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Biliary microbiota and mucin 4 impact the calcification of cholesterol gallstones

Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 61-66页

作者： feng-Ling Hu Hong-Tan Chen Fang-Fang Guo ming Yang Xin Jiang Jing-Hua Yu fen-ming zhang Guo-Qiang Xu Department of Gastroenterology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Cholesterol gallstones account for over 80%of gallstones,and the pathogenesis of gallstone formation involves genetic and environmental ***,data on the evolution of cholesterol gallstones with various densities are *** study aimed to determine the roles of microbiota and mucins on the formation of calcified cholesterol gallstones in patients with ***:Paired gallbladder tissues and bile specimens were obtained from cholelithiasis patients who were categorized into the isodense group and calcified group according to the density of *** relative abundance of microbiota in gallbladder tissues was *** and enzyme-linked immunosorbent assay were performed to detect the expression levels of MUC1,MUC2,MUC3a,MUC3b,MUC4,MUC5ac and MUC5b in gallbladder tissues and *** correlation of microbiota abundance with MUC4 expression was evaluated by linear ***:A total of 23 patients with gallbladder stones were *** density of gallstones in the isodense group was significantly lower than that of the calcified group(34.20±1.50 vs.109.40±3.84 HU,P<0.0001).Compared to the isodense group,the calcified group showed a higher abundance of gram-positive bacteria at the fundus,in the body and neck of gallbladder *** concentrations of MUC1,MUC2,MUC3a,MUC3b,MUC5ac and MUC5b in the epithelial cells of gallbladder tissues showed no difference between the two groups,while the concentrations of MUC4 were significantly higher in the calcified group than that in the isodense group at the fundus(15.49±0.69 vs.10.23±0.54 ng/mL,P<0.05),in the body(14.54±0.94 vs.11.87±0.85 ng/mL,P<0.05)as well as in the neck(14.77±1.04 vs.10.85±0.72 ng/mL,P<0.05)of gallbladder ***,the abundance of bacteria was positively correlated with the expression of MUC4(r=0.569,P<0.05)in the calcified ***:This study showed the potential clinical relevance among biliary microbiota,mucins

关键词： Cholesterol gallstones Calcification Mucins Microbiota

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Esophageal bronchogenic cyst excised by endoscopic submucosal tunnel dissection: A case report

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World Journal of Clinical Cases 2020年第2期8卷 353-361页

作者： fen-ming zhang Hong-Tan Chen Long-Gui Ning Yue Xu Guo-Qiang Xu Department of Gastroenterology The First Affiliated Hospital Zhejiang University School of MedicineZhejiang University

BACKGROUND Esophageal bronchogenic cyst(EBC) is a rare congenital disease that is difficult to diagnose preoperatively, and treatment remains *** SUMMARY We report a 53-year-old Chinese woman hospitalized in our hospital following the discovery of a submucosal protruding mass of the esophagus by upper endoscopy. A preliminary diagnosis of EBC was made by endoscopic ultrasonography(EUS), and treatment was accomplished by endoscopic submucosal tunnel dissection(ESTD). The pathological results verified the diagnosis. No scar changes or cystic lesion within the original lesion were found under EUS after a 3-mo *** EUS is valuable for the preliminary diagnosis of EBC and surveillance. ESTD is a safe and effective treatment for EBC. Further evaluation of complications and long-term follow-ups are required.

关键词： Esophageal bronchogenic cyst Endoscopic ultrasonography Endoscopic submucosal tunnel dissection Diagnosis and treatment Case report

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Simplified calculation of bile cholesterol saturation index

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 293-294页

作者： fen-ming zhang Xin Jiang Sha Li Long-Gui Ning Fang-Fang Guo Guo-Qiang Xu Department of Gastroenterology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

>Gallstones (cholelithiasis) are masses in the gallbladder or biliary tract that are caused by abnormally high levels of either cholesterol or bilirubin in bile [1]. It is a multifactorial disease and the main pathogenesis is the increased secretion of bile cholesterol,which can increase the cholesterol saturation index (CSI) of *** with CSI greater than 1 are more likely to develop *** is a kind of dark green to yellowish-brown liquid containing> 90% ***,lecithin and bile salts are the three main lipid species in bile and combined to form the main components of gallstones[1].

关键词： bile cholesterol saturation

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Helicobacter pylori infection is associated with gallstones: Epidemiological survey in China

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World Journal of Gastroenterology 2015年第29期21卷 8912-8919页

作者： fen-ming zhang Chao-Hui Yu Hong-Tan Chen Zhe Shen feng-Ling Hu Xiao-Ping Yuan Guo-Qiang Xu Department of Gastroenterology The First Affiliated Hospital Zhejiang University School of Medicine Department of International Health Care Center The First Affiliated Hospital of Zhejiang University School of Medicine

AIM: To elucidate the prevalence and risk factors for gallstones, primarily focusing on Helicobacter pylori(H. pylori) infection. METHODS: A total of 10016 Chinese subjects, who had undergone physical examination, fasting 13 C urea breath test and abdominal ultrasonography, had sufficient blood test data, and had finished a questionnaire, were included in this cross-sectional study. Participants(n = 1122) who had previous eradication of H. pylori were studied separately. RESULTS: Gallstones were discovered in 9.10% of men and 8.58% of women, with no significant sex difference. Multivariate analyses displayed that age, aspartate aminotransferase, total cholesterol, H. pylori infection, hepatitis C virus(HCV) infection, and fattyliver had a significant association with gallstones(P 40 years. The prevalence of gallstones among H. pylori-positive, H. pylori-eradicated, and H. pylori-negative subjects was 9.47%, 9.02%, and 8.46%, respectively. The matched analysis showed that gallstones among H. pylori eradicated subjects was significantly lower compared with H. pylori-positive subjects(P < 0.05).CONCLUSION: H. pylori infection and fatty liver have a significant positive association with gallstones. H. pylori eradication may lead to prevention of gallstones.

