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Exposure to bifenthrin disrupts the development of testis in male Sebastiscus marmoratus

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Acta Oceanologica Sinica 2017年第2期36卷 57-61页

作者： LI Jinshou luo fen LIU Liyue RUAN Junfeng WANG Nannan Department of Biology Ningde Normal University Ningde 352100 China

Bifenthrin（BF） is a pyrethroid insecticide that is widely used in agriculture, horticulture, and for residential purposes. However, few studies addressing the reproductive toxicity of BF on fishes are available. The present study was conducted to investigate the effects of BF on testicular development in Sebastiscus marmoratus and to gain insight into its mechanism. After exposure to 1, 10 and 100 ng/L BF for 50 days, there was a reduced number of mature sperm and an abundance of the late stages of spermatocysts in the testes. The levels of 17β-estradiol and testosterone were decreased significantly after BF exposure. The activity of caspase-3 was increased in a dosedependent manner after BF exposure, TUNEL assay indicated that BF exposure resulted in the occurrence of apoptosis in the testes, which might be main reason for the inhibition of spermatogenesis.

关键词： bifenthrin apoptosis reproductive toxicity Sebastiscus marmoratus

Ab initio Predictions of Structural and Thermodynamic Properties of Zr2AIC Under High Pressure and High Temperature

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Chinese Journal of Chemical Physics 2015年第3期28卷 263-268,I0001页

作者： fen luo Zhi-cheng Guo Xiu-lu Zhang Chang-ying Yuan Ling-cang Cai Laboratory for Extreme Conditions Matter Properties Southwest University of Science and Technol- ogy Mianyang 521900 China National Key Laboratory for Shock Wave and Detonation Physics Research Institute of Fluid Physics Chinese Academy of Engineering Physics Mianyang 521900 China

The structural and thermodynamic properties of Zr2A1C at high pressure and high temper- ature are investigated by first principles density functional theory method. The calculated lattice parameters of Zr2A1C are in good agreement with the available theoretical data. The pressure dependences of the elastic constants, bulk modulus, shear modulus, Young＇s mod- ulus, and Vickers hardness of Zr2A1C are successfully obtained. The elastic anisotropy is examined through the computation of the direction dependence of Young＇s modulus. By using the quasiharmonic Debye model, the thermodynamic properties including the Debye temperature, heat capacity, volume thermal expansion coefficient, and Griineisen parameter at high pressure and temperature are predicted for the first time.

关键词： Elastic property Thermodynamic property Density functional theory

Laparoscopic approach for managing intussusception in children:Analysis of 65 cases

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World Journal of Clinical Cases 2022年第3期10卷 830-839页

作者： Sheng-Miao Li Xiao-Ying Wu Chun-fen luo Lin-Jun Yu Department Pediatric Surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000Zhejiang ProvinceChina

BACKGROUND Intussusception can be managed by pneumatic reduction,ultrasound-guided hydrostatic reduction,open or laparoscopic surgery,but laparoscopy in such cases remains *** To explore the clinical characteristics,effectiveness,and complications of surgical reduction for intussusception using laparoscopy in *** This study was a retrospective case series of pediatric patients with intussusception who underwent surgical reduction by laparoscopy from May 2011 to April 2016 at Taizhou Hospital of Zhejiang *** characteristics(operation time,intraoperative blood loss,conversion rate of laparotomy,reasons for conversion,postoperative hospital stay,and adverse events)were *** The 65 patients included 45 boys and 20 *** average age was 2.3 years(27.5±24.5 mo).Of the 65 patients,61 underwent surgical reduction by laparoscopy after a failed enema reduction of intussusception,and four underwent the procedure *** patients were treated successfully and 57(87.7%)patients underwent successful laparoscopic surgery,two of which had a spontaneous *** the remaining cases,one was converted to open surgery via right upper quadrant incision,and seven required enlarged umbilical *** resection was performed in 5 patients because of abnormal bowel *** were no complications(intestinal perforations,wound infections,or intestinal adhesions)during the follow-up of 3 years to 8 *** patients experienced a recurrence of intussusception;one was resolved with pneumatic reduction,and the other underwent a second laparoscopic *** Laparoscopic approach for pediatric intussusception is feasible and *** resection if required can be performed by extending umbilical incision without the conventional laparotomy.

