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Next-Generation Imaging: New Insights from Multicolor Microscopy in Liver Biology and Disease

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Engineering 2022年第2期8卷 17-21页

作者： felix Heymann Adrien Guillot Moritz Peiseler Frank Tacke Department of Hepatology and Gastroenterology Charité–Universitätsmedizin BerlinBerlin 13353Germany

*** Our current understanding of the complex biology of solid organs,such as the liver,has been tremendously advanced by a wide variety of methodological approaches based on cell biology,biochemistry,molecular biology,and *** methods such as the morphological assessment of tissue structure by histology and immunohistochemistry have generated valuable knowledge and revealed improved treatment options for various liver ***,due to recent technological advances,it has been possible to gain deeper insights into physiological and pathological tissue organization,as well as dynamic processes taking place in *** novel methods include single-cell tar-geted transcriptome analysis,mass spectrometry-based metabolite and protein expression studies,and considerable advances in two-and three-dimensional(2D/3D)*** commentary will briefly review the recent progress that has been made in the field of imaging-based liver research,highlighting the novel possibilities of high-dimensional,multiparametric imaging in two and three dimensions,as well as those of dynamic time-lapse in vitro and in vivo imaging(Fig.1).We will also highlight some potential applications of these techniques for specific research questions in liver biology and disease.

关键词： organs dimensions advances

Embeddings Based Models-for Predicting Information Diffusion in Social Networks

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Embeddings Based Models-for Predicting Information Diffusion...

作者： felix Ingabire 北京邮电大学

学位级别：硕士

在这篇论文中,我们研究了社会网络中的信息扩散使用基于嵌入的模型,这种方法把每个社会网路用户表示为一个很长的向量。更好的泛化能力所提供的使用这样的投影空间允许我们的方法,提出了良好的性能,在各种现实世界的数据集,扩散预测和... 详细信息

在这篇论文中,我们研究了社会网络中的信息扩散使用基于嵌入的模型,这种方法把每个社会网路用户表示为一个很长的向量。更好的泛化能力所提供的使用这样的投影空间允许我们的方法,提出了良好的性能,在各种现实世界的数据集,扩散预测和影响关系推理任务。我们的方法不依赖于任何类型的网络结构,节点的度,投影空间的使用使我们的模型来处理更大的社会网络。1章介绍概念和方法在信息扩散下一章谈论相关的工作,3章介绍了该模型的学习,社交网络的用户,可以嵌入在预测或分类任务,4章介绍了实验和不同的数据集上的5章是论文的结论和未来的工作,

关键词：社会网络信息扩散扩散预测机器学习

Tuning the particle size and morphology of high energetic material nanocrystals

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Defence Technology（防务技术） 2015年第4期11卷 382-389页

作者： Raj KUMAR Prem felix SIRIL Pramod SONI School of Basic Sciences and Advanced Materials Research Centre Indian Institute of Technology Mandi Terminal Ballistics Research Laboratory

Morphology controlled synthesis of nanoparticles of powerful high energetic compounds(HECs) such as l,3,5-trinitro-l,3,5-triazinane(RDX) and 1,3,5,7-tetranitro-l,3,5,7-tetrazocane(HMX) were achieved by a simple solvent—antisolvent interaction(SAI) method at 70 ℃.The effects of different solvents on particle size and morphology of the prepared nano-HECs were studied *** size and morphology of the nano-HECs was characterized using field emission scanning electron microscopy(FE-SEM) imaging.X-ray diffraction(XRD) and Fourier transform infrared(FTIR) spectroscopy studies revealed that RDX and HMX were precipitated in their most stable polymorphic forms,i.e.a and P,*** analysis coupled with differential scanning calorimetry(TGA-DSC) studies showed that the thermal response of the nanoparticles was similar to the respective *** nanoparticles with spherical and rod shaped morphology were observed under different solvent *** mean particle size also varied considerably with the use of different solvents.

关键词：平均粒径高含能材料形貌纳米晶体场发射扫描电子显微镜差示扫描量热法纳米颗粒纳米粒子

Impact of radiation pressure and circumstellar dust on motion of a test particle in Manev’s field

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Astrodynamics 2021年第2期5卷 77-89页

作者： Jagadish Singh Solomon Okpanachi Omale Lawrence O.Inumoh felix Ale Department of Mathematics Faculty of Physical SciencesAhmadu Bello UniversityZariaNigeria Engineering and Space Systems Department National Space Research and Development Agency(NASRDA)Obasanjo Space CentreAbujaNigeria

In this paper,we present a study on the impact of radiation pressure and circumstellar dust on the motion of a test particle in the framework of the restricted four-body problem under the Manev’s *** show that the distribution of equilibrium points on the plane of motion is slightly different from that of the classical Newtonian *** the aid of the Lyapunov characteristic exponents,we show that the system is sensitive to changes in initial conditions;hence,the orbit of the system is found to be chaotic in the phase space for the given initial ***,a numerical application of this model to a stellar system(Gliese 667C)is considered,which validates the dependence of the equilibrium points on the mass *** show that the non-collinear equilibrium points of this stellar system are distributed symmetrically about the x-axis,and five of them are linearly *** basins of attraction of the system show that the equilibrium points have irregular boundaries,and we use the energy integral and the Manev parameter to illustrate the zero-velocity curves showing the permissible region of motion of the test particle with respect to the Jacobi constant.

