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Radical Hysterectomy in Cervical Cancer: Patients’ Epidemiological and Clinical Profiles and Perioperative Outcome in Two Referral Hospitals in Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第3期14卷 466-479页

作者： Théophile Njamen Nana Robert Tchounzou Fulbert Nkwele Mangala Alphonse Ngalame Henri Essome Sedrick Tiokeng Sidonie Noa Ananga Andrew Tassang Humphry Tatah Neng Isaac Mboh Eyong Gaetan Andre Wambo Simo felix Adolphe Elong Fidelia Kobenge Mbi Junior Cédric Nana Njamen Charlotte Tchente Nguefack Thomas Obinchemti Egbe Gregory Ekane Halle Emile Telesphore Mboudou Marcellin Ngowe Ngowe Department of Obstetrics and Gynaecology Douala General Hospital Douala Cameroon Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Buea Buea Cameroon Department of Obstetrics and Gynaecology Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pathology Douala General Hospital Douala Cameroon Faculté Des Sciences De La Santé Université Joseph Kizerbo Ouagadougou Burkina Faso

Background: Cervical cancer (CC) is one of the most frequent cancers and the leading cause of death from gynecological cancer in Low and middle income countries, Cameroon inclusive. Surgery is the primary treatment modality when the disease is diagnosed at early stage. Radical hysterectomy in cervical cancer has not been evaluated in recent years in Cameroon. The purpose of this study is thus to evaluate the epidemiological and clinical features and short term outcomes of patients who underwent surgery. Patients and methods: This retrospective study was conducted at the Douala Gynaeco-obstetric and Pediatric Hospital and the Douala General Hospital. Cervical cancer patients who underwent Radical hysterectomy between January 2015 and December 2020 were included. A pre-established data collection tool was used to record socio-demographic, clinical and outcomes information from patients’ files;additional outcome information was obtained from phone calls. Descriptive analysis was done using the SPSS version 26. Bivariate analysis was used to determine associations between disease and patients characteristics and occurrence of adverse postoperative outcome. P value of 0.05 was considered. Results: Sixty one patients were enrolled. Their ages ranged from 33 to 74 years with a mean age of 51.95 ± 10.29 years. Over 85% of women were married, 65.57% were unemployed and 86.88% were multiparous. Only 28% had never done cervical cancer screening. Most patients had stage IB1 to IB2 stage disease (57.1%). Less than 9% underwent radical hysterectomy and 8 of those (13.11%) suffered intraoperative complications. Twenty-five patients (40.98%) presented immediate and short term complications. There was no significant association between the disease or patients’ characteristics and adverse outcomes. Conclusion: Cervical cancer patients are relatively young in our settings and only 9% of them reach the hospital at early stage. Postoperative adverse outcomes rate is higher than that rep

关键词： Cervical Cancer Radical Hysterectomy Epidemiological and Clinical Profiles Outcomes Cameroon

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三选一的信号开关

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电子设计技术 EDN CHINA 2006年第6期13卷 110-110页

作者： felix Matro JL Audio Corp Phoenix AZ JL Audio Corp PhoenixAZ

本设计实例使用一个单刀瞬时接触开关，通过滚动三个输出态选择三个信号源中的一个。图1中的电路包括常用的CD4000 CMOS逻辑系列器件．以及一只通用NPN晶体管。所有元件的总成本不超过1美元。在任何一个时点上，电路的三个输出CH1、CH2... 详细信息

本设计实例使用一个单刀瞬时接触开关，通过滚动三个输出态选择三个信号源中的一个。图1中的电路包括常用的CD4000 CMOS逻辑系列器件．以及一只通用NPN晶体管。所有元件的总成本不超过1美元。在任何一个时点上，电路的三个输出CH1、CH2或CH3都只有一个为低，可以用这些输出控制模拟开关、继电器或JFET开关的栅极。只要电路加电．选定的输出就不会变化，因而该电路很适合于需要非易失性操作的应用。