关键词： Laparoscopy Intussusception Air reduction Benefits Complications

Empirical research on construction of a measurement framework for tourism carbon emission in China

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Chinese Journal of Population,Resources and Environment 2015年第3期13卷 240-249页

作者： Yongde Zhong Shengyi Shi Shihong Li fen luo Weiliang luo Qiong Xiao College of Tourism Central South University of Forestry & Technology

According to the logic process of carbon reduction in China which arises from the measurement to reduction,from reduction to offsetting,the measurement of carbon emission in the tourism industry was the first and key *** on the life cycle assessment theory and input-output analysis,this article used economic and environmental measurement technologies,The System of National Accounting(SNA),Tourism Satellite Account(TSA),System of Integrated Environment and Economic Accounting(SEEA),and so on,and built up a top-down carbon emission analysis framework for the tourism industry and estimated carbon emission of the tourism industry in China in *** finding showed that the total carbon emission of the tourism industry in China in 2007 was 169.78 million tons,covering 2.71%of carbon emission of all industries in China in 2007,and 2.44%of the total carbon emission in China in *** direct carbon emission of the tourism industry in China in 2007 was 73.56 million tons,including transportation(50.14 million tons),sightseeing(1.33 million tons),lodging(4.19 million tons),accommodation(4.73 million tons),shopping(8.14 million tons),entertainment(0.67 million tons),communication(0.45 million tons),and others(3.90 million tons).The indirect carbon emission of the tourism industry in China in 2007 was 96.23 million tons,mostly contributed by coking,gas,and petroleum processing industries,transportation and warehousing industry,machinery and equipment manufacturing industry,and food manufacturing and tobacco processing industry,which covered 57%.

关键词： climate change carbon emission tourism industry measurement framework

Two new Stephanodiscaceae species(Bacillariophyta)from SW China

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Journal of Oceanology and Limnology 2024年第6期42卷 2024-2033页

作者： Pan YU fen luo Qingmin YOU John Patrick KOCIOLEK Wanting PANG Yue CAO Quanxi WANG School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200235China College of Life Sciences Shanghai Normal UniversityShanghai 200234China College of Chemistry Biology and Environment Yuxi Normal UniversityYuxi 653100China Museum of Natural History and Department of Ecology and Evolutionary Biology University of ColoradoUCB 218Boulder CO 80309USA

Two new freshwater centric diatom species were described from the southwest of China based on light and scanning electron *** weixiense *** a transversely undulate valve face,marginal fultoportulae situated at the end of the hyaline strips,central fultoportulae forming a ring positioned in a circular pattern,each with 3-4(usually 3)satellite pores,and a single rimoportula located at the base of the inner distal end of the *** aspera *** an uneven valve face with small granules that may be present on the marginal area and valve mantle,marginal fultoportulae situated on each costa close to the margin of the valve,6-7 central fultoportulae forming a ring near the valve center each with two satellite pores,and one rimoportula located on the valve face/mantle junction in the middle of costa on the internal *** *** the first reported extant species in the *** study played an important role in studying the taxonomic status and ecological information of the genus,and the establishment of the two new taxa will help demonstrate the unique nature of freshwater diatom flora in the southwest of China.

关键词： diatom centric new species Pliocaenicus Tertiarius China

Effect of spleen operation on antiviral treatment in hepatitis Cvirus-related cirrhotic patients

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World Journal of Gastroenterology 2014年第41期20卷 15387-15397页

作者： Bo feng Wei Zhang Bi-fen luo Guang-Jun Song Jian Wang Qian Jin Hong Qin Lai Wei Peking University People’s Hospital Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases

AIM: To investigate the impact of spleen operation (SO) on interferon-α (IFN-α)-based antiviral treatment in patients with hepatitis C virus (HCV)-related cirrhosis.

