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Commentary on"PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons"

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Neural Regeneration Research 2023年第2期18卷 341-341页

作者： Macarena S.Arrázola felipe a.court Center for Integrative Biology Faculty of SciencesUniversidad Mayor Geroscience Center for Brain Health and Metabolism(GERO) SantiagoChile Buck Institute for Research on Aging NovatoCAUSA

See related article,pp 357-363Several decades have passed since programmedcell death(PCD)was *** was first defined by Kerr in 1972,and later described by the Nobel Prices in Physiology or Medicine 2002,Sydney Brenner,John Sulston and Robert Horwitz,who defined genetic regulators of apoptosis(Diamantis et al.,2008).However,it was in 1858 when the German pathologist and biologist Rudolf Virchow identified for the first time the phenomenon of apoptosis,which he named necrobiosis,arguing that this form of cell death was completely different from the uncontrolled necrosis,suggesting the existence of two different types of cell ***,the knowledge in the field of cell death regulation is extensive,but still under continuous expansion.

关键词： expansion death Sydney

Compartmentalized necroptosis activation in excitotoxicityinduced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology

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Neural Regeneration Research 2019年第8期14卷 1385-1386页

作者： Macarena S. Arrazola felipe A. court Center for Integrative Biology Faculty of Sciences Universidad Mayor de Chile Santiago CnileFONDAP Center for Geroscience Brain Health and Metabolism Santiago Chile Buck Institute for Research on Ageing Novato San Francisco CA USA

Excitotoxicity and neuronal cell death: Glutamate is the main excitatory neurotransmitter of the central nervous system and functionally involved in most brain activities, including brain development, synaptic plasticity, learning and memory. Exc让atory synaptic transmission is primarily mediated by ligana-gated ion channels, including a-amino-3-hydroxy-5-methylisoxazoIe-4-propionic acid (AMPA), N-methyl-D-aspartate (NMDA) and kainate receptors. Activation of glutamate receptors, particularly NMDA receptors, usually leads to calcium influx, whicn can act as a second messenger for several processes to mediate synaptic activity and brain function. Nevertheless, excessive release of glutamate neurotransmitter may produce intracellular calcium overload, leading to a cascade of events mediating cytoskeleton damage accompanied w让h reactive oxygen species (ROS) generation, mitochondrial dysfunction and ultimately neuronal cell death. These toxic effects of glutamate are known as excitotoxicity. Neuronal excitotoxicity has been linked to several acute and chronic brain diseases, such as stroke/ischemia, epilepsy and a range of neurodegenerative disorders, including Alzheimer's disease (AD), Huntingtons disease, amyotrophic lateral sclerosis (ALS) and Parkinsons disease (PD), contributing to the neuronal lost in different brain regions. Unfortunately, treating nervous system disorders with general glutamate receptor blockers has been associated with undesirable side effects, becoming increasingly necessary to unravel downstream effectors in the excitotoxicity-dependent cell death pathway in order to develop novel therapeutic strategies.

关键词： Compartmentalized necroptosis activation excitotoxicityinduced axonal neurodegenerative disease

Magnetic and superconducting phase diagrams and transition temperatures predicted using text mining and machine learning

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npj Computational Materials 2020年第1期6卷 1521-1529页

作者： Callum J.court Jacqueline M.Cole Cavendish Laboratory Department of PhysicsUniversity of CambridgeJ.J.Thomson AvenueCambridge CB30HEUK ISIS Neutron and Muon Source STFC Rutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotOxfordshire OX110QXUK Argonne National Laboratory 9700 South Cass AvenueArgonneIL 60439USA Department of Chemical Engineering and Biotechnology University of CambridgeWest Cambridge SitePhilippa Fawcett DriveCambridge CB30FSUK

Predicting the properties of materials prior to their synthesis is of great importance in materials *** and superconducting materials exhibit a number of unique properties that make them useful in a wide variety of applications,including solid oxide fuel cells,solid-state refrigerants,photon detectors and metrology *** all these applications,phase transitions play an important role in determining the feasibility of the materials in ***,we present a pipeline for fully integrating data extracted from the scientific literature into machine-learning tools for property prediction and materials *** advanced natural language processing(NLP)and machine-learning techniques,we successfully reconstruct the phase diagrams of well-known magnetic and superconducting compounds,and demonstrate that it is possible to predict the phase-transition temperatures of compounds not present in the *** provide the tool as an online open-source platform,forming the basis for further research into magnetic and superconducting materials discovery for potential device applications.

