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1000 Wh L-1 lithium-ion batteries enabled by crosslink-shrunk tough carbon encapsulated silicon microparticle anodes

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National Science Review 2021年第9期8卷 77-87页

作者： Fanqi Chen Junwei Han Debin Kong Yifei Yuan Jing Xiao Shichao Wu Dai-Ming Tang Yaqian Deng Wei Lv Jun lu feiyu Kang Quan-Hong Yang Nanoyang Group State Key Laboratory of Chemical Engineering School of Chemical Engineering and Technology Tianjin University Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate School Tsinghua University CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Chemical Sciences and Engineering Division Argonne National Laboratory International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS) Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University

Microparticulate silicon（Si）, normally shelled with carbons, features higher tap density and less interfacial side reactions compared to its nanosized counterpart, showing great potential to be applied as high-energy lithium-ion battery anodes. However, localized high stress generated during fabrication and particularly,under operating, could induce cracking of carbon shells and release pulverized nanoparticles, significantly deteriorating its electrochemical performance. Here we design a strong yet ductile carbon cage from an easily processing capillary shrinkage of graphene hydrogel followed by precise tailoring of inner *** a structure, analog to the stable structure of plant cells, presents ‘imperfection-tolerance' to volume variation of irregular Si microparticles, maintaining the electrode integrity over 1000 cycles with Coulombic efficiency over 99.5%. This design enables the use of a dense and thick(3 m Ah cm–2) microparticulate Si anode with an ultra-high volumetric energy density of 1048 Wh L–1 achieved at pouch full-cell level coupled with a Li Ni0.8Co0.1Mn0.1O2cathode.

关键词： lithium-ion batteries anode silicon microparticles volumetric capacity mechanical stability

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2021年第3期6卷 1033-1045页

作者： Ning Wang Hor-Yue Tan Yuanjun lu Yau-Tuen Chan Di Wang Wei Guo Yu Xu Cheng Zhang feiyu Chen Guoyi Tang Yibin Feng School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARPeople's Republic of China School of Life Sciences Jilin UniversityChangchun CityJilin ProvincePeople's Republic of China

Altered energy metabolism of cancer cells shapes the immune cell response in the tumor microenvironment that faclitates ***,we reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene Silencing 1(PWL1)in mediatingthe crosstlk of fatty acid metabolism and immune response of human hepatocellular carcinoma(HCC).PlWIL1 expression in HCCwas increased compared to normal hepatic tissues and was positively correlated with the proliferation rate of HCC cell ***1overexpression accelerated in vitro proliferation and in vivo growth of HCC tumors,while PIWL1 knockdown showed ***1 increased oxygen consumption and energy production via fatty acid metabolism without altering aerobic *** of fatty acid metablism abolished PWIL1-induced HCC prolferation and ***-seq analysis revealed that immunesystem regulation might be involved,which was echoed by the experimental observation that PIWL1-overexpressing HCC cellsattracted myeloid-derived suppressor cells(MDSCs)into the tumor *** depletion reduced the prolferationand growth of PlWIL1-overexpressing HCC *** C3,whose secretion was induced by PIWL1 in HCC cells,mediatesthe interaction of HCC cells with MDSCs by activated p38 MAPK signaling in MDSCs,which in turn initiated expression of immunosuppressive cytokine *** lL10 secretion reduced the immunosuppressive activity of MDSCs in the microenvironment of PIWL1-overexpressing *** together,our study unraveled the critical role of PIWL1 in initiating theinteraction of cancer cell metabolism and immune cell response in *** cell-expressed PlIWL1 may be a potential target forthe devellopment of novel HCC treatment.

关键词： metabolism microenvironment hepatocellular

Spatio-temporal patterns and climatic drivers of spring phenology in eight forest communities across the north-south transitional zone of China

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Journal of Geographical Sciences 2025年第1期 17-38页

作者： ZHU Wenbin lu Yu Institute of Geographic Sciences and Natural Resources Research CAS School of Geographical Science Nanjing University of Information Science & Technology

The Qinba Mountains are climatically and ecologically recognized as the northsouth transitional zone of *** of its phenology is critical for comprehending the response of vegetation to climatic *** retrieved the start of spring phenology （SOS）of eight forest communities from the MODIS products and adopted it as an indicator for spring *** analysis,partial correlation analysis,and Geo Detector were employed to reveal the spatio-temporal patterns and climatic drivers of *** results indicated that the SOS presented an advance trend from 2001 to 2020,with a mean rate of–0.473 d yr–*** SOS of most forests correlated negatively with air temperature （TEMP） and positively with precipitation （PRE）,suggesting that rising TEMP and increasing PRE in spring would forward and delay SOS,*** dominant factors influencing the sensitivity of SOS to climatic variables were altitude,forest type,and latitude,while the effects of slope and aspect were relatively *** response of SOS to climatic factors varied significantly in space and among forest communities,partly due to the influence of altitude,slope,and aspect.

