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基于校企合作的房地产市场调查实训课程教学

中国冶金教育 2024年第4期 62-65页

作者：赵芬山东华宇工学院经济管理学院山东德州253034

提出了以学生为中心,以职业能力培养为核心,以项目式教学为基础的教学理念和思路,在校企共建课程标准和实训基地的基础上,优化师资和课程评价体系。

关键词：校企合作教学改革项目式教学

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智能制造背景下数控加工实训教学改革与实践

模具制造 2024年第9期24卷 50-52页

作者：李同一赵锋泰安技师学院山东泰安271000

基于数控加工实训教学改革与实践,探讨了智能制造背景下数控加工实训教学的现状、教学理论与方法、技术应用、教师培训与校企合作、学生能力培养与评价体系等方面的关键问题,旨在为促进数控加工实训教学质量提升、培养适应现代制造业发... 详细信息

基于数控加工实训教学改革与实践,探讨了智能制造背景下数控加工实训教学的现状、教学理论与方法、技术应用、教师培训与校企合作、学生能力培养与评价体系等方面的关键问题,旨在为促进数控加工实训教学质量提升、培养适应现代制造业发展需要的高素质人才提供理论指导和实践参考。

关键词：智能制造数控加工实训教学改革与实践

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Soil moisture estimation based on BeiDou Bl interference signal analysis

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Science China Earth Sciences 2016年第12期59卷 2427-2440页

作者： YAN SongHua zhao fen CHEN NengCheng GONG JianYa School of Electronic Information Wuhan University State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan University

BeiDou Navigation Satellite System reflectometry(BDS-R) is an emerging area of BD(BeiDou) applications that uses multipath reflected signals in microwave remote *** moisture estimation is one of the potential important applications of *** study aims to investigate the feasibility of soil moisture estimation based on BD B1 band interference signals,which are composed of direct and reflected BD signals and can be readily captured using low-cost commercial BDS *** this paper,a theoretical background for soil estimation from interference signals was introduced,and an analysis of field experimental data was ***,a cosine model for the interference signal power was built,and a non-uniform power spectrum analysis was performed on the received interference signals to determine its main ***,a least squares curve fitting was applied on the interference signal power to extract its *** relationship between the soil moisture and the phase was then *** months of experimental data were collected at BaoXie,Wuhan and analyzed for further *** results show that the phase of the interference signals increases with the increase of soil *** correlation coefficient between the phase and the in-situ soil moisture value is approximately ***,the relationship between the phase and soil moisture is employed to estimate soil *** show that using BDS-R to measure soil moisture is feasible,which demonstrates a great potential of new application of the BD system.

关键词： BDS-R Soil moisture estimation Interference signal Non-uniform power spectrum Least squares curve fitting SNR

A novel alkaloid from the fruiting bodies of Ganoderma sinense zhao,Xu et Zhang

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Chinese Chemical Letters 2010年第2期21卷 197-199页

作者： Liu, Chao zhao, fen Chen, RuoYun Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Minist Educ Key Lab Bioact Substances & Resources Utilizat Ch Beijing 100050 Peoples R China

A new alkaloid,sinensine(1),had been isolated from the fruiting bodies of Ganoderma sinense zhao,Xu et *** structure was elucidated on the basis of 1D and 2D spectral *** alkaloid exhibited activity in protecting the ... 详细信息

关键词： Alkaloid Ganoderma sinense Sinensine

DNA Binding and Cleavage Property of Pyrenyl-macrocyclic Polyamine Conjugate

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Chinese Chemical Letters 2006年第9期17卷 1185-1188页

作者： Qiang YIN Zhen ZHANG Yu fen zhao The Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084

We reported the synthesis of a simple bifunctional molecule and the interaction between this molecule and DNA were studied by UV and the DNA cleavage behavoior was determined by agarose gel electrophoresis.

关键词： DNA cleavage ESI-MS UV agarose gel electrophoresis

Theoretical Study of the Sensitivity-Improvement Effect of Phosphoryl Group in Mass Spectrometry of Small Peptides

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Chinese Chemical Letters 2001年第9期12卷 807-808页

作者： Yang JIANG Bo TAN Yu fen zhao The Key Laboratory of Bioorganic Phosphorus Chemistry Ministry of EducationDepartment of ChemistrySchool of Life Sciences and EngineeringTsinghua UniversityBeijing 100084

It was found that phosphorylation of small peptide could improve the sensitivity in mass spectrometry. Density functional theory calculations showed that the energy for the protonation of N-(O,O'-dimethyl) phosphoryl ... 详细信息

关键词： Phosphoryl group small peptide mass spectrometry relative energy

亚胺培南治疗脓毒症致急性呼吸窘迫综合征的效果

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中国药物应用与监测 2024年第2期21卷 140-143页

