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Hemophagocytic lymphohistiocytosis caused by STAT1 gain-offunction mutation is not driven by interferon-γ:A case report

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World Journal of Clinical Cases 2020年第23期8卷 6130-6135页

作者： Nan Liu fen-ying zhao Xiao-Jun Xu Department of Hematology-oncology Children’s HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening hyperinflammatory syndrome caused by many genetic ***1 is a DNAbinding factor that regulates gene *** caused by STAT1 gain-offunction(GOF)mutations has rarely been reported and its clinical manifestations and mechanisms are not clearly *** SUMMARY A 2-year-old boy presented to our hospital with recurrent fever for>20 *** patient had a personal history of persistent oral candidiasis and inoculation site infection during the past 2 *** was *** blood cell count showed severe anemia,thrombocytopenia and *** laboratory tests showed liver dysfunction,hypertriglyceridemia and decreased *** was found in the bone *** computed tomography showed a cavitary *** for fungal infection were *** T helper(Th)1/Th2 cytokine determination demonstrated moderately elevated levels of interleukin(IL)-6 and IL-10 with normal interferon(IFN)-γ*** bovis was identified in bronchoalveolar lavage fluid by polymerase chain *** testing identified a heterozygous mutation of c.1154C>T causing a T385M amino acid substitution in *** antibacterial and antifungal therapy,the febrile disease was not *** signs of HLH were relieved after HLH-94 protocol administration,except *** was not resolved until he received anti-tuberculosis *** stem cell transplantation was refused and the patient died six months later due to severe *** Patients with STAT1 GOF mutation have broad clinical manifestations and may develop *** form of HLH presents with normal IFN-γlevel without cytokine storm.

关键词： Hemophagocytic lymphohistiocytosis Signal transducer and activator of transcription 1 Gain-of-function Interferon gamma Mycobacterial disease Case report

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Efficacy of inactivated SARS-CoV-2 vaccination in pediatric hematology/oncology patients:a real-world study

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World Journal of Pediatrics 2023年第10期19卷 1017-1021页

作者： Jing Miao Jing-ying Zhang Juan Liang fen-ying zhao Hua Song Wei-Qun Xu Yong-Min Tang Xiao-Jun Xu Qiang Shu Children’s Hospital Zhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health HangzhouChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been spreading globally since its initial outbreak in *** evidence has revealed that children who are receiving antitumor therapy or hematopoietic stem cell transplantation(HSCT)present higher rates of severe illness and mortality[1].It is important to identify infected children with hematology and oncology diseases who have the tendency to develop worse outcomes of coronal virus disease 2019(COVID-19)during the early stage of *** studies have demonstrated that vaccination against SARS-CoV-2 in adults can reduce the likelihood of infection and reduce the severity and mortality of COVID-19 when SARS-CoV-2 breakthrough infection occurs[2,3,4].However,the effectiveness of SARS-CoV-2 vaccination in children with hematology and oncology diseases is poorly defined due to the lack of relevant data,which might lead to vaccine hesitancy[5,6].

关键词： vaccination mortality respiratory

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Utilizing BP neural networks to accurately reconstruct the tritium depth profile in materials for BIXS

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Nuclear Science and Techniques 2025年第1期36卷 103-114页

作者： Chen zhao Wei Jin Yan Shi Chang-An Chen Yi-ying zhao Institute of Materials China Academy of Engineering PhysicsJiangyou 621908China

β-ray-induced X-ray spectroscopy(BIXS)is a promising method for tritium detection in solid materials because of its unique advantages,such as large detection depth,nondestructive testing capabilities,and low requirements for sample ***,high-accuracy reconstruction of the tritium depth profile remains a significant challenge for this *** this study,a novel reconstruction method based on a backpropagation(BP)neural network algorithm that demonstrates high accuracy,broad applicability,and robust noise resistance is *** average reconstruction error calculated using the BP network(8.0%)was much lower than that obtained using traditional numerical methods(26.5%).In addition,the BP method can accurately reconstruct BIX spectra of samples with an unknown range of tritium and exhibits wide applicability to spectra with various tritium ***,the BP network demonstrates superior accuracy and stability compared to numerical methods when reconstructing the spectra,with a relative uncertainty ranging from 0 to 10%.This study highlights the advantages of BP networks in accurately reconstructing the tritium depth profile from BIXS and promotes their further application in tritium detection.