关键词：信号开关输出控制 NPN晶体管设计实例 CMOS 模拟开关 JFET 非易失性电路信号源

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地壳中的超长周期构造波

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世界地质 1993年第1期 131-131页

作者： Tatiana Bazavluk felix Yudakhin 李春华

利用近12年吉尔吉斯天然地震测站所获得的数据,进行天然地震波的转换数据统计分析,已经注意到波的脉动特性是随时间变化的。在地壳中转换波是可排列的地区,其局部值根据形如Lissagou的形状在空间运移。可以看出在那些与深度和横向对应... 详细信息

利用近12年吉尔吉斯天然地震测站所获得的数据,进行天然地震波的转换数据统计分析,已经注意到波的脉动特性是随时间变化的。在地壳中转换波是可排列的地区,其局部值根据形如Lissagou的形状在空间运移。可以看出在那些与深度和横向对应着的纬线和子午线各向异性的区域,地壳中规则特性的应力结构随时间是变化的。

关键词：地壳地球外壳地球内部

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《COMET职业能力测评方法手册》

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教育学报 2020年第1期16卷 62-62页

作者：赵志群菲利克斯·劳耐尔不详

近十年来,职业能力测评已经逐渐成为国内外公认的职业教育质量保障与质量提升的重要工具。过去,中国开展的职业能力测评主要是学校内部的专业教学质量监控活动,采用的模型和评价指标体系有较强的学校或区域性特征,无法藉此进行专业间、... 详细信息

近十年来,职业能力测评已经逐渐成为国内外公认的职业教育质量保障与质量提升的重要工具。过去,中国开展的职业能力测评主要是学校内部的专业教学质量监控活动,采用的模型和评价指标体系有较强的学校或区域性特征,无法藉此进行专业间、校际间和区域间的比较。由于相关理论研究不足,能力模型和测评方法无法反映职业认知能力的发展,也没有建立起对测评结果与能力发展阶段对应关系的解释模型。

关键词：职业能力测评教育质量保障教学质量监控区域性特征质量提升解释模型能力模型测评方法

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Musical and Photographic Stimulations on the Symptomatology of Alzheimer’s Disease in Elderly

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World Journal of Neuroscience 2020年第4期10卷 155-165页

作者： Jamylly Ferreira Targino Silva Mayara Leite Alves da Silva Maykon Wanderley Leite Alves-da-Silva Douglas Nijenhuis de Castro Euclides Maurício Trindade Filho Janise Dal Pai Lysien Ivania Zambrano Valtuir Barbosa felix Elionai Dias Soares Camila Conceição Luz Soares Albérico José de Moura Saldanha Filho Magnúcia de Lima Leite Emanuel Guilherme de Almeida Carvalho Matheus Santos Freitas José Claudio da Silva State University of Health Sciences of Alagoas (UNCISAL) Maceió Brazil CESMAC University Center Maceió Brazil Federal University of São Paulo (UNIFESP) S&#227o Paulo Brazil Facultad de Ciencias Medicas Universidad Nacional Autónoma de Honduras Tegucigalpa Honduras Division of Therapeutic Support and Diagnosis of HUPAA/UFAL/EBSERH Maceió Brazil Tiradentes University Center (UNIT-AL) Maceió Brazil Faculdade Tiradentes (FITS) Recife Brazil

Background: Alzheimer’s disease is a progressive and neurodegenerative disorder characterized by deterioration of brain functions. Psychosocial interventions such as music and photographic stimuli may contribute to cognitive and sensory exercise or rehabilitation. Objective: Evaluate musical and photographic stimuli in elderly people with Alzheimer’s disease. Methods: It is an uncontrolled clinical trial, before-after type, eleven subjects composing the sample. Participants were submitted to Katz Index, Autobiographical Memory Test, GDS-15, Mini-Mental State Examination. The collection instruments were used on the first and last day of intervention, individually. There were 2 sessions in the week with duration of 50 minutes totaling 20 sessions. Data were analyzed by descriptive and inferential statistics and as variables expressed as mean standard deviation. Results: There was a significant effect of cognitive activity (P , it was observed that a small advance (P = 0.05) of the daily life activities. With the analysis of GDS-15, it is verified that they are more effective for the increase of the previous self-estimation of the therapy (P = 0.94). In the application of the AMT, it is observed that there was a better recruitment of the memory for the neutral words. Conclusion: Musical and photographic stimuli had a positive effect on the cognitive level, daily life activities and autobiographical memory in seniors with Alzheimer’s disease.

