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The Role of the Solar Cycle in the Relationship Between the North Atlantic Oscillation and Northern Hemisphere Surface Temperatures

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Advances in Atmospheric Sciences 2007年第2期24卷 191-198页

作者： laura de la TORRE Luis GIMENO Juan Antonio AEL Raquel NIETO Universidad de vigo Facultad de Ciencias de Ourense 32004OurenseSpain

The North Atlantic Oscillation （NAO） is one of the leading modes of climate variability in the Northern Hemisphere. It has been shown that it clearly relates to changes in meteorological variables, such as surface temperature, at hemispherical scales. However, recent studies have revealed that the NAO spatial pattern also depends upon solar forcing. Therefore, its effects on meteorological variables must vary depending upon this factor. Moreover, it could be that the Sun affects climate through variability patterns, a hypothesis that is the focus of this study. We find that the relationship between the NAO/AO and hemispheric temperature varies depending upon solar activity. The results show a positive significant correlation only when solar activity is high. Also, the results support the idea that solar activity influences tropospheric climate fluctuations in the Northern Hemisphere via the fluctuations of the stratospheric polar vortex .

关键词： solar activity North Atlantic Oscillation Arctic Oscillation Northern Hemisphere surface temperature

Management of lung cancer in the COVID-19 pandemic:a review

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 145-157页

作者： Fernando Maroto Piñeiro Carmen Trinidad López Javier de la Fuente Aguado department of Internal Medicine Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain Radiology Service Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain.

Since its inception,the COVID-19 pandemic has affected health care as a *** patients in general and those suffering from lung cancer in particular are a vulnerable group because of their many intrinsic characteristics and care *** SARS-CoV-2(COVID-19)infection affects these patients regarding their risk of infection and outcome in this patient cohort is still to be *** this review,we tried to summarize our main concerns regarding COVID-19 in the context of cancer patients from a clinical and multidisciplinary *** types of lung cancer treatments(chemotherapy,radiation therapy and immunotherapy)may also influence the risk of infection and condition the patient´s risk of having a worse *** cancer patients require frequent radiologic study follow-ups,which may be affected by COVID-19 ***-19 related incidental radiologic findings can appear in routinely scheduled radiology tests,which may be difficult to *** cancer treatment induced pneumonitis may have similar radiologic features similar to those in acute SARS-CoV-2 pneumonia and lead to a wrong *** different health care needs,the requirement for continuous health care access and follow-ups,and the clinical traials in which this patient population might be enrrolled are all being affected by the current COVID-19 health *** COVID-19 pandemic has put health care providers and institutions in difficult situations and obliged them to face challenging ethical *** issues,in turn,have also affected the psychological well-being of health care workers.

关键词： COVID-19 cancer ethics CT thorax lung cancer cancer treatment chemotherapy immunotherapy

Dietary supplementation with n-3 polyunsaturated fatty acids:Effects on reproductive and productive performance and meat quality in rabbit breeding

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Animal Nutrition 2023年第3期14卷 70-78页

作者： Stella Agradi Majlind Sulce laura Menchetti Daniele vigo Marta Castrica Olimpia Barbato Egon Andoni Alda Quattrone Albana Munga Maria laura Marongiu Giulio Curone Gabriele Brecchia department of Veterinary Medicine and Animal Sciences University of MilanLodiItaly Faculty of Veterinary Medicine Agricultural University of TiranaTiranaAlbania School of Bioscience and Veterinary Medicine University of CamerinoCamerinoItaly department of Veterinary Medicine University of PerugiaPerugiaItaly department of Veterinary Medicine University of SassariSassariItaly

Rabbit breeding has many critical aspects related to reproduction,production,and animal welfare,which reduce its profitability as well as consumer *** supplementation with n-3 polyunsaturated fatty acids(PUFA)seems to be a good nutritional strategy to improve several aspects of rabbit breeding,enhance animal welfare and produce a new functional food considered healthy for human *** this reason,the main available scientific research regarding the physiological effects of n-3 PUFA rich products supplemented to the rabbit diet will be *** particular,consequences on the reproductive performances of both doe and buck,the productive parameters,and the meat quality will be analysed.