关键词： phase transition superconducting

Rosuvastatin‑Eluting Gold‑Nanoparticle‑Loaded Perivascular Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model

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Advanced Fiber Materials 2023年第6期5卷 1986-2001页

作者： Carleigh Klusman Benjamin Martin Joy Vanessa D.Perez Allan John R.Barcena Marvin R.Bernardino Erin Marie D.San Valentin Jossana A.Damasco Huckie C.Del Mundo Karem a.court Biana Godin Gino Martin Canlas Natalie Fowlkes Richard Bouchard Jizhong Cheng Steven Y.Huang Marites P.Melancon Department of Interventional Radiology The University of Texas MD Anderson Cancer CenterHouston 77030USA Baylor College of Medicine Houston 77030USA College of Medicine University of the Philippines Manila1000 ManilaPhilippines Department of Nanomedicine Houston Methodist Research InstituteHouston 77030USA Department of Chemistry Lamar UniversityBeaumont 77710USA Department of Veterinary Medicine and Surgery The University of Texas MD Anderson Cancer CenterHouston 77030USA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHouston 77030USA Section of Nephrology Department of MedicineSelzman Institute for Kidney HealthBaylor College of MedicineHouston 77030USA The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences Houston 77030USA

Arteriovenous fistulas(AVFs)are a vital form of AV access for patients requiring hemodialysis,but they link to overall morbidity and mortality when they fail to *** most common cause of AVF non-maturation is neointimal hyperplasia(NIH).To minimize the deleterious effects of NIH,a perivascular wrap composed of polycaprolactone(PCL),rosuvastatin(ROSU),and gold nanoparticles(AUNPs)was *** study assessed the impact of ROSU-eluting,radiopaque resorbable perivascular wraps on pathologic NIH in a chronic kidney disease(CKD)rodent model of *** PCL wraps containing AuNPs and/or ROSU were monitored for in vitro tensile strength,AuNP release,ROSU elution,and effect on cellular *** wraps were then implanted around an AVF in a CKD rodent model for in vivo ultrasound(US)and micro-computed tomography(mCT)*** specimens were collected for histological *** viability was preserved in the presence of both AuNP-and ROSU-containing *** vitro release of ROSU and AuNPs correlated with in vivo findings of decreasing radiopacity on mCT over ***-loaded wraps had higher radiopacity(1270.0-1412.0 HU at week 2)compared with other wraps(103.5-456.0 HU),which decreased over *** addition of ROSU decreased US and histologic measurements of *** reduced NIH seen with ROSU-loaded perivascular wraps suggests a synergistic effect between mechanical support and anti-hyperplasia ***,AuNP loading increased wrap ***,our results show that AuNP-and ROSU-loaded PCL wraps induce AVF maturation and suppress NIH while facilitating optimal implanted device visualization.

