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^(18)f-脱氧葡萄糖正电子发射型计算机断层对心肌梗死后缺血性心肌病病人临床治疗决策的影响

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心血管病学进展 2006年第6期27卷 808-809页

作者： felix RCM Correa PL de Azevedo JC 程希富（摘译）马康华（校）不详重庆医科大学附属第一医院

成功的抗血栓治疗和血管成形术已大大减少了急性心肌梗死(AMI)的死亡率,但存活者左室功能障碍的发生率很高。作为核医学检测方法之一的^18f-脱氧葡萄糖(fDG)正电子发射型计算机断层(PET)在检测存活心肌方面的应用十分引人注意。巴西学... 详细信息

成功的抗血栓治疗和血管成形术已大大减少了急性心肌梗死(AMI)的死亡率,但存活者左室功能障碍的发生率很高。作为核医学检测方法之一的^18f-脱氧葡萄糖(fDG)正电子发射型计算机断层(PET)在检测存活心肌方面的应用十分引人注意。巴西学者报道了本国应用^18f-fDG叠合线路显像PET检测存活心肌后对心肌梗死后缺血性心肌病病人临床治疗决策的影响。[第一段]

关键词： 18f-脱氧葡萄糖发射型计算机断层急性心肌梗死缺血性心肌病临床治疗正电子死后医学检测方法

Dev Cell:科学家阐明人类胚胎原生殖细胞发育的分子机制

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现代生物医学进展 2016年第35期16卷 I0002-I0002页

作者： ferdinand von Meyenn Rebecca V. Berrens Simon Andrews fátima Santos Amanda J. Collier felix Krueger Rodrigo Osorno Wendy Dean Peter J. Rugg-Gunn Wolf Reik Wellcome Trust Sanger Institute Hinxton CB10 1SA UK

近日,刊登于国际杂志Developmental Cell上的一项研究报道中，来自巴布拉汉研究所（Babraham Insdtute）的研究人员通过研究调查了原生殖细胞发育的早期阶段，同时他们在实验室开发了一种产生类似细胞的策略，这种酷似人类原始生殖细胞... 详细信息

近日,刊登于国际杂志Developmental Cell上的一项研究报道中，来自巴布拉汉研究所（Babraham Insdtute）的研究人员通过研究调查了原生殖细胞发育的早期阶段，同时他们在实验室开发了一种产生类似细胞的策略，这种酷似人类原始生殖细胞的产生对于未来生殖领域的研究，以及分析人类潜在的继代基因调控的遗传机制非常重要。

关键词：生殖细胞发育人类胚胎 Cell 分子机制科学家原始生殖细胞早期阶段研究人员

成人IDH野生型星形细胞瘤从生物学和临床上归为其他肿瘤类型

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临床与实验病理学杂志 2015年第9期31卷 970-970页

作者： David E R Annekathrin K felix S 李晓玲王行富不详福建医科大学附属第一医院病理科福州350005

WHO III级的IDH野生型间变性星形细胞瘤预后差。为了对星形细胞瘤进行分子亚组分型或诊断上的重新分类,作者分析160例成人IDH野生型星形细胞肿瘤的分子标志性变异,并行甲基化和拷贝数分析,其中包括120例 WHO III级的间变性星形细胞瘤和4... 详细信息

WHO III级的IDH野生型间变性星形细胞瘤预后差。为了对星形细胞瘤进行分子亚组分型或诊断上的重新分类,作者分析160例成人IDH野生型星形细胞肿瘤的分子标志性变异,并行甲基化和拷贝数分析,其中包括120例 WHO III级的间变性星形细胞瘤和40例WHO II级的弥漫型星形细胞瘤。基于分子谱系和标志性变异特征,将这些肿瘤分为四个主要亚型。78%肿瘤诊断为传统胶质母细胞瘤分子亚型。9%为GBM-H3f3A突变（GBM-H3）亚型。8%具有独特的甲基化特征,与GBM-H3-K27相似,但缺乏H3f3A突变,这组肿瘤主要发生在幕下及中线部位,并且预后较好。120例IDH野生型的间变性星形细胞瘤除1例外均可归入上述3种亚型中。40例WHO II级的弥漫型星形细胞瘤中7例具有不同的分子特征,其中6例重新归类为其他不同的低级别肿瘤类型。有趣的是,TERT突变只发生在分子亚型的GBM （78%）,且预后不良。 GBM-H3组缺乏 TERT突变,然而其预后更差。

关键词：间变性星形细胞瘤肿瘤类型野生型 IDH 成人生物学分子亚型临床

Tango Controls and data pipeline for petawatt laser experiments

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High Power Laser Science and Engineering 2023年第4期11卷 2-8页

