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Chinese Journal of Structural Chemistry 2005年第4期24卷 413-418页

作者： FANJian-fen LUYun-xiang WANGQiu-Xia WULi-fen SUNYun-Peng DepartmentofChemistry SuzhouUniversitySuzhou215006China

Density functional theory (DFT) has been applied to study the enantioselective reduction of 3-morpholin-4-yl-1-phenyl-1-propanone with borane catalyzed by (S)-4-benzyl-5,5- diphenyl-1,3,2-oxazaborolidine at the B3LYP/6-31G* level. All molecular species involved in the four reaction steps have been fully optimized and the structural parameters are provided, and the micro process of reaction was also investigated. The catalyst-alkoxyborane adduct formed in step III exhibits a B-O-B-N tetra-atomic ring. Reaction coordination calculations show that BH3 can react with 3-morpholin-4-yl-1-phenyl-1-propanone spontaneously, resulting in the need of 2 mol BH3 in the reaction.

关键词： B3LYP/6-31G* 3-morpholin-4-yl-1-phenyl-1-propanone enantioselective reduction

Clinical significance of serum biochemistry changes in mice with targeted disruption of βB2-crystallin gene

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 55-58页

作者： fen-fen xiang, Wen-Jie Li Department of Laboratory Diagnosis Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Ophthalmology Changhai Hospital Second Military Medical University Shanghai 200433 China

AIM: To explore the pathogenesis, influencing factors, ways of medical intervention and evaluation indicators of cataract by observing changes in serum biochemical indices in mice with targeted disruption of βB2-crystallin. · METHODS: Nine 6-week-old male mice with targeted knockout of βB2-crystallin were used as the study group, and nine age- and sex-matched normal wild-type mice as the control group. The genetype of the modeled mice was identified by PCR technique. Tropicamide and phenylephrine eye drops were used as the cycloplegic agents to observe changes in lens opacity with a slit-lamp. The lens was then removed and blood was collected for biochemical evaluation in the serum. · RESULTS: Two genotypes were successfully identified by PCR technique. Slit-lamp observation showed that the lens cortex was opaque and GSH level in the lens cortex was remarkably decreased in mice with βB2-crystallin deficiency compared with the control group (P 0.05). · CONCLUSION: Compared with the wild-type mice, serum biochemical indices underwent significant changes in mice with targeted disruption of βB2-crystallin gene, especially with abnormal distribution of Na+&Ca2+, which induced the formation of cataract.

关键词： βB2-crystallin knockout cataract mice serum biochemistry

Recent Progress on Fabrications and Applications of Boron Nitride Nanomaterials:A Review

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Journal of Materials Science & Technology 2015年第6期31卷 589-598页

作者： xiang-fen Jiang Qunhong Weng Xue-Bin Wang Xia Li Jun Zhang Dmitri Golberg Yoshio Bando World Premier International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)Namiki 1-1TsukubaIbaraki 3050044Japan International Center for Young Scientists(ICYS) NIMSNamiki 1-1TsukubaIbaraki 3050044Japan College of Engineering and Applied Sciences Nanjing University School of Materials Science and Engineering Hebei University of Technology

Boron nitride(BN) nanostructures with complementary functions to their carbon counterparts are one of the most intriguing *** we devote a compact review on the syntheses of BN nanomaterials:typical zero-dimensional(OD) fullerenes and nanoparticles,one-dimensional(1D) nanotubes and nanoribbons,two-dimensional(2D) nanosheets as well as three-dimensional(3D) nanoporous *** low-dimensional quantum confinement and surface effects with unique physical and chemical properties of BN,*** electric insulation,wide band gap,and high chemical and thermal stability,BN nanomaterials have drawn particular attention in a variety of potential applications,***,functional composites,hydrogen accumulators,and advanced insulators,which are also reviewed.

关键词： Boron nitride Nanoparticle Nanotube Nanosheet Poro

MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第16期20卷 4723-4729页

作者： xiang-fen Ji Yu-Chen Fan Shuai Gao Yang Yang Jian-Jun Zhang Kai Wang Department of Hepatology Qilu Hospital of Shandong University Institute of Hepatology Shandong University

AIM: To investigate the potential of promoter methylation of two tumor suppressor genes (TSGs) as biomarkers for hepatocellular carcinoma (HCC).

