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Computer Modeling in Engineering & Sciences 2023年第2期134卷 1137-1158页

作者： Hongliang Wang Jiahua Hu Danhuang Dong Cenfeng Wang feixia tang Yizheng Wang Changsen Feng Economic Research Institute of State Grid Hangzhou310016China College of Information Engineering Zhejiang University of TechnologyHangzhou310023China

With the rapid and wide deployment of renewable energy,the operations of the power system are facing greater challenges when dispatching flexible resources to keep power balance.The output power of renewable energy is uncertain,and thus flexible regulation for the power balance is highly demanded.Considering the multi-timescale output characteristics of renewable energy,a flexibility evaluation method based on multi-scale morphological decomposition and a multi-timescale energy storage deployment model based on bi-level decision-making are proposed in this paper.Through the multi-timescale decomposition algorithm on the basis of mathematical morphology,the multi-timescale components are separated to determine the flexibility requirements on different timescales.Based on the obtained flexibility requirements,a multi-timescale energy resources deployment model based on bi-level optimization is established considering the economic performance and the flexibility of system operation.This optimization model can allocate corresponding flexibility resources according to the economy,flexibility and reliability requirements of the power system,and achieve the trade-off between them.Finally,case studies demonstrate the effectiveness of our model and method.

关键词： Multi-timescale morphological decomposition flexibility evaluation energy storage deployment

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei tang Gang Chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with CKD.We included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life behavior.Using isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD prevalence.Leisure-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working population.In stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long sleepers.More pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active way.The U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical activity.The divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

O-GlcNAcylation Coordinates Glutaminolysis by Regulating the Stability and Membrane Trafficking of ASCT2 in Hepatic Stellate Cells

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1107-1116页

作者： feixia Wang Li Chen Biyun Zhang Zhanghao Li Min Shen Li tang Zili Zhang Jiangjuan Shao Feng Zhang Shizhong Zheng Shanzhong Tan Department of Integrated TCM and Western Medicine Nanjing Hospital Affiliated to Nanjing University of Chinese MedicineNanjingJiangsuChina Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nan-jing University of Chinese MedicineNanjingJiangsuChina Department of Nuclear Medicine Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsuChina

Background and Aims:Recognition of excessive activa-tion of hepatic stellate cells(HSCs)in liver fibrosis prompt-ed us to investigate the regulatory mechanisms of HSCs.We aimed to examine the role of O-GlcNAcylation modifica-tion of alanine,serine,cysteine transporter 2(ASCT2)in HSCs and liver fibrosis.Methods:The expression of O-Glc-NAcylation modification in fibrotic mice livers and activated HSCs was analyzed by western blotting.Immunoprecipita-tion was used to assess the interaction of ASCT2 and O-Glc-NAc transferase(OGT).In addition,ASCT2 protein stability was assayed after cycloheximide(CHX)treatment.The O-GlcNAcylation site of ASCT2 was predicted and mutated by site-directed mutagenesis.Real-time PCR,immunofluores-cence,kit determinations and Seahorse assays were used to clarify the effect of ASCT2 O-GlcNAcylation on HSC glu-taminolysis and HSC activation.Western blotting,immuno-chemistry,and immunohistofluorescence were used to ana-lyze the effect of ASCT2 O-GlcNAcylation in vivo.Results:We observed significantly increased O-GlcNAcylation modi-fication of ASCT2.ASCT2 was found to interact with OGT to regulate ASCT2 stability.We predicted and confirmed that O-GlcNAcylation of ASCT2 at Thr122 site resulted in HSCs activation.We found Thr122 O-GlcNAcylation of ASCT2 me-diated membrane trafficking of glutamine transport and attenuated HSC glutaminolysis.Finally,we validated the expression and function of ASCT2 O-GlcNAcylation after in-jection of AAV8-ASCT2 shRNA in CCl4-induced liver fibrosis mice in vivo.Conclusions:Thr122 O-GlcNAcylation regu-lation of ASCT2 resulted in stability and membrane traf-ficking-mediated glutaminolysis in HSCs and liver fibrosis.Further studies are required to assess its role as a putative therapeutic target.

