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Sustained adenosine release:Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells

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Engineered Regeneration

Engineered Regeneration 2024年第2期5卷 255-268页

作者： Hadi Hajiali Jane McLaren Cristina Gonzalez-García Salah Abdelrazig Dong-Hyun Kim Matthew J.Dalby Manuel Salmerón-Sánchez felicity R.A.J.Rose School of Pharmacy Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Healthcare Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellular Microenvironment University of GlasgowGlasgowUK Centre for Analytical Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Marine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

Non-healing fractures,a global health concern arising from trauma,osteoporosis,and tumours,can lead to severe ***,integral to cellular energy metabolism,gains prominence in bone regeneration via adeno-sine A2 B receptor *** study introduces a controlled-release system for localized adenosine delivery,fostering human mesenchymal stromal cell(hMSC)differentiation into functional bone *** study investi-gates how the ratio of lactic acid to glycolic acid in microparticles can influence adenosine release and explores the downstream effects on gene expression and metabolic profiles of osteogenic differentiation in hMSCs cultured in growth and osteoinductive *** into adenosine-modulated signalling pathways during MSC differenti-ation,with osteogenic factors,provide a comprehensive understanding of the pathways *** gene expression and metabolic profiles unravels adenosine’s regulatory mechanisms in MSC *** adenosine release from microparticles induces mineralization,synergizing with osteogenic media supplements,showcasing the potential of adenosine for treating critical bone defects and metabolic *** study high-lights the efficacy of a polymeric microparticle-based delivery system,offering novel strategies for bone *** adenosine’s roles and associated signalling pathways advances our comprehension of molecular mech-anisms steering bone regeneration,propelling innovative biomaterial,combined with metabolites,approaches for clinical use.

关键词： Adenosine release Osteogenic signalling pathways Human mesenchymal stromal cells Bone regeneration

Modelling the mechanism and kinetics of ascorbic acid diffusion in genipin-crosslinked gelatin and chitosan networks at distinct pH

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Food Bioscience 2022年第2期46卷 684-694页

作者： felicity A.Whitehead Stefan Kasapis School of Science RMIT UniversityMelbourneVictoria3083Australia

Crosslinked biopolymers were prepared for controlled release to investigate the diffusion of ascorbic acid from swelling high-solid networks in neutral and acidic pH *** swelling was measured at pH 2.8 and pH 6.8 and change in microstructural properties,including network mesh size and average molecular weight between crosslinks of genipin-crosslinked gelatin and genipin-crosslinked chitosan systems,were *** mathematical modelling was applied to the first 60%of ascorbic acid diffusion and statistical analysis was used to determine the model that best fits the experimental *** transport from the gelatin-based networks was best described by the Peppas-Sahlin model whereas the distinct effect of pH on chitosan structure formation brought into consideration the zero-order *** modelling of bioactive compound release from swelling biopolymer matrices at different pH conditions is essential for the design of efficient targeted delivery matrices for functional food and nutraceutical applications.

关键词： Gelatin Chitosan Genipin crosslinking Ascorbic acid Diffusion kinetics

Trajectories of deagrarianization in South Africa−Past,current and emerging trends:A bibliometric analysis and systematic review

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Geography and Sustainability 2022年第4期3卷 325-333页

作者： felicity Aphiwe Mkhongi Walter Musakwa Department of Geography Environmental Management and Energy StudiesUniversity of JohannesburgAuckland ParkJohannesburg 2093South Africa

Inquiries into rural households’engagement with smallholder agriculture remain ambiguous and *** this reason,research on cultivation patterns has been informed by numerous articles published in recent ***,studies detailing the development and progress of deagrarianization remain *** attempts to bridge this knowledge gap,the study aims to provide empirical insights into the trajectories of deagrarianization in South *** published between 1996 and 2021 were retrieved from Clarivate Web of Science for analysis.A combination of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)and bibliometric analysis was adopted to provide a comprehensive review of deagrarianization *** findings emphasize that the field of deagrarianization is gaining momentum as publications gradually emerge to indicate that although cultivation is dominant among rural households,there is a reduction in field cultivation and an increase in home-gardening in former homelands of South ***,common keywords in deagrarianization literature,from a global,African and South African perspective include poverty and liveli*** that majority of deagrarianization studies analyze patterns,drivers and consequences of the phenomenon,future research needs to consider novel methodologies such as participatory GIS and new avenues that incorporate,but are not limited to,other livelihood issues such as social identities and food *** is advised that strategies for enhancing rural development and agricultural policies focus on broader solutions that do not only sustain home-gardens but also revitalize both active and abandoned fields.

