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PEPTIDES FORMATION FROM DIPP-HIS

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Chinese Chemical Letters 1995年第3期6卷 211-214页

作者： Yao Wu SHAO Yu fen zhao (Department of Chemistry,Tsinghua University,Beijing.100084) Tsing Hua Univ Dept Chem Beijing 100084 Peoples R China

When DIPP-HIS was incubated in water, citrate buffer. DMF and other mixed solvents. phosphoryl dipeptide, tripeptide even tetrapeptide were found. When DIPP-HIS was incubated with aspartic acid tinder the same conditi... 详细信息

关键词： PEPTIDES FORMATION FROM DIPP-HIS

Synthesis and structure-activity relationships study ofα-aminophosphonate derivatives containing a quinoline moiety

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Chinese Chemical Letters 2017年第7期28卷 1514-1518页

作者： Xi-feng Zhu Jing Zhang Shuo Sun Yan-Chun Guo Shu-Xia Cao Yu-fen zhao The College of Chemistry and Molecular Engineering The Key Laboratory of Chemical Biology and Organic Chemistry of Henan ProvinceZhengzhou UniversityZhengzhou 450001China Department of Chemistry International College of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450001China Department of Chemistry College of Chemistry and Chemical EngineeringThe Key Laboratory for Chemical Biology of Fujian ProvinceXiamen University Xiamen 361005China

Two series of a-aminophosphonate derivatives containing a quinoline moiety have been designed and synthesized by introducing bioactive quinoline scaffold to a-aminophosphonate. The in vitro cytotoxic activities of target compounds were first investigated against two human cancer cell lines including Eca109 and Huh7 by MTT assay. Results revealed that most of target compounds exhibited moderate to high antitumor activities against the tested cancer cell lines and some demonstrated more potent inhibitory activities compared with Sunitinib. Among them, compounds 4b2 and 4b4 containing methylsubstituted aniline group were found to be more active than Sunitinib against both of two cancer cell lines, with IC50 in the range of 2.26 mmol/L–7.46 mmol/L.

关键词： Quinoline a-Aminophosphonate Synthesis Antitumor activity In vitro

The Cleavage Effect of Histidyl-Lysine on RNA

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Chinese Chemical Letters 1998年第4期9卷 333-334页

作者： Xiang Hong LI Rong WAN Qiong ZHANG Yu fen zhao(Department of Chemistry, Tsinghua University, Bejing 100084) Tsing Hua Univ Dept Chem Beijing 100084 Peoples R China

The cleavage activity of histidyl-lysine dipeptide (His-Lys) on RNA was studied and compared with that of histidine. With the addition of the lysine residue, the cleavage activity was increased about 10-fold compared ... 详细信息

关键词： RNA cleavage histidyl-lysine

Synthesis and Cleavage Activity of Artifical Minic Polypeptides

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Chinese Chemical Letters 2006年第9期17卷 1197-1200页

作者： Yong YE Xiao Lian HU Ping LI Ming Yu NIU Li feng CAO Yu fen zhao Department of Chemistry Key Laboratory of Chemical Biology and Organic Chemistry Zhengzhou University Zhengzhou 450052 Key laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084

Two artificial minic polypeptides which are synthetic analogues of natural products with DNA affinity were synthesized, and theirs cleavage activity with DNA were examined. The structures of these compounds was confir... 详细信息

关键词： DNA artificial minic polypeptide cleavage agents.

O-phosphorylation of Oligopeptides with Phosphoramidite

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Chinese Chemical Letters 1998年第12期9卷 0-0+0-0页

作者： Yan Met LI Yu fen zhao (Bio-organic Phosphorus Chemistry Laboratory, Department of Chemistry,Tsinghua University, Beijing 100084)Herbert WALDMANN (Institute of Organic Chemistry, University of Karlsruhe, 76128 Karlsfuhe, Germany) Tsing Hua Univ Dept Chem Bioorgan Phosphorus Chem Lab Beijing 100084 Peoples R China Univ Karlsruhe Inst Organ Chem D-76128 Karlsruhe Germany

Phosphopeptides were synthesized with bis-alkyloxy-N,N-dialkylphosphorfollowed by oxidation. Many hydroxyl groups in oligopeptides can be O-phosphorylated in onestep.

