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Targeted community based interventions improved malaria management competencies in rural Ghana

Global Health Research and Policy 2017年第1期2卷 64-73页

作者： Isabella A.Quakyi George O.Adjei David J.Sullivan Jr Judith K.Stephens Amos Laar Vivian N.Ama Aubyn Richmond Owusu Kwame S.Sakyi Nathaniel Coleman Francis D.Krampa Linda Vanotoo Julliette Tuakli Bernard B.Bortei Edward Essuman felix Sorvor Isaac A.Boateng Constance Bart-Plange Ebenezer A.Addison Peter Winch Andrew A.Adjei Department of Biological Environmental and Occupational Health SciencesSchool of Public HealthCollege of Health SciencesUniversity of GhanaP.O.Box LG 13LegonAccraGhana Office of Research Innovation and DevelopmentUniversity of GhanaLegonAccraGhana Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health615 N.Wolfe StBaltimoreMD 21205USA Department of Population Familyand Reproductive HealthSchool of Public HealthUniversity of GhanaLegonAccraGhana National Malaria Control Programme Ministry of HealthAccraGhana Department of Health Policy Planning and ManagementSchool of Public HealthUniversity of GhanaLegonAccraGhana Department of International Health Social and Behavioural Interventions ProgramJohns Hopkins Bloomberg School of Public Health615 N.Wolfe StBaltimoreMD 21205USA Department of Biochemistry Cell and Molecular BiologyUniversity of GhanaLegonAccraGhana Regional Health Directorate Ghana Health ServicesAccraGhana Child and Associates AccraGhana Asante-Akim Central Municipal Health Directorate Ghana Health ServicesKonongoGhana Kpone Katamanso District Health Directorate Ghana Health ServicesKponeTemaGhana Worldwide Universities Network University of GhanaP.O.Box LG 13LegonAccraGhana

Background:Malaria is one of the most challenging public health concerns in the developing *** address its impact in endemic regions,several interventions are implemented by *** Affordable Medicine Facility-malaria(AMFm)is an example of such *** activities include communication interventions to enhance the knowledge of caregivers of children under five years,licensed chemical sellers(LCS)and prescribers on malaria management with artemisinin-based combination therapy(ACT).This study was conducted to evaluate the effectiveness of the AMFm activities on malaria among targeted groups in two rural communities in ***:A communication intervention study was conducted in the Asante-Akim North and South Districts of *** cross-sectional pre and post surveys were *** malaria messages were designed and used to develop the information,education and communication(IEC)tools for the *** the aid of posters and flipcharts developed by our study,community health workers(CHWs),prescribers,and licenced chemical sellers provided proper counselling to clients on malaria *** CHWs and community based volunteers educated caregivers of children under five years on malaria management at their homes and at public gatherings such as churches,mosques,***-square tests and logistic regression were run to determine associations and control for demographic differences ***:There was significantly high exposure to malaria/ACT interventions in the intervention district than in the comparison district(OR=16.02;95%CI=7.88–32.55)and same for malaria/ACT-related knowledge(OR=3.63;95%CI=2.52–5.23).The participants in the intervention district were also more knowledgeable about correct administration of dispersible drug for children<5 years than their counterparts in the unexposed ***:Our data show that targeted interventions improve malaria based competences in rural commun

关键词： malaria district gathering

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云端回廊

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现代装饰 2016年第1期 122-125页

作者：马岩松党群早野洋介 Flora Lee felix Amiss Johanna Tan Wenshen Xie Colby Suter

“我们认为住宅建筑本身就是对自然和环境的反应和强调,而高层建筑的设计更是对地理和社会环境的一种有力的陈述。所以我们要设计的是一个从多方面更接近于自然属性和社会属性的建筑,它不再屈服于现代主义的简化原则,而是表达出一种更... 详细信息

“我们认为住宅建筑本身就是对自然和环境的反应和强调,而高层建筑的设计更是对地理和社会环境的一种有力的陈述。所以我们要设计的是一个从多方面更接近于自然属性和社会属性的建筑,它不再屈服于现代主义的简化原则,而是表达出一种更高层次的复杂性,不确定性和模糊性。”

关键词：简化原则社会环境如何生活住宅单元城市密度层次的城市天际线城市肌理公共空间地铁沿线

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β5整合素在造血细胞上的表达及其与细胞增殖和诱导凋亡的作用

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中国病理生理杂志 2000年第10期16卷 176-176页