关键词： ASCT2 O-GlcNacylation Stability Trafficking Liver fibrosis

《本草纲目》与《东医宝鉴》的历史性对话——从中韩“申遗战”说起

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亚太传统医药 2008年第12期4卷 1-2页

作者：罗飞霞唐莉江汉大学人文学院武汉430056 湖北省中医院图书馆武汉430061

从《本草纲目》与《东医宝鉴》之间的"申遗战"展开论述,提出了申遗不仅是推动国际社会了解一个民族文化精髓的重要手段,而且对各国传统文化事业的保护和发展起着重要促进作用的观点,同时还指出申遗的最终价值体现是保护、传承和弘扬传... 详细信息

从《本草纲目》与《东医宝鉴》之间的"申遗战"展开论述,提出了申遗不仅是推动国际社会了解一个民族文化精髓的重要手段,而且对各国传统文化事业的保护和发展起着重要促进作用的观点,同时还指出申遗的最终价值体现是保护、传承和弘扬传统文化。

关键词：本草纲目东医宝鉴申遗文化遗产

归神汤加减联合阿立哌唑片治疗心脾两虚型精神分裂症临床研究

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新中医 2021年第20期53卷 23-26页

作者：郑飞霞衢州市第三医院精神科浙江衢州324000

目的:观察归神汤加减联合阿立哌唑片治疗心脾两虚型精神分裂症的疗效。方法:纳入86例心脾两虚型精神分裂症患者,按随机数字表法分为2组各43例。2组均服用阿立哌唑片,观察组加予归神汤加减方内服,2组均连续治疗3个月。治疗前、治疗3个月... 详细信息

目的:观察归神汤加减联合阿立哌唑片治疗心脾两虚型精神分裂症的疗效。方法:纳入86例心脾两虚型精神分裂症患者,按随机数字表法分为2组各43例。2组均服用阿立哌唑片,观察组加予归神汤加减方内服,2组均连续治疗3个月。治疗前、治疗3个月后评定阳性与阴性症状量表(PANSS)评分、自我感受负担量表(SPBS)评分,检测血清肿瘤坏死因子(TNF)-α及白细胞介素(IL)-6水平。比较2组的临床疗效。结果:治疗3个月后,观察组临床疗效总有效率高于对照组(P<0.05)。2组PANSS阳性症状、阴性症状、一般精神病理评分与SPBS身体因素、情感因素、经济因素评分均较治疗前减少(P<0.01),观察组6项评分均低于对照组(P<0.01)。2组血清TNF-α及IL-6水平均较治疗前下降(P<0.01),观察组血清TNF-α、IL-6水平均低于对照组(P<0.01)。结论:归神汤加减联合阿立哌唑片治疗心脾两虚型精神分裂症疗效明显,可有效缓解患者的临床症状,改善其心理健康水平,减轻神经细胞炎症损伤程度。

关键词：精神分裂症心脾两虚证归神汤阳性与阴性症状量表自我感受负担量表肿瘤坏死因子-α 白细胞介素-6

中西医结合治疗糖尿病周围神经病变临床疗效分析

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新中医 2015年第12期47卷 96-98页

作者：高赛赛杨宏沈飞霞温州医科大学浙江温州325000 温州市中西医结合医院内分泌科浙江温州325000 温州医科大学附属第一医院内分泌科浙江温州325000

目的:观察中西医结合治疗糖尿病周围神经病变的临床疗效。方法:选取120例糖尿病周围神经病变患者,按照随机数字表法随机分为观察组和对照组各60例,对照组给予甲钴胺注射液和注射用鼠神经生长因子治疗,观察组在对照组治疗基础上给予黄芪... 详细信息

目的:观察中西医结合治疗糖尿病周围神经病变的临床疗效。方法:选取120例糖尿病周围神经病变患者,按照随机数字表法随机分为观察组和对照组各60例,对照组给予甲钴胺注射液和注射用鼠神经生长因子治疗,观察组在对照组治疗基础上给予黄芪桂枝五物汤治疗。2组均以30天为1疗程,治疗2疗程。观察2组治疗前后的运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)、多伦多临床评分系统(TCSS)评分,比较2组的临床疗效。结果:治疗1疗程后,观察组总有效率95.00%,显著高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,2组正中神经及腓总神经的MNCV及SNCV均较治疗前改善(P<0.05,P<0.01),观察组改善较对照组更为明显(P<0.05);2组TCSS评分均较治疗前下降(P<0.01),观察组下降较对照组更为明显(P<0.01)。结论:中西医结合治疗糖尿病周围神经病变疗效确切,能有效改善患者的临床症状和体征,值得在临床推广使用。

