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Nano Research 2023年第12期16卷 13042-13055页

作者： fenfen li Ying Zhao Guangjun Nie School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 101408China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China GBA National Institute for Nanotechnology Innovation Guangzhou 510530China

liver fibrosis and hepatic carcinoma(HCC)pose a huge challenge worldwide due to the lack of effective treatment options for end-stage liver *** to their functions and roles,hepatic myofibroblasts mainly include nontumoral fibroblasts(mainly activated hepatic stellate cells(HSCs)),which are involved in the wound-healing process of liver fibrosis,and cancer-associated fibroblasts(CAFs)in hepatic *** play a significant role in regulating extracellular matrix(ECM)deposition in progressive liver *** can be derived from activated HSCs and differentiate into ECM-producing ***,growing evidence shows that CAFs are the primary regulators of the HCC microenvironment,releasing growth factors and cytokines and suppressing the antitumor immune *** therapeutic strategies show reduced drug resistance and side ***-based combined strategies aim to improve the delivery efficiency of various therapeutic agents with reduced toxicity via multiple *** this review,we will discuss recent developments in combinational strategies based on nanotechnology that regulate myofibroblasts and the diseased microenvironment for liver fibrosis and HCC *** will also identify the major challenges that the field is facing and offer some insights for future drug discovery.

关键词： fibroblasts liver fibrosis hepatic carcinoma nanotechnology

Taxonomy and Phylogeny of a New Marine Planktonic Ciliate, Strombidium pseudorapulum sp. n. (Protozoa, Ciliophora, Oligotrichia)

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Journal of Ocean University of China 2020年第4期19卷 954-960页

作者： li fenfen HUANG Yaoyao YU Ying liU Weiwei liN Xiaofeng Laboratory of Protozoology Guangzhou Key Laboratory of Subtropical Biodiversity and BiomonitoringCollege of Life ScienceSouth China Normal UniversityGuangzhou 510631China Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of ScienceGuangzhou510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou Guangzhou511458China Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of SciencesGuangzhou 510301China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem College of the Environment and EcologyXiamen UniversityXiamen 361005China

As one of the main groups of marine planktonic protozoa,oligotrich ciliates have shown a high ***,a new aloricate oligotrich ciliate,Strombidium pseudorapulum *** isolated from coastal waters of southeast *** living morphology and infraciliature of this species were studied using live cell observation and protargol *** pseudorapulum *** from its congeners by having a radish-like body with a bumped anterior end and an elongated tail-like posterior end,possessing a red‘eyespot’in apical protrusion of cell,adoral zone of membranelles composed of 12–16 collar and 9–12 buccal membranelles,one spindle-shaped macronucleus,girdle kinety in anterior 2/5 of cell with 45–60 densely spaced dikinetids,and ventral kinety occupying about the posterior 1/3 of the cell with 16–19 *** pseudorapulum *** together with those species having‘eyespot’in apical protrusion in the phylogenetic tree based on the small subunit rRNA gene *** is a sister species of *** with 31 unmatched nucleotides between their SSU rRNA gene sequences.

关键词： aloricate oligotrichs morphology new species SSU rRNA gene sequence

Anti-lymphangiogenesis for boosting drug accumulation in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2161-2175页

作者： Chunling Wang Junchao Xu Xiaoyu Cheng Ge Sun fenfen li Guangjun Nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Sino-Danish College University of Chinese Academy of SciencesBeijing 100190China Sino-Danish Center for Education and Research Beijing 100190China Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for *** strategies aiming at regulating the intratumoral permeability of therapeutic drugs have been explored in preclinical studies,with a primary focus on vascular regulation and stromal ***,these methods may trigger or facilitate tumor metastasis as a ***,there is an urgent need for innovative strategies that boost intratumoral drug accumulation without compromising treatment *** another important factor affecting drug tumor accumulation besides vasculature and stroma,the impact of tumor-associated lymphatic vessels(LVs)has not been widely *** the current research,we verified that anlotinib,a tyrosine kinase inhibitor with anti-lymphangiogenesis activity,and SAR131675,a selective VEGFR-3 inhibitor,effectively decreased the density of tumor lymphatic vessels in mouse cancer models,further enhancing drug accumulation in tumor *** combining anlotinib with therapeutic drugs,including doxorubicin(Dox),liposomal doxorubicin(lip-Dox),and anti-PD-L1 antibody,we observed improved anti-tumor efficacy in comparison with monotherapy ***,this strategy significantly reduced tumor metastasis and elicited stronger anti-tumor immune *** work describes a new,clinically transferrable approach to augmenting intratumoral drug accumulation,which shows great potential to address the current,unsatisfactory efficacies of therapeutic drugs without introducing metastatic risk.