作者： Nils Weiße Leonard Doyle Johannes Gebhard felix Balling florian Schweiger florian Haberstroh Laura D.Geulig Jinpu Lin faran Irshad Jannik Esslinger Sonja Gerlach Max Gilljohann Vignesh Vaidyanathan Dennis Siebert Andreas Münzer Gregor Schilling Jörg Schreiber Peter G.Thirolf Stefan Karsch Andreas Döpp Ludwig-Maximilians-Universität München GarchingGermany

The Centre for Advanced Laser Applications in Garching,Germany,is home to the ATLAS-3000 multi-petawatt laser,dedicated to research on laser particle acceleration and its applications.A control system based on Tango Controls is implemented for both the laser and four experimental *** device server approach features high modularity,which,in addition to the hardware control,enables a quick extension of the system and allows for automated data acquisition of the laser parameters and experimental data for each laser *** this paper we present an overview of our implementation of the control system,as well as our advances in terms of experimental operation,online supervision and data *** also give an outlook on advanced experimental supervision and online data evaluation–where the data can be processed in a pipeline–which is being developed on the basis of this infrastructure.

关键词： data processing high-power laser experiments laser-plasma acceleration online diagnostics

Antioxidant drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis:What does evidence suggest?

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World Journal of Gastroenterology 2015年第21期21卷 6745-6753页

作者： Clotilde fuentes-Orozco Carlos Davalos-Cobian Jesus Garcia-Correa Gabriela Ambriz-Gonzalez Michel Dassaejv Macias-Amezcua Jesus Garcia-Renteria Jorge Rendon-felix Mariana Chavez-Tostado Lizbeth Araceli Cuesta-Marquez Andrea Socorro Alvarez-Villasenor Ana Olivia Cortes-flores Alejandro Gonzalez-Ojeda Research Unit in Clinical Epidemiology Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Department Gastrointestinal Endoscopy Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Department of Pediatric Surgery.Children’s Hospital.Western National Medical Center Mexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Health Research Coor-dination.Mexican Institute of Social Security Baja Californa Sur 23000 Mexico

AIM:To determine whether or not the use of antioxidant supplementation aids in the prevention of post-endoscopic retrograde cholangiopancreatography ***:A systematic review of randomized controlled trials(RCTs) was made to evaluate the preventive effect of prophylactic antioxidant supplementation in post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP).The inclusion criteria included:acute post-endoscopic retrograde cholangiopancreatography pancreatitis in adults; randomized clinical trials with the use of any antioxidant as an intervention compared with placebo,to reduce *** outcome measure was the incidence and severity of *** RCTs involving 3110 patients since 1999 *** antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),N-acetylcysteine(NAC) in three trials,and allopurinol in six *** group of patients treated with NAC received different doses; either oral or intravenous,and allopurinol-treated patients received five different oral doses in two different administration *** results are expressed with raw numbers,proportions,as well as mean and standard *** incidence of pancreatitis between groups was analyzed with Pearson's χ2 test or fisher's exact test(f).The main outcome is expressed as relative risks and 95%***:The incidence of pancreatitis in all antioxidant treatment groups was 8.6%,whereas it was 9.7% in the control *** antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),NAC in three trials,and allopurinol in six *** allopurinol trials,three different dosifications were used; two trials reported a low dosage(of less than 400 mg),two trials reported a moderate dose(600 mg) and the remaining two employed higher doses(more than 900 mg).Supplementation was not associated with a significant reduction in the incidence of PEP [relative risk(RR) = 0.93; 95%CI:0.82-1.06; P = 0.28].In addition,the incid

关键词： Antioxidant drugs Endoscopic retrograde cholangiopancreatography Pancreatitis Prophylaxis

Proposed nomenclature for Pseudallescheria,Scedosporium and related genera

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fungal Diversity 2014年第4期67卷 1-10页

