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Targeting gut microbiota in type 2 diabetes mellitus:Potential roles of dietary flavonoids

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Food Bioscience 2022年第1期45卷 8-19页

作者： Shuai Han Yi luo Zuomin Hu Dandan Qin feijun luo National Engineering Laboratory for Deep Process of Rice and Byproducts Hunan Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Key Laboratory of Forestry Edible Resources Safety and ProcessingHunan Key Laboratory of Processed Food for Special Medical PurposeCentral South University of Forestry and TechnologyChangsha410004HunanChina Department of Clinic Medicine Xiangya School of MedicineCentral South UniversityChangsha410008HunanChina

Type 2 diabetes mellitus(T2DM)is a common endocrine and progressive metabolic disorder disease,which seriously threatens peoples’lives and *** to the high cost of clinical treatments and obvious side effects,looking for effective bioactive ingredients in the diet is an important strategy to prevent or even reduce the risk of *** studies have suggested that dietary flavonoids have a potential antidiabetic effect,but the underlying mechanism remains *** evidences indicates that gut microbiota has become an important target of dietary *** plays essential roles in the digestion and absorption of flavonoids and affects the occurrence and progression of *** review systematically summarized the progress of dietary flavonoids targeting gut microbiota to ameliorate T2DM and analyzed possible molecular *** suggests that flavonoids may prevent T2DM for healthy people and ameliorate health situations for T2DM *** addition,microbiota-based nutrition aims to provide personalized nutritional guidance to alter an individual’s microbiota and further improve response to dietary flavonoids,which will benefit to achieve a more effective diet for the prevention and management of T2DM.

关键词： Human health Type 2 diabetes mellitus(T2DM) Gut microbiota Dietary flavonoids Dietary recommendations

Octacosanol and health benefits:Biological functions and mechanisms of action

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Food Bioscience 2022年第3期47卷 1-16页

作者： Yaping Zhou Fuliang Cao feijun luo Qinlu Lin National Engineering Laboratory for Deep Process of Rice and Byproducts Hunan Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Key Laboratory of Processed Food for Special Medical PurposeCollege of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha410004HunanChina Co-innovation Center for the Sustainable Forestry in Southern China College of ForestryNanjing Forestry UniversityNanjing210037JiangsuChina

Octacosanol is a widely distributed natural higher aliphatic alcohol that can be isolated and purified from rice bran,sugarcane,beeswax,insect wax,*** exerts various biological effects,including anti-fatigue,anti-hypoxia,antioxidant,anti-inflammatory,antitumor,***,it has the effects of regulating the body's immune function and energy metabolism and has potential benefits for cardiovascular disease,cerebrovascular disorders,diabetes,Parkinson's disease,and *** is primarily responsible for regulating multiple signaling pathways,such as AMPK,PI3K/Akt,and MAPK/NF-κB,to achieve different physiological *** review systemically summarized the progress in characterization,extraction and purification,biological functions,molecular mechanisms,and bioavailability of *** study will provide a reference for many investigators to further explore the physiological functions of higher aliphatic alcohols and apply them as supplements in functional foods.

关键词： Octacosanol Phytochemical extraction and purification Biological functions Molecular mechanisms Bioavailability

Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice

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Food Science and Human Wellness 2024年第3期13卷 1422-1438页

作者： Xiuxiu Wu Tianyi Guo Biao Li Shuai Han Zuomin Hu Yi luo Dandan Qin Yaping Zhou feijun luo Qinlu Lin National Research Center of Rice Deep Process and Byproducts Hunan Provincial Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Provincial Key Laboratory of Forestry Edible Resources Safety and ProcessingCentral South University of Forestry and TechnologyChangsha 410004China College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China Department of Clinical Medicine Medical College of XiangyaCentral South UniversityChangsha 410008China

Dietary parboiled rice(PR)has a low risk of disease,but little is known about the contribution of PR to the prevention of *** potential role and underlying mechanisms of PR in hyperlipidemia were evaluated in this *** C57BL/6J mice were fed with a normal diet,high-fat diet(HFD)containing refined rice(HFDRR)or PR(HFDPR).It was found that PR intervention improved lipid accumulation in *** data analysis revealed that 27 genes were up-regulated(mostly involved in lipid breakdown)and 86 genes were down-regulated(mostly involved in inflammatory responses)in the HFDPR group compared to the HFDRR *** 15 differentially expressed genes(DEGs)were validated by quantitative real-time PCR(RT-qPCR),while protein interaction network showed that protein tyrosine phosphatase receptor type C(PTPRC)has a central *** gut microbiota of mice was also altered after different dietary treatments,with higher ratio of Firmicutes and Bacteroidetes,increased abundances of Ruminococcaceae,Lachnospiraceae,Christensenellaceae,Porphyromonadaceae,Rikenellaceae and Prevotellaceae,and decreased abundances of Lactobacillaceae,Peptostreptococcaceae,Erysipelotrichaceae and Actinobacteria in the HFDRR *** addition,it was observed that PPAR signaling pathway may act as a bridge between DEGs and differential gut *** results suggested that PR can prevent hyperlipidemia by modulating liver genes and gut microbiota.

