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Molecule Statistical Thermodynamics Simulation of Nanoindentation of Single Crystal Copper with EAM Potential

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Chinese Physics Letters 2011年第4期28卷 167-170页

作者： TAN Hao WANG Hai-Ying XIA Meng-fen KE fu-Jiu BAI Yi-Long State Key Laboratory of Nonlinear Mechanics(LNM) Institute of MechanicsChinese Academy of SciencesBeijing 100190 Graduate University of Chinese Academy of Sciences Beijing 100049 School of Physics and Nuclear Energy Engineering Beijing University of Aeronautics and AstronauticsBeijing 100191

The quasistatic nanoindentation process of a spherical indenter in a single crystal copper is investigated with the molecular statistical thermodynamics(MST)method based on the embedded atom method(EAM)*** indentation modulus obtained in the MST simulation is 129.9 GPa,which agrees well with the theoretical prediction(129GPa).In the elastic regime,the obtained maximum displacement of the indenter is two times the contact depth and the contact area is qualitatively proportional to the contact depth,which agrees well with Hertzian elastic theory of *** MST simulation can reproduce the nucleation of dislocation as ***,the efficiency of the MST method is about 8 times higher than that of traditional MD simulations.

关键词： Copper thermodynamics Crystal

The expression of oxidative stress genes related to myocardial ischemia reperfusion injury in patients with ST-elevation myocardial infarction

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World Journal of Emergency Medicine 2022年第2期13卷 106-113页

作者： Qian-lin Gu Peng Jiang Hui-fen Ruan Hao Tang Yang-bing Liang Zhong-fu Ma Hong Zhan Emergency Department the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000China Huangpu District Emergency Department the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000China

BACKGROUND:We aimed to investigate the gene expression of myocardial ischemia/reperfusion injury(MIRI)in patients with acute ST-elevation myocardial infarction(STEMI)using stress and toxicity pathway gene chip technology and try to determine the underlying ***:The mononuclear cells were separated by ficoll centrifugation,and plasma total antioxidant capacity(T-AOC)was determined by the ferric reducing ability of plasma(FRAP)*** expression of toxic oxidative stress genes was determined and verified by oligo gene chip and quantitative real-time polymerase chain reaction(qRT-PCR).Additionally,gene ontology(GO)enrichment analysis was performed on DAVID website to analyze the potential mechanism ***:The total numbers of white blood cells(WBC)and neutrophils(N)in the peripheral blood of STEMI patients(the AMI group)were significantly higher than those in the control group(WBC:11.67±4.85×10^(9)/L vs.6.41±0.72×10^(9)/L,Pfusion injury

关键词： Acute myocardial infarction Myocardial ischemia/reperfusion injury Oxidative stress TNFSF6 CYP1A1 Unfolded protein response

骨髓增殖性肿瘤患者血栓/出血事件的影响因素分析及其风险预测

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中国实验血液学杂志 2024年第4期32卷 1165-1172页

作者：赵阳阳冯友繁魏小芳李青芬黄秀娟伏媛张启科甘肃省人民医院血液科甘肃兰州730000

目的:分析骨髓增殖性肿瘤(MPN)患者的临床特征、血栓/出血事件的发生情况,探讨其影响因素并进行风险预测。方法:收集2016年1月至2021年9月就诊于甘肃省人民医院血液科的126例BCR-ABL融合基因阴性的MPN患者的临床资料,对其临床特征、血栓... 详细信息

目的:分析骨髓增殖性肿瘤(MPN)患者的临床特征、血栓/出血事件的发生情况,探讨其影响因素并进行风险预测。方法:收集2016年1月至2021年9月就诊于甘肃省人民医院血液科的126例BCR-ABL融合基因阴性的MPN患者的临床资料,对其临床特征、血栓/出血事件发生情况及影响因素进行回顾性分析和总结,并构建风险预测模型。结果:在126例MPN患者中,50例(39.7%)发生过血栓/出血事件,其中发生血栓事件44例(34.9%),出血事件6例(4.8%)。血栓性疾病中以脑血栓最常见(23/44,52.3%),其次是以指端和趾端动脉缺血、闭塞和坏疽为主要表现的四肢动脉血栓,共9例(9/44,20.5%);出血事件包括脑出血和胃肠道出血。单因素分析结果表明,高血压病史、高同型半胱氨酸血症、白细胞计数≥10×10^(9)/L、血细胞比容≥49%、血小板计数≥600×10^(9)/L以及JAK2V617F基因突变是MPN患者发生血栓/出血事件的危险因素,而CALR基因突变是保护性因素。多因素分析结果表明,高血压病史和血小板计数≥600×10^(9)/L为MPN患者发生血栓/出血事件的独立危险因素。构建的风险预测模型拟合优度P=0.872,ROC曲线下面积为0.838。临床验证模型预测的灵敏度为78.85%,特异度为87.83%,准确率为84.13%。结论:高白细胞计数伴有高血压和高同型半胱氨酸血症的MPN患者发生血栓/出血事件的风险更高,控制高血压及高同型半胱氨酸血症,降低白细胞和血小板数,有助于预防血栓/出血事件的发生,从而提高患者生存质量。

