检索结果-南通市图书馆

New avenues for the treatment of immunotherapy-resistant pancreatic cancer

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： Luis Guilherme de Oliveira Silva Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Mariana dos santos Calmon Gabriel lima Correa santos Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases ***,due to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,including familial genetic factors associated with risk factors such as obesity,diabetes mellitus,chronic pancreatitis,and *** in genes such as KRAS,TP53,and SMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and,consequently,*** this context,some therapies are used for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC due to various resistance mechanisms that contribute to a drop in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and non-cellular elements create an immunosuppressive environment,characterized by a dense desmoplastic stroma with cancerassociated fibroblasts,pancreatic stellate cells,extracellular matrix,and immunosuppressive *** to this are genetic mutations in TP53 and immunosuppressive factors that act on T cells,resulting in a shortage of CD8+T cells and limited expression of activation markers such as *** this way,finding new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME modulators that block receptors and stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the modulation of extrinsic and intrinsic factors associated with T cells,and,above all,therapeutic models that combine these modulation techniques constitute the promising future of PC ***,this study aims to elucidate the main mechanisms of resistance to immunotherapy in PC and new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adsorption of yttrium(Y^(3+)) and concentration of rare earth elements from phosphogypsum using chitin and chitin aerogel

引用

Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson S.dos Reis Diana Pinto Sabrina F.Lütke Eder C.lima Luis F.O.Silva Irineu A.S.De Brum Guilherme L.Dotto Department of Forest Biomaterials and Technology Biomass Technology Centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad De La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of Chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

Chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).Chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption *** the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder *** contrast,no big pH influence was detected for chitin *** interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and ***,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin *** aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex *** complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths Sustainable material Chitin powder Chitin porous aerogel Yttrium adsorption and recovery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Atmospheric Pollutants in a Commercial Region of Fortaleza, Ceará, Brazil: Integration of Health, Environment and Economy in Urban Planning to Improve Air Quality

引用

Journal of Geoscience and Environment Protection 2024年第5期12卷 92-112页

作者： Mônica Giovana Alves Cardoso Ratts Brenna Kessy Silva lima Gilvan Ribeiro dos santos Fladimir de lima Gondim Rinaldo santos Araújo Mona Lisa Moura de Oliveira Francisco Sales Ávila Cavalcante Daniel Silveira Serra Science and Technology Center State University of Cear&#225 Cear&#225 Brazil Department of Chemistry and Environment Federal Institute of Cear&#225 Cear&#225 Brazil Center of Technological Sciences State University of Cear&#225 Cear&#225 Brazil

The accelerated growth of the vehicular fleet, the modernization of large urban centers, and the few adjustments to the road network in Fortaleza have intensified the problems of traffic and emissions of atmospheric pollutants, highlighting the necessity for strategic urban planning initiatives to address the escalating issues of traffic and pollution. With the objective of analyzing the indices of concentrations of atmospheric pollutants and estimating how these levels can affect human health, this work consists of a study of the analysis of air quality in the intense trade region of Fortaleza. For this, the analysis zone was divided into three perimeters (Major - Medium - Minor), where each perimeter was analyzed at 7 am, 12 noon and 5 pm. Concentrations of the type of O3, particulate matter (PM2.5 and PM10), CO2 and HCHO were collected. Our results demonstrate that most of the analyses are within the limits of current legislation;however, at certain times and perimeters, the analyses of CO2 and HCHO exceeded the established limits. In view of the above, we conclude that public policies to control air quality are necessary to reduce the damage to human health and the environment caused by pollutants.

关键词： Air Quality Urban Planning Particulate Material Health Impacts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

引用

Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.L Silva L.A.O.Nunes S.M.lima L.H.C.Andrade Optical and Photothermal Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pseudo-discontinuum model to simulate hard-rock mine pillars

引用

Underground Space 2023年第4期11卷 81-95页

作者： Erick Ro genes Alessandra dos santos Gomes Marcio Muniz de Farias Leandro lima Rasmussen Faculty of Technology University of BrasiliaDF 70910-900BrasiliaBrazil

In this study,the pseudo-discontinuum modeling technique,called continuum Voronoi block model(CVBM),was applied to repre-sent the behavior of hard-rock pillars from underground mines subjected to high field *** CVBM’s ability to produce numerical results consistent with the observed behavior of pillars is demonstrated through the numerical analysis of a hypothetical case and a back analysis of the Creighton mine *** results show that the model can capture convergence displacements and explicitly show the formation of macro-fractures parallel to excavation walls,intact rock slabs,and V-shaped *** components are characteristics of brittle failure induced by highly stressed ground *** studies presented in this work confirm the CVBM as a convenient tool for the numerical modeling of intact rock pillars excavated in deep underground mines.