关键词： β-ray-induced X-ray spectroscopy Tritium detection BP network Ridge regression Reconstruction problem

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Taurine: A Comprehensive Review of Its Origin， Pharmacological Properties， Potential Health Benefits， Therapeutic Applications， and Safety Profile

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Food Science and Human Wellness 2025年

作者： Pengfei zhao ying Qi Department of Pharmacology， School of Pharmacy， China Medical University (Shenyang) Department of Radiology， Shengjing Hospital of China Medical University

Taurine， a multifunctional sulfur-containing amino acid and conditionally essential nutrient for humans， plays a key role in various biological processes and has attracted significant attention for its therapeutic potential. Originally isolated from ox bile， taurine has broad applications， but a comprehensive understanding of its pharmacological properties， health benefits， and safety profile remains incomplete. In this review， we critically evaluate the existing evidence on taurine’s effects based on an extensive literature search of multiple databases， including PubMed， Web of Science， Scopus， ScienceDirect， Google Scholar， CNKI， and Baidu Scholar， up to May 2024. Taurine demonstrates a range of beneficial effects， including antioxidant and anti-inflammatory activities， modulation of lipid metabolism， neuroprotection， and cardiovascular protection. It has shown substantial impacts on anti-tumor activity， immune system modulation， blood pressure and lipid regulation， glycemic control， hepatobiliary protection， and potential anti-aging effects. However， the precise regulatory pathways underlying these benefits are not yet fully understood. Epidemiological studies indicate a correlation between high taurine dosage and a reduced risk of diseases. However， direct evidence from interventional studies remains insufficient， and existing clinical trials require further in-depth investigation. Concerns about improper use and potential health risks also highlight the need for thorough safety assessments. To address these gaps， we recommend conducting well-designed， long-term randomized controlled trials to establish effective doses for disease prevention and assess taurine’s potential as a primary or adjunct therapy. This review aims to guide future research and support public health efforts， ultimately improving health outcomes.

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Dynamic compressive characteristics of a green sandstone under coupled hydraulic-mechanical loading: Experiments and theoretical modeling

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 126-138页

作者： Bangbiao Wu Geli zhao ying Xu Kaiwen Xia State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation School of Civil EngineeringTianjin UniversityTianjin300072China Yalong River Hydropower Development Company Ltd.Chengdu610065China Institute of Geosafety China University of Geosciences(Beijing)Beijing100083China

Deep rock is under a complex geological environment with high geo-stress, high pore pressure, and strong dynamic disturbance. Understanding the dynamic response of rocks under coupled hydraulic-mechanical loading is thus essential in evaluating the stability and safety of subterranean engineering structures. Nevertheless, the constraints in experimental techniques have led to limited prior investigations into the dynamic compression behavior of rocks subjected to simultaneous high in-situ stress and pore pressure conditions. This study utilizes a triaxial split Hopkinson pressure bar (SHPB) system in conjunction with a pore pressure loading cell to conduct dynamic experiments on rocks subjected to hydraulic-mechanical loading. A porous green sandstone (GS) was adopted as the testing rock material. The findings reveal that the dynamic behavior of rock specimens is significantly influenced by multiple factors, including the loading rate, confining stress, and pore pressure. Specifically, the dynamic compressive strength of GS exhibits an increase with higher loading rates and greater confining pressures, while it decreases with elevated pore pressure. Moreover, the classical Ashby-Sammis micromechanical model was augmented to account for dynamic loading and pore pressure considerations. By deducing the connection between crack length and damage evolution, the resulting law of crack expansion rate is related to the strain rate. In addition, the influence of hydraulic factors on the stress intensity factor at the crack tip is introduced. Thereby, a dynamic constitutive model for deep rocks under coupled hydraulic-mechanical loading was established and then validated against the experimental results. Subsequently, the characteristics of introduced parameter for quantifying the water-induced effects were carefully discussed.

关键词： Deep rock Split hopkinson pressure bar(SHPB) Compressive behavior Pore pressure Coupled hydraulic-mechanical loading

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A New Approach for the Calculation of Slope Failure Probability with Fuzzy Limit-State Functions

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Fluid Dynamics & Materials Processing 2025年第1期21卷 141-159页

作者： Jianing Hao Dan Yang Guanxiong Ren ying zhao Rangling Cao Department of Engineering Management Sichuan College of Architectural TechnologyDeyang61800China Department of Transport and Municipal Engneering Sichuan College of Architectural TechnologyDeyang61800China Department of Basic Teaching Sichuan College of Architectural TechnologyDeyang61800China Sichuan Hongye Construction Software Co. Ltd.Chengdu610081China

