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Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model

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World Journal of Hepatology 2019年第4期11卷 359-369页

作者： Francielle Graus-Nunes felipe de Oliveira Santos Thatiany de Souza Marinho Carolline Santos Miranda Sandra Barbosa-da-Silva Vanessa Souza-Mello Laboratorio de Morfometria Metabolismo e Doencas Cardiovasculares Departamento de Anatomia Instituto de Biologia Roberto Alcantara Gomes

BACKGROUND Obesity has been associated with hepatic overexpression of the renin-angiotensin system(RAS).AIM To evaluate the action of two angiotensin II(ANGII) receptor blockers(losartan or telmisartan) on the modulation of local hepatic RAS and the resulting metabolic effects in a diet-induced obesity murine *** Twenty C57 BL/6 mice were randomly divided into two nutritional groups for 10 wk: control group(C, n = 5, 10% of energy as fat) or high-fat group(HF, n = 15,50% of energy as fat). After treatment started, the HF group was randomly divided into three groups: untreated HF group(n = 5), HF treated with losartan(HFL, n = 5) and HF treated with telmisartan(HFT, n = 5). The treatments lasted for 5 wk, and the dose was 10 mg/kg body *** HF diet induced body mass gain(+28%, P demonstrated by reduced hepatic triacylglycerol levels coupled with reduced PLIN 2 expression and improved glycemic control.

关键词： Liver Telmisartan Losartan Obesity Angiotensin Ⅱ type 1 receptor C57BL/6 mouse

Graphene opens pathways to a carbon-neutral cement industry

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Science Bulletin 2022年第1期67卷 5-8,M0003页

作者： felipe Basquiroto de Souza Xupei Yao Wenchao Gao Wenhui Duan department of Civil Engineering Monash UniversityClaytonVictoria 3800Australia

Global cement production has increased 30 times since 1950 and nearly 4 times since 1990,becoming the third-largest source of anthropogenic carbon dioxide(CO_(2))emissions after fossil fuels and land-use changes[1].But the cement industry is under *** order to achieve the Paris Agreement’s targets and reach net-zero CO_(2)emissions by 2050.

关键词：水泥行业碳中和石墨烯

Intelligent collision risk detection in medium-sized cities of developing countries,using naturalistic driving:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 912-929页

作者： Juan Jose Paredes Santiago felipe Yepes Ricardo Salazar-Cabrera Alvaro Pachon dela Cruz Juan Manuel Madrid Molina Telematics Engineering Research Group(GIT) Telematics DepartmentUniversidad Del CaucaPopayanColombia Information Technology and Telecommunications Research Group(12T) Universidad IcesiCaliColombia

Traffic accidents are one of the most serious problems worldwide,being one of the leading causes of death and economic loss in the ***-and middle-income countries,mainly their medium-sized cities,are among the most affected by this problem.93%of traffic accidents occur in low and middle-income countries,even though these countries have approximately 60%of the world’s *** occurs mainly because in these types of countries,especially in medium-sized cities(target context),there are no ideal conditions for driving,such as adequate road infrastructure,good condition of vehicles,and rigorous safety *** data analysis techniques including machine learning(ML)have increasingly been used to solve this *** driving(ND)can be applied as a data collection method that provides information on traffic *** commonly uses a vehicle’s kinematic data to detect high-risk driving behaviors that could cause an *** objectives of this document are to present a review of different alternatives that help in data collection and creation of intelligent solutions related to detection of possible traffic accidents,principally using ND;and to propose an intelligent collision risk detection system(ICRDS)for identification of areas with a high probability of TA in the target *** the review,it was possible to analyze and evaluate the devices,variables and algorithms that help characterize a risk event in driving,considering the target *** development of a prototype of an ICRDS for a medium-sized city in a developing country is considered viable,considering the identified components,with the aim of identifying risk events in driving,and areas of high probability of accidents in the city.