关键词： Brittle failure Spalling Bulking Voronoi tessellation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temporal trends in areas at risk for concomitant tuberculosis in a hyperendemic municipality in the Amazon region of Brazil

引用

Infectious Diseases of Poverty 2020年第4期9卷 162-162页

作者： Alexandre Tadashi Inomata Bruce Thais Zamboni Berra felipe lima dos santos Yan Mathias Alves Ludmilla Leidianne Limirio Souza Antônio Carlos Vieira Ramos Luiz Henrique Arroyo Juliane de Almeida Crispim Ione Carvalho Pinto Pedro Fredemir Palha Aline Aparecida Monroe Mellina Yamamura Regina Célia Fiorati Ana Carolina Scarpel Moncaio Dulce Maria de Oliveira Gomes Ricardo Alexandre Arcêncio Department of Maternal-Infant and Public Health Nursing University of São Paulo at Ribeirão Preto College of NursingRibeirão PretoSão PauloBrazil Department of Nursing Federal University of São CarlosSão CarlosSão PauloBrazil Department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical School of the University of São PauloRibeirão PretoSão PauloBrazil Department of Nursing Federal University of CatalãoCatalãoGoiásBrazil Mathematics Department University ofÉvoraÉvoraPortugal

Background Although preventable and curable,tuberculosis(TB)still occurs in poor or developing countries,mainly in metropolitan regions of larger *** disease is a serious public health problem,and is directly linked to social *** analyzed temporal trend variations in areas at risk for concomitant TB,and characterized the clinical and epidemiological profiles of cases in a hyperendemic municipality in the Amazon region of *** This ecological study was performed in the municipality of Manaus,in northern *** population comprised cases with concomitant pulmonary and extrapulmonary TB,registered on the Notifiable Diseases Information System(SINAN),between January 1,2009 and December 31,*** risk cluster detection,spatial and spatiotemporal scanning statistical techniques were *** Spatial Variation in Temporal Trends(SVTT)approach was used to detect and infer clusters for significantly different time *** Between 2009 and 2018,873 concomitant TB cases were registered in *** using purely spatial scanning statistics,we identified two risk *** relative risk(RR)of the clusters was 2.21(95%confidence interval[CI]:1.57–2.88;P=0.0031)and 2.03(95%CI:1.58–2.58;P=0.0029).Using space-time scanning,we identified a risk cluster with an RR of 3.57(95%CI:2.84–4.41;P=0.014),between 2017 and *** SVTT analyses,three clusters with spatial variations were detected in the significant temporal trends:SVTT 1(P=0.042),SVTT 2(P=0.046)and SVTT 3(P=0.036).Conclusions In Brazil,several TB-determining factors such as race/color,gender,low educational level and low income overlap in needy urban areas and communities,demonstrating that it is unlikely to reach the goals,agreed and launched with the END TB Strategy within the deadlines of international agreements,if there is no reduction in existing inequities determinants and risk of illness in the country.

关键词： Tuberculosis Public health Epidemiology Spatial analysis Spatio-temporal analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enriched Artemia Nauplii with Commercial Probiotic in the Larviculture of Angelfish Pterophyllum scalare Lichtenstein (1823)

引用

Journal of Fisheries Science 2020年第1期2卷 17-21页

作者： Natalino da Costa Sousa José Araújo da Silva Emilly Monteiro Lopes Arthur felipe lima dos santos Francisco Alex lima Barros Carlos Alberto Martins Cordeiro Peterson Emmanuel Guimarães Paixão Estela dos santos Medeiros João Carlos Nunes de Souza Márcia Valéria Silva do Couto Federal University of Pará(UFPA) Campus BragançaAlameda Leandro RibeiroBragança68600-000PABrazil Tiradentes University(UNIT)-Av.Murilo Dantas 300-FarolândiaCEP 49032-490AracajuSergipeBrazil Faculdade Pio Décimo Av.Pres.Tancredo Neves 5655-Jabotiana49095-000Aracaju-SE.Brazil

This study evaluated the effect of enriched artemia nauplii with commercial probiotic for angelfish larvae determining growth perfomance,survival and modulation of the intestinal ***,it experiment occurred in completely randomized design with five treatments(T1-0.0,T2-1.5,T3-3.0,T4-4.5 and T5-6.0g of commercial probiotic)and four replaces during 20 *** larvaculture,post larvae passed by biometric procedures to determine productive performance and then microbiological *** reduction of total heterotrophic bacteria while increased lactic acid bacteria in the intestinal tract from the post larvae for treatments T3,T4 and *** commercial probiotic also increased the survival and performance as final weight,weight gain and specific growth *** these reasons,the use of 3g of commercial probiotic promotes greater performance and intestinal modulation for angelfish larvae.