关键词： Omega 3 Nutraceutical Linseed Fish oil Algae

Proteomics for discovery of candidate colorectal cancer biomarkers

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World Journal of Gastroenterology 2014年第14期20卷 3804-3824页

作者： Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano Unidad de Proteómica Servicio de Determinación EstructuralProteómica y GenómicaCentro de Apoyo Científico y Tecnológico a la InvestigaciónUniversidad de VigoCampus As Lagoas-Marcosende área de Bioquímica y Biología Molecular Departamento de BioquímicaGenética e InmunologíaFacultad de BiologíaUniversidad de VigoCampus As Lagoas-Marcosende

Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early *** it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome ***,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal *** important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single *** review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein ***,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers.

关键词： Colorectal cancer Serum Tissue Proteins Biomarkers Proteomics Protein identification Mass spectrometry

Potential of soluble CD26 as a serum marker for colorectal cancer detection

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World Journal of Clinical Oncology 2011年第6期2卷 245-261页

作者： Oscar J Cordero Monica Imbernon Loretta de Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal department of Biochemistry and Molecular Biology University of Santiago de CompostelaSchool of BiologyCIBUUS BuildingCampus Vida15782 Santiago de CompostelaSpain department of Biochemistry Genetics and ImmunologyUniversity of VigoSchool of BiologyAs Lagoas-Marcosende s/n36310 VigoSpain

Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is ***,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and *** in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period *** show a better prognosis when the neoplasm is diagnosed *** the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been *** found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early ***26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic *** 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)***-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and *** studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here.

关键词： Antibody arrays Bioinformatics Biomarkers cancer Clustering Cytometric beads Diagnosis Dipeptidyl peptidaseⅣ Enzyme linked immunosorbent assay Prognosis Soluble CD26 Screening Serum

Transcatheter mitral valve repair in nonagenarians

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Journal of Geriatric Cardiology 2022年第1期19卷 90-94页

作者： Pedro Luis Cepas-Guillén Isaac Pascual Eulogio Garcia Pilar Jimenez-Quevedo Alfonso Jurado-Roman Tomás Benito-González Rodrigo Estevez-Loureiro Pedro Li Dabit Arzamendi Bruno Melica Eduardo Infante de Oliveira Pedro Martín Lorenzo felipe Fernández-Vázquez Guillermo Galeote Luis Nombela-Franco Leire Unzue Pablo Avanzas Manel Sabate Xavier Freixa Cardiology department Cardiovascular Institute(ICCV)Hospital ClinicIDIBAPSUniversity of BarcelonaBarcelonaSpain Interventional Cardiology Unit Hospital Universitario Central de AsturiasDepartment of MedicineUniversity of OviedoOviedoSpain Servicio de Hemodinámica y Cardiología Intervencionista HM CIEC-Centro Integral de Enfermedades CardiovascularesHospital Universitario HM MontepríncipeHM HospitalesMadridSpain Facultad de Medicina Universidad CEU San PabloMadridSpain Cardiology department Cardiovascular InstituteHospital Clínico San CarlosIdISSCMadridSpain Division of Interventional Cardiology University Hospital La PazIdiPAZCIBER-CVMadridSpain department of Cardiology University Hospital of LeónLeónSpain Interventional Cardiology Unit HospitalÁlvaro CunqueiroVigoSpain Interventional Cardiology Unit Hospital Sant Pau i Santa CreuBarcelonaSpain Serviço de Cardiologia Centro Hospitalar de Vila Nova de Gaia/Espinho-EPEVila Nova de GaiaPortugal Serviço de Cardiologia Hospital de Santa MariaCentro Hospitalar Lisboa NorteCentro Académico Médico de LisboaLisboaPortugal Servicio de Cardiología Hospital Universitario de Gran Canaria Dr.NegrínLas Palmas de Gran CanariaSpain

Given the increase in life expectancy indeveloped countries,nonagenarian population will become clinically and numerically relevant in our daily routine practice in the near *** has been observed to exert a profound influence on the prevalence of severe mitral regurgitation (MR) in the population.[1]Mitral valve surgery remains the gold standard of care for patients with symptomatic severe MR.