作者：殷莲华,赵新永,付四清,felix Garacia-Sanchez,Deisse roth 上海医科大学病理生理学教研室!上海200032 上海医科大学病理生理学教研室!上海200032 SectionofMedicalOncology YaleUniversitySchoolofMedicine NewHaven CT06520-8023 SectionofMedicalOncology YaleUniversitySchoolofMedicine NewHaven CT06520-8023

目的:整合素(integrins)是一类广泛存在于细胞表面的糖蛋白.在造血细胞的整合素由α和β两个亚基组成,参与细胞与胞外基质、细胞骨架的莲接,并通过酪氨酸和丝氨酸蛋白激酶系统介导细胞信息的传递.αvβ5的过度表达与肿瘤转移及血管形成... 详细信息

目的:整合素(integrins)是一类广泛存在于细胞表面的糖蛋白.在造血细胞的整合素由α和β两个亚基组成,参与细胞与胞外基质、细胞骨架的莲接,并通过酪氨酸和丝氨酸蛋白激酶系统介导细胞信息的传递.αvβ5的过度表达与肿瘤转移及血管形成有关.αvβ3也已证实与血管形成时的能动性调节及肿瘤的转移有关.αvβ3和αvβ5均可作用在摄取腺病毒易感的细胞,因而αvβ3和αvβ5的上调可引起腺病毒与易感细胞再结合增加.为研究αvβ5的功能及其对血源性细胞的作用,我们成功的构建了逆转录病毒载体系统和四环素控制下的诱导表达载体系统,并研究其对造血细胞整合素表达时细胞凋亡和增殖的影响;方法:用去除血清的方法,观察血源性细胞凋亡和分化时αvβ5和αvβ3的变化;用抗αvβ5单克隆抗体封闭血源性细胞上的αvβ5时,观察它们对凋亡和增殖的影响.结果和结论:用pGβ5CHT载体转导造血细胞,β5 cDNA未得到表达,用无血清培养诱导血源性细胞分化和凋亡时,αvβ5和αvβ3发生不平衡表达,αvβ5表达升高,αvβ3表达下降,与有血清培养相比,αvβ5和αvβ3比例是增加的,与K562相比,αvβ5对αvβ3的比例从有血清1.146升到无血清1.370,BV173细胞从0.147到0.464,U937从0.188到0.370,HL60从0.220到0.610,这些结果提示αvβ5的表达增加可促进无血清培养细胞的凋亡;用抗αvβ5单抗隆抗体封闭U937细胞,发现U937细胞的磷脂酰丝氨酸密度显著下降,这提示封闭细胞表面αvβ5可抑制细胞无血清引起的细胞凋亡;K562细胞β5表达水平的增加可抑制细胞的增殖.通过对β5反义转录单位的诱导表达研究发现,四环素可阻止tet/vp 16调控的反义β5基因的表达,从而导致外源性和内源性β5基因的表达,β5基因表达的提高可抑制细胞增殖,因而反义β5表达的缺乏与β5表达水平的增加及细胞生长抑制有关.

关键词：造血细胞整合素血源性

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罗莎别墅——气动居住单元

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城市环境设计 2020年第4期126卷 28-29页

作者：沃尔夫·狄·普瑞克斯海默特·斯维茨斯基 Michael Holzer COOP HIMMELBLAU felix Waske Michael Pilz

罗莎别墅代表着一种如云一般富于变化的建筑设计理念。无支撑的气动结构以空气作为建筑材料,使得建筑体量能够变化,这在当时是最新的一种做法。新的形式通过色彩投影、声音和气味的映射来影响空间内部体验的品质。气动单元的原型由三个...

罗莎别墅代表着一种如云一般富于变化的建筑设计理念。无支撑的气动结构以空气作为建筑材料,使得建筑体量能够变化,这在当时是最新的一种做法。新的形式通过色彩投影、声音和气味的映射来影响空间内部体验的品质。气动单元的原型由三个空间组成:配有旋转床、投影仪和音效程序的脉动空间。

关键词：

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穿行法网

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网球大师 2016年第6期 56-56页

作者： felix

申根签证48小时就能出签，定一家Airbnb，再买张机票，就到了巴黎。从市区坐9号线或者10号线都能到罗兰．加洛斯，球场坐落于城市的西南边，比起中网或者上海大师赛，离市中心近得多。

关键词：市中心市区球场

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Analysis of Air Exchange System Influence on Thermal and Concentration Modes in the Local Working Area under Radiant Heating Conditions

