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Efficacy and safety of Huangqi Jianzhong decoction in the treatment of chronic atrophic gastritis:A meta-analysis

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World Journal of Clinical Cases 2023年第24期11卷 5710-5720页

作者： Xin-Peng Yan Wen Si Ming-Sheng Ding yuan-fen Tian Zhuang Guo Department of Traditional Chinese Medicine Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Department of Endocrinology Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Children’s Rehabilitation and Health Care Department Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Department of Gastroenterology Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina

BACKGROUND Chronic atrophic gastritis is a persistent disorder of the digestive system where the gastric mucosa epithelium and glands undergo atrophy,leading to a decrease in their number and thinning of the gastric *** is worth noting that the prevalence of chronic atrophic gastritis is higher in China compared to the global average,and it is also considered a precancerous condition for gastric *** To evaluate the efficacy of Huangqi Jianzhong decoction in treating chronic atrophic *** atrophic gastritis is a persistent illness characterized by the progressive disappearance of healthy gastric glands due to repeated *** Jianzhong decoctions are widely used in China to treat chronic atrophic ***,there is limited scientific evidence regarding their efficacy in treating this *** The present meta-analysis adhered to the PRISMA guidelines and used the Cochrane Collaboration *** performed a comprehensive search for clinical trials investigating the use of Huangqi Jianzhong decoction in treating chronic atrophic gastritis published until January *** risk of bias and the quality of the included studies were evaluated using the Cochrane Handbook ***,a meta-analysis was conducted using the RevMan 5.4 softRESULTS This study included a total of 13 articles,comprising 1269 *** meta-analysis was conducted on these 13 articles,yielding the following results:I2=0%,P=0.60,[RR=1.24,95%CI:1.18 to 1.30,P<0.00001].The forest plot analysis of the Helicobacter pylori clearance rate revealed I2=0%,P=0.36,[RR=1.20,95%CI:1.05 to 1.38,P=0.009].The forest plot of PG-I level showed I2=99%,P<0.00001,[MD=4.99,95%CI:-1.59 to 11.58,P=0.14].The forest plot of stomach pain demonstrated I2=54%,P=0.04,[MD=-0.63,95%CI:-0.68 to-0.58,P<0.00001].The forest plot of reflux indicated I2=82%,P=0.0009,[MD=-0.48,95%CI:-0.63 to-0.33,P<0.00001].The forest plot of recurrence rate exhibited I2=0%,P=0.92,[RR=0.15,95

关键词： Meta-analysis Chronic atrophic gastritis Huangqi Jianzhong decoction Safety

Bifurcations of traveling wave solutions and exact solutions to generalized Zakharov equation and Ginzburg-Landau equation

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Applied Mathematics and Mechanics(English Edition) 2011年第12期32卷 1615-1622页

作者：戴振祥徐园芬 School of Information and Art Ningbo Institute of Education Junior College Zhejiang Wanli University

This paper studies the dynamic behaviors of some exact traveling wave solutions to the generalized Zakharov equation and the Ginzburg-Landau equation. The effects of the behaviors on the parameters of the systems are also studied by using a dynamical system method. Six exact explicit parametric representations of the traveling wave solutions to the two equations are given.

关键词： planar dynamical system periodic wave solution nonlinear wave equation

Effects of combined administration of furosemide and kanamycin on rat auditory nerve

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Journal of Otology 2011年第1期6卷 26-30页

作者： GUO Weiwei yuan fen-qian LIU Hui-zhan YANG Shi-ming Department of Otolaryngology Head ＆ Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 P.R. China Department of Head and Neck Surgery Jiangxi Cancer Hospital Nanchang 330029 China

Objective To determine the effects of combined administration of furosemide and kanamycin on inner ear structures and the auditory nerve in rats. Methods The rats in the treatment group received intravenous injections of combined furosemide and kanamycin sulfate, and the rats in the normal control group received no treatment. The auditory brainstem response （ABR） test was carried out 7 days after drug administration to determine the effects of drug administration on hearing. Cochlear slice and cochlear wholcmount were prepared after 7 days of drug treatment. Results After 7 days of drug administration, ABR thresholds were significantly higher in the treatment group than in the control group and neurofilaments were significantly reduced, although the number of spiral ganglia showed no decrease and there were no signs of supporting cell injury. Conclusions Combined administration of furosemide and kanamyein sulfate has an apparent synergistic ototoxic effect. Although spiral ganglion damage may not be apparent within a short time period of drug administration, damage to auditory nerve fibers is obvious.