关键词： drugs angiogenesis metastasis

A tomato HD-zip I transcription factor, VAHOX1, acts as a negative regulator of fruit ripening

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Horticulture Research 2023年第1期10卷 140-151页

作者： fenfen li Mengjie Fu Shengen Zhou Qiaoli Xie Guoping Chen Xuqing Chen Zongli Hu Laboratory of Molecular Biology of Tomato Bioengineering CollegeChongqing UniversityChongqingChina Institute of Grassland Flowers and EcologyBeijing Academy of Agriculture and Forestry SciencesBeijingChina

Homeodomain-leucine zipper(HD-Zip)transcription factors are only present in higher plants and are involved in plant development and stress ***,our understanding of their participation in the fruit ripening of economical plants,such as tomato(Solanum lycopersicum),remains largely ***,we report that VAHOX1,a member of the tomato HD-Zip I subfamily,was expressed in all tissues,was highly expressed in breaker+4 fruits,and could be induced by *** repression of VAHOX1(VAHOX1-RNAi)resulted in accelerated fruit ripening,enhanced sensitivity to ethylene,and increased total carotenoid content and ethylene ***,VAHOX1 overexpression(VAHOX1-OE)in tomato had the opposite ***-Seq results showed that altering VAHOX1 expression affected the transcript accumulation of a series of genes involved in ethylene biosynthesis and signal transduction and cell wall ***,a dual-luciferase reporter assay,histochemical analysis of GUS activity and a yeast one-hybrid(Y1H)assay revealed that VAHOX1 could activate the expression of *** findings may expand our knowledge about the physiological functions of HD-Zip transcription factors in tomato and highlight the diversities of transcriptional regulation during the fruit ripening process.

关键词： effect. fruit tomato

Overexpression of SlOFP20 affects floral organ and pollen development

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Horticulture Research 2019年第1期6卷 154-169页

作者： Shengen Zhou Zongli Hu fenfen li Shibing Tian Zhiguo Zhu Anzhou li Guoping Chen Laboratory of Molecular Biology of Tomato Bioengineering CollegeChongqing UniversityChongqingPeople’s Republic of China Institute of Vegetable Research Chongqing Academy of Agricultural SciencesChongqingPeople’s Republic of China

The OVATE gene was initially identified in tomato and serves as a key regulator of fruit *** are 31 OFP members in the tomato ***,their roles in tomato growth and reproductive development are largely ***,we cloned the OFP transcription factor *** plants overexpressing SlOFP20 displayed several phenotypic defects,including an altered floral architecture and fruit shape and reduced male ***20 overexpression altered the expression levels of some brassinosteroid(BR)-associated genes,implying that SlOFP20 may play a negative role in the BR response,similar to its ortholog OsOFP19 in ***,the transcript accumulation of gibberellin(GA)-related genes was significantly affected in the transgenic ***20 may play an important role in the crosstalk between BR and *** pollen germination assay suggested that the pollen germination rate of SlOFP20-OE plants was distinctly lower than that of WT *** addition,the tomato pollen-associated genes SlCRK1,SlPMEI,LePRK3,SlPRALF,and LAT52 were all suppressed in the transgenic *** data imply that SlOFP20 may affect floral organ and pollen development by modulating BR and GA signaling in tomato.