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Frontiers in Heat and Mass Transfer 2024年第6期22卷 1597-1612页

作者： Boris Borisov Geniy Kuznetsov Vyacheslav Maksimov Tatiana Nagornova felix Salikhov School of Earth Sciences&Engineering National Research Tomsk Polytechnic UniversityTomsk634050Russia

One of the effective options for energy saving in terms of heat costs for the formation of routine thermal conditions of working areas of large-sized industrial premises is the replacement of traditional convective(water)heating systems with systems,the main part of which are gas infrared *** the mass introduction of such systems based on emitters was held back until recently by the lack of scientific and technical foundations for ensuring not only the routine thermal conditions of local working areas,but also ensuring acceptable concentrations of carbon dioxide,which is formed during the operation of a gas *** the latter problem by the method of experimental selection of heating and air exchange modes is practically impossible due to the multivariate nature of possible solutions to this ***,the purpose of the work is to analyze the results of theoretical studies of the possibility of ensuring an acceptable level of carbon dioxide concentrations in local working areas during the operation of gas infrared emitters and an air exchange *** modeling of heat and mass transfer processes under such conditions was performed in a fairly wide range of the main significant factors:air flow rate in the air exchange system from 0.01 to 0.04 kg/s,the position of the air inlet and outlet channels relative to the radiator and the local workplace(height from 0.3 to 4.1 m).It was found that by varying the numerical values of these factors,it is possible to ensure carbon dioxide concentrations in the local working area within the permissible limits of up to 1400 ppm.

关键词： Gas infrared heater air exchange system local working areas temperature fields CO2 concentration fields

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子宫内膜癌雌激素受体基因多态性的研究

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癌症 1999年第5期18卷 557-559页

作者：刘继红黄胡信 AnabelKearney SujathaS.E.Fernando 中山医科大学肿瘤防治中心肿瘤医院妇科广州510060 澳大利亚悉尼利物浦医院妇产科澳大利亚悉尼利物浦医院病理科

目的：探讨子宫内膜癌雌激素受体（ＥＲ）基因多态性表现的临床及病理学意义。方法：应用聚合酶链反应（ＰＣＲ）和酶切电泳技术，检测３３例原发性子宫内膜癌石蜡包埋切片中ＥＲ基因Ｐｖｕ Ⅱ限制性片段长度多态性（ＲＥＬＰ） ... 详细信息

目的：探讨子宫内膜癌雌激素受体（ＥＲ）基因多态性表现的临床及病理学意义。方法：应用聚合酶链反应（ＰＣＲ）和酶切电泳技术，检测３３例原发性子宫内膜癌石蜡包埋切片中ＥＲ基因Ｐｖｕ Ⅱ限制性片段长度多态性（ＲＥＬＰ），分析其与免疫组织化学测定的ＥＲ表达状态、临床分期、肿瘤组织学类型和分化程度、肌层浸润深度、宫颈和血管受累情况，以及患者年龄之间的关系。结果：ＥＲ基因ＤＮＡ为２２０ｂｐ，鉴别出三种ＥＲ基因型。４例为Ｐｖｕ Ⅱ纯合子２２０ｂｐ型；２７型为杂合子２２０／１８６ｂｐ型，占８２％；仅２例为纯合子１８６ｂｐ型。ＥＲ基因的ＲＦＬＰ与ＥＲ表达及上述临床病理学特征之间无显著相关（Ｐ＞０－０５）。结论：在子宫内膜癌中存在着ＥＲ的Ｐｖｕ Ⅱ基因多态性，并提示子宫内膜癌ＥＲ基因为杂合子型者，肿瘤的病理组织学分化好，通常无血管及宫颈侵犯。

关键词：子宫内膜癌雌激素受体基因多态性

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实时光电学设备TruScreen~筛查宫颈癌的临床价值

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中国肿瘤临床与康复 2013年第2期20卷 101-106页

作者：张薇刘志红李鹃乌兰娜王纯周艳秋张礼婕 felix Wong 吴瑞芳北京大学深圳医院宫颈癌早诊早治中心深圳510836 澳大利亚新南威尔士大学妇产科

目的评价实时光电学设备TruScreen检测技术在人群宫颈癌筛查中的价值。方法研究对象为2007年3月至2007年12月参加北京大学深圳医院针对深圳市贫困女性进行的宫颈癌筛查的妇女391名,年龄20～67岁。对所有接受筛查的妇女采用实时光电学... 详细信息