关键词： kanamycin furosemide deafness model hair cell injury

Inhibitory Effect of Isoflavones on Prostate Cancer Cells and PTEN Gene

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Biomedical and Environmental Sciences 2006年第1期19卷 35-41页

作者： fenG CAO TAI-YI JIN yuan-fen ZHOU Department of Occupational Health and Toxicology School of Public Health Fudan University Shanghai 200032 China

Objective To explore the mechanisms by which genistein and daidzein inhibit the growth of prostate cancer cells. Methods LNCaP and PC-3 cells were exposed to genistein and daldzein and cell viability was determined by MTF assay and cytotoxicity of the drugs by LDH test. Flow cytometry （FCM） was used to assess the cell cycle in LNCaP and PC-3 cells. Reverse transcription-polymerase chain reaction （RT-PCR） was applied to examine the expression of PTEN gene （a tumor suppressor gene）, estrogen receptor alpha gene （ERα）, estrogen receptor beta gene （ERβ）, androgen receptor gene （AR） and vascular endothelial growth factor gene （VEGF）. Results The viability of PC-3 and LNCaP cells decreased with increasing concentrations and exposure time of genistein and daidzein. Genistein increased G2/M phase cells in PC 3 cells while decreased S phase cells in LNCaP cells in a dose-dependent manner. Daidzein exerted no influence on the cell cycle of LNCaP and PC-3 cells, but the apoptosis percentage of LNCaP cells was elevated significantly by daidzein, Genistein induced the expression of PTEN gene in PC-3 and LNCaP cells. Daidzein induced the expression of PTEN gene in LNCaP but not in PC-3 cells. The expression of VEGF, ERα and ERβ genes decreased and AR gene was not expressed after incubation with genistein and daldzein in PC-3 cells. In LNCaP cells, the expression of VEGF and AR gene decreased but there was no change in the expression of ERα and ERβ gene after incubation with genistein and daidzein. Conclusion Genistein and daidzein exert a timeand dose-dependent inhibitory effect on PC-3 and LNCaP cells. The down-regulation of ER gene by daidzein influences the growth of PC-3 ceils directly, The inhibition of PC-3 cells by genistein and that of LNCaP cells by genistein and daidzein may be via Alct pathway that is repressed by PTEN gene, which subsequently down-regulates the expression of AR and VEGF genes. Our results suggest that the expression of PTEN gene plays a key role and s

关键词： Isoflavones Genistein Daidzein PC-3 LNCaP PTEN ERα ERβ VEGF

Metallothionein 1 Isoform Gene Expression Induced by Cadmium in Human Peripheral Blood Lymphocytes

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Biomedical and Environmental Sciences 2006年第2期19卷 104-109页

作者： XIU-LI CHANG TAI-YI JIN yuan-fen ZHOU Department of Occupational Medicine School of Public Health Fudan University Shanghai 200032 China

Objective To study the gene expression of metallothionein 1 （MT-1） isoforms in human peripheral blood lymphocytes （HPBLs）. Methods The expression of mRNA representing the seven active MT-I genes was determined in HPBLs by quantitative RT-PCR before and after exposure to cadmium. Results Basal expressions of MT-IX, and MT-1A in HPBLs were similar to expression of housekeeping gene. In contrast, the basal gene expressions of MT- 1 H, IF, 1E, and 1G were a little transcripts in human HPBLs. No signal was detected for MT-1B. There was a sex difference （P〈0.05）. in basal gene expression of MT-1E. The levels of gene expression of MT-1A, 1E, IF, 1G, 1H, and 1X increased, but the level of MT-1B did not increase after exposure to cadmium. Conclusions Gene expressions of MT-1 G, MT-1 H, MT-1 F, and MT-1X in HPBLs can be used as a potential biomarker of cadmium exposure.

