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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma

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Frontiers of Medicine 2023年第1期17卷 119-131页

作者： Yingxi Du Yarui Ma Qing Zhu Yong Fu Yutong Li Ying Zhang Mo Li feiyue feng Peng Yuan Xiaobing Wang State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Clinical Laboratory Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Township Health Center in Tanggou Town Wuhu 24100China Thoracic Surgery Department National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Treating patients with esophageal squamous cell carcinoma(ESCC)is challenging due to the high chemoresistance.Growth differentiation factor 15(GDF15)is crucial in the development of various types of tumors and negatively related to the prognosis of ESCC patients according to our previous research.In this study,the link between GDF15 and chemotherapy resistance in ESCC was further explored.The relationship between GDF15 and the chemotherapy response was investigated through in vitro and in vivo studies.ESCC patients with high levels of GDF15 expression showed an inferior chemotherapeutic response.GDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation via TGFBR2.Through an in vivo study,we further validated that the anti-GDF15 antibody improved the tumor inhibition effect of cisplatin.Metabolomics showed that GDF15 could alter cellular metabolism and enhance the expression of UGT1A.AKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A,indicating that TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to cisplatin.The present investigation suggests that a high level of GDF15 expression leads to ESCC chemoresistance and that GDF15 can be targeted during chemotherapy,resulting in beneficial therapeutic outcomes.

关键词： GDF15 esophageal squamous cell carcinoma chemoresistance cellular metabolism TGFBR2 AKT

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Low-temperature-pyrolysis preparation of nanostructured graphite towards rapid potassium storage with high initial Coulombic efficiency

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Nano Research 2024年第6期17卷 5138-5147页

作者： Jingke Ren Boyu Xing Wen Luo Binyang Luo Xinfei Wu Xin Yan Wencong feng feiyue Wang Chaojie Cheng Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Physics School of ScienceWuhan University of TechnologyWuhan 430070China

Industrially prepared artificial graphite(AG)is attractive for potassium-ion batteries(PIBs),but its rate performance is poor and the production process is energy intensive,so developing an efficient strategy to produce novel graphite with low energy consumption and high performance is economically important.Herein,a nanostructured graphite composed of multi-walled carbon nanotubes(MWCNTs)and graphite shells was prepared by one-pot method through low-temperature pyrolysis of iron-based metal-organic framework(MOF)and carbon source.The high graphitization degree of nanostructured graphite makes the initial Coulombic efficiency(ICE)exceed 80%,and the three-dimensional(3D)conductive network ensures a specific capacity of 234 mAh·g^(−1)after 1000 cycles at a high current density of 500 mA·g^(−1).In addition,the typical graphite potassium storage mechanism is also demonstrated by in situ X-ray diffraction(XRD)and in situ Raman spectroscopy,and its practicality is also proved by the voltage of the full cells.This work provides a feasible way to optimize the practical production process of AG and expand its application in energy storage.

关键词： graphite anode potassium-ion batteries high graphitization degree low-temperature pyrolysis initial Coulombic efficiency

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Surgical Treatment and Prognosis of Synchronous Double Primary Lung Cancer： a Report of 31 Cases

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Chinese Journal of Clinical Oncology 2005年第5期2卷 824-828页

作者： feiyue feng Dechao Zhang Xiangyang Liu Yonggang Wang Yousheng Mao Department of Thoracic Surgery Cancer Hospital/Institute Chinese Academy of Medical Sciences＆Peking Union Medical College Beijing 100021 China.