关键词： MT1M MT1G Methylation Serum biomarker Hepatocellular carcinoma

Hepatitis of unknown etiology in children:Current evidence and association

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World Journal of Clinical Cases 2022年第35期10卷 12837-12843页

作者： Rui Zhong feng Yi fen xiang Yan-Fang Qiu Lei Zhu Yan-Hui Zou Wei Wang Qiong Zhang Department of Medical Oncology Digestive and Urinary UnitHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Emergency Yueyang Central HospitalYueyang 414100Hunan ProvinceChina Department of Radiation Therapy Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013Hunan ProvinceChina School of Nursing Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Health Service Centre Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013Hunan ProvinceChina

Two years after the coronavirus disease 2019(COVID-19)pandemic,acute hepatitis of unknown etiology in children(AHUCD)began to be reported *** novel coronavirus and adenovirus were found in pathogen and antibody tests in AHUCD cases reported by the World Health *** are not exposed to the viruses that children are generally exposed to owing to COVID-19 infection preventive measures such as isolation and wearing masks;therefore,some researchers have speculated that this disease is related to reduced exposure to *** scientists have also speculated that the disease is related to liver injury and adenoviral hepatitis,which are the sequelae of *** evidence also suggests a weak association between the disease and COVID-19 ***,further research and investigation of the pathogenesis,preventive measures,and early treatment of hepatitis of unknown etiology are *** study aimed to synthesize available evidence to further elucidate this disease in order to treat and prevent it effectively.

关键词： Acute hepatitis of unknown etiology Coronavirus disease Adenovirus Immune system Vaccine Multi-system inflammatory syndrome in children

Analysis of the Relations between Highway Geometric Design and Traffic Safety in Bangladesh,China,and America

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Frontiers Research of Architecture and Engineering 2022年第1期5卷 19-25页

作者： Licai Zhang Kai Hua fen xiang China Railway Eryuan Engineering Group Co.Ltd.(CREEC) ChengduSichuan610000China

Transportation plays a critical role in the economic sector in *** its independence,infrastructure has been developing rapidly,includ-ing land,water,and air *** economy is increasing at a relatively high rate,leading to the better-off of people’s *** the living standards keep improving,people are more concerned about safety issues in *** article makes an analysis of the status quo of traffic safety in Bangladesh and compares the Bangladeshi code with American code AASHTO from the geometric aspects of horizontal and vertical align-ment,in an effort to provide reference to the highway design in *** a reasonable design,the traffic safety will be under control and accident rate as well as economic loss will be minimized.

关键词： Geometric design Traffic safety Highway

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范式裂变:延安新闻观的兴起

兰州大学学报（社会科学版） 2019年第6期47卷 55-63页

作者：向芬中国社会科学院新闻与传播研究所北京100021

中国共产党延安新闻观的兴起涉及新闻文化政策的调整,体现党与知识分子、党与群众、知识分子与群众关系的重塑,催生了一种新政治、新文化、新组织,创造了一种新文体、新话语、新传播。通过关注中国共产党新闻理论与实践自身内在的视野... 详细信息

中国共产党延安新闻观的兴起涉及新闻文化政策的调整,体现党与知识分子、党与群众、知识分子与群众关系的重塑,催生了一种新政治、新文化、新组织,创造了一种新文体、新话语、新传播。通过关注中国共产党新闻理论与实践自身内在的视野与源流,将中国共产党延安新闻观与既往新闻观比较,寻找其突破性何在。延安新闻观展现了社会主义中国的现代构想,通过一套全新的价值衡量标准,配合行之有效的制度,将新闻事业植入到革命组织与革命斗争的实践中去。在中国共产党的新闻理论与实践中,也能提炼出普遍性的理论资源,从中外新闻传播观念交流中发现理论交叠。

关键词：延安新闻观整风运动政党文化

Integrated analysis of miRNAs and transcriptomes in Aedes albopictus midgut reveals the differential expression profiles of immune-related genes during dengue virus serotype-2 infection

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Insect Science 2016年第3期23卷 377-385页