关键词： Metallothionein 1 Gene Human peripheral blood lymphocytes Cadmium

Insulin Expression in Rats Exposed to Cadmium

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Biomedical and Environmental Sciences 2007年第4期20卷 295-301页

作者： LI-JIAN LEI TAI-YI JIN yuan-fen ZHOU Department of Occupational Health School of Public Health Fudan University Shanghai 200032 China

To investigate the effects of cadmium exposure on insulin expression in rats. Methods Eighteen adult SD rats were administered cadmium subcutaneously （0.5, 1.0, and 2.0 mg/kg bw）. The effects on endocrine of pancreas were assessed. The levels of cadmium and zinc in pancreas, blood and urine glucose, serum insulin and urine NAG （N-acyetyl-β-glucosaminidase） were determined. The gene expressions of metallothionein （MT） and insulin were also measured, and the oral glucose tolerance tests （OGTT） were carried out. Results The contents of cadmium in pancreas in cadmium-treated rats were higher than that in the control group, which was associated with slight increase of zinc in pancreas. Cadmium-exposed rats （1.0 and 2.0 mg/kg bw） demonstrated a marked glucose intolerance. But the levels of serum insulin did not change significantly after cadmium administration, and the UNAG had no change in Cd-treated group. The gene expression of insulin decreased in 1.0 and 2.0 mg/kg bw cadmium-exposed groups, compared with the control group. The expression of MT-I was higher in the groups exposed to 1.0 and 2.0 mg/kg bw cadmium while the expression of MT-II was higher in the group exposed to 2.0 mg/kg bw cadmium. Conclusions Cadmium may be accumulated in the pancreas, resulting in the change of the expression of insulin, MT-I and MT-Ⅱ genes. Cadmium can influence the biosynthesis of insulin, but does not induce the release of insulin. The dysfunction of pancreas occurs earlier than that of kidney after administration of cadmium.

关键词： Cadmium Endocrine Insulin Metallothionein Oral glucose tolerance test

THE　DETERMINATION　AND　REFINEMENT　OF　THREE－DIMENSIONAL　STRUCTURE　OF　β－MOMORCHARIN　AT　2．4A　RESOLUTION

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Chinese Chemical Letters 1995年第12期6卷 1053-1054页

作者： Yu fen yuan Jian Ping XIONG Zong Xiang XIA (Shanghai Institute of Organic Chenistry The Chinese Academy of Sciences. Shanghai 200032) Chinese Acad Sci Shanghai Inst Organ Chem Shanghai 200032 Peoples R China

The crystal structure of β-momorcharin has been determined using molecular replacement method. The structure has been refined at 2.4A resolution giving an R-factor of 0.204. when the oligosaccharide was absent in the model. with r. m. *** of 0.018A and 3.32°from ideal bond lengths and bond angles, *** three-dimensional structure ofβ-momorcharin is similar to that of trichosanthin.

关键词： AT REFINEMENT THE AND DETERMINATION

Preoperative prediction of lymphovascular and perineural invasion in gastric cancer using spectral computed tomography imaging and machine learning

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World Journal of Gastroenterology 2024年第6期30卷 542-555页

作者： Hui-Ting Ge Jian-Wu Chen Li-Li Wang Tian-Xiu Zou Bin Zheng yuan-fen Liu Yun-Jing Xue Wei-Wen Lin Department of Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Digestive Hematological and Breast MalignanciesClinical Research Center for Radiology and Radiotherapy of Fujian ProvinceFuzhou 350001Fujian ProvinceChina Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Diagnostic Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina School of Electrical and Computer Engineering University of OklahomaOklahomaOK 73019United States