OBJECTIVE The concept of double primary lung cancer (DPLC) has been generally accepted. Recently, an increasing incidence of synchronous DPLC has been reported, while the diagnostic standard and treatment strategies remain to be improved. This study was conducted to investigate effective surgical treatment and prognosis of synchronous DPLC.METHODS From January 1983 to April 2004, 31 patients with synchronous DPLC were operated in our department. Clinical data, such as surgical pattern, postoperative complications, and survival status, of all these patients were reviewed retrospectively.RESULTS The 31 patients with synchronous DPLC accounted for 0.67% of all the 4,649 patients operated for primary lung cancer in our department during the same period. Both tumors of the synchronous DPLC were resected with Iobectomy or pneumonectomy in 12 patients, while among the other 19 patients at least 1 tumor was treated with partial pulmonary resection. The postoperative morbidity was 29%(9/31), including 1 case of respiratory insufficiency, 3 cases of atelectasis, 2 cases of atrial fibrillation, 1 case of haemoptysis, 1 case of pleural effusion, and 1 case of wound fat necrosis.No deaths occurred during the operations or within 30 days postoperatively.The postoperative 1 -, 3-, and 5-year survival rates were 52%, 29%, and 20%, respectively.CONCLUSION The incidence of synchronous DPLC is low. An aggressive and reasonable surgical approach can achieve a satisfactory outcome in patients with synchronous DPLC. The postoperative morbidity is low. Some patients might achieve long-term survival.

关键词：手术治疗疾病预后原发性肺癌肺切除术呼吸功能

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Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center

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Chinese Medical Journal 2014年第4期127卷 747-752页

作者： Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang feng feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie Department of Thoracic Surgical Oncology Cancer Institute &amp Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Background In order to minimize the injury reaction during the surgery and reduce the morbidity rate,hence reducing the mortality rate of esophagectomy,minimally invasive esophagectomy （MIE） was introduced.The aim of this study was to compare the postoperative outcomes in patients with esophageal squamous cell carcinoma undergoing minimally invasive or open esophagectomy （OE）.Methods The medical records of 176 consecutive patients,who underwent minimally invasive esophagectomy （MIE） between January 2009 and August 2013 in Cancer Institute ＆amp; Hospital,Chinese Academy of Medical Sciences,were retrospectively reviewed.In the same period,142 patients who underwent OE,either Ivor Lewis or McKeown approach,were selected randomly as controls.The clinical variables of paired groups were compared,including age,sex,Charlson score,tumor location,duration of surgery,number of harvested lymph nodes,morbidity rate,the rate of leak,pulmonary morbidity rate,mortality rate,and hospital length of stay （LOS）.Results The number of harvested lymph nodes was not significantly different between MIE group and OE group （median 20 vs.16,P=0.740）.However,patients who underwent MIE had longer operation time than the OE group （375 vs.300 minutes,P 〈0.001）.Overall morbidity,pulmonary morbidity,the rate of leak,in-hospital death,and hospital LOS were not significantly different between MIE and OE groups.Morbidities including anastomotic leak and pulmonary morbidity,inhospital death,hospital LOS,and hospital expenses were not significantly different between MIE and OE groups as well.Conclusions MIE and OE appear equivalent with regard to early oncological outcomes.There is a trend that hospital LOS and hospital expenses are reduced in the MIE group than the OE group.

关键词： surgical procedures minimally invasive esophagectomy comparative study

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家庭光伏储能直流微电网下垂控制优化

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上海电机学院学报 2023年第5期26卷 269-274页

作者：朱学畅迟长春(指导) 冯菲玥上海电机学院电气学院上海201306

针对分布式直流微电网系统的储能单元在充放电过程中蓄电池组的荷电不均衡及直流母线电压跌落问题,分析了一种利用收敛因子和均值系数比配合的优化下垂系数方法,优化储能单元的充放电速度。对于直流母线电压跌落问题,增加电压补偿损失电... 详细信息

针对分布式直流微电网系统的储能单元在充放电过程中蓄电池组的荷电不均衡及直流母线电压跌落问题,分析了一种利用收敛因子和均值系数比配合的优化下垂系数方法,优化储能单元的充放电速度。对于直流母线电压跌落问题,增加电压补偿损失电压,使母线电压稳定。通过搭建仿真模型分别在Matlab/Simulink和RT-LAB实时数字仿真平台进行实验,验证了该策略的有效性。

关键词：直流微电网负荷分配下垂控制电压补偿

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基于荷电状态改进下垂控制的直流微网储能系统

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上海电机学院学报 2021年第6期24卷 325-331页

作者：冯菲玥迟长春上海电机学院电气学院上海201306

下垂控制是一种广泛运用于直流微网储能系统的控制手段,能够分配负荷电流、维持母线电压。在负载功率发生变化时,运用传统下垂控制对蓄电池变换器进行操作,会带来荷电状态(SOC)不均衡、电压偏离给定值等问题。针对以上缺陷提出了一种基... 详细信息