关键词： Bibliometric analysis Deagrarianization PRISMA South Africa VOSviewer

Evolution of gastroenterology training

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World Journal of Gastroenterology 2009年第15期15卷 1793-1798页

作者： Hanna Telleman Trevlyn felicity Burger Chris Jacob Johan Mulder Department of Gastroenterology and Hepatology VU Medical Center Department of Gastroenterology Witwatersrand University

There have been rapid developments in gastroenterology(GE)over the last *** until the late 1980s,GE-training was incorporated in Internal Medicine *** introduction of endoscopy has necessitated the need for additional *** the world different national boards have developed their own curricula which will be discussed in this paper. Emphasis will be placed on the curriculum recently introduced in The *** internal medicine component has become a two-year requirement (Common Trunk)and the duration of training in GE has been extended to four *** of the growing complexity of GE,there are now four subspecialties:Interventional Endoscopy,Neuromotility, Oncology and Hepatology that trainees can choose *** subspecialties each have predefined specific *** World Gastroenterology Organization has drawn up a standard curriculum which can be of help to the boards in different countries. The curriculum emphasizes the knowledge and skill *** curriculum also defines the training recommendations,the requirements of training facilities and competence evaluation of fellows and facilities,while less is said about research,finance and the number of gastroenterologists *** the coming decades the curriculum will need to be revised *** of the curriculum will be the next challenge for the years to come.

关键词： Career Common Trunk Curriculum Endoscopy Fellow Fellowship Gastroenterology Hepatology Program Training

Improving International Arbitration in Mainland China:Problems and Recommendations on National and Institutional Levels

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北京仲裁 2012年第3期 150-187页

作者： felicity Conrad New York University School of Law McGill University

I. Introduction Arbitration in the People’s Republic of China ( "PRC") is growing at a rapid rate.①Yet international parties,who are free to stipulate their choice of international arbitration institution in their commercial contracts,often shy away from Chinese institutions.②Instead they opt for regional bodies such as the Singapore International Arbitration Centre ( "SIAC") ,or internationally recognized institutions such as the

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Taxonomic and community composition of epigeal arthropods in monoculture and mixed tree species plantations in a deciduous forest of Ghana

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Journal of Forestry Research 2023年第3期34卷 641-653页

作者： Frederick Gyasi Damptey Emmanuel Opuni-Frimpong Collins Ayine Nsor James Addai Daniel Kwame Debrah Benjamin Schnerch felicity Bentsi-Enchill Henn Korjus Department of Ecology Brandenburg University of Technology Cottbus-Senftenberg03046 CottbusGermany CSIR-Forestry Research Institute of Ghana KumasiGhana School of Natural Resources University of Energy and Natural Resources(UENR)SunyaniGhana Department of Forest Resources Technology Kwame Nkrumah University of Science and TechnologyKumasiGhana Forest Service Division of the Forestry Commission Accra Department of Biology Education Faculty of Science EducationUniversity of EducationWinnebaGhana Institute of Forestry and Rural Engineering Estonian University of Life SciencesTartuEstonia

Tropical forests provide several ecosystem services and functions and support approximately two-thirds of the world’s biodiversity but are seriously threatened by *** to counteract this menace have revolved around aff orestation with several or a single tree *** thus investigated how plantation forests with either a single or several tree species infl uenced arthropod taxonomic and community composition using pitfall traps to sample selected groups of epigeal arthropods(Araneae,Coleoptera,Orthoptera and Hymenoptera)and with environmental variables assessed *** results revealed 54 taxonomic groups with signifi cantly higher taxonomic richness,activity density,and diversity in the mixed stands than in the monoculture *** significant differences in community composition were mainly driven by families including Lycosidae,Formicidae,Staphylinidae,Scotylidae,Hydrophilidae,Gryllidae and Scarabaeidae and were explained by distinct habitat characteristics(canopy openness,litter depth,deadwood volume,and tree height).While the diverse tree communities and heterogeneous vegetation structure off ered food and habitat resources for diverse arthropod groups,the allelopathic nature coupled with homogenous stand characteristics of the Tectona grandis stands in the monoculture suppressed the growth of understorey vegetation that could otherwise serve as food and habitat resources for arthropods,which might have led to limited activities and diversity of arthropods in the monoculture plantation *** fi ndings thus highlight the need to promote mixed tree plantations in degraded tropical areas,especially when restoring biodiversity is the prime management focus.