目的评价实时光电学设备TruScreen检测技术在人群宫颈癌筛查中的价值。方法研究对象为2007年3月至2007年12月参加北京大学深圳医院针对深圳市贫困女性进行的宫颈癌筛查的妇女391名,年龄20～67岁。对所有接受筛查的妇女采用实时光电学设备TruScreen进行宫颈癌筛查,并采集宫颈脱落细胞,以液基细胞学技术行宫颈细胞学检查,以第二代杂交捕获(HC-Ⅱ)技术进行高危型HPV-DNA(HR-HPV)检测。筛查同时行阴道镜检查,对阴道镜疑诊低度鳞状上皮内病变(LSIL)及以上病变者,在可疑病变处取活检。为客观评价各种筛查方法,对各检测结果均采取盲法保存,于各检测结果确定后解盲。凡HC-Ⅱ检测HR-HPV阳性伴液基细胞学≥ASCUS,和(或)液基细胞学≥LSIL及TruScreen检查结果阳性,而筛查当时未取活检(阴道镜诊断非LSIL及以上病变)者,均于3个月内再次阴道镜下活检,明确诊断。病理为CINⅡ及以上病变者行宫颈电热圈坏切术(LEEP)手术,并取活检。有多次病理检查者以其中最高级别病理结果为该患者的最终诊断,病理诊断作为本研究4种筛查方法的评价标准。结果病理诊断CIN I 110例、CINⅡ5例、CINⅢ7例、宫颈浸润癌5例;慢性宫颈炎和鳞状上皮化生59例。TruScreen检测阳性率为28.2%;液基细胞学检测无明确诊断意义的鳞状上皮细胞病变(ASCUS)以上为23.3%,LSIL以上为7.2%;HR-HPV阳性率为34.3%。TruScreen、液基细胞学及HC-Ⅱ法HPV检查,各筛查方法对检出≥CINⅡ病变的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为76.5%、77.3%、77.2%、13.3%和98.6%;液基细胞学以≥ASCUS为阳性各筛查评价指标分别为88.2%、79.7%、80.1%、16.5%和99.3%;以LSIL为阳性界值各指标为70.6%、95.7%、94.6%、42.9%和98.6%;HC-Ⅱ法HPV为94.1%、68.5%、69.6、11.9%和99.6%。结论实时光电学设备TruScreen进行宫颈癌初筛,筛查效率指标中虽敏感性不及HC-Ⅱ法HPV检测高,但与宫颈细胞学检查相当。作为一种新的宫颈癌筛查技术,具有检测无创无痛、用时较短、实时报告结果等优点,适用于贫困地区大样本人群筛查。

关键词： TruScreen 宫颈上皮内瘤样病变液基细胞学杂交捕获

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Introducing 3D-potting:a novel production process for artificial membrane lungs with superior blood flow design

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Bio-Design and Manufacturing 2022年第1期5卷 141-152页

作者： Fellx Hesselmann Jannls M.Focke Peter C.Schlansteln NIklas B.Steuer Andreas Kaesler Sebastlan D.Relnartz Thomas Schmltz-Rode Ulrlch SteInselfer Sebastlan V.Jansen Jutta Arens Department of Cardiovascular Engineering Instituteof Applied Medical EngineeringHelmholtz.InstituteRWTH Aachen UniversityPauwelsstrasse 2052074 AachenGermany Department of Diagnostic and Interventional Radiology Uniklinik RWTH AachenPauwelsstrasse 3052074 AachenGermany Department of Biomechanical Engineering Faculty of EngineeringTechnology University of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands

Currently,artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers,achieving diffusive gas *** both ends of the fibers,the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood *** a uniaxial centrifugation process,the glue forms the“potting.”The shape of the cured potting is then determined by the centrifugation process,limiting design possibilities and leading to unfavorable stagnation zones associated with blood *** this study,a new multiaxial centrifugation process was developed,expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting ***-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets.A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs,resulting in good agreement with the *** summary,this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes,eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.

关键词： Potting process Flow design Membrane lung Artificial lung Hollow fiber membrane module Manufacturing

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Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

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World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler Department of General Internal Medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal Genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of Medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research Dr.PifarréFoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium Department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham Digestive Diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany Department of Medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal Medicine II Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany Division of Microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland Medicine in Digestive Disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score Depression Anxiety Somatization

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