关键词： Manev potential circumstellar dust Lyapunov characteristic exponents(LCEs) stability chaos basins of attraction

Catheter-based renal denervation： treating hypertension or beyond？

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Chinese Medical Journal 2014年第6期127卷 1166-1169页

作者： felix Mahfoud Dominik Linz Michael B(o)hm Department of Internal Medicine Saarland University Homburg 66421 Germany

The sympathetic nervous system regulates cardiac output,blood pressure(BP)and volume,electrolyte balance,and the composition of body *** afferent nervous signals to the brain are regulated by mechano-sensitive

关键词： renal sympathetic denervation hypertension sympathetic nervous system

Effects of Gd solutes on hardness and yield strength of Mg alloys

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Progress in Natural Science:Materials International 2018年第6期28卷 724-730页

作者： Yuling Xu felix Gensch Zhen Ren Karl Ulrich Kainer Norbert Hort MagIC-Magnesium Innovation Center Helmholtz-Zentrum Geesthacht TU Berlin Forschungszentrum Strangpressen China North Material Science and Engineering Technology Group

Relative contribution of individual strengthening mechanisms to the yield strength of Mg–0–15 wt%Gd alloys were *** with different grain size were prepared by adding Zr and hot *** and tensile/compression yield strength were tested on the alloys after solid solution treatment and *** constants were calculated with hardness and tensile/compressive *** results showed that the hardness of Mg–Gd alloys with similar Gd content and different grain size were almost the same,which indicates that grain size had little effect on *** hardness linearly increased with rising Gd content(d Hv/dc≈25 kg mm-2/at%Gd).The tensile and compressive yield strengths enhanced with the increase of Gd content for all alloys in different *** addition,the tensile/compressive(t/c)yield asymmetry of extruded alloys decreased with increasing Gd *** t/c yield asymmetry ratio(1.77)was observed for pure Mg,and with increasing Gd content this value decreased to *** the increasing of tensile strength,the stress intensity factor,ky,decreased from 0.27 MPa m1/2for Mg–2 wt%Gd alloy to 0.19 MPa m1/2for Mg–5 wt%Gd alloy,then increased to 0.29 MPa m1/2for Mg–15 wt%Gd ***,kyincreased linearly form 0.16–0.31 MPa for compression *** influence of grain size strengthening was eliminated,and the yield strength of tension and compression both linearly increased with cn,where c is the atom concentration of Gd,and n=1/2 or 2/3.

关键词： Mg–Gd alloy Solid solution strengthening Hardness Yield strength

Effects of obstructive sleep apnea and its treatment over the erectile function： a systematic review

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Asian Journal of Andrology 2017年第3期19卷 303-310页

作者： felix Campos-Juanatey Marcos Fernandez-Barriales Monica Gonzalez Jose A Portillo-Martin Urology Department Marques de Valdecilla University Hospital Santander 39008 Spain Institute of Investigation Marques de Valdecilla Santander 39011 Spain Oral and Maxillofacial Surgery Department Araba University Hospital Araba 01004 Spain Sleep and Ventilation Unit Marques de Valdecilla University Hospital Santander 39008 Spain Medical and Surgical Sciences Department School of Medicine University of Cantabria Santander 39011 Spain.

Erectile dysfunction （ED） is considered a condition with a broad range of etiologies. Obstructive sleep apnea （OSA） syndrome is one of the lesser studied risk factors for ED. We intend to summarize the current evidence on the relationship between OSA and sexual impairment, focusing on the results in terms of erectile function of the different therapies offered to OSA patients. A systematic review was conducted, selecting articles related to the physiology of OSA and ED, and to the treatments of OSA syndrome and their reported outcomes in erectile and sexual function. Higher prevalences of ED in the OSA groups have been published. However, whether this effect on the erectile function occurs in the entire range of OSA severities remains unclear. Several hypotheses were proposed to explain the physiology of this association. Continuous Positive Airway Pressure as a treatment for OSA patients with ED has achieved a significative improvement in the sexual parameters in most of the studies. Phosphodiesterase type 5 inhibitors （iPDE5） on demand are useful as a treatment for ED in this subgroup of patients, with high satisfaction rates. The surgical treatment for the OSA evidenced benefits over the erectile function, and the effect on the sexual satisfaction of the therapy using Mandibular Advancement Devices is still undefined.