作者： Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro ferreira Moreno Sarah A.Ahmed fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose f.Cano-Lira Josep Guarro Josepa Gené fabiola fernández Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques f.Meis ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer felix Gilgado Vania A.Vicente Elena Piecková Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar francoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquerdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes Division of Hygiene and Medical Microbiology Innsbruck Medical UniversityInnsbruckAustria CBS fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Medical University of Graz GrazAustria Centre for Infectious Diseases and Microbiology Westmead HospitalWestmeadAustralia Laboratoire de Parasitologie-Mycologie Centre Hospitalier UniversitaireAngersFrance Unitats de Microbiologia i d’Anatomia Patològica Facultat de Medicina i Ciències de la Salut IISPVUniversitat Rovira i VirgiliReusSpain Universidade federal do Estado do Rio de Janeiro Rio de JaneiroBrazil Institute of Medical Microbiology University Hospital RWTHAachenGermany Institute of Microbiology Academy of SciencesPragueCzech Republic Institut Pasteur Unitéde Mycologie MoléculaireCentre National de Référence Mycoses Invasives et AntifongiquesParisFrance Department of Medical Microbiology and Infectious Diseases Canisius-Wilhelmina HospitalNijmegenThe Netherlands Department of Medical Microbiology RadboudumcNijmegenThe Netherlands Institute of Microbiology eopold-Franzens-University InnsbruckInnsbruckAustria Molecular Mycology Research Laboratory Centre for Infectious Diseases and MicrobiologySydneyMedical School—Westmead HospitalMarie Bashir Institute for Infectious Diseases and BiosecurityThe University of SydneyWestmead Millennium InstituteWestmeadNSWAustralia Basic Pathology Department Federal University of ParanáStateCuritibaParanáBrazil fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) BrasíliaBrazil Institute of Preventive and Clinical Medicine BratislavaSlovakia Institut für Hygiene und Mikrobiologie Landesklinikum St.Pölten St.PöltenAustria Institute of Medical Microbiology University Hospital EssenEssenGermany Nursing School of Unigranrio Rio de JaneiroBrazil Scientific Institute of Public Health Culture Collectio

As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be *** of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied *** generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic *** that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are *** minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and ***,*** prolificans is renamed as Lomentospora prolificans.

关键词： Graphium Lomentospora Petriella Scedosporium apiospermum complex Microascaceae Nomenclature

Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

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World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun Dong Nikola fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler Department of General Internal Medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal Genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of Medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research Dr.Pifarréfoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium Department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham Digestive Diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany Department of Medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal Medicine II Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany Division of Microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland Medicine in Digestive Disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(f_(depressive)=7.475,P_(depressive)=0.006;f_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(f=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score Depression Anxiety Somatization

Implementing uterine balloon tamponade(UBT)device for immediate postpartum hemorrhage management:Leveraging resource allocation and highlighting noteworthy experiences

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Gynecology and Obstetrics Clinical Medicine 2023年第3期3卷 175-180页

作者： Mian Dehi Boston Guie Privat Apollinaire Horo Aka Edele Kouakou Konan Virginie Aholoupke Bruno KonéSeydou Rochon Sarah Boni Serge Burke Thomas f felix Houphouet Boigny University Cote d’Ivoire Division of Global Health and Human Rights Department of Emergency MedicineCote d’Ivoire National Mother and Child Health Program Côte d'Ivoire Cote d’Ivoire Massachusetts General Hospital Division of Global Health and Human Rights BostonMAUSA Harvard T.H.Chan School of Public Health BostonMAUSA Harvard Medical School BostonMAUSA

Background The use of uterine balloon tamponade(UBT)devices for intrauterine packing and management of vaginal bleeding by uterine atony has shown promising results in improving the quality of care and reducing maternal *** This report aims to provide an overview of progress made in implementing UBT devices in northern Cote d'*** and methods A four-year retrospective study was conducted in the North-East(163,645),North-Center(351,909),and North-West(57,983).In 2017,UBT was adopted by members of the healthcare ***,5 national and 32 regional trainers have been *** training session was a theoretical and practical program with a low *** is a male condom tied to a urinary catheter,filled with *** outcomes included stopping bleeding,avoiding the need for surgery,and preventing maternal deaths(MD).In 2018,3,515 UBT devices were *** 2019,monitoring tools and transmission circuits of the data were *** 2020,the collection of data and local manufacturing was *** During the process,978 health workers,mainly midwife(52.0%)and nurses(32.2%)out of the 1,295 assigned were *** number of trained individuals decreased from 209 in 2019 to 160 in 2020.A total of 1,715 UBT devices were locally manufactured,adding to the existing gift of 5,080 devices,with total availability of 6,*** distribution of devices increased from 2017 to 2019 but decreased in *** rates increased from 87.3%in 2017(365/418)to 95.0%in 2019(556/585)and slightly decreased in 2020 to 98.0%(681/695).Adverse outcomes(144/2,193),included MD(35/2,193)and medical evacuation to the surgical center(109/2,193).Conclusion The implementation of UBT in northern Cote d'Ivoire successfully reduced maternal death rates caused by immediate post-partum hemorrhage(IPPH).However,to ensure sustainability,further improvements are needed,including increased monitoring,ongoing training,and device availability.

关键词： Implementation Uterine balloon tamponade Post-partum hemorrhage Health providers Health regions

孕期妇女血浆多不饱和脂肪酸浓度与儿童肥胖症:从胚胎期到青春期的前瞻性队列研究

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孕期妇女血浆多不饱和脂肪酸浓度与儿童肥胖症:从胚胎期到青春期...