作者： Yan-Xia Liu fen-xiang Li Zhuan-Zhuan Liu Zhi-Rong Jia Yan-He Zhou Hao Zhang Hui Yan Xian-Qiang Zhou Xiao-Guang Chen Key Laboratory of Prevention and Control of Emerging Infectious Diseases of Guangdong Higher Education Institutes Department ofPathogen Biology School of Public Health and Tropical Medicine Southern Medical University Guangzhou Laboratory of EmergingInfectious Diseases and Division of Laboratory Medicine Zhujiang Hospital Southern Medical University Guangzhou BGI-Shenzhen Shenzhen Guangdong Province China

Mosquito microRNAs （miRNAs） are involved in host-virus interaction, and have been reported to be altered by dengue virus （DENV） infection in Aedes albopictus （Diptera： Culicidae）. However, little is known about the molecular mechanisms of Aedes albopictus midgut--the first organ to interact with DENV--involved in its resistance to DENV. Here we used high-throughput sequencing to characterize miRNA and messenger RNA （mRNA） expression patterns in Aedes albopictus midgut in response to dengue virus serotype 2. A total of three miRNAs and 777 mRNAs were identified to be differentially expressed upon DENV infection. For the mRNAs, we identified 198 immune-related genes and 31 of them were differentially expressed. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses also showed that the differentially expressed immune-related genes were involved in immune response. Then the differential expression patterns of six immune-related genes and three miRNAs were confirmed by real-time reverse transcription polymerase chain reaction. Furthermore, seven known miRNA-mRNA interaction pairs were identified by aligning our two datasets. These analyses of miRNA and mRNA transcriptomes provide valuable information for uncovering the DENV response genes and provide a basis for future study of the resistance mechanisms in Aedes albopictus midgut.

关键词： Aedes albopictus DENV host-pathogen interaction midgut miRNA mRNA

“双战构造”中两岸媒体的记忆政治——以“二二八事件”为中心的考察

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江西师范大学学报（哲学社会科学版） 2022年第4期55卷 127-137页

作者：向芬中国社会科学院大学新闻传播学院北京102401 中国社会科学院新闻与传播研究所北京100021

对“二二八事件”历史话语解释权的把握,需要在长时段中进行比较历史研究,采用内战和冷战的“双战构造”框架来分析两岸“二二八事件”的媒体话语特征及变迁轨迹,进而审视在不同历史时期的记忆政治。研究发现,两岸媒体的报道和话语转化... 详细信息

对“二二八事件”历史话语解释权的把握,需要在长时段中进行比较历史研究,采用内战和冷战的“双战构造”框架来分析两岸“二二八事件”的媒体话语特征及变迁轨迹,进而审视在不同历史时期的记忆政治。研究发现,两岸媒体的报道和话语转化所形成的媒体记忆是被政治化的,在各据一方的意识形态和现实政治需求之中,报道的主题和叙事折射出两岸主导价值的差异以及记忆政治的延续与变化。两岸和平与发展最终取决于能否形成新的共识,未来需要着重讨论两岸分别发展的不同政治话语将如何被整合,并从中找寻更具兼容性的思想资源。

关键词：二二八事件两岸媒体双战构造记忆政治

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台湾民主转型中新闻传播的变迁与发展——一项基于对台湾新闻传播界深度访谈的研究

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厦门大学学报（哲学社会科学版） 2015年第3期65卷 75-86页

作者：向芬中国社会科学院新闻与传播研究所北京100026

对于台湾新闻传播与民主转型的关系问题,台湾新闻传播学界和业界相关人士无疑具有发言权,通过对他们的访谈,可以看到更加真实、全面和透彻的台湾民主转型中台湾新闻传播的历史过往和现实图景。台湾新闻传播在管制与自由、侍从与合谋、... 详细信息

对于台湾新闻传播与民主转型的关系问题,台湾新闻传播学界和业界相关人士无疑具有发言权,通过对他们的访谈,可以看到更加真实、全面和透彻的台湾民主转型中台湾新闻传播的历史过往和现实图景。台湾新闻传播在管制与自由、侍从与合谋、西化与本土这几个问题上有比较集中的叙说和解读,在报禁解除后的自由环境中,被访者强调应以"非无限"的自由与合理的管制去除市场之虞,长远规划符合本土的新闻传播政策。总体来看,有序合理的新闻传播政策与良性理想的媒体环境是被访者的共同期待。

关键词：台湾民主转型新闻传播报禁深度访谈