关键词： Arthropod community Forest plantations Structural complexity Tree diversity Tropical deforestation

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Low back pain and osteoarthritis pain:a perspective of estrogen

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骨研究:英文版 2023年第3期11卷 443-456页

作者： Huiwen Pang Shihui Chen David M.Klyne David Harrich Wenyuan Ding Sidong Yang felicity Y.Han Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt.LuciaBrisbaneQLD 4072Australia NHMRC Centre of Clinical Research Excellence in Spinal Pain Injury and HealthThe University of QueenslandSt.LuciaBrisbaneQLD 4072Australia Department of Cell and Molecular Biology QIMR Berghofer Medical Research InstituteHerstonQLD 4006Australia Department of Spine Surgery The Third Hospital of Hebei Medical University139 Ziqiang RoadShijiazhuang 050051China Hebei Joint International Research Center for Spinal Diseases 139 Ziqiang RoadShijiazhuang 050051China

Low back pain(LBP)is the world's leading cause of disability and is increasing in prevalence more rapidly than any other pain *** disc(IVD)degeneration and facet joint osteoarthritis(FJOA)are two common causes of LBP,and both occur more frequently in elderly women than in other ***,osteoarthritis(OA)and OA pain,regardless of the joint,are experienced by up to twice as many women as men,and this difference is amplified during *** in estrogen may be an important contributor to these pain *** for estrogen have been found within IVD tissue and nearby joints,highlighting the potential roles of estrogen within and surrounding the IVDs and *** addition,estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression,indicating its potential use as a therapeutic agent for people with LBP and OA *** review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical *** potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed.

关键词： agent degeneration pain

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Acceptability and Feasibility of YouthCHAT to Detect Psychosocial Problems in Young People with Congenital Heart Disease

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International Journal of Mental Health Promotion 2021年第2期23卷 221-230页

作者： Hiran Thabrew Harshali Kumar Vanessa Garcia-Hoyos felicity Goodyear-Smith Department of Psychological Medicine Faculty of Medical and Health SciencesUniversity of AucklandAuckland1023New Zealand Adult Congenital Heart Disease Service Paediatric and Congenital CardiologyStarship HospitalAuckland1023New Zealand Department of General Practice and Primary Health Care University of AucklandAuckland1023New Zealand

Objective:Young people with congenital heart disease(CHD)are at increased risk of psychosocial issues,includ-ing anxiety and depression that can affect their medical care and quality of *** open trial investigated the acceptability,feasibility and preliminary effectiveness of YouthCHAT,a tablet-based screener,designed to identify similar issues to a face to face psychosocial assessment,with young people who have ***:Youth-CHAT was administered to 44 such young people aged 15–25 years attending a specialist outpatient clinic at a New Zealand tertiary *** outcomes were(i)acceptability and(ii)feasibility of YouthCHAT,assessed via feedback from young people and clinicians and(iii)detection rates for each domain of YouthCHAT,measured by mental health or lifestyle issue being‘present’or‘absent’.Results:YouthCHAT was quick to complete(mean 9 min and 7 s)and well-received by young people(overall rating 7 out of 10)and *** of anxiety,substance use and other issues were similar to those in a previous study of young people with mixed long-term physical ***,rates of depression(41%)and life stresses(98%)were notably ***:Although further research is required,our results provide initial evidence that YouthCHAT is a viable and accep-table psychosocial screener with which to improve the holistic care of young people with CHD.

关键词： Screening adolescent anxiety depression congenital heart disease

A PHYLOGENETIC STUDY OF AUSTRALASIAN PECTINIDAE

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A PHYLOGENETIC STUDY OF AUSTRALASIAN PECTINIDAE