关键词： Arteriovenous fistula Chronic kidney disease Nanoparticles Polycaprolactone Radiopacity Rosuvastatin

MAKING MAJOR RETAIL ESTABLISHMENTS SUSTAINABLE:THE CASE OF THE MALL AT ROBINSON

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Journal of Green Building 2007年第4期2卷 14-22页

作者： Matthew M.Mehalik court Gould Beth Edwards Sustainable Pittsburgh 425 Sixth AvenueSuite 1335PittsburghPA 15261 Sustainable Pittsburgh The Mall at Robinson

INTRODUCTION This case serves as a leadership example of what is initially possible for existing mall retail establishments regarding *** discussion consists of a case study of how a multidisciplinary team of Pittsburgh-regional experts conducted a comprehensive analysis using a systems approach[1]to identify and provide recommendations for sustainable business solutions to benefit a large retail shopping mall in the Pittsburgh Region,The Mall at *** convening organization for this project was Sustainable *** from the assessment include solutions that will save or make money and increase the mall’s effectiveness and resource *** impacts include recommendations for becoming better stewards of the environment and community and increasing the mall’s public *** project approach has been to focus on opportunities for continuous improvement where the interests of people,business,and environment meet.

关键词： Sustainable CASE shopping

ULTRASOUND INDUCED AND LASER ENHANCED COLD FUSION CHEMISTRY

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Nuclear Science and Techniques 1995年第4期6卷 198-203页

作者： T. V. Prevenslik (2/E Greenery court, Discovery Bay, Hong Kong)

The standard model of sonoluminescence suggests that the Coulomb barrier to deuterium fusion may be overcome by high bubble gas temperatures caused by compression heating if the bubble diameter remains spherical during bubble ***, in the more likely collapse geometry of a pancake shape, the temperature rise in the bubbles is negligible. But the collapsing pancake bubble is found to significantly increase the frequency of the infrared energy available in the vibrational state of the water molecules at ambient temperature. For a collapse to liquid density, ultraviolet radiation at about 10eV is found. Although the ultraviolet radiation is of a low intensity, higher intensities may be possible if the bubble collapse is enhanced by visible and infrared lasers. Neither hot nor cold fusion is predicted in bubble collapse,but the ultraviolet energy at about 10eV developed in the bubble is sufficient to provide the basis for a new field of chemistry called ultrasound induced and laser enhanced cold fusion chemistry.

关键词： Cold fusion Ultrasound Ultraviolet Theory

Sonoluminescence and the probability of isothermal bubble collapse

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Nuclear Science and Techniques 1997年第4期8卷 236-238页

作者： Thomas V Prevenslik ( 2E Greenery court, Discovery Bay, Hong Kong) 2EGreenerycourt DiscoveryBayHongKong

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关键词：冷聚变声致发光等温泡消失

Providing Strong Judicial Guarantees for Innovation-Driven Development

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Qiu Shi 2021年第2期13卷 30-37页

作者： The Intellectual Property court of the Supreme People's court The Intellectual Property court of the Supreme People’s court

In his speech at the 25th Group Study Session of the Political Bureau of the 19th CPC Central Committee,General Secretary Xi Jinping thoroughly examined a series of theoretical and practical issues concerning our direction,principles,and underpinning for reform and development in the field of intellectual property(IP)*** speech provides a fundamental and practical guide for the work of strengthening IP protection in *** the adjudication of IP cases.

关键词： Strong thoroughly concerning

Extraction of physical Schottky parameters using the Lambert function in Ni/AIGaN/GaN HEMT devices with defined conduction phenomena

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Journal of Semiconductors 2017年第1期38卷 95-99页

作者： O.Latry A.Divay D.Fadil P.Dherbécourt Normandie Université URGPM CNRS UMR 663476801 St-Etienne-du-RouvrayFrance

Electrical characterization analyses are proposed in this work using the Lambert function on Schottky junctions in GaN wide band gap semiconductor devices for extraction of physical *** Lambert function is used to give an explicit expression of the current in the Schottky *** function is applied with defined conduction phenomena,whereas other work presented arbitrary（or undefined）conduction mechanisms in such parameters＇ *** upon AlGaN/GaN HEMT structures,extractions of parameters are undergone in order to provide physical *** work highlights a new expression of current with defined conduction phenomena in order to quantify the physical properties of Schottky contacts in AlGaN/GaN HEMT transistors.

关键词： GaN Schottky junction conduction mechanisms Lambert function parameters extraction