关键词： continuous positive airway pressure erectile dysfunction obstructive sleep apnea operative surgical procedures phosphodiesterase type 5 inhibitors

Fabrication of Metallic Structure Using Micro-stereolithography

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Fabrication of Metallic Structure Using Micro-stereolithogra...

作者： MAIYO felix KIPCHIRCHIR 湖南大学

学位级别：硕士

3D打印工艺(以前称为快速成型(RP))是一种附加制造工艺,而不是传统方法的减材制造。与传统制造不同的是,传统制造从一块材料开始,机械地去除不需要的材料,直到形成所需的零件,3D打印需要一个自下而上的过程,从零开始创建3D有形零件,逐... 详细信息

3D打印工艺(以前称为快速成型(RP))是一种附加制造工艺,而不是传统方法的减材制造。与传统制造不同的是,传统制造从一块材料开始,机械地去除不需要的材料,直到形成所需的零件,3D打印需要一个自下而上的过程,从零开始创建3D有形零件,逐层构建。该技术可广泛应用于工程领域,包括储能装置材料、低密度高强度复合材料等,但某些技术的材料选择有限,限制了其应用。因此,有必要对三维打印进行更多的研究,以确定如何提高储能装置的性能。一般而言,3D打印过程从使用计算机辅助设计(CAD)或扫描真实物理对象的计算机中的数字模型开始。将数字模型切片,生成许多有限厚度的横截面层,然后发送到3D打印机,该打印机将这些层依次组合,直到形成物理部件。在这一领域的大量研究已经产生了大量的添加剂制造技术,包括但不限于:熔融沉积建模(FDM)、选择性激光烧结(SLS)、立体光刻(SLA)。例如,利用由切片软件获得的模型横截面图,利用紫外激光逐层选择性地固化光敏聚合物树脂来制作物体。本论文旨在探讨微立体光刻技术之制程,以期找到一种方法来设计与制造一个具有微尺度孔隙的复杂金属结构。由于依赖光聚合工艺固化聚合物树脂的微立体光刻无法直接制备金属结构,因此研究了金属化等其他方法,以获得沿结构所有轮廓表面均匀的镍涂层。本文还研究了化学镀镍工艺的操作参数,以获得均匀粘附镍层的最佳工艺条件,从而进一步转化为适合超级电容器的电极材料。这项研究的最后一个重要部分是对储能装置的研究,特别是对超级电容器的研究。这是为了找出最佳的结构可以用来缓解EDLCS和超级电容器的假电容电极材料的缺点,以提高其能量密度。对两个过程的结果进行测试,以确定是否实现了目标。

关键词：微立体光刻 3D打印快速成型添加剂制造金属化化学镀镍光聚合树脂

Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect

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Neural Regeneration Research 2023年第6期18卷 1371-1377页

作者： Stefanie Scheid Adrien Lejarre Jakob Wollborn Hartmut Buerkle Ulrich Goebel felix Ulbrich Department of Anesthesiology and Critical Care Medical Center-University of FreiburgFaculty of MedicineFreiburgGermany Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Anesthesiology and Critical Care Medicine St.Franziskus-HospitalMuensterGermany

The noble gas argon has the potential to protect neuronal cells from cell *** far,this effect has been studied in treatment after acute *** using argon has not yet been *** this study,human neuroblastoma SH-SY5Y cells were treated with different concentrations of argon(25%,50%,and 74%;21%O_(2),5%CO_(2),balance nitrogen)at different time intervals before inflicting damage with rotenone(20μM,4 hours).Apoptosis was determined by flow cytometry after annexin V and propidium iodide *** expressions of Toll-like receptors 2 and 4 were also *** were also processed for analysis by western blot and qPCR to determine the expression of apoptotic and inflammatory proteins,such as extracellular-signal regulated kinase(ERK1/2),nuclear transcription factor-κB(NF-κB),protein kinase B(Akt),caspase-3,Bax,Bcl-2,interleukin-8,and heat shock *** staining was performed for TLR2 and 4 and *** were also pretreated with OxPAPC,an antagonist of TLR2 and 4 to elucidate the molecular *** showed that argon preconditioning before rotenone application caused a dose-dependent but not a time-dependent reduction in the number of apoptotic *** with 74%argon for 2 hours was used for further experiments showing the most promising *** decreased the surface expression of TLR2 and 4,whereas OxPAPC treatment partially abolished the protective effect of *** increased phosphorylation of ERK1/2 but decreased NF-κB and *** inhibited mitochondrial apoptosis and the heat shock *** also suppressed the expression of the pro-inflammatory cytokine *** confirmed the alteration of TLRs and *** reversed the argon effect on ERK1/2,Bax,Bcl-2,caspase-3,and interleukin-8 expression,but not on NF-κB and the heat shock *** together,argon preconditioning protects against apoptosis of neuronal c

关键词： apoptosis inflammation interleukin-8 neuroprotection rotenone SH-SY5Y Toll-like receptor 2 Toll-like receptor 4