关键词： Phosphopeptide phosphoramidite

^(31)P NMR Spectral Evidence for the Formation of Amino Acid Highcoordinated Phosphorus Intermediates

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Chinese Chemical Letters 1998年第10期9卷 953-955页

作者： He Gui GONG Hua FU zhao Long LI Yu fen zhao(Bioorganic phosphorus chemistry Lab., Department of Chemistry, Tsinghua Univ., Beijing 100084) Bioorganic Phosphorus Chemistry Lab Department of Chemistry Tsinghua Univ. Beijing 100084 China

The active intermediates of hexacoordinated 4-nitrotrispirophosphoric amino acid (P(6)-AA), which were formed by the reaction of 4-nitro-O,O-phenylene phosphochloridate (NOPPC) with silanizing serine, threonine and cysteine, were observed by 31P NMR spectra. The reaction mechanism of these processes was discussed. In addition, some interesting results were observed by mixing 4-nitro-2,2,2-tricloro-1,3,2-benzodioxaphosph(v)ole (NTB) with silanizing serine and histidine.

关键词： highcoordinated phosphorus amino acids

Kinetic Studies on Reactions of Monocyclic Oxyphosphoranes with Ethylene Glycol

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Chinese Chemical Letters 1997年第2期8卷 149-152页

作者： Nan Ting ZHANG Xin CHEN Yu fen zhao(Bioorganic Phosphorus Chemistry Laboratory Department of ChemistryTsinghua University, Beiing, 100084) TSING HUA UNIV DEPT CHEMBIOORGAN PHOSPHORUS CHEM LABBEIJING 100084PEOPLES R CHINA

The reaction of monocyclic oxyphosphorane compounds 1a,1b,1c with ethylene glycol in pyridine was studied by P-31 NMR. The results show that compound 1a with an unsaturated five-membered ring reacts faster than compound 1b with a saturated ring attached by two trans p-nitro phenyl groups, which in turn reacts greatly faster than the cis- compound 1c. To interpret the mechanism, a hexacoordinate intermediate whose five-membered ring occupied the e-, e- position was proposed.

关键词： Ethylene

The Synthesis of a Series of Phosphoryl Coumarins

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Chinese Chemical Letters 2005年第9期16卷 1140-1142页

作者： Chui Lin RONG Xin Cheng LIAO Jian Chen ZHANG Shu Xia CAO Lun LIU Yu fen zhao Department of Chemistry The Key Laboratory of Chemical Biology Zhengzhou University Zhengzhou 450052 Department of Chemistry The Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education School of Life Sciences and Engineering Tsinghua University Beijing 100084

Different hydroxy substituted coumarins were successfully phosphorylated with diisopropylphophite （DIPPH） by the Atherton-Todd reaction in 76-89% yields. Moreover, the reaction activities of different hydroxys of th... 详细信息

关键词： Phosphorylation Atherton-Todd reaction coumarin phosphoryl coumarins.

Effect of high temperature cooking on the quality of rice porridge

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International Journal of Agricultural and Biological Engineering 2021年第5期14卷 247-254页

作者： Cunshe Chen Siyuan Jiang Mengfei Li You Li He Li fen zhao Zhihua Pang Xinqi Liu Beijing Engineering and Technology Research Center of Food Additives Beijing 100048China Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing 100048China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

In order to explore the effect of high-temperature cooking instant porridge on the taste and quality of porridge,this study explored the changes in the taste quality of rice porridge under different heating times(15 min,20 min,25 min and 30 min)at a higher initial temperature(100°C),and compared with that cooked at room temperature(25°C),and explained the reasons for the *** the perspective of migration rate in moisture content,the rice porridge with special treatment has a more rapid moisture change,which makes texture,whiteness,smell and other factors change in a shorter time and increases the taste *** was concluded that under special treatment condition of starting with 100°C water and heating for 15 min,the kinds of rice flavor increased 2.2 times,the white of rice decreased by 10.04%,hardness decreased by 3.54 times,and the elasticity decreased by 35.48%*** general,cooking with higher initial temperature(100°C)is more valuable than cooking from 25°C,in terms of the texture,flavor,saving time,and stable quality during the household and industrial production of instant porridge.

关键词： rice porridge low frequency NMR sensory evaluation GC-MS confocal laser scanning microscope