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5Ws of Green and Sustainable Software

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Tsinghua Science and Technology 2020年第3期25卷 401-414页

作者： Coral Calero Javier Mancebo felix garcia Maria Angeles Moraga Jose Alberto garcia Berna Jose Luis Fernandez-Aleman Ambrosio Toval the Institute of Technology and Information Systems University of Castilla-La ManchaCiudad Real 13071Spain. the Department of Informatics and Systems University of MurciaMurcia 30003Spain

Green and Sustainable Software has emerged as a new and highly active area in the software community.After several years of research and work,we believe that it is now necessary to obtain a general snapshot of how the research in this area is evolving.To do so,we have applied the 5 Ws(why,when,who,where,and what),a formula for getting the complete story on a subject.We have therefore carried out a study,using 542 publications related to Green and Sustainable Software research;these were recovered using SCOPUS.The results obtained allow us to conclude that it is important to identify key elements of the research to allow researchers be fully aware of the state of the research on Green and Sustainable Software(why);the study uses papers published between 2000 and the beginning of November 2018(when);the most prolific authors are mainly from Europe,although the USA is the most active country,Green and Sustainable Software being a very interactive area with a good number of multinational publications(who);the top five keywords related to sustainable aspects are Green Software,Green IT,Software Sustainability,Energy Consumption,and Energy Efficiency(what);finally,as regards the places authors prefer to publish in,there is almost a complete balance between conferences and journals,with a trend towards an increase in the number of publications(where).

关键词： Green Software Sustainable Software Software Engineering Software Sustainability Energy Efficiency Energy Utilization

PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis

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World Journal of Gastroenterology 2010年第46期16卷 5869-5873页

作者： Mauricio garcia-Saenz-de-Sicilia Francisco Sanchez-Avila Norberto C Chavez-Tapia Gustavo Lopez-Arce Sandra garcia-Osogobio Roberto Ruiz-Cordero felix I Tellez-Avila Department of Gastroenterology Instituto Nacional de Ciencias Medicas y Nutrición Salvador ZubiranMexico CityMexico Medica Sur Clinic and Fundation Endoscopy Department Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranMexico City14000Mexico

AIM:To determine if proton pump inhibitor use in cirrhotic patients with endoscopic findings of portal hypertension is associated with a lower frequency of gastrointestinal bleeding.METHODS:Patients with cirrhosis and endoscopic findings related to portal hypertension,receiving or not receiving proton pump inhibitor (PPI) therapy,were included retrospectively.We assigned patients to two groups:group 1 patients underwent PPI therapy and group 2 patients did not undergo PPI therapy.RESULTS:One hundred and five patients with a median age of 58 (26-87) years were included,57 (54.3%) of which were women.Esophageal varices were found in 82 (78%) patients,portal hypertensive gastropathy in 72 (68.6%) patients,and gastric varices in 15 (14.3%) patients.PPI therapy was used in 45.5% of patients (n=48).Seventeen (16.1%) patients presented with upper gastrointestinal bleeding;in 14/17 (82.3%) patients,bleeding was secondary to esophageal varices,and in 3/17 patients bleeding was attributed to portal hypertensive gastropathy.Bleeding related to portal hypertension according to PPI therapy occurred in 18.7% (n=9) of group 1 and in 14% (n=8) of group 2 (odds ratio:0.83,95% confidence interval:0.5-1.3,P=0.51).CONCLUSION:Portal hypertension bleeding is not associated with PPI use.These findings do not support the prescription of PPIs in patients with chronic liver disease with no currently accepted indication.