关键词：骨髓增殖性肿瘤血栓/出血事件临床特征影响因素风险预测

金龟子绿僵菌CQMa421和球孢白僵菌ZJU435对红火蚁毒力及聚硅氧烷的增效作用研究

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环境昆虫学报 2024年第2期46卷 377-388页

作者：吴慧敏白卫辉邓杰夫彭李亚林馥芬李珉珉陆永跃许益镌文引李平东王磊华南农业大学植物保护学院广州510642 深圳市农业科技促进中心深圳518057 重庆聚立信生物工程有限公司重庆401120

为探索红火蚁Solenopsis invicta的生物防治方法,本文系统评估了金龟子绿僵菌Metarhizium anisopliae CQMa421和球孢白僵菌Beauveria bassiana ZJU435对红火蚁的毒力以及聚硅氧烷对其的增效作用,并评估了两株虫生真菌对红火蚁的田间防... 详细信息

为探索红火蚁Solenopsis invicta的生物防治方法,本文系统评估了金龟子绿僵菌Metarhizium anisopliae CQMa421和球孢白僵菌Beauveria bassiana ZJU435对红火蚁的毒力以及聚硅氧烷对其的增效作用,并评估了两株虫生真菌对红火蚁的田间防治效果。结果显示,以处理第10天时的死亡率计算,金龟子绿僵菌CQMa421对红火蚁工蚁的致死中浓度LC_(50)为9.16×106孢子/mL;以8×10^(8)孢子/mL的死亡率计算,其对红火蚁工蚁的致死中时LT_(50)为3.534 d。以处理第10天时的死亡率计算,球孢白僵菌ZJU435对红火蚁工蚁的致死中浓度LC_(50)为1.5×10^(5)孢子/mL;以1×10^(9)孢子/mL的死亡率计算,其对红火蚁工蚁的致死中时LT_(50)为0.218 d。混入0.5μL/mL及以上浓度的聚硅氧烷可显著提高低浓度金龟子绿僵菌CQMa421及球孢白僵菌ZJU435对红火蚁毒力。田间试验结果显示,混入0.5μL/mL聚硅氧烷的3.2×10^(7)孢子/mL金龟子绿僵菌CQMa421和4×10^(7)孢子/mL球孢白僵菌ZJU435对红火蚁的综合防效分别为83.99%和90.44%,低于商品制剂0.1%茚虫威饵剂的综合防效93.89%。研究结果表明,金龟子绿僵菌CQMa421和球孢白僵菌ZJU435对红火蚁具有较高毒力,在红火蚁生物防治中具有较高开发潜力。

关键词：红火蚁金龟子绿僵菌球孢白僵菌表面活性剂灌巢

Characteristics of amino acid metabolism in colorectal cancer

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世界临床病例杂志 2023年第27期11卷 6318-6326页

作者： fen Xu Hong-Liang Jiang Wei-Wei feng Chen fu Jiang-Chang Zhou Department of Gastroenterology Xinhua Hospital Affiliated to Dalian UniversityDalian 116000Liaoning ProvinceChina

In recent years,metabolomics research has become a hot spot in the screening and treatment of *** is a popular technique for the quantitative characterization of small molecular compounds in biological cells,tissues,organs or *** study of the tumor revealed that amino acid changes may occur early in the *** rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino *** abundant supply of amino acids is important for cancer to maintain its proliferative driving *** in amino acid metabolism can be used to screen malignant tumors and improve therapeutic ***,it is particularly important to study the characteristics of amino acid metabolism in colorectal *** article reviews several specific amino acid metabolism characteristics in colorectal cancer.

关键词： Metabolomics Amino acid metabolism Colorectal cancer Glutamine

宏基因组二代测序在异基因造血干细胞移植后耶氏肺孢子菌肺炎诊断中的意义

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中华血液学杂志 2024年第1期45卷 62-67页

作者：符蓉林韧范志平黄芬许娜宣丽黄怡霏刘慧赵珂王治香蒋玲戴敏孙竞刘启发南方医科大学南方医院血液科南方医科大学血液病研究所广东省血液系统疾病临床医学研究中心广州510515

目的评估宏基因组二代测序(mNGS)对异基因造血干细胞移植(allo-HSCT)患者耶氏肺孢子菌肺炎(PJP)的诊断价值。方法纳入2019年6月至2023年8月南方医科大学南方医院血液科allo-HSCT后疑似肺感染并接受肺泡灌洗液病原学检测的98例患者,比较m... 详细信息