关键词： Parboiled rice Blood lipids Transcriptome Gut microbiota PPAR Signaling pathway

Bioactive peptides alleviating oxidative stress-associated diseases by targeting the Nrf2 signaling pathway

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Food Science and Human Wellness 2024年

作者： Dandan Qin Zuomin Hu Shuai Han Yi luo Feiyan Yang Tiantian Xie feijun luo Hunan Key Laboratory of Grain-oil Deep Process and Quality Control， Hunan Key Laboratory of Forestry Edible Resources Safety and Processing， College of Food Science and Engineering， Central South University of Forestry and Technology Department of Gastroenterology， Xiangya Hospital， Central South University

Oxidative stress is caused by an imbalance of the antioxidant defense system and excessive production of free radicals， which can damage biological macromolecules such as proteins， lipids and nucleic acids， which can cause aging， ischemia-reperfusion injury， inflammatory injury， liver and kidney injury and other diseases. The nuclear factor erytheroid-2-related factor 2 (Nrf2) is a major regulator of redox balance. The Nrf2 pathway also exerts a central function in cell apoptosis， oxidative stress damage and metabolic diseases. Bioactive peptides are small molecular peptides composed of amino acid residues. They have many biological activities and play important physiological roles in human body. Antioxidant peptide is a kind of peptide which can reduce oxidative stress damage. They are safe， non-toxic and easily absorbed. In this review， we summarized the mechanism of bioactive peptides in regulating oxidative stress， especially antioxidant peptides， through regulating the Nrf2 signaling pathway and the expressions of oxidative stress-related genes， to alleviate oxidative stress-induced damage. The paper will provide valuable reference to investigators in the antioxidant peptide field and also promote the applications of antioxidant peptides in the oxidative stress-associated diseases.

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Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars

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Science China(Life Sciences) 2020年第1期63卷 116-124页

作者： Wenjie Tang Jian Wu Shunshun Jin Liuqin He Qinlu Lin feijun luo Xingguo He Yanzhong Feng Binsheng He Pingping Bing Tiejun Li Yulong Yin Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionChangsha 410125China National Engineering Laboratory for Deep Process of Rice and Byproducts Hunan Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Key Laboratory of Processed Food for Special Medical PurposeCollege of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China Academics Working Station at The First Affiliated Hospital Changsha Medical UniversityChangsha 410219China Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China ^Changsha Green LecrfBiotechnology Co. Ltd.Changsha 610066Hunan Heilongjiang Academy of Agricultural Sciences Harbin 150086China

Several potential oxidative agents have damaging effects on mammalian reproductive *** study was conducted to investigate the effects of glutamate(Glu)and aspartate(Asp)supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2.A total of 24 healthy boars were randomly divided into 4 treatment groups:control(basal diet,saline-treated),H2O2(basal diet,H2O2-challenged outer scrotum(1 m L kg^–1 BW)),Glu(basal diet+2%Glu,H2O2-challenged),and Asp(basal diet+2%Asp,H2O2-challenged).Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated *** and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone ***,the m RNA expression of CAT,Cu Zn SOD,and GPx4 was altered in the testes and epididymis of boars treated with Asp and *** and Asp supplementation also modulated the expression of TGF-β1,IL-10,TNF-α,IL-6 and IL-1βin the testis and *** results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress.

关键词： glutamate aspartate boars oxidative stress inflammatory cytokines

Anti-hepatocarcinoma effect of polysaccharides extracted from Lactarius hatsudake Tanaka mushroom: in vitro and in vivo studies

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Food Science and Human Wellness 2024年

作者： Qiao Yang Songlin Chang Yiming Tian Hui Zhang feijun luo Wang Li Jiali Ren Hunan Key Laboratory of Forestry Edible Sources Safety and Processing， College of Food Science and Engineering， Central South University of Forestry and Technology