关键词： Hepatitis C virus cirrhosis Interferon Ribavirin Splenectomy Partial splenic embolization

Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice

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Neuroscience Bulletin 2020年第8期36卷 919-931页

作者： Li-Bin Zhang Jie Zhang Meng-Jia Sun Hao Chen Jie Yan fen-Lan luo Zhong-Xiang Yao Ya-Min Wu Bo Hu Department of Physiology College of Basic Medical SciencesArmy Medical UniversityChongqing 400038China State Key Laboratory of Trauma Bums and Combined InjuryDaping Hospital/Research Institute of SurgeryArmy Medical UniversityChongqing 400042China Squadron 10 Battalion 3College of Basic Medical SciencesArmy Medical UniversityChongqing 400038China

Cerebellar malfunction can lead to sleep disturbance such as excessive daytime sleepiness,suggesting that the cerebellum may be involved in regulating sleep and/or ***,understanding the features of cerebellar regulation in sleep and wakefulness states requires a detailed characterization of neuronal activity within this *** performing multiple-unit recordings in mice,we showed that Purkinje cells(PCs)in the cerebellar cortex exhibited increased firing activity prior to the transition from sleep to ***,the increased PC activity resulted from the inputs of lowfrequency non-PC units in the cerebellar ***,the increased PC activity was accompanied by decreased activity in neurons of the deep cerebellar nuclei at the nonrapid eye-movement sleep-wakefulness *** results provide in vivo electrophysiological evidence that the cerebellum has the potential to actively regulate the sleep-wakefulness transition.

关键词： Sleep Wakefulness Multiple-unit recording Purkinje cell Deep cerebellar nuclei

CDH1, a Novel Surface Marker of Spermatogonial Stem Cells in Sheep Testis

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Journal of Integrative Agriculture 2014年第8期13卷 1759-1765页

作者： ZHANG Yan WU Sachula luo fen-hua Baiyinbatu LIU Lin-hong HU Tian-yuan YU Bo-yang LI Guang-peng WU Ying-ji The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology Inner Mongolia University School of Basic Medical Sciences Inner Mongolia Medical University

Spermatogonial stem cells（SSCs） are unique stem cells in adult body that can transmit genetic information to the next generation. They have self-renewal potential and can continuously support spermatogenesis throughout life of a male animal. However, the SSC population is extremely small, isolation and purification of the SSCs is challenging, especially for livestock animals. It has been confirmed that CDH1（cadherin-1, also known as E-cadherin） can be expressed in undifferentiated SSCs of mouse and rats, but it has not been verified in sheep. Here, CDH1 was found as a novel surface marker for sheep SSCs. In this paper, sheep antiCDH1 polyclonal antibodies were prepared and its activity was checked. Using the obtained antibodies and immunohistochemistry analysis, we confirmed that CDH1 can be expressed by SSCs in sheep testis.

关键词： sheep spermatogonial stem cells CDH1 polyclonal antibodies immunofluorescent staining

Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir

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World Journal of Gastroenterology 2018年第40期24卷 4554-4564页

作者： Xiao-Xiao Wang Bi-fen luo Han-Ji Jiang Xu Cong Qian Jin Dan-Li Ma Lai Wei Bo feng Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Peking University People's Hospital

AIM To investigate how natural killer(NK) cells are affected in the elimination of hepatitis C virus(HCV) by sofosbuvir/ledipasvir, two highly effective direct-acting antivirals(DAAs). METHODS Thirteen treatment-na?ve and treatment-experienced chronic hepatitis C(CHC) patients were treated with sofosbuvir/ledipasvir, and NK cells were detected at baseline, weeks 2, 4, 8 and 12 during therapy, and week post of treatment(Pt)-12 and 24 after the end of therapy by multicolor flow cytometry and compared with those from 13 healthy controls. RESULTS All patients achieved sustained virological response. There was a significant decline in CD56^(bright) NK cell frequencies at week 8(P = 0.002) and week 12(P = 0.003), which were altered to the level comparable to healthy controls at week Pt-12, but no difference was observed in the frequency of CD56^(dim) NK cells. Compared with healthy controls, the expression levels of NKG2A, NKp30 and CD94 on NK cells from CHC patients at baseline were higher. NKG2A, NKp30 and CD94 started to recover at week 12 and reached the levels similar to those of healthy controls at week Pt-12 or Pt-24. Before treatment, patients have higher interferon(IFN)-γ and perforin levels than healthy controls, and IFN-γ started to recover at week 8 and reached the normalized level at week Pt-12. CONCLUSION NK cells of CHC patients can be affected by DAAs, and phenotypes and function of NK cells recover not at early stage but mainly after the end of sofosbuvir/ledipasvir treatment.

关键词： Direct-acting antivirals therapy Hepatitis C virus Natural killer cells Natural killer subsets