关键词： floral expressing pollen

M2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy

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Journal of Materials Science & Technology 2021年第22期81卷 77-87页

作者： Wenshen Wang fenfen li Shibo li Yi Hu Mengran Xu Yuanyuan Zhang Muhammad Imran Khan Shaozhen Wang Min Wu Weiping Ding Bensheng Qiu National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering University of Science and Technology of ChinaHefei230027China The First Affiliated Hospital of Anhui Medical University Hefei230022China

Tumor-associated macrophages(TAMs)play an important role in tumor development and *** particular,M2 TAMs can promote tumor growth by facilitating tumor progression and malignant *** targeted elimination of M2 TAMs to inhibit tumor progression is of great significance for cancer *** oxide nanoparticles based magnetic hyperthermia therapy(MHT)is a classical approach to destroy tumor tissue with deep penetration *** this study,we developed a typical M2 macrophage-targeted peptide(M2pep)functionalized superparamagnetic iron oxide nanoparticle(SPIO)for magnetic resonance imaging(MRI)-guided MHT in an orthotopic breast cancer mouse *** obtained multifunctional SPIO-M2pep with a hydrodynamic diameter of 20 nm showed efficient targeting capability,high transverse relaxivity(149 mM^(-1) s^(-1))and satisfactory magnetic hyperthermia performance in *** vivo studies demonstrated that the SPIO-M2pep based MRI can monitor the distribution of nanoparticles in tumor and indicate the suitable timing for *** M2 macrophage-targeted MHT significantly reduced the tumor volume and the population of pro-tumoral M2 TAMs in *** addition,the SPIO-M2pep based MHT can remodel the tumor immune microenvironment(TIME).The multifunctional SPIO-M2pep with M2 macrophage-targeting ability,high magnetic hyperthermia efficiency,MR imaging capability and effective role in remodeling the TIME hold great potential to improve clinical cancer therapy outcomes.

关键词： M2 macrophages-targeted peptide Iron oxide nanoparticles Magnetic resonance imaging Magnetic hyperthermia therapy Tumor immune microenvironment

Self-assembly of CXCR4 antagonist peptide-docetaxel conjugates for breast tumor multi-organ metastasis inhibition

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3849-3861页

作者： Chen li Jiayan Lang Yazhou Wang Zhaoxia Cheng Mali Zu fenfen li Jingyi Sun Yating Deng Tianjiao Ji Guangjun Nie Ying Zhao CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center of Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Pancreas Centre the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001China School of Basic Medical Sciences Zhengzhou UniversityZhengzhou 450001China

As a representative chemotherapeutic drug,docetaxel(DTX)has been used for breast cancer treatment for ***,the poor solubility of DTX limits its efficacy,and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4(CXCR4)expression during the ***,we conjugated CXCR4 antagonist peptide(CTCE)with DTX(termed CTCE-DTX)as an anti-metastasis agent to treat breast ***-DTX could selfassemble to nanoparticles,targeting CXCR4-upregulated metastatic tumor cells and enhancing the DTX ***,the CTCE-DTX NPs achieved promising efficacy on inhibiting both bonespecific metastasis and lung metastasis of triple-negative breast *** work provided a rational strategy on designing peptide-drug conjugates with synergistic anti-tumor efficacy.

关键词： Triple-negative breast cancer CXCR4 Docetaxel Drug delivery Peptide-drug conjugates Tumor metastasis Drug formulation

A Case of Secondary Glaucoma due to Bilateral Anterior Chamber Shallowing Caused by Marfan′s Syndrome

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Eye Science 2011年第2期26卷 111-114页

作者： Chengguo Zuo fenfen Yu Mei li Yi Sun Xing liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen UniversityGuangzhou 510060 China