关键词： Drug prescription Liver cirrhosis Portal hypertension Proton pump inhibitors Upper gastrointestinal bleeding

Electrochemically driven phenothiazine modification of carbon nanodots

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Nano Research 2018年第12期11卷 6405-6416页

作者： Monica Mediavilla Emiliano Martinez-Perinan Iria Bravo Tania garcia-Mendiola Monica Revenga-Parra felix Pariente Encarnacion Lorenzo Departamento de Qufmica Analftica yAndlisis Instrumental UniversidadAutonoma de MadridMadrid28049Spain Instituto Madrileno de Estudios Avanzados (IMDEA)Nanociencia Faraday9Campus UAMCantoblancoMadrid28049Spain Institute for Advanced Research in Chemical Sciences (IAdChem) UniversidadAutonoma de MadridMadrid 28049Spain

Carbon nanodots (CNDs) with enriched periphery carboxylic groups were synthesized using the low-cost starting material glucose. The obtained CNDs were assembled onto Au electrodes following one of two strategies: covalent bonding, using cystamine as a cross-linker, or by drop-casting. The immobilized CNDs were covalently modified with the phenothiazine Azure A via electron transfer chemistry; in particular via reactions with aryl diazonium salts. The reaction mechanism for the diazonium functionalization of CNDs was investigated. Spectroelectrochemistry experiments confirmed that electrografting, rather than adsorption, governs the functionalization of CNDs with Azure A. Finally, the application of these CNDs as electrocatalysts for the oxidation of hydrazine was demonstrated.

关键词： carbon nanodots Azure A electrografting phenothiazine

Farm-scale evaluation of the impact of CrylAb Bt maize on canopy nontarget arthropods： a 3-year study

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Insect Science 2018年第1期25卷 87-98页

作者： Maria Arias-Martin Matias garcia Pedro Castanera felix Ortego Gema P. Farinos Centro de Investigaciones Biologicas CSIC Departamento de Biologia Medioambiental Grupo de Interaccion Planta-lnsecto Ramiro deMaeztu 9 28040 Madrid Spain

The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

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Cellular & Molecular Immunology 2015年第6期12卷 777-779页

作者： Jose AG Agundez Elena garcia-Martin Carmen Martinez Julian Benito-Leon Julian Benito-Leon Jorge Millan-PascualMaria Diaz-Sanchez Patricia Calleja Diana Pisa Laura Turpin-Fenoll Hortensia Alonso-Navarro Lucia Ayuso-Peralta Dolores Torrecillas Esteban Garcla-Albea Jose Francisco Plaza-Nieto felix Javier Jimenez-Jimenez Department of Pharmacology University of Extremadura CAceres Spain Department of Biochemistry and Molecular Biology University of Extremadura Caceres Spain CiBERNED Centro de InvestigaciOn BiomEdica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain Service of Neurology Hospital Universitario Doce de Octubre Madrid Spain Department of Medicine University Complutense Madrid Spain Section of Neurology Hospital La Mancha-Centro Alcazar de San Juan (Ciudad Real) Spain Centro de Biologfa Molecular Severo Ochoa (CSIC-UAM) Facultad de Ciencias Universidad Autonoma Cantoblanco 28049 Madrid Spain Department of Medicine-Neurology Hospital 'Principe de Asturias' Universidad de Alcala Alcala de Henares (Madrid) Spain Section of Neurology Hospital Universitario del Sureste Arganda del Rey (Madrid) Spain Correspondence: Dr FJ Jimenez-Jimenez C/Marroquina 14 3° B E-28030 Madrid Spain.

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.

关键词： associated increased sclerosis

Application of Arbuscular Mycorrhizae Glomus iranicum var. tenuihypharum var. nova in Intensive Agriculture： A Study Case

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Journal of Agricultural Science and Technology(B) 2017年第4期7卷 221-247页

作者： felix Femandez Martin Jesus Juarez Molina Emilio Nicolas Nicolas Juan Jose Alarcan Martin Kirchmair Francisco Jose garcia Antonio Jose Bemabe garcia Camille Bemal SYMBORG S.L. Campus de Espinardo 7 Edificio CEEIM CP Murcia 30100 Spain CEBAS-CSIC Campus de Espinardo CP Murcia 30100 Spain Universitat lnnsbruck Institut fur Mikrobiologie Technikerstr 25 lnnsbruck A-6020 Austria