作者：郦弈帆林兆奋上海长征医院急诊危重症医学科上海200003

目的探讨亚胺培南治疗脓毒症致急性呼吸窘迫综合征的效果。方法纳入上海长征医院急诊危重症医学科2020年1月—2023年12月收治的98例脓毒症致急性呼吸窘迫综合征患者,以随机数字表法分为对照组、观察组,对照组49例患者进行连续性血液净... 详细信息

目的探讨亚胺培南治疗脓毒症致急性呼吸窘迫综合征的效果。方法纳入上海长征医院急诊危重症医学科2020年1月—2023年12月收治的98例脓毒症致急性呼吸窘迫综合征患者,以随机数字表法分为对照组、观察组,对照组49例患者进行连续性血液净化治疗,观察组49例患者进行连续性血液净化与亚胺培南联合治疗,对比两组疗效、炎症指标变化、序贯器官衰竭评估(SOFA)评分以及急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分变化。结果观察组、对照组治疗总有效率分别为91.84%、77.55%,P<0.05;观察组患者治疗后的白细胞计数(WBC)、降钙素原(PCT)、C反应蛋白(CRP)分别为(8.38±2.17)×10^(9)·L^(-1)、(0.29±0.20)μg·L^(-1)、(7.22±1.97)mg·L^(-1),均低于对照组患者的(12.57±2.25)×10^(9)·L^(-1)、(0.88±0.24)μg·L^(-1)、(10.15±2.06)mg·L^(-1),P<0.05;治疗后,观察组患者的SOFA评分为(4.17±2.00)分,APACHEⅡ评分为(7.34±2.19)分,分别低于对照组患者的(7.67±2.04)分、(11.46±2.82)分,P<0.05。结论脓毒症致急性呼吸窘迫综合征患者采取亚胺培南治疗效果良好,可较好降低机体炎症水平,改善患者病情。

关键词：脓毒症急性呼吸窘迫综合征亚胺培南炎症健康状况器官衰竭

A chitosan-mediated inhalable nanovaccine against SARS-CoV-2

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Nano Research 2022年第5期15卷 4191-4200页

作者： Shao-Hua Zhuo Jun-Jun Wu Lang zhao Wen-Hao Li Yu-fen zhao Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Institute for Brain Disorders Beijing 100069China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Institute of Drug Discovery Technology Ningbo UniversityNingbo 315221China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),with several antigenic variants,has grown into a global challenge,and the rapid establishment of an immune barrier is crucial to achieving long-term control of the *** has led to a great demand for easy preparation and scalable vaccines,especially in low-income ***,we present an inhalable nanovaccine comprising chitosan and SARS-CoV-2 spike *** chitosan-mediated nanovaccine enabled a strong spike-specific antibody immune response and augmented local mucosal immunity in bronchoalveolar lavage and lungs,which might be capable of protecting the host from infection without systemic *** addition,the enhanced adaptive immunity stimulated by chitosan showed potential protection against ***,inhalation of the nanovaccine induced a comparable antibody response compared to intramuscular *** inhalable nanovaccine against SARS-CoV-2 offers a convenient and compliant strategy to reduce the use of needles and the need for medical staff.

关键词： severe acute respiratory syndrome coronavirus 2(SASR-CoV-2) inhalation nanovaccine chitosan

Hemophagocytic lymphohistiocytosis caused by STAT1 gain-offunction mutation is not driven by interferon-γ:A case report

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World Journal of Clinical Cases 2020年第23期8卷 6130-6135页

作者： Nan Liu fen-Ying zhao Xiao-Jun Xu Department of Hematology-oncology Children’s HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening hyperinflammatory syndrome caused by many genetic ***1 is a DNAbinding factor that regulates gene *** caused by STAT1 gain-offunction(GOF)mutations has rarely been reported and its clinical manifestations and mechanisms are not clearly *** SUMMARY A 2-year-old boy presented to our hospital with recurrent fever for>20 *** patient had a personal history of persistent oral candidiasis and inoculation site infection during the past 2 *** was *** blood cell count showed severe anemia,thrombocytopenia and *** laboratory tests showed liver dysfunction,hypertriglyceridemia and decreased *** was found in the bone *** computed tomography showed a cavitary *** for fungal infection were *** T helper(Th)1/Th2 cytokine determination demonstrated moderately elevated levels of interleukin(IL)-6 and IL-10 with normal interferon(IFN)-γ*** bovis was identified in bronchoalveolar lavage fluid by polymerase chain *** testing identified a heterozygous mutation of c.1154C>T causing a T385M amino acid substitution in *** antibacterial and antifungal therapy,the febrile disease was not *** signs of HLH were relieved after HLH-94 protocol administration,except *** was not resolved until he received anti-tuberculosis *** stem cell transplantation was refused and the patient died six months later due to severe *** Patients with STAT1 GOF mutation have broad clinical manifestations and may develop *** form of HLH presents with normal IFN-γlevel without cytokine storm.

关键词： Hemophagocytic lymphohistiocytosis Signal transducer and activator of transcription 1 Gain-of-function Interferon gamma Mycobacterial disease Case report