关键词： mitral routine surgery

Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology department Hospital Universitario San JuanAlicanteSpain Cardiology department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology department Hospital Universitario Puerta del MarCadizSpain Cardiology department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology department Hospital Universitario de CrucesBilbaoSpain Cardiology department Hospital Regional Universitario de MálagaMalagaSpain Cardiology department Hospital Universitario Puerta de HierroMadridSpain Cardiology department Hospital Alvaro CunqueiroVigoSpain Cardiology department Hospital Juan Ramon JimenezHuelvaSpain Cardiology department Hospital Universitario de BadajozBadajozSpain Cardiology department Hospital Universitario Lucus AugustiLugoSpain Cardiology department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology department Hospital Santa CruzLisboaPortugal Cardiology department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology department Hospital Universitario Miguel ServetZaragozaSpain Cardiology department Hospital Germans Trias i PujolBadalonaSpain Cardiology department Hospital de MeridaMeridaSpain Cardiology department Hospital São BernardoSetúbalPortugal Cardiology department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology department Hospital do Espirito SantoEvoraPortugal Cardiology department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology department Hospital de CabueñesGijonSpain Cardiology department Hospital Garcia de OrtaAlmadaPortugal Cardiology department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

Pulmonary vein stenosis:Etiology,diagnosis and management

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World Journal of Cardiology 2016年第1期8卷 81-88页

作者： Pablo Pazos-López Cristina García-Rodríguez Alba Guitián-González Emilio Paredes-Galán María ángel de la Guarda álvarez-Moure Marta Rodríguez-álvarez José Antonio Baz-Alonso Elvis Teijeira-Fernández Francisco Eugenio Calvo-Iglesias Andrés íniguez-Romo department of Cardiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro department of Radiology Complexo Hospitalario Universitario de Vigo Hospital álvaro Cunqueiro Diagnostic Imaging Unit Galaria Empresa Pública de Servicios Sanitarios Hospital do Meixoeiro

Pulmonary vein stenosis(PVS) is rare condition characterized by a challenging diagnosis and unfavorable prognosis at advance stages. At present, injury from radiofrequency ablation for atrial fibrillation has become the main cause of the disease. PVS is characterized by a progressive lumen size reduction of one or more pulmonary veins that, when hemodynamically significant, may raise lobar capillary pressure leading to signs and symptoms such as shortness of breath, cough, and hemoptysis. Image techniques(transesophageal echocardiography, computed tomography, magnetic resonance and perfusion imaging) are essential to reach a final diagnosis and decide an appropriate therapy. In this regard, series from referral centers have shown that surgical and transcatheter interventions may improve prognosis. The purpose of this article is to review the etiology, assessment and management of PVS.

关键词： Pulmonary vein stenosis Pulmonary vein stenosis etiology Pulmonary vein stenosis causes Pulmonary vein stenosis diagnosis Pulmonary vein stenosis management Pulmonary vein stenosis treatment

Current treatment landscape for oligometastatic non-small cell lung cancer

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World Journal of Clinical Oncology 2022年第6期13卷 485-495页

作者： Javier Garde-Noguera Margarita Martín-Martín Andres Obeso Miriam López-Mata Inigo Royo Crespo Lira Pelari-Mici O Juan Vidal Xabier Mielgo-Rubio Juan Carlos Trujillo-Reyes felipe Couñago department of Medical Oncology Hospital Arnau de VilanovaValencia 46015Spain department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain department of Thoracic Surgery Hospital Clínico Universitario de Santiago de CompostelaVigo 15706Spain department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009Spain department of Thoracic Surgery Hospital Universitari Vall d’HebronBarcelona 08035Spain department of Medical Oncology Hospital Universitario y Politécnico La FeValencia 46026Spain department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The management of patients with advanced non-small cell lung carcinoma(NSCLC)has undergone major changes in recent *** the one hand,improved sensitivity of diagnostic tests,both radiological and endoscopic,has altered the way patients are *** the other hand,the arrival of new drugs with antitumoral activity,such as targeted therapies or immunotherapy,has changed the prognosis of patients,improving disease control and prolonging ***,the development of radiotherapy and surgical and interventional radiology techniques means that radical ablative treatments can be performed on metastases in any location in the *** of these advances have impacted the treatment of patients with advanced lung cancer,especially in a subgroup of these patients in which all of these treatment modalities *** poses a challenge for physicians who must decide upon the best treatment strategy for each patient,without solid evidence for one optimal mode of treatment in this patient *** aim of this article is to review,from a practical and multidisciplinary perspective,published evidence on the management of oligometastatic NSCLC *** evaluate the different alternatives for radical ablative treatments,the role of primary tumor resection or radiation,the impact of systemic treatments,and the therapeutic *** short,the present document aims to provide clinicians with a practical guide for the treatment of oligometastatic patients in routine clinical practice.

关键词： Oligometastatic Non-small cell lung carcinoma Non-small cell lung cancer Oligometastasis