BACKGROUND Lymphovascular invasion(LVI)and perineural invasion(PNI)are important prognostic factors for gastric cancer(GC)that indicate an increased risk of metastasis and poor *** preoperative prediction of LVI/PNI status could help clinicians identify high-risk patients and guide treatment ***,prior models using conventional computed tomography(CT)images to predict LVI or PNI separately have had limited *** CT provides quantitative enhancement parameters that may better capture tumor *** hypothesized that a predictive model combining clinical and spectral CT parameters would accurately preoperatively predict LVI/PNI status in GC *** To develop and test a machine learning model that fuses spectral CT parameters and clinical indicators to predict LVI/PNI status *** This study used a retrospective dataset involving 257 GC patients(training cohort,n=172;validation cohort,n=85).First,several clinical indicators,including serum tumor markers,CT-TN stages and CT-detected extramural vein invasion(CT-EMVI),were extracted,as were quantitative spectral CT parameters from the delineated tumor ***,a two-step feature selection approach using correlation-based methods and information gain ranking inside a 10-fold cross-validation loop was utilized to select informative clinical and spectral CT parameters.A logistic regression(LR)-based nomogram model was subsequently constructed to predict LVI/PNI status,and its performance was evaluated using the area under the receiver operating characteristic curve(AUC).RESULTS In both the training and validation cohorts,CT T3-4 stage,CT-N positive status,and CT-EMVI positive status are more prevalent in the LVI/PNI-positive group and these differences are statistically significant(P<0.05).LR analysis of the training group showed preoperative CT-T stage,CT-EMVI,single-energy CT values of 70 keV of venous phase(VP-70 keV),and the ratio of standardized iodine co

关键词： Spectral computed tomography Gastric cancer Lymphovascular invasion Perineural invasion

七氟烷对新生大鼠学习记忆功能以及海马区凋亡的影响

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中国免疫学杂志 2017年第2期33卷 201-205页

作者：袁芬华中科技大学同济医学院附属梨园医院麻醉科武汉430077

目的:观察并探讨新生大鼠接受七氟烷麻醉后,生长至断乳期的学习记忆功能的变化以及海马区神经元细胞凋亡的变化。方法:健康6~8日龄新生SD大鼠100只,随机数字表法分成5组,每组20只:Ⅰ组大鼠吸入体积分数为3%的七氟烷以及25%氧气2 h;Ⅱ组... 详细信息

目的:观察并探讨新生大鼠接受七氟烷麻醉后,生长至断乳期的学习记忆功能的变化以及海马区神经元细胞凋亡的变化。方法:健康6~8日龄新生SD大鼠100只,随机数字表法分成5组,每组20只:Ⅰ组大鼠吸入体积分数为3%的七氟烷以及25%氧气2 h;Ⅱ组大鼠仅吸入25%氧气2 h;Ⅲ组大鼠分别在出生后第6、7、8天接受一次体积分数为3%的七氟烷以及25%氧气2 h;Ⅳ组大鼠仅吸入3次25%氧气2 h;Ⅴ组大鼠仅放入麻醉箱,不做任何处理。麻醉后待大鼠生长至16~21 d时,采用Morris水迷宫实验检测大鼠的空间学习和记忆能力,并且取大鼠海马区检测caspase-3的表达,用TUNEL法观察海马区凋亡细胞的变化。结果:1Morris水迷宫实验显示:在大鼠生长至16~21 d时进行定向航行实验,与第Ⅳ组大鼠相比,第Ⅰ组大鼠的逃避潜伏期无明显变化,差异无统计学意义(P>0.05);第Ⅲ组大鼠的逃避潜伏期明显延长,和其他组相比,差异均有统计学意义(P<0.05);2在水迷宫的空间探索实验中,与第Ⅳ组相比,第Ⅰ组大鼠的穿越平台的次数无明显的变化;第Ⅲ组大鼠穿越平台的次数明显减少,并且较第Ⅰ组以及其他各组大鼠也显著减少,差异有统计学意义(P<0.05);3第Ⅲ组大鼠的游泳速度明显慢于其他组别;4与第Ⅳ组大鼠比,Ⅰ组大鼠caspase-3的表达稍有增加,Ⅲ组大鼠caspase-3的表达明显增加,差异有统计学意义(P<0.05)。5仅接受一次七氟烷麻醉的大鼠海马区染色阳性的细胞稍有增加,而接受三次七氟烷麻醉的大鼠海马区染色阳性的细胞明显增加,差异有统计学意义(P<0.05)。结论:新生6~8 d的大鼠接受三次七氟烷麻醉后,待其生长至16~21 d,其空间学习记忆能力明显受到影响,可能与海马区神经元细胞凋亡有关。

关键词：七氟烷海马区学习记忆功能凋亡