关键词： Alzheimer’s Disease Health of the Elderly Depression Memory

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South American SLR stations monitoring ground displacement caused by the M8.8 Chilean earthquake of 2010

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Chinese Science Bulletin 2011年第8期56卷 738-742页

作者： YIN ZhiQiang HAN YanBen PODESTA Ricardo LIU WeiDong PACHECO Ana ALONSO Ester ACTIS Eloy HUANG DongPing ZHAO LiMin WANG Rui XIA JinChao National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Observatorio Astronomico felix Aguilar San Juan University San Juan 5400 Argentina

The M8.8 Chilean earthquake of February 27,2010 caused a large surface displacement near its *** Laser Ranging(SLR) station 7405,cooperatively operated by Germany and Chile about 130 km from the epicenter was affected by the *** SLR station,No.7406,operated jointly by the National Astronomical Observatories of the Chinese Academy of Sciences and San Juan University of Argentina,was about 600 km from the *** the observations of these two SLR stations with global SLR station observations,we calculate the geocentric coordinates of the two stations based on *** results show that the coordinates of the two stations have changed by varying ***-7405 moved substantially towards the southwest with displacements of about 3.11,0.52 and 0.49 m in X,Y,Z directions;the corresponding displacements for SLR-7406 are about 0.02,0.03 and 0.02 *** solution,as an independent result derived from SLR observations,could provide an essential external check for other positioning techniques such as GPS.

关键词：地表位移 8级地震 SLR 智利 ITRF2000 GPS定位技术中国科学院国家天文台

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a小调第三交响曲 Op.56“苏格兰” Op.56 'Scottish'

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丛书名：奥伊伦堡 CD+总谱

2006年

作者：费利克斯·门德尔松·巴托尔迪（felix Mendelssohn Bartholdy）作曲鲍利斯·冯·哈肯（Boris von Haken）马丁·罗德维格（Martin Roddewig）编订

并列题名：Symphony No.3 in A minor/ a-moll

ISBN: (纸本)7540438010

并列题名：Symphony No.3 in A minor/ a-moll

关键词：交响曲总谱德国近代

来源：汇雅图书（南通市图书馆... 畅想之星图书光盘版（南... 评论

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency

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世界最新医学信息文摘 2016年第11期 8-8页

作者： felix Distelmaier Henk-Jan Visch Jan A.M.Smeitink Ertan Mayatepek Werner J.H.Koopman Peter H.G.M.Willems

Malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative diseases. Previous work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ros） and reductions in both total Ca2+content of the endoplasmic reticulum(ERCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]c; [Ca2+]M) and ATP（[ATP]C; [ATP]M） concentration. Here, we determined the mitochondrial membrane potential（Δψ） in patient skin fibroblasts and show significant correlations with cellular ros levels and ERCa, i.e., the less negative Δψ, the higher these levels and the lower ERCa. Treatment with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized Δψ and Bk-induced increases in [Ca2+]Mand [ATP]M. these effects were accompanied by an increase in ERCaand Bkinduced increase in [Ca2+]c. together, these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress Mitochondrial membrane potential Endoplasmic reticulum Ca2+ content Mitochondrial disease Antioxidant Human skin fibroblasts

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The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex Ⅰ deficiency

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世界最新医学信息文摘 2017年第30期 281-281页

作者： felix Distelmaier Henk-Jan Visch Jan A.M.Smeitink Ertan Mayatepek Werner J.H.Koopman Peter H.G.M.Willems

Malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative *** work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ROS） and reductions in both total Ca2+content of the endoplasmic reticulum(ERCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]C;[Ca2+]M) and ATP（[ATP]C;[ATP]M） ***,we determined the mitochondrial membrane potential（Aw） in patient skin fibroblasts and show significant correlations with cellular ROS levels and ERCa,i.e.,the less negative Aw,the higher these levels and the lower *** with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized △Ψ and Bk-induced increases in[Ca2+]Mand[ATP]*** effects were accompanied by an increase in ERCaand Bkinduced increase in[Ca2+]***,these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress Mitochondrial membrane potential Endoplasmic reticulum Ca2+ content Mitochondrial disease Antioxidant Human skin fibroblasts

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