关键词： Naturalistic driving Near-crash Traffic accident Vehicle data collection

Production Cross-Section Estimates for Strongly-Interacting Electroweak-Symmetry Breaking Sector Resonances at Particle Colliders

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Communications in Theoretical Physics 2015年第12期64卷 701-709页

作者： Antonio Dobado GUO Feng-Kun felipe J.Llanes-Estrada departamento de Física Teórica Universidad Complutense de Madrid State Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of Science Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat Bonn

We are exploring a generic strongly-interacting Electroweak Symmetry Breaking Sector(EWSBS) with the low-energy effective field theory for the four experimentally known particles(W_L~±,Z_l,h) and its dispersion-relation based unitary *** this contribution we provide simple estimates for the production cross-section of pairs of the EWSBS bosons and their resonances at proton-proton colliders as well as in a future e^-e^+(or potentially aμ^-μ^+) collider with a typical few-TeV *** examine the simplest production mechanisms,tree-level production through a W(dominant when quantum numbers allow) and the simple effective boson approximation(in which the electroweak bosons are considered as collinear partons of the colliding fermions).We exemplify with custodial isovector and isotensor resonances at 2 TeV,the energy currently being discussed because of a slight excess in the ATLAS 2-jet *** find it hard,though not unthinkable,to ascribe this excess to one of these W_lW_l rescattering *** isovector resonance could be produced at a rate smaller than,but close to earlier CMS exclusion bounds,depending on the parameters of the effective *** ZZ excess is then problematic and requires additional physics(such as an additional scalar resonance).The isotensor one(that would describe all charge combinations) has smaller cross-section.

关键词： strongly interacting electroweak symmetry breaking

Prey and predators perceive orb-web spider conspicuousness differently: evaluating alternative hypotheses for color polymorphism evolution

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Current Zoology 2019年第5期65卷 559-570页

作者： Nathalia G.XIMENES felipe M.GAWRYSZEWSKI Animal Colouration and Evolution Lab Departamento de ZoologiaInstituto de Ciencias BiologicasUniversidade de BrasiliaBrasiliaDF70910-900Brazil Pos-Graduaqao em Ecologia e Evoluqao Universidade Federal de GoiasCampus SamambaiaGoianiaGO74690-900Brazil

Color polymorphisms have been traditionally attributed to apostatic *** perception of color depends on the visual system of the *** models predict that differently perceived degrees of conspicuousness by two predator and prey species may cause the evolution of polymorphisms in the presence of anti-apostatic and apostatic *** spider Gasteracantha cancriformis(Araneidae)possesses several conspicuous color *** orb-web spiders,the prey attraction hypothesis states that conspicuous colors are prey lures that increase spider foraging success via flower ***,polymorphism could be maintained if each morph attracted a different prey species(multiple prey hypothesis)and each spider mimicked a different flower color(flower mimicry hypothesis).Conspicuous colors could be a warning signal to predators because of the spider's hard abdomen and *** predators could perceive morphs differently and exert different degrees of selective pressures(multiple predator hypothesis).We explored these 3 hypotheses using reflectance data and color vision modeling to estimate the chromatic and achromatic contrast of *** morphs as perceived by several potential prey and predator *** results revealed that individual taxa perceive the conspicuousness of morphs ***,the multiple prey hypothesis and,in part,the multiple predator hypothesis may explain the evolution of color polymorphism in ***,even in the presence of anti-apostatic *** flower mimicry hypothesis received support by color metrics,but not by color vision *** parameters not evaluated by color vision models could also affect the perception of morphs and influence morph survival and polymorphism stability.

关键词： aposematism Araneidae Gasteracantha cancriformis luring prey attraction visual communication

Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

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International Journal of Oral Science 2020年第3期12卷 199-208页

作者： Mohit Sharma felipe Paiva Fonseca Keith D.Hunter Raghu Radhakrishnan department of Oral Pathology Sudha Rustagi College of Dental Sciences and ResearchFaridabadHaryanaIndia department of Oral Surgery and Pathology School of DentistryFederal University of Minas GeraisBelo HorizonteMGBrazil Academic Unit of Oral and Maxillofacial Medicine and Pathology School of Clinical DentistryUniversity of SheffieldClaremont CrescentSheffieldUK department of Oral Pathology Manipal College of Dental SciencesManipal Academy of Higher EducationManipalKarnatakaIndia

The integrity of the basal stem cell layer is critical for epithelial *** this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in *** the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal *** vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,CD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and *** downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

关键词： epithelium malignant mucosal

LIBRA:an adaptative integrative tool for paired single-cell multi-omics data

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Quantitative Biology 2023年第3期11卷 246-259页