关键词： Gallstones Helicobacter pylori Crosssectionalstudy

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Misdiagnosis of hemangioma of left triangular ligament of the liver as gastric submucosal stromal tumor:Two case reports

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2351-2357页

作者： Jing-Jie Wang fen-ming zhang Wei Chen Hua-Tuo Zhu Ning-Long Gui Ai-Qing Li Hong-Tan Chen Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Extragastric lesions are typically not misdiagnosed as gastric submucosal tumor(SMT).However,we encountered two rare cases where extrinsic lesions were misdiagnosed as gastric *** SUMMARY We describe two cases of gastric SMT-like protrusions initially misdiagnosed as gastric SMTs by the abdominal contrast-enhanced computed tomography(CT)and endoscopic ultrasound(EUS).Based on the CT and EUS findings,the patients underwent gastroscopy;however,no tumor was identified after incising the gastric *** surgical exploration revealed no gastric lesions in both patients,but a mass was found in the left triangular ligament of the *** patients underwent laparoscopic tumor resection,and the postoperative diagnosis was hepatic *** During EUS procedures,scanning across different layers and at varying degrees of gastric cavity distension,coupled with meticulous image analysis,has the potential to mitigate the likelihood of such misdiagnoses.

关键词： Submucosal tumor Extragastric compression Endoscopic ultrasonography Computed tomography Hemangioma of the left triangular ligament of the liver Case report

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Endoscopic ultrasound-guided lauromacrogol injection for treatment of colorectal cavernous hemangioma:Two case reports

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 966-973页

作者： Hua-Tuo Zhu Wen-Guo Chen Jing-Jie Wang Jia-Nan Guo fen-ming zhang Guo-Qiang Xu Hong-Tan Chen Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage,and can be misinterpreted as *** resection is currently the mainstay of treatment,with an emphasis on sphincter *** SUMMARY We present details of two young patients with a history of persistent hematochezia diagnosed with colorectal cavernous hemangioma by endoscopic ultrasound(EUS).Cavernous hemangioma was relieved by several EUS-guided lauromacrogol injections and the patients achieved favorable clinical *** Multiple sequential EUS-guided injections of lauromacrogol is a safe,effective,cost-efficient,and minimally invasive alternative for colorectal cavernous hemangioma.

关键词： Endoscopic ultrasound Lauromacrogol injection Colorectal cavernous hemangioma Case report

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du ming Gao Yanbin Yin Jiongming zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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苦瓜保健含片的工艺研究

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食品科技 2004年第9期29卷 31-32,35页

作者：张雁张瑞芬张名位丘银清广东省农业科学院生物技术研究所广州510640

以苦瓜浓缩汁、麦芽糖醇、山梨糖醇和低聚异麦芽糖为主要原料,经混合、造粒、干燥、压片等工序,制成了低热量、具有保健功能的苦瓜含片。

关键词：苦瓜功能性甜味剂保健型含片

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Structural characterization of a 2-O-acetylglucomannan from Dendrobium officinale stem

Structural characterization of a 2-O-acetylglucomannan from ...

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首届长三角科技论坛——长三角生物医药发展论坛

作者： Yun-fen Hua~a ming zhang~b Cheng-xin Fu~(a,*) zhang-hui Chen~b ~aLab of Plant Systematic Evolution and Biodiversity,College of life Science,Zhejiang University ~bInstitute of biotechnology,College of life Science,Zhejiang University,Hangzhou 3113012,China

A heteropolysaccharide,obtained from an aqueous extract of dried stem of Dendrobiumofficinale Kimura et Migo by anion-exchange chromatography and gel-permeationchromatography,was investigated by chemical techniques and NMR spectroscopy,and isdemonstrated to be a 2-O-acetyl glucomannan,composed of mannose,glucose and arabinose in40.2:8.4:1 molar *** has a backbone of(1?4)-linked β-D-mannopyranosyl residues andβ-D-glucopyranosyl residues,with branches at O-6 consisting of terminal and(1?3)-linked Manp,(1?3)-linked Glcp,and a small proportion of arabinofuranosyl residues at the terminal *** acetyl groups are substituted at O-2 of (1?4)-linked Manp and *** main repeating unitof the polysaccharide is reported.

关键词： Dendrobium officinale Kimura et Migo Polysaccharide Glucomannan Structure

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MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei ming Longfu Chen Tianliang Song Moxi Yele Hao zhang Long Yang Gegen Sarula Benliang Liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

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