Edible mushroom polysaccharides demonstrate a range of bioactivities and have been investigated as potential adjuvant therapies for cancer treatment. Our prior research found Lactariks hatsudake Tanaka polysaccharide (LHP) effective against hepatocellular carcinoma， but the mechanisms remain unclear. This study aims to clarify the anti-cancer molecular mechanisms by examining the effects on specific signaling pathways through in vivo and in vitro analyses. Animal studies showed that LHP significantly inhibited the growth of transplanted liver cancer without toxicity. Histological and immunohistochemical analyses revealed that LHP increased nuclear cohesion in tumor cells and altered the expression of key regulatory proteins such as Ak strain transformation， nuclear factor kappa B， caspase-3， p21， and p53. These findings suggest that LHP's anticancer effects involve promoting apoptosis and disrupting the cell cycle. At the cellular level， assays such as MTS， flow cytometry， and transwell invasion confirmed that LHP inhibited cancer cell proliferation and induced apoptosis. Polymerase chain reaction and western blot assays revealed that LHP intervention reduced cyclin-dependent kinase 4 activity by upregulating p53 and p21， leading to cell cycle arrest and inhibited cell proliferation. LHP also promoted apoptosis by altering Bcl-2-associated X protein， B-cell lymphoma 2， and cleaved caspase-3 levels. Moreover， LHP could affect the Ak strain transformation， nuclear factor kappa B， and mitogen-activated protein kinase signaling pathways to exert anticancer effects. These findings underscore the potential of LHP as a novel and multifaceted therapeutic agent. Furthermore， the elucidation of LHP-related mechanisms offers a crucial theoretical foundation for developing innovative and effective treatments for hepatocellular carcinoma. Additionally， this supports its potential development as a functional food or adjuvant therapy for cancer， which holds significant implication

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Discovery and mechanism of anti-hypertensive effect of a novel tripeptide(SYP) from medicinal fungus Ganoderma lingzhi

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Food Science and Human Wellness 2024年

作者： Qiang Wu feijun luo Jia Huang Ping Huang Yongnan Liu Xiaoling Wang Gaoqiang Liu Hunan Provincial Key Laboratory of Forestry Biotechnology and International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology， Central South University of Forestry and Technology Microbial Variety Creation Center，Laboratory of Yuelushan Seed Industry College of Food and Chemical Engineering， Shaoyang University Laboratory of Molecular Nutrition， National Engineering Laboratory for Rice and Byproducts， Central South University of Forestry and Technology

Ganoderma lingzhi is a new species of the prize medicinal mushroom Ganoderma (Agaricomycetes). Using angiotensin I-converting enzyme (ACE) as a target， a tripeptide Ser-Tyr-Pro (SYP) was discovered with preponderant ACE inhibitory activity with an 50% inhibiting concentration (IC50) value of 62.50 μg/mL attribute to the formed salt bridge and hydrogen bonds between SYP and ACE. SYP even maintained superior bioactivity after intestinal digestion， and exerted no cytotoxicity， but presented incomplete bioavailability in blood of spontaneous hypertensive rats (SHRs). Furthermore， it performed antihypertensive effect in vivo by inhibiting the influx of Ca2+through activating endothelial NO synthase (eNOS)/NO/guanosine 3’，5’-cyclic monophosphate (cGMP) pathway， accompanied by attenuating angiotensin Ⅱ (Ang Ⅱ)/NADPH oxidase (NOX)/ROS pathway. This work not only discoverers a novel pharmacological ingredient from medicinal mushroom G. lingzhi for hypertension therapy， but also provides an insight into molecular mechanism of the ACE inhibitory peptide (ACEIP) on lowering blood pressure.

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膳食纤维抗癌作用及其分子机理的研究进展

食品与生物技术学报 2015年第12期34卷 1233-1238页

作者：罗非君聂莹中南林业科技大学食品科学与工程学院稻谷及副产物深加工国家工程实验室湖南长沙410004

综述了膳食纤维流行病学和动物实验方面的抗癌证据,以及膳食纤维的量与不同类型癌症发生率的关系,分析了膳食纤维通过排毒、消炎、肠道菌群和脂代谢的调控参与抗癌的机理;在分子细胞水平,总结了膳食纤维对癌细胞周期阻滞和促使癌细胞凋... 详细信息

综述了膳食纤维流行病学和动物实验方面的抗癌证据,以及膳食纤维的量与不同类型癌症发生率的关系,分析了膳食纤维通过排毒、消炎、肠道菌群和脂代谢的调控参与抗癌的机理;在分子细胞水平,总结了膳食纤维对癌细胞周期阻滞和促使癌细胞凋亡的分子机理,以及其对癌变信号通路的调控。近年来的研究发现,膳食纤维具有抗肥胖、抗心脑血管疾病、消炎和抗糖尿病等生理功能,已成为维系人类身体健康、不能被其它物质所替代的一种营养素,被誉为人体的"第七营养素"。本文将为深入研究膳食纤维的抗癌分子机理和进一步开发膳食纤维功能性食品提供参考。

关键词：膳食纤维生理功能抗癌机理

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藤茶及二氢杨梅素的生物学功能研究进展

食品与生物技术学报 2022年第2期41卷 8-21页

作者：罗非君丁锦屏