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负责任的社会科学数据治理的内涵、特征与层次

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现代情报 2025年第1期45卷 124-134页

作者：王英卢国强湖北大学历史文化学院湖北武汉430062 吉林大学商学与管理学院吉林长春130012

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任... 详细信息

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任的数据治理的概念要素及维度,按照国际标准ISO704:2009的概念关系,结合社会科学数据的特性,阐释负责任的社会科学数据治理的内涵及其与相关概念的关系、特征、层次与内容,旨在构建一个较为全面且系统的概念体系。[结果/结论]负责任的社会科学数据治理是多元主体在现有的数据治理环境之下,运用相应的治理机制和手段,将负责任的研究与创新的理念和原则融入社会科学数据全生命周期,以确保所有涉及社会科学数据的流程和成果的责任性的过程,具有责任性、反思性、前瞻性、开放性和工具性特征,可划分为战略层、数据层和活动层。

关键词：社会科学数据负责任的数据治理数据治理

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3767-3782页

作者： Jiang He Liyu Liu feiyu Tang You Zhou Huan Liu Can lu Deyun Feng Hong Zhu Yitao Mao Zhi Li lu Zhang Yuemei Duan Zhi Xiao Musheng Zeng Liang Weng lun-Quan Sun Department of Oncology Xiangya Cancer CenterXiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Molecular Radiation Oncology Hunan Province Changsha 410008China Department of Pathology Tongji Medical College Union HospitalHuazhong University of Science and TechnologyWuhan 430022China Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410078China Department of Radiology Xiangya HospitalCentral South UniversityChangsha 410078China Institute of Gerontological Cancer Research National Clinical Research Center for GerontologyChangsha 410008China Department of Breast Surgery Xiangya HospitalCentral South UniversityChangsha 410078China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer Changsha 410008China Center for Molecular Imaging of Central South University Xiangya HospitalChangsha 410008China

Epstein-Barr virus(EBV)and human papillomavirus(HPV)infection is the risk factors for nasopharyngeal carcinoma and cervical carcinoma,***,clinical analyses demonstrate that EBV or HPV is associated with improved response of patients,although underlying mechanism remains ***,we reported that the oncoproteins of DNA viruses,such as LMP1 of EBV and E7 of HPV,inhibit PERK activity in cancer cells via the interaction of the viral oncoproteins with PERK through a conserved *** of PERK led to increased level of reactive oxygen species(ROS)that promoted tumor and enhanced the efficacy of chemotherapy in ***,disruption of viral oncoprotein-PERK interactions attenuated tumor growth and chemotherapy in both cancer cells and tumor-bearing mouse *** findings uncovered a paradoxical effect of DNA tumor virus oncoproteins on tumors and highlighted that targeting PERK might be an attractive strategy for the treatment of NPC and cervical carcinoma.

关键词： chemotherapy epithelium cervical

Surplus energy utilization of spent lithium-ion batteries for high-profit organolithiums

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Carbon Energy 2023年第6期5卷 11-20页

作者： Jian lu Yun Zhao Yuqiong Kang Chenglei Li Yawen Liu Liguang Wang Hao Du Meicen Fan Yunan Zhou John Wozny Tao Li Naser Tavajohi feiyu Kang Baohua Li Shenzhen Key Laboratory on Power Battery Safety Tsinghua Shenzhen International Graduate School(SIGS)Shenzhen Geim Graphene CenterShenzhenChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhouChina Institute of Zhejiang University QuzhouChina Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIllinoisUSA Department of Chemistry UmeåUniversityUmeåSweden

It is challenging to efficiently and economically recycle many lithium-ion batteries(LIBs)because of the low valuation of commodity metals and materials,such as LiFePO_(4).There are millions of tons of spent LIBs where the barrier to recycling is economical,and to make recycling more feasible,it is required that the value of the processed recycled material exceeds the value of raw commodity *** presented research illustrates improved profitability and economics for recycling spent LIBs by utilizing the surplus energy in lithiated graphite to drive the preparation of organolithiums to add value to the recycled lithium *** study methodology demonstrates that the surplus energy of lithiated graphite obtained from spent LIBs can be utilized to prepare high-value organolithiums,thereby significantly improving the economic profitability of LIB ***(R-O-Li and R-Li)were prepared using alkyl alcohol(R-OH)and alkyl bromide(R-Br)as substrates,where R includes varying hindered alkyl *** organolithiums extracted from per kilogram of recycled LIBs can increase the economic value between$29.5 and$226.5 kg^(−1) *** value of the organolithiums is at least 5.4 times the total theoretical value of spent materials,improving the profitability of recycling LIBs over traditional pyrometallurgical($0.86 kg^(−1) cell),hydrometallurgical($1.00 kg^(−1) cell),and physical direct recycling methods($5.40 kg^(−1) cell).

关键词： lithiated graphite lithium-ion batteries recycling regeneration spent lithium-ion batteries

5-脂氧合酶及其相关产物与心脑血管损伤的研究进展

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中国药理学通报 2025年第1期41卷 13-18页

作者：黄林露彭军中南大学湘雅药学院药理学系湖南长沙410013

5-脂氧合酶(5-lipoxygenase,5-LOX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LOX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密... 详细信息

5-脂氧合酶(5-lipoxygenase,5-LOX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LOX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密切相关。靶向抑制5-LOX及其相关产物级联反应中的酶和受体能够对心脑血管损伤起到保护作用,表明5-LOX及其相关产物可能是治疗心脑血管疾病潜在的靶点。已有的相关抑制剂包括5-LOX/5-LOX激活蛋白抑制剂、白三烯A4水解酶/白三烯C4合成酶抑制剂、白三烯受体拮抗剂,这些抑制剂通过不同的机制减轻炎症,抑制促炎介质白三烯的产生,促进抗炎脂质介质的形成,在心肌缺血/再灌注损伤和动脉粥样硬化的治疗中显示出了潜在的价值。该文综述了5-LOX及其相关产物在心脑血管疾病中的作用,同时总结了相关抑制剂在心脑血管应用中的研究进展。

关键词： 5-脂氧合酶心肌缺血/再灌注心肌梗死缺血性脑损伤动脉粥样硬化 5-脂氧合酶抑制剂