目的评估宏基因组二代测序(mNGS)对异基因造血干细胞移植(allo-HSCT)患者耶氏肺孢子菌肺炎(PJP)的诊断价值。方法纳入2019年6月至2023年8月南方医科大学南方医院血液科allo-HSCT后疑似肺感染并接受肺泡灌洗液病原学检测的98例患者,比较mNGS与常规方法、实时定量PCR(RQ-PCR)对PJP的诊断效能。结果12例患者最终诊断为PJP(确诊11例、临床诊断1例)。确诊患者中1例为常规方法和RQ-PCR检测均阳性,10例仅RQ-PCR阳性。12例患者mNGS均检出耶氏肺孢子菌。mNGS诊断PJP的敏感性为100%,高于常规方法(8.3%,P=0.001),与RQ-PCR(91.6%)相当(P=1.000)。75%的PJP患者为肺混合感染,合并EB病毒和巨细胞病毒最为常见。mNGS检出混合感染8例,RQ-PCR检出5例,常规方法未检出(P=0.008)。结论mNGS在allo-HSCT患者PJP诊断中具有良好的敏感性,在混合感染病原检测方面具有优势,可作为常规检测方法及RQ-PCR的有效补充。

关键词：耶氏肺孢子菌肺炎异基因造血干细胞移植宏基因组二代测序

Role of cytoplasmic lncRNAs in regulating cancer signaling pathways

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第1期20卷 1-8页

作者： Pei-fen.fu Xin ZHENG Xiao FAN Ai-fu LIN The Breast Centre the First Affiliated Hospital School of Medicine Zhejiang University MOE Laboratory of Biosystems Homeostasis & Protection College of Life Sciences Zhejiang University

Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades. Novel biomarkers for diagnosis and therapeutic strategies are urgently needed. In recent years, long noncoding RNAs(lncRNAs) have been reported to be aberrantly expressed in tumors and show crosstalk with key cancer-related signaling pathways. In this review, we summarized the current progress of research on cytoplasmic lncRNAs and their roles in regulating cancer signaling and tumor progression, further characterization of which may lead to effective approaches for cancer prevention and therapy.

关键词： Long noncoding RNA(lncRNA) Cancer signaling Cancer therapy Biomarker

Competition Ability Dependence on Uniqueness in General Cooperation-Competition Systems

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Chinese Physics Letters 2011年第2期28卷 243-246页

作者： LIU Ai-fen XU Xiu-Lian fu Chun-Hua WANG Jian HE Da-Ren College of Physics Science and Technology Yangzhou UniversityYangzhou 225002

We discuss the dependence of competition ability on uniqueness for the general cooperation-competition *** empirical investigation of the 15 real world systems is *** find that the dependence varies with the change of *** most of the systems show positive tendency,we find that a special system shows negative *** relationship between the heterogeneity indexes for the distributions of competition ability and uniqueness is also discussed analytically and empirically.

关键词： uniqueness empirical system

Synthesis and Antitumor Activities of 1,3,4-Thiadiazole Derivatives Possessing Benzisoselenazolone Scaffold

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Chemical Research in Chinese Universities 2014年第5期30卷 764-769页

作者： ZHAO Jie XUAN Lina ZHAO Haichuan CHENG Ji fu Xiaoyun LI Sha JING fen LIU Yuming CHEN Baoquan School of Chemistry and Chemical Engineering Tianjin University of Technology Tianjin 300384 P. R. China

A series of novel 1,3,4-thiadiazole derivatives possessing benzisoselenazolone scaffold were designed and synthesized, and their antitumor activities against human cervix adenocarcinoma（HeLa）, human liver cancer cell（SMMC-7721）, human breast cancer cell（MCF-7） and human lung cancer cell（A549） lines were evaluated by CCK-8 assay, The bioassay results demonstrate that most of the tested compounds showed potent antiproliferative effects against various cell lines. furthermore, compounds 7c, 7e, 7h, 7i and 7k showed significant antiproliferative activities against SMMC-7721 cells, with IC5o values of 2.38, 2.67, 1.35, 2.75 and 2.48 μmol/L, respectively. Com- pounds 7a, 7e, 7j and 71 exhibited highly effective antitumor activities against MCF-7 cells, with IC50 values of 2.89, 2.95, 1.12 and 2.75 μmol/L, respectively. Compound 7j was found to be the most potent compound against A549 cells, with an IC50 value of 1.25 μmol/L. The pharmacological results suggest that the substituents of benzylthio-moiety at position 2 on 1,3,4-thiadiazole are vital for modulating antitumor activities against various cancer cell lines.

关键词： 1,3,4-Thiadiazole derivative Benzisoselenazolone Antitumor activity