案进行对比分析。结果表明:多目标方案的相对接近度大于单目标方案,基于多目标函数确定的避洪转移安置分配方案更加合理。

关键词：避洪转移安置方案时间成本矩阵多目标函数洪水灾害

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虚拟演播室多机位特技窗口切换的设计与应用

广播与电视技术 2024年第8期51卷 91-94页

作者：冯迪辽宁110004

本文设计了一种虚拟演播室内多机位取景切换至特技窗口的录制形式,利用虚拟机的无轨控制功能实现了有限通道下的多场景制作,通过开发切换台SME级抠像功能制作了通道外的虚拟信号,使导播在节目录制中可独自操作切换台的信号分配与窗口切换。

关键词：虚拟演播室多机位特技窗口无轨控制 SME