关键词：糖尿病周围神经病变(DNP) 中西医结合疗法黄芪桂枝五物汤神经传导速度多伦多临床评分系统(TCSS)评分

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猪骨桥蛋白基因的组织差异表达

仲恺农业工程学院学报 2013年第1期26卷 5-8页

作者：李仕新李加琪田允波陈赞谋古飞霞唐军仲恺农业工程学院生命科学学院广东广州510225 华南农业大学动物科学学院广东省农业动物基因组学与分子育种重点实验室广东广州510642

为了研究猪骨桥蛋白基因(Osteopontin,OPN)组织特异性的表达规律,采用实时荧光定量PCR(Real-time quantitative PCR,qRT-PCR)分析方法,以β-actin基因为内参,对猪OPN基因在心、肝、脾、肺、肾、大脑、小脑、垂体、下丘脑和子宫内膜等10... 详细信息

为了研究猪骨桥蛋白基因(Osteopontin,OPN)组织特异性的表达规律,采用实时荧光定量PCR(Real-time quantitative PCR,qRT-PCR)分析方法,以β-actin基因为内参,对猪OPN基因在心、肝、脾、肺、肾、大脑、小脑、垂体、下丘脑和子宫内膜等10种组织中的mRNA表达水平进行了检测.结果表明,OPN基因在子宫内膜的表达量为最高,其次是在小脑,在心、肝、脾和肺也有不同程度的表达,而在肾、下丘脑和垂体的表达量很少,从而提示OPN基因在子宫内膜中可发挥重要作用.

关键词：猪 OPN基因组织特异性表达实时荧光定量PCR mRNA

柴胡加龙骨牡蛎汤加减联合西药治疗冠心病合并焦虑症(少阳不和)随机平行对照研究

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实用中医内科杂志 2020年第4期34卷 59-62页

作者：唐升刘振玉王晓垒周海瀛李飞侠张盼奎许滔许昌市中医院河南许昌461000 贵州中医药大学第二附属医院贵州贵阳550000

目的观察柴胡加龙骨牡蛎汤加减治疗冠心病合并焦虑症(少阳不和证)的临床疗效。方法使用随机平行对照方法,将60例住院及门诊患者按随机数字表法随机分为两组;对照组采用西医常规治疗,治疗组在常规西医治疗的基础上予柴胡加龙骨牡蛎汤加减... 详细信息

目的观察柴胡加龙骨牡蛎汤加减治疗冠心病合并焦虑症(少阳不和证)的临床疗效。方法使用随机平行对照方法,将60例住院及门诊患者按随机数字表法随机分为两组;对照组采用西医常规治疗,治疗组在常规西医治疗的基础上予柴胡加龙骨牡蛎汤加减,比较两组患者治疗前后心绞痛症状疗效、中医证候积分及汉密尔顿焦虑量表(HAMA)积分。结果连续治疗4周,心绞痛症状疗效治疗组总有效率90. 0%(27/30)优于对照组50. 0%(15/30)(P<0. 05);中医临床症状疗效治疗组有效率86. 6%,对照组有效率23. 3%,有显著统计学差异(P <0. 05)。对照组HAMA量表得分治疗前(17. 60±1. 96)与治疗后(17. 30±4. 20)对比差异无明显统计学意义,治疗组治疗前HAMA量表得分(18. 30±2. 60)较治疗后得分(7. 30±1. 35)明显改善,具有统计学意义(P <0. 05),治疗组治疗后的HAMA量表得分明显低于对照组,具有统计学意义(P <0. 05)。结论柴胡加龙骨牡蛎汤加减对冠心病合并焦虑症(少阳不和证)患者疗效显著,可有效缓解患者心绞痛及焦虑症状,改善中医症候,为"双心"疾病的诊疗提供了新思路、新方法,值得临床推广应用。

关键词：柴胡加龙骨牡蛎汤少阳证冠心病焦虑症伤寒论

2型糖尿病长期治疗后合并冠心病及脑梗死的多因素分析

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重庆医学 2018年第17期47卷 2266-2269页

作者：蒋飞霞苏宏业唐华民朱晓玲黄炫赓黄济华张薇广西医科大学第二附属医院内分泌科南宁530007 广西医科大学第二附属医院急诊重症科南宁530007 广西壮族自治区南宁市第三人民医院/广西壮族自治区南宁市心血管病专科医院重症医学科 530007