作者： Xabier Martinez-de-Morentin Sumeer AKhan Robert Lehmann Sisi Qu Alberto Maillo Narsis AKiani felipe Prosper Jesper Tegner David Gomez-Cabrero Navarrabiomed Complejo Hospitalario de Navarra(CHN)Universidad Pública de Navarra(UPNA)IdiSNAPamplona 31001Spain Biological and Environmental Sciences and Engineering Division King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Algorithmic Dynamic Lab Department of Oncology and PathologyCenter for Molecular MedicineKarolinska InstituteStockholm 17177Sweden Division of Hemato-Oncology Center for Applied Medical Research CIMACancer Center University of Navarra(CCUN)Navarra Institute for Health Research(IDISNA)CIBERONCPamplona 31008Spain department of Hematology Clinica Universidad de NavarraCIBERONC Pamplona 31008Spain Computer Electrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia

Background:Single-cell multi-omics technologies allow a profound system-level biology understanding of cells and ***,an integrative and possibly systems-based analysis capturing the different modalities is *** response,bioinformatics and machine learning methodologies are being developed for multi-omics single-cell *** is unclear whether current tools can address the dual aspect of modality integration and prediction across modalities without requiring extensive parameter ***:We designed LIBRA,a neural network based framework,to learn translation between paired multi-omics profiles so that a shared latent space is ***,we implemented a variation,aLIBRA,that allows automatic fine-tuning by identifying parameter combinations that optimize both the integrative and predictive *** model parameters and evaluation metrics are made available to users with minimal user ***,aLIBRA allows experienced users to implement custom *** LIBRA toolbox is freely available as R and Python libraries at GitHub(TranslationalBioinformaticsUnit/LIBRA).Results:LIBRA was evaluated in eight multi-omic single-cell data-sets,including three combinations of *** observed that LIBRA is a state-of-the-art tool when evaluating the ability to increase cell-type(clustering)resolution in the integrated latent ***,when assessing the predictive power across data modalities,such as predictive chromatin accessibility from gene expression,LIBRA outperforms existing *** expected,adaptive parameter optimization(aLIBRA)significantly boosted the performance of learning predictive models from paired ***:LIBRA is a versatile tool that performs competitively in both“integration”and“prediction”tasks based on single-cell multi-omics *** is a data-driven robust platform that includes an adaptive learning scheme.

关键词： single-cell multi-omic Autoencoder auto-finetuning

Settlement predictions of footings on sands using probabilisticanalysis

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第2期8卷 198-203页

作者： felipe carvalho bungenstab kátia vanessa bicalho federal university of espirito santo VitóriaBrazil

The design of footings on sands is often controlled by settlement rather than bearing ***,settlement predictions are essential in the design of shallow ***,predicted settlements of footings are highly dependent on the chosen elastic modulus and the used *** paper presents the use of probabilistic analysis to evaluate the variability of predicted settlements of footings on sands,focusing on the load curve(predicted settlements)*** methodologies,the first-and second-order second-moment(FOSM and SOSM),and Monte Carlo simulation(MCS),for calculating the mean and variance of the estimated settlements through Schmertmann(1970)’s equation,are presented and *** soil beneath the footing is treated as an uncorrelated layered material,so the total settlement and variance are found by adding up the increments of the *** deformability modulus(ESi)is considered as the only independent random *** an example of application,a hypothetical case of a typical subsoil in the state of Espirito Santo,southeast of Brazil,is *** results indicate that there is a significant similarity between the SOSM and MCS methods,while the FOSM method underestimates the results due to the non-consideration of the high-order terms in Taylor’s *** contribution of the knowledge of the uncertainties in settlement prediction can provide a safer design.

关键词： Footings Settlements Probabilities deformability modulus

Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease

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Neural Regeneration Research 2017年第6期12卷 916-917页

作者： Willian O.Castillo Andres felipe Aristizabal-Pachon department of Biology University of Cauca department of Genetics Ribeirao Preto Medical SchoolUniversity of Sao Paulo–USP

Alzheimer’s disease（AD）is the most common type of dementia in elderly *** a growing aging population not only in the United States but also in the worldwide,AD constitutes an emergent public health problem.

关键词： DNA Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer’s disease AChE