下垂控制是一种广泛运用于直流微网储能系统的控制手段,能够分配负荷电流、维持母线电压。在负载功率发生变化时,运用传统下垂控制对蓄电池变换器进行操作,会带来荷电状态(SOC)不均衡、电压偏离给定值等问题。针对以上缺陷提出了一种基于蓄电池SOC改进的下垂控制,根据蓄电池SOC变化实时调整下垂系数,SOC过大的蓄电池组多放少充、SOC过小的蓄电池组多充少放,实现输出电流的均分。在此基础上针对电压波动问题增加二次电压控制,进一步改善波形的生成,仿真验证了改进后的下垂控制的有效性。

关键词：改进下垂控制蓄电池荷电状态(SOC) 二次电压控制储能系统

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胸腔镜肺上叶切除术后单、双胸管引流的前瞻性随机对照研究

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中华胸心血管外科杂志 2016年第3期32卷 162-164页

作者：邱斌冯飞跃高树庚中国医学科学院肿瘤医院胸外科北京100021

目的比较胸腔镜肺上叶切除术后单、双胸管引流方式的优劣。方法2012年8月至2014年8月前瞻性入组100例非小细胞肺癌患者，由同一组术者完成胸腔镜肺上叶切除术，采用信封法和随机余数分组法随机分为单胸管组（49例）与双胸管组（51例）... 详细信息

目的比较胸腔镜肺上叶切除术后单、双胸管引流方式的优劣。方法2012年8月至2014年8月前瞻性入组100例非小细胞肺癌患者，由同一组术者完成胸腔镜肺上叶切除术，采用信封法和随机余数分组法随机分为单胸管组（49例）与双胸管组（51例），比较两组患者术后恢复情况及术后疼痛评分等。结果两组患者的一般资料（性别、年龄、吸烟史、并发症手术部位、病理类型、肿瘤大小和病理分期）以及术后恢复情况（术后引流总量、引流天数、术后住院时间、术后并发症）差异均无统计学意义，P〉0．05。与双胸管组相比，单胸管组术后第2天VAS疼痛评分（4．06±0．97对4．47±0．86，P=0．027）和术后1个月VAS疼痛评分（1．31±0．68对1．61±0．64，P=0．024）都显著低于双胸管组。结论胸腔镜肺上叶切除术后放置单胸管引流安全、有效，且有助于减轻患者术后疼痛。

关键词：电视胸腔镜手术癌非小细胞肺肺上叶切除胸腔闭式引流疼痛评分

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乳腺癌化疗患者的焦虑抑郁及其与化疗毒副反应的相关性

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现代肿瘤医学 2024年第2期32卷 270-276页

作者：陈超杨世威冯丽郭飞跃秦政张静河北省人民医院腺体外科河北石家庄050051 河北医科大学研究生学院河北石家庄050017

目的:观察乳腺癌化疗患者抑郁和焦虑的发病率及其影响因素,并研究焦虑抑郁和化疗毒副反应的相关性。方法:本研究回顾性收集了2020年2月至2023年2月在我院腺体外科住院手术并化疗的乳腺癌患者为研究对象,采用自行设计的一般资料调查表、... 详细信息

目的:观察乳腺癌化疗患者抑郁和焦虑的发病率及其影响因素,并研究焦虑抑郁和化疗毒副反应的相关性。方法:本研究回顾性收集了2020年2月至2023年2月在我院腺体外科住院手术并化疗的乳腺癌患者为研究对象,采用自行设计的一般资料调查表、抗癌药物常见毒副反应分级标准(WHO)、不良事件通用术语标准(CTCAE)5.0版、医院焦虑抑郁量表(HADS)进行问卷调查。分析影响乳腺癌术后化疗患者抑郁和焦虑的独立危险因素,以及焦虑抑郁和化疗毒副反应的相关性。结果:141例乳腺癌患者中焦虑症患者为72例(51.06%);抑郁症患者为61例(43.26%)。文化程度高、经济负担重、手术方式为乳房切除术是乳腺癌合并焦虑或抑郁的独立危险因素。焦虑评分与腹泻、口腔黏膜炎、疼痛、手足综合征、间接胆红素升高呈正相关(P<0.05);抑郁评分与腹泻、手足综合征、间接胆红素升高、尿素升高呈正相关(P<0.05)。结论:乳腺癌化疗患者抑郁、焦虑的发病率较高,并受患者的文化程度、经济水平及手术方式的影响。焦虑、抑郁评分与化疗毒副反应存在一定联系。在临床工作中,医护人员可通过患者的一般特征对患焦虑或抑郁的高危人群重点关注,采取有效的心理干预,降低患者焦虑、抑郁等负性情绪的发生,提高患者生活质量,改善其预后。