关键词： Ornamental fish Probiotic Larvaculture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distinguishing the Regional Atmospheric Controls on Precipitation Isotopic Variability in the Central-Southeast Portion of Brazil

引用

Advances in Atmospheric Sciences 2022年第10期39卷 1693-1708,I0018-I0020页

作者： Vinícius dos santos Peter MARSHALL FLEMING Luís HENRIQUE MANCINI Stela DALVA santos COTA Graziele Beatriz de lima Rafaela RODRIGUES GOMES Roberto Eduardo KIRCHHEIM Ricardo SANCHÉZ-MURILLO Didier GASTMANS São Paulo State University(UNESP) Environmental Studies Center.Av.24ABased1515-Bela Vista13.506-900Rio Claro(SP)Brazil Center for the Development of the Nuclear Technology(CDTN-CNEN) Av.Presidente Antônio Carlos6.627Campus da UFMG-Pampulha31270-90Belo Horizonte(MG)Brazil Universidade de Brasília-UnB Instituto de GeociênciasLaboratório de Isótopos Estáveis.Campus"Darcy Ribeiro"Asa Norte70.910-900Brasília(DF)Brasil Hydrology and Territorial Management Directory(DHT) The Geological Survey of Brazil(CPRM-SGB)São Paulo(SP)Brazil University of Texas at Arlington Earth and Environmental Sciences Department500 Yates StreetArlingtonTexas76019USA Stable Isotopes Research Group and Water Resources Management Laboratory Universidad NacionalHerediaCosta Rica

Precipitation isotope ratios(O and H)record the history of water phase transitions and fractionation processes during moisture transport and rainfall ***,we evaluated the isotopic composition of precipitation over the central-southeastern region of Brazil at different *** isotopic compositions were associated with classical effects(rainfall amount,seasonality,and continentality),demonstrating the importance of vapor recirculation processes and different regional atmospheric systems(South American Convergence Zone-SACZ and Cold Fronts-CF).While moisture recycling and regional atmospheric processes may also be observed on a daily timescale,classical effects such as the amount effect were not strongly correlated(δ^(18)O-precipitation rate r≤-0.37).Daily variability revealed specific climatic features,such asδ^(18)O depleted values(~-6‰to-8‰)during the wet season were associated with strong convective activity and large moisture *** isotopic analysis revealed the role of different moisture sources and transport *** ratios combined with d-excess explain how atmospheric recirculation processes interact with convective activity during rainfall formation *** findings provide a new understanding of rainfall sampling timescales and highlight the importance of water isotopes to decipher key hydrometeorological processes in a complex spatial and temporal context in central-southeastern Brazil.

关键词： precipitation stable water isotopes d-excess moisture source and transport southern Atlantic Ocean and Amazon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

引用

World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos santos Gabriel lima Correa santos Hanna santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GML following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GML patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Apparent soil electrical conductivity in the delineation of management zones for cocoa cultivation

引用

Information Processing in Agriculture 2022年第3期9卷 443-455页

作者： Samuel de Assis Silva Railton Oliveira dos santos Daniel Marcal de Queiroz Juliao Soares de Souza lima Levi Fraga Pajehua Caique Carvalho Medauar Center for Agricultural Sciences and Engineering Federal University of Espirito SantoAlegre CampusEspirito Santo 29500-000Brazil Department of Agricultural Sciences Santa Cruz State UniversityIlheusBahia 45662-900Brazil Department of Agricultural Engineering Federal University of Vic¸osaVic¸osaMinas Gerais 36570-900Brazil

Apparent electrical conductivity is an important parameter for describing the spatial vari-ability of physical and chemical attributes of the soil and for the delineation of manage-ment *** objective of this work is to outline management zones for the cocoa cultivation based on the spatial variability of the productivity and the apparent electrical conductivity(ECa)of the *** collection was performed in a regular sample grid con-taining 120 points in an area cultivated with cocoa trees,located in the municipality of Ilhe´us,state of Bahia,*** each sampling point(cocoa tree),soil samples were col-lected to determine chemical *** was measured for one year,counting,monthly,the number of fruits,which were classified into off-season cocoa,harvest and annual *** of the apparent electrical conductivity of the soil were performed at different times of the year using a portable conductivity *** data were analyzed using classical statistics and *** management zones were delin-eated using the fuzzy k-means *** ideal number of class was defined using the fuzziness performance index(FPI)and the entropy of the modified partition(MPE)*** Kappa coefficient was used to validate the management zones,assessing their agreement with the chemical attributes of the *** ECa of the soil values pre-sented moderate temporal variation,with maximum amplitude of 19.37 mS m1 and min-imum of 0.82 mS m1 between measurement periods;higher averages of the ECa coincided with the highest levels of water in the *** measurements of the ECa of the soil carried out in April and October showed greater correlation with the chemical attributes of the soil,with significant values for 11 and 8 of the 17 attributes evaluated,*** man-agement zones from the ECa measured in April showed:a)reduced number of classes;b)spatial continuity between classes,and;c)agreement from reasonable(kappa between

关键词： Theobroma cacao Precision agriculture Spatial variability Fuzzy k-means

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：