Purpose:To report the clinical manifestations and treatment of a case of secondary glaucoma evolving from bilateral anterior chamber flattening caused by Marfan′s syndrome. Methods:The ophthalmic and systemic features,B-scan and UBM characteristics were *** and efficacy were analyzed. Results:Marfans syndrome,in this case,caused bilateral iris-lens diaphragm anterior dislocation,anterior chamber flattening, pupillary block, angle closure,and finally resulted in persistent increased intraocular pressure (IOP). After undergoing pars plana vitrectomy and lensectomy combined with anterior chamber reformation, the visual acuity of the patient's right eye increased from 6/150 to 6/7.5.(best-corrected) and that of the left eye was improved from 6/100 to 6/10 (best-corrected). The IOP of the right eye fell to 18 mm Hg, and the left eye to 12 mm Hg. Conclusion:Marfan′s syndrome can cause bilateral anterior chambers flattening,and induce secondary angle closure *** pars plana vitrectomy, lensectomy and anterior chamberplasty can re-form the anterior chamber, control IOP and maintain visual function.

关键词：综合征青光眼继发性双边案例变浅毫米汞柱临床表现

Genomic instability and eye diseases

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Advances in Ophthalmology Practice and Research 2023年第3期3卷 103-111页

作者： Hongyan liu Jun Cheng Xiaoyun Zhuang Benxiang Qi fenfen li Bining Zhang Eye Institute of Shandong First Medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdaoChina School of Ophthalmology Shandong First Medical UniversityQingdaoChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdaoChina Eye Institute of Shandong First Medical University Eye Hospital of Shandong First Medical University(Shandong Eye Hospital)JinanChina Department of Ophthalmology School of Clinical MedicineWeifang Medical UniversityWeifangChina The Eye Hospital of Wenzhou Medical University HangzhouChina

Background:Genetic information is stored in the bases of double-stranded ***,the integrity of DNA molecules is constantly threatened by various mutagenic agents,including pollutants,ultraviolet light(UV),and *** counteract these environmental damages,cells have established multiple mechanisms,such as producing molecules to identify and eliminate damaged DNA,as well as reconstruct the original DNA *** or insufficiency of these mechanisms can cause genetic ***,the role of genome stability in eye diseases is still under-researched,despite extensive study in cancer *** text:As the eye is directly exposed to the external environment,the genetic materials of ocular cells are constantly under *** of the proteins essential for DNA damage repair,such as pRb,p53,and RAD21,are also key during the ocular disease *** this review,we discuss five ocular diseases that are associated with genomic *** and pterygium are linked to abnormal cell ***’corneal endothelial dystrophy and age-related macular degeneration are related to the accumulation of DNA damage caused by oxidative damage and *** mutation of the subunit of the cohesin complex during eye development is linked to ***:Failure of DNA damage detection or repair leads to increased genomic *** the role of genomic instability in ocular diseases can lead to the development of new treatments and strategies,such as protecting vulnerable cells from risk factors or intensifying damage to unwanted cells.

关键词： Genomic instability Ocular diseases Retinoblastoma Cornea Pterygium

TTA as a potential hole transport layer for application in conventional polymer solar cells

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Journal of Energy Chemistry 2020年第3期29卷 210-216页

作者： Le liu Saisai Zhou Chengjie Zhao Tonggang Jiu Fuzhen Bi Hongmei Jian Min Zhao Guodong Zhang Lejia Wang fenfen li Xunwen Xiao College of Material Science and Chemical Engineering Ningbo University of TechnologyNingbo 315211ZhejiangChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101ShandongChina

Hole transport layers(HTLs)play a vital role in organic solar cells(OSCs).In this work,a derivative of tetrathiafulvalene with four carboxyl groups TTA was introduced as a novel HTL to fabricate OSC with high *** a better energy level match between HTL and active layers,the TTA based devices show a peak power conversion efficiency of 9.09%,which is comparable to the devices based on PEDOT:*** favorable surface morphology recorded via atomic force microscopy,low series loss and charge recombination indicated by electrochemical impedance spectroscopy,synchronously verify the potential of TTA for application in OSCs as a valid kind of HTLs.

关键词： Organic solar cells Hole transport layer TTA Energy level Charge recombination