关键词：乳腺癌焦虑抑郁影响因素化疗毒副反应

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253例直径≤1cm的孤立性肺结节的胸腔镜诊治经验

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中华胸部外科电子杂志 2014年第1期1卷 54-57页

作者：邱斌冯飞跃高树庚中国医学科学院北京协和医学院肿瘤医院胸外科 100021

目的探讨直径≤1cm的孤立性肺结节的临床诊治策略以及胸腔镜外科处理指征和方法。方法回顾性分析2011年7月至2014年6月中国医学科学院肿瘤医院胸外科经胸腔镜手术治疗的253例直径≤1cm的孤立性肺结节的临床资料。根据病理结果进行病理分... 详细信息

目的探讨直径≤1cm的孤立性肺结节的临床诊治策略以及胸腔镜外科处理指征和方法。方法回顾性分析2011年7月至2014年6月中国医学科学院肿瘤医院胸外科经胸腔镜手术治疗的253例直径≤1cm的孤立性肺结节的临床资料。根据病理结果进行病理分类,并分析病变大小与病变性质的关系。结果该组患者均采用胸腔镜下手术,其中3例中转辅助小切口。楔形切除98例,解剖性肺段切除52例,肺叶切除103例。全组平均手术时间(93.0±29.6)min;术中平均出血量(45±31)ml;术后平均住院时间(5.6±1.8)d;术后平均胸管留置时间(3.9±1.2)d;术后平均引流总量(394±254)ml。术后并发症46例,无住院期间死亡病例。病理结果良性79例,恶性174例;转移瘤34例,肺原发恶性肿瘤140例。结论肺部小结节的诊断、随访和处理对临床医师提出了新的挑战,临床决策主要应依据病变的影像学特征及大小的动态变化,肺部小结节的胸腔镜微创外科诊治一体化模式安全、有效,为肺部小结节的诊治提供了新的途径。

关键词：肺结节孤立性胸腔镜肺癌

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Single‐precursor phase‐controlled synthesis of copper selenide nanocrystals and their conversion to amorphous hollow nanostructures

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SmartMat 2023年第3期4卷 120-132页

作者： Feifan Chen Yadong Zhang Lijun Hu Lifang Zheng feiyue Ge Changsheng feng Dan Xu Chen‐Lei Tao Xue‐Jun Wu State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina

The crystal phases are essential to the physicochemical properties and functionalities of materials.Copper selenide has emerged as an important and appealing semiconductor,which can exist in a variety of polymorphic phases.However,the richness of polymorphs also makes it a challenge to the direct preparation of copper selenide nanocrystals with tunable phases.Herein,two polymorphs,that is,quasitetragonal Cu2−xSe nanocubes and metastable wurtzite Cu2Se nanodisks,are successfully synthesized by using a single precursor,copper(I)selenocyanate(CuSeCN),as the Cu and Se sources.The key to phase modulation is the optimal choice of the ligand in the synthesis.The as‐prepared nanocrystals possess different morphologies and compositions,giving rise to distinct optical properties and electrical conductivities.Interestingly,the copper selenide nanocrystals can provide a platform for the rational construction of two types of amorphous hollow Au─Cu─Se nanostructures by reaction with Au(I)precursor,in which their final shapes are well kept as that of the original nanocrystal templates.This work provides an easy strategy for the phase‐controlled synthesis of copper selenide nanocrystals and enables the design of new materials for broad applications.

关键词： amorphous copper selenides hollow nanostructures metastable polymorphs

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