Intensive agriculture contributes to a decrease in microbial biomass and crop yields, while accelerating soil degradation. Arbuscular mycorrhizae associations have direct benefits for plant nutrition, and may be considered a useful tool in modern agriculture. Notwithstanding the widespread knowledge of these benefits, their use in intensive farming systems has until now been ineffectual, because most mycorrhizal species have low tolerance toward high concentrations of nutrients and are poorly adapted to the soil and/or mycorrhizal functioning. The aim of this work was to test the efficacy of an arbuscular mycorrhizal (AM) fungus, Glomus iranicum var. tenuihypharum on lettuce and table grape crops in different intensive farming systems. The variables studied were root colonization percentage, external mycelium concentration, gas exchange, photosynthetic activity, root starch concentration and plant nutrition. The main finding was that the fungus is tolerant of a wide range of soil pH values, high salinity levels and abundant external mycelium. In lettuce, it produced significant increases in plant physiological activity and productivity (10%-15%); and in table grapes, increases of 12%-45% in yield were achieved for more than three years in Crimson variety, and significant increases in fruit cluster weight, color uniformity and Brix (°Bx). The AM species is protected by two patents and is a component of MycoUp, MycoUp Activ, Resid HC and Resid MG, whose commercial application has spread to more than 30 countries, with increments in crop yields of 8%-45% in lines as varied as leaf vegetables, berries, fruit, olives, grapes, greenhouse crops and cereals.

关键词： Arbuscular mycorrhizal Glomus iranicum var. tenuihypharum intensive agriculture gas exchange root starch concentration photosynthetic activity

MORTl/FADD is involved in liver regeneration

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World Journal of Gastroenterology 2005年第46期11卷 7248-7253页

作者： Marcus Schuchmann felix Rückert Jose F garcia-Lazaro Andrea Karg Jürgen Burg Natalia Knorr Jürgen Siebler Eugene E Varfolomeev David Wallach Wolfgang Schreiber Ansgar W Lohse Peter R Galle Department of Medicine University of Mainz Langenbeckstr.1Mainz 55101 Germany Institute of RadiologyUniversity of Mainz Langenbeckstr.1Mainz 55101Germany Institute of PathologyUniversity of Mainz Langenbeckstr. 1 Mainz 55101 Germany Department of MedicineUniversity of Mainz Langenbeckstr.1Mainz 55101Germany GenentechSouth San Francisco CAUnited States The Weizmann Institute of ScienceRehovot Israel Institute of RadiologyUniversity of Mainz Langenbeckstr.1Mainz 55101 Germany Department of Medicine University of Mainz Langenbeckstr.1Mainz 55101 Germany

AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group. CONCLUSION: Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/ FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.

关键词： MORTI FADD 肝脏再生治疗临床表现

Antioxidant drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis:What does evidence suggest?

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World Journal of Gastroenterology 2015年第21期21卷 6745-6753页

作者： Clotilde Fuentes-Orozco Carlos Davalos-Cobian Jesus garcia-Correa Gabriela Ambriz-Gonzalez Michel Dassaejv Macias-Amezcua Jesus garcia-Renteria Jorge Rendon-felix Mariana Chavez-Tostado Lizbeth Araceli Cuesta-Marquez Andrea Socorro Alvarez-Villasenor Ana Olivia Cortes-Flores Alejandro Gonzalez-Ojeda Research Unit in Clinical Epidemiology Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Department Gastrointestinal Endoscopy Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Department of Pediatric Surgery.Children’s Hospital.Western National Medical Center Mexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Health Research Coor-dination.Mexican Institute of Social Security Baja Californa Sur 23000 Mexico