This study presents an innovative approach to calculating the failure probability of slopes by incorporating fuzzylimit-state functions,a method that significantly enhances the accuracy and efficiency of slope stability *** traditional probabilistic techniques,this approach utilizes a least squares support vector machine(LSSVM)optimized with a grey wolf optimizer(GWO)and K-fold cross-validation(CV)to approximate the limit-statefunction,thus reducing computational *** novelty of this work lies in its application to one-dimensional(1D),two-dimensional(2D),and three-dimensional(3D)slope models,demonstrating its versatility andhigh *** proposed method consistently achieves error margins within 3%of Monte Carlo simulation(MCS)results,while substantially reducing computation time,particularly for 2D and 3D *** makes theapproach highly practical for real-world engineering ***,by applying fuzzy mathematics tohandle uncertainties in geotechnical properties,the method offers a more realistic and comprehensive understandingof slope *** water is the main factor influencing the stability of slopes,this aspect is investigatedby calculating the phreatic line after the change in water *** examples are used to show that the failureprobability of a slope under water wading condition can increase by more than 20%(increase rates in 1D,2D and3D conditions being 25%,27%and 31%,respectively)compared with the natural *** influence ofdiverse fuzzy membership functions—linear,normal,and Cauchy—on failure probability is also *** not only provides a strategy for better calculation of the slope failure probability but also pioneers theintegration of computational intelligence,fuzzy logic and fluid-dynamics in geotechnical engineering,presentingan innovative and efficient tool for slope stability analysis.

关键词： Least Squares Support Vector Machine(LSSVM) Grey Wolf Optimizer(GWO) slope stability analysis fuzzy set theory failure probability estimation

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Mechanism study of the molluscicide candidate PBQ on Pomacea canaliculata using a viscosity-sensitive fluorescent probe

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Chinese Chemical Letters 2025年第1期36卷 447-452页

作者： Lanyun Zhang Weisi Wang Yu-Qiang zhao Rui Huang Yuxun Lu ying Chen Liping Duan ying Zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and TechnologyYunnan UniversityKunming 650091China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Centre for Tropical DiseasesNational Key Laboratory of Inteligent Tracking and Forecasting for Infectious DiseasesKey Laboratory on Parasite and Vector Biology MinistryofHealthShanghai200025China

PBQ[1-(4-chlorophenyl)-3-(pyridin-3-yl)urea],an enormous potent molluscicide,showed excellent Pomacea canaliculata(***)control activity and low toxicity for other aquatic organisms,but its snail-killing mechanisms are still not fully *** employed an optical method to elucidate PBQ action via a novel fluorescent viscosity probe,*** the viscosity in the test solutions increased,compared with that in pure ethanol,a 54-fold fluorescence intensity enhancement of NCV was observed in 310 cP of 90%***,NCV successfully exhibited a selective fluorescence response towards monensin-induced cellular viscosity changes in HepG2 *** liver,stomach,and foot plantar of the tested snails were frozen and sectioned for fluorescent imaging experiments after the treatment with different PBQ concentrations over various times.A significant fluorescent increase in the snail's liver was observed upon exposure to 0.75 mg/L PBQ for 72 h,which highlighted an increase in *** and eosin(HE)staining further supported PBQ-induced liver damage with a viscosity increase in *** study provides a new rapid optical visualization method to study the killing mechanisms of PBQ and may help discover new chemicals that control snail populations.

关键词： Fluorescence sensor Viscosity Pomacea canaliculata Molluscicide mechanisms Bio-imaging

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Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing Weng zhao-ying Ding ying-Chao Li Yuan-feng Wu Yuan-Yang Xu Rui Chen Xiao-Lei zhao Hai-Yong Wang Da-Lei Zhang Yu-Long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

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A highly efficient soybean transformation system using GRF3-GIF1 chimeric protein

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Journal of Integrative Plant Biology 2025年第1期67卷 3-6页

作者： ying zhao Peng Cheng ying Liu Chunyan Liu Zhenbang Hu Dawei Xin Xiaoxia Wu Mingliang Yang Qingshan Chen National Key Laboratory of Smart Farm Technologies and Systems College of AgricultureNortheast Agricultural UniversityHarbin 150000China

Soybean(Glycine max(Linn.)Merr.)is among the most important global sources of edible protein and oil used for human consumption,livestock rearing,and industrial *** regeneration efficiency frequently limits the potent... 详细信息

关键词： soybean transformation system

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi ying zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterState Key Laboratory of Photovoltaic Materials and CellsNankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Tianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells(IPSCs),which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid(5-MVA)was introduced as a strain buffer to release the residual strain of CsPbI_(2.85)Br_(0.15)*** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb^(2+)through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI_(2.85)Br_(0.15)perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI_(2.85)Br_(0.15),resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency(PCE)of NiOxbased inverted IPSCs increased from 19.25%to 20.82%with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI_(2.85)Br_(0.15)perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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