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Effects of electrolyte balance on intestinal barrier, amino acid metabolism, and mTORC1 signaling pathway in piglets fed lowprotein diets

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Animal Nutrition 2024年第2期17卷 408-417页

作者： Qian Lin Xiaodian Tu Xin Li feiyang gou Lin Ding Zeqing Lu Jie Feng Yongfei Ying Caihong Hu College of Animal Sciences Zhejiang University Key Laboratory of Molecular Animal Nutrition (Zhejiang University) Ministry of Education Animal Husbandry Technology Promotion and Breeding Livestock and Poultry Monitoring Station of Zhejiang Province

A proper dietary electrolyte balance(dEB) is essential to ensure optimal growth performance of piglets. In the low-protein diet, this balance may be affected by the reduction of soybean meal and the inclusion of high levels of synthetic amino acids. The objective of this experiment was to evaluate the optimal dEB of low-protein diets and its impact on the growth performance of piglets. A total of 108 piglets(initial age of35 d) were randomly divided into 3 groups with 6 replicates of 6 pigs each as follows: low electrolyte diet(LE group; dEB = 150 milliequivalents [mEq]/kg); medium electrolyte diet(ME group; dEB = 250 m Eq/kg);high electrolyte diet(HE group; d EB = 350 mEq/kg). Results indicated that the LE and HE diet significantly decreased the average daily gain, average daily feed intake, and crude protein digestibility(P < 0.05) in piglets. Meanwhile, LE diets disrupted the structural integrity of the piglets' intestines and decreased jejunal tight junction protein(occludin and claudin-1) expression(P < 0.05). Additionally, the pH and HCO3 in the arterial blood of piglets in the LE group were lower than those in the ME and HE groups(P < 0.05).Interestingly, the LE diet significantly increased lysine content in piglet serum(P < 0.05), decreased the levels of arginine, leucine, glutamic acid, and alanine(P < 0.05), and inhibited the mammalian target of rapamycin complex 1(mTORC1) pathway by decreasing the phosphorylation abundance of key proteins. In summary, the dietary electrolyte imbalance could inhibit the activation of the mTORC1 signaling pathway,which might be a key factor in the influence of the dEB on piglet growth performance and intestinal ***, second-order polynomial(quadratic) regression analysis showed that the optimal dEB of piglets in the low-protein diet was 250 to 265 mEq/kg.

关键词： Low-protein Dietary electrolyte balance Piglet Mammalian target of rapamycin complex 1

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