目的研究2型糖尿病长期治疗后合并冠状动脉粥样硬化性心脏病(简称冠心病)、脑梗死病变的患病率及相关危险因素。方法收集广西医科大学第二附属医院前后两次住院时间间隔4~12年的2型糖尿病患者185例。第一次住院185例为A组,前后两次住院... 详细信息

目的研究2型糖尿病长期治疗后合并冠状动脉粥样硬化性心脏病(简称冠心病)、脑梗死病变的患病率及相关危险因素。方法收集广西医科大学第二附属医院前后两次住院时间间隔4~12年的2型糖尿病患者185例。第一次住院185例为A组,前后两次住院时间间隔5年左右(4~7年)的85例为B组,前后两次住院时间间隔10年左右(8~12年)的100例为C组。收集所有研究对象前后两次住院的临床资料,包括血压、血糖、糖化血红蛋白(HBA1c)、血脂、心肌酶学、心电图、冠状动脉造影、头颅CT或MRI检查。比较冠心病及脑梗死的患病率,对冠心病及脑梗死与各危险因子做回归分析。结果患者第一次住院与5~10年左右再次住院比较,收缩压(DBP)、空腹血糖(FBG)、餐后2h血糖(PBG2h)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均较第一次住院时有所下降,冠心病及脑梗死患病率随着病程延长而增高。10年左右后返回住院,冠心病患者中的脑梗死患病率比无冠心病患者中的脑梗死患病率显著增高(P<0.05)。分别以冠心病和脑梗死为因变量的Logistic回归分析显示,DBP和FBG是脑梗死的危险因素,年龄是冠心病的危险因素,HDL-C是冠心病的保护性因素。结论 2型糖尿病合并的冠心病和脑梗死患病率随着病程的延长而增高,治疗10年左右冠心病与脑梗死患病率呈现出显著相关性。

关键词：糖尿病 2型冠心病脑梗死

超声引导下周围型肺病变穿刺活检术的诊断价值及影响因素

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中华肺部疾病杂志（电子版） 2021年第2期14卷 174-178页

作者：刘菲霞周兴华何炼图汤庆张雨欣胡毅李颖珊广州医科大学附属第一医院超声科广州510120

目的探讨超声引导下周围型肺病变穿刺活检的诊断价值及相关影响因素,总结提高确诊率的方法和技巧。方法分析2018年1月至2019年1月因周围型肺病变在广州医科大学附属第一医院住院,行超声引导下肺穿刺活检术且具有穿刺病理结果的病例共31... 详细信息

目的探讨超声引导下周围型肺病变穿刺活检的诊断价值及相关影响因素,总结提高确诊率的方法和技巧。方法分析2018年1月至2019年1月因周围型肺病变在广州医科大学附属第一医院住院,行超声引导下肺穿刺活检术且具有穿刺病理结果的病例共311例。通过单因素分析以及多因素Logistic回归分析的统计学方法,分别分析患者的性别、年龄、病变位置、病变大小、病变与胸膜接触面直径、病变内有无坏死以及进针次数是否为超声引导下周围型肺病变穿刺活检术确诊率的影响因素。结果311例超声引导下周围型肺病变穿刺活检的病例整体确诊率为86.2%(268/311),总并发症发生率为10.3%(32/311),其中气胸发生率为2.3%(7/311),咯血发生率为6.1%(19/311),胸腔积液发生率为1.0%(3/311),胸膜反应发生率为1.0%(3/311)。单因素分析发现:病变大小、病变与胸膜接触面直径、病变内有无坏死是超声引导下周围型肺病变穿刺活检确诊率的影响因素(P0.05)。多因素Logistic回归分析发现:病变大小并非超声引导下周围型肺病变穿刺活检确诊率的独立影响因素(P>0.05);而病变与胸膜接触面直径是确诊率的保护因子(P<0.05,β=1.059,OR=2.882)、病变内有无坏死是确诊率的危险因子(P<0.05,β=-0.895,OR=0.409)。结论病变与胸膜接触面直径、病变内有无坏死是影响超声引导下周围型肺病变穿刺活检确诊率的重要因素。所以,掌握病变与胸膜接触面较小的病变的穿刺技巧以及避开病变的坏死区域能更好地提高超声引导下周围型肺病变穿刺活检的确诊率。

关键词：超声引导下周围型肺病变穿刺活检确诊率影响因素