AIM:To determine whether or not the use of antioxidant supplementation aids in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.METHODS:A systematic review of randomized controlled trials(RCTs) was made to evaluate the preventive effect of prophylactic antioxidant supplementation in post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP).The inclusion criteria included:acute post-endoscopic retrograde cholangiopancreatography pancreatitis in adults; randomized clinical trials with the use of any antioxidant as an intervention compared with placebo,to reduce PEP.The outcome measure was the incidence and severity of PEP.Twelve RCTs involving 3110 patients since 1999 wereincluded.The antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),N-acetylcysteine(NAC) in three trials,and allopurinol in six trials.The group of patients treated with NAC received different doses; either oral or intravenous,and allopurinol-treated patients received five different oral doses in two different administration periods.The results are expressed with raw numbers,proportions,as well as mean and standard deviations.The incidence of pancreatitis between groups was analyzed with Pearson's χ2 test or Fisher's exact test(F).The main outcome is expressed as relative risks and 95%CI.RESULTS:The incidence of pancreatitis in all antioxidant treatment groups was 8.6%,whereas it was 9.7% in the control group.The antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),NAC in three trials,and allopurinol in six trials.In allopurinol trials,three different dosifications were used; two trials reported a low dosage(of less than 400 mg),two trials reported a moderate dose(600 mg) and the remaining two employed higher doses(more than 900 mg).Supplementation was not associated with a significant reduction in the incidence of PEP [relative risk(RR) = 0.93; 95%CI:0.82-1.06; P = 0.28].In addition,the incidences of PEP in patients treated with allopurino

关键词： Antioxidant drugs Endoscopic retrograde cholangiopancreatography Pancreatitis Prophylaxis

Refractive errors among children, adolescents and adults attending eye clinics in Mexico

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 796-802页

作者： Francisco Gomez-Salazar Abraham Campos-Romero Humberto Gomez-Campana Cinthia Cruz-Zamudio Mariano Chaidez-felix Nidia Leon-Sicairos Jorge Velazquez-Roman Hector Flores-Villasenor Secundino Muro-Amador Alma Marlene Guadron-Llanos Javier J.Martinez-garcia Joel Murillo-Llanes Jaime Sanchez-Cuen Alejando Llausas-Vargas Gerardo Alapizco-Castro Ana Irineo-Cabrales Enrique Graue-Hernandez Tito Ramirez-Luquin Adrian Canizalez-Roman Salud Digna Para Todos I.A.P Culiacan Sinaloa 80000Mexico CIASaP School of Medicine Autonomous University of Sinaloa Culiacan Sinaloa 80246 Mexico Pediatric Hospital of Sinaloa Culiacan Sinaloa 80200Mexico The Women's Hospital Secretariat of Health Culiacan Sinaloa 80127 Mexico Department of Gastroenterology Regional Hospital ISSSTECuliacan 80230 Sinaloa Mexico Education and Research Department Regional general Hospital No. 1 IMSS Culiacan Sinaloa 80220 Mexico Department of Cornea and Refractive Surgery Institute of Ophthalmology 'Conde de Valenciana' Mexico City 06800Mexico

AIM：To assess the proportion of refractive errors in the Mexican population that visited primary care optometry clinics in fourteen states of Mexico. METHODS：Refractive data from 676 856 patients aged 6 to 90 y were collected from optometry clinics in fourteen states of Mexico between 2014 and 2015. The refractive errors were classified by the spherical equivalent（SE）, as follows：sphere＋？ cylinder. Myopia（SE〉-0.50 D）, hyperopia（SE〉＋0.50 D）, emmetropia（-0.50≤SE≤＋0.50）, and astigmatism alone（cylinder≥-0.25 D）. A negative cylinder was selected as a notation.RESULTS：The proportion（95% confidence interval） among all of the subjects was hyperopia 21.0%（20.9-21.0）, emmetropia 40.7%（40.5-40.8）, myopia 24.8%（24.7-24.9） and astigmatism alone 13.5%（13.4-13.5）. Myopia was the most common refractive error and frequency seemed to increase among the young population（10 to 29 years old）, however, hyperopia increased among the aging population（40 to 79 years old）, and astigmatism alone showed a decreasing trend with age（6 to 90y; from 19.7% to 10.8%）. There was a relationship between age and all refractive errors（approximately 60%, aged 50 and older）. The proportion of any clinically important refractive error was higher in males（61.2%） than in females（58.3%; P〈0.0001）. From fourteen states that collected information, the proportion of refractive error showed variability in different geographical areas of Mexico.CONCLUSION：Myopia is the most common refractive error in the population studied. This study provides the first data on refractive error in Mexico. Further programs and studies must be developed to address the refractive errors needs of the Mexican population.

关键词： refractive errors hyperopia myopia astigmatism