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Effects of obstructive sleep apnea and its treatment over the erectile function： a systematic review

Asian Journal of Andrology 2017年第3期19卷 303-310页

作者： felix campos-juanatey Marcos Fernandez-Barriales Monica Gonzalez Jose A Portillo-Martin Urology Department Marques de Valdecilla University Hospital Santander 39008 Spain Institute of Investigation Marques de Valdecilla Santander 39011 Spain Oral and Maxillofacial Surgery Department Araba University Hospital Araba 01004 Spain Sleep and Ventilation Unit Marques de Valdecilla University Hospital Santander 39008 Spain Medical and Surgical Sciences Department School of Medicine University of Cantabria Santander 39011 Spain.

Erectile dysfunction （ED） is considered a condition with a broad range of etiologies. Obstructive sleep apnea （OSA） syndrome is one of the lesser studied risk factors for ED. We intend to summarize the current evidence on the relationship between OSA and sexual impairment, focusing on the results in terms of erectile function of the different therapies offered to OSA patients. A systematic review was conducted, selecting articles related to the physiology of OSA and ED, and to the treatments of OSA syndrome and their reported outcomes in erectile and sexual function. Higher prevalences of ED in the OSA groups have been published. However, whether this effect on the erectile function occurs in the entire range of OSA severities remains unclear. Several hypotheses were proposed to explain the physiology of this association. Continuous Positive Airway Pressure as a treatment for OSA patients with ED has achieved a significative improvement in the sexual parameters in most of the studies. Phosphodiesterase type 5 inhibitors （iPDE5） on demand are useful as a treatment for ED in this subgroup of patients, with high satisfaction rates. The surgical treatment for the OSA evidenced benefits over the erectile function, and the effect on the sexual satisfaction of the therapy using Mandibular Advancement Devices is still undefined.

关键词： continuous positive airway pressure erectile dysfunction obstructive sleep apnea operative surgical procedures phosphodiesterase type 5 inhibitors

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Single-stage tubular urethral reconstruction using oral grafts is an alternative to classical staged approach for selected penile urethral strictures

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Asian Journal of Andrology 2020年第2期22卷 134-139页

作者： felix campos-juanatey Simon Bugeja Mariya Dragova Anastasia V Frost Stella L Ivaz Daniela E Andrich Anthony R Mundy Reconstructive Urology Unit Institute of UrologyUniversity College London HospitalsLondon W1G 8PHUK Department of Urology Marques de Valdecilla University HospitalInstitute of Investigation Valdecilla(IDIVAL)Santander 39008Spain Urology Unit Mater Dei HospitalMsida MSD 2090Malta

Penile urethral strictures have been managed by a staged surgical *** selected cases,spongiofibrosis can be excised,a neo-urethral plate created using buccal mucosa graft(BMG)and tubularized during the same procedure,performing a“twoin-one”stage *** aim to identify stricture factors which indicate suitability for this two-in-one stage *** assess surgical outcome and compare with staged *** conducted an observational descriptive *** data were prospectively collected from two-in-one stage and staged penile urethroplasties using BMG in a single center between 2007 and *** minimum follow-up was 6 *** were assessed clinically,radiologically,and by flow-rate *** was defined as recurrent stricture or any subsequent surgical or endoscopic *** analysis of stricture characteristics and statistical comparison was made between *** 425 penile urethroplasties,139 met the inclusion criteria:59 two-in-one stage and 80 *** mean stricture length was 2.8 cm(single stage)and 4.5 cm(staged).Etiology was lichen sclerosus(LS)52.5%(single stage)and 73.8%hypospadias related(staged).40.7%of patients had previous failed urethroplasties in the single-stage group and 81.2%in the *** most common stricture locations were navicular fossa(39.0%)and distal penile urethra(59.3%)in the single-stage group and mid or proximal penile urethra(58.7%)in the staged *** rates were 89.8%(single stage)and 81.3%(staged).A trend toward a single-stage approach for select penile urethral strictures was *** conclude that a single-stage substitution penile urethroplasty using BMG as a“two-in-one”approach is associated with excellent functional *** most suitable strictures for this approach are distal,primary,and LS-related strictures.

关键词： anterior urethral stricture hypospadias lichen sclerosus oral mucosa reconstructive surgical procedures tissue transplants

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Management of penile urethral strictures: Challenges and future directions

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World Journal of Clinical Urology 2016年第1期5卷 1-10页

作者： felix campos-juanatey Simon Bugeja Stella L Ivaz Anastasia Frost Daniela E Andrich Anthony R Mundy Institute of Urology University College London Hospitals Marques de Valdecilla University Hospital

The anatomy of the penile urethra presents additional challenges when compared to other urethral segments during open stricture surgery particularly because of its unsuitability for excision and primary anastomosis and its relatively deficient corpus spongiosum. Stricture aetiology, location, length and previous surgical intervention remain the primary factors influencing the choice of penile urethroplasty technique. We have identified what we feel are the most important challenges and controversies in penile urethral stricture reconstruction, namely the use of flaps vs grafts, use of skin or oral mucosal tissue for augmentation/substitution and when a single or a staged approach is indicated to give the best possible outcome. The management of more complex cases such as panurethral lichen-sclerosus strictures and hypospadias "cripples" is outlined and potential developments for the future are presented.

关键词： Reconstructive surgical procedures Anterior urethral stricture Oral mucosa Tissue transplants Skin grafting Hypospadias Lichen sclerosus

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Funneling of the bladder neck - radiological appearance after radical retropubic prostatectomy and clinical relevance

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Asian Journal of Andrology 2020年第2期22卷 152-153页

作者： Simon Bugeja Anastasia Frost Stella Ivaz felix campos Daniela E Andrich Anthony R Mundy University College London Hospitals NHS Foundation TrustReconstructive Urology UnitLondon NW12PGUK

Several authors have commented on the anatomical changes following radical prostatectomy(RP)for prostate cancer and their characteristic radiological appearances.1,2 Most of these relate to periurethral fibrosis and its clinical significance in patients with postprostatectomy sphincter weakness incontinence.3,4 On magnetic resonance imaging(MRI),this postsurgical fibrosis appears as a focus of low-signal intensity in the periurethral tissues at and around the level of the vesicourethral anastomosis(VUA)which is appreciable on both T1-and T2-weighted images.

关键词： bladder clinical radiological

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High throughput sequencing unravels tomato-pathogen interactions towards a sustainable plant breeding

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Horticulture Research 2021年第1期8卷 2416-2427页

作者： Maria Doroteia campos Maria do Rosario felix Mariana Patanita Patrick Materatski Carla Varanda MED–Mediterranean Institute for Agriculture Environment and DevelopmentInstituto de Investigacao e Formaçao AvancadaUniversidade de EvoraPolo da MitraAp.947006-554 EvoraPortugal MED–Mediterranean Institute for Agriculture Environment and Development&Departamento de FitotecniaEscola de Ciencias e TecnologiaUniversidade de EvoraPolo da MitraAp.947006-554 EvoraPortugal

Tomato(Solanum lycopersicum)is one of the most economically important vegetables throughout the *** is one of the best studied cultivated dicotyledonous plants,often used as a model system for plant research into classical genetics,cytogenetics,molecular genetics,and molecular *** plants are affected by different pathogens such as viruses,viroids,fungi,oomycetes,bacteria,and nematodes,that reduce yield and affect product *** study of tomato as a plant-pathogen system helps to accelerate the discovery and understanding of the molecular mechanisms underlying disease resistance and offers the opportunity of improving the yield and quality of their edible *** use of functional genomics has contributed to this purpose through both traditional and recently developed techniques,that allow the identification of plant key functional genes in susceptible and resistant responses,and the understanding of the molecular basis of compatible interactions during pathogen ***-generation sequencing technologies(NGS),which produce massive quantities of sequencing data,have greatly accelerated research in biological sciences and offer great opportunities to better understand the molecular networks of plant–pathogen *** this review,we summarize important research that used high-throughput RNA-seq technology to obtain transcriptome changes in tomato plants in response to a wide range of pathogens such as viruses,fungi,bacteria,oomycetes,and *** findings will facilitate genetic engineering efforts to incorporate new sources of resistance in tomato for protection against pathogens and are of major importance for sustainable plant-disease management,namely the ones relying on the plant’s innate immune mechanisms in view of plant breeding.

关键词： breeding sustainable quantities

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Refractive errors among children, adolescents and adults attending eye clinics in Mexico

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 796-802页

作者： Francisco Gomez-Salazar Abraham campos-Romero Humberto Gomez-Campana Cinthia Cruz-Zamudio Mariano Chaidez-felix Nidia Leon-Sicairos Jorge Velazquez-Roman Hector Flores-Villasenor Secundino Muro-Amador Alma Marlene Guadron-Llanos Javier J.Martinez-Garcia Joel Murillo-Llanes Jaime Sanchez-Cuen Alejando Llausas-Vargas Gerardo Alapizco-Castro Ana Irineo-Cabrales Enrique Graue-Hernandez Tito Ramirez-Luquin Adrian Canizalez-Roman Salud Digna Para Todos I.A.P Culiacan Sinaloa 80000Mexico CIASaP School of Medicine Autonomous University of Sinaloa Culiacan Sinaloa 80246 Mexico Pediatric Hospital of Sinaloa Culiacan Sinaloa 80200Mexico The Women's Hospital Secretariat of Health Culiacan Sinaloa 80127 Mexico Department of Gastroenterology Regional Hospital ISSSTECuliacan 80230 Sinaloa Mexico Education and Research Department Regional general Hospital No. 1 IMSS Culiacan Sinaloa 80220 Mexico Department of Cornea and Refractive Surgery Institute of Ophthalmology 'Conde de Valenciana' Mexico City 06800Mexico

AIM：To assess the proportion of refractive errors in the Mexican population that visited primary care optometry clinics in fourteen states of Mexico. METHODS：Refractive data from 676 856 patients aged 6 to 90 y were collected from optometry clinics in fourteen states of Mexico between 2014 and 2015. The refractive errors were classified by the spherical equivalent（SE）, as follows：sphere＋？ cylinder. Myopia（SE〉-0.50 D）, hyperopia（SE〉＋0.50 D）, emmetropia（-0.50≤SE≤＋0.50）, and astigmatism alone（cylinder≥-0.25 D）. A negative cylinder was selected as a ***：The proportion（95% confidence interval） among all of the subjects was hyperopia 21.0%（20.9-21.0）, emmetropia 40.7%（40.5-40.8）, myopia 24.8%（24.7-24.9） and astigmatism alone 13.5%（13.4-13.5）. Myopia was the most common refractive error and frequency seemed to increase among the young population（10 to 29 years old）, however, hyperopia increased among the aging population（40 to 79 years old）, and astigmatism alone showed a decreasing trend with age（6 to 90y; from 19.7% to 10.8%）. There was a relationship between age and all refractive errors（approximately 60%, aged 50 and older）. The proportion of any clinically important refractive error was higher in males（61.2%） than in females（58.3%; P〈0.0001）. From fourteen states that collected information, the proportion of refractive error showed variability in different geographical areas of ***：Myopia is the most common refractive error in the population studied. This study provides the first data on refractive error in Mexico. Further programs and studies must be developed to address the refractive errors needs of the Mexican population.

关键词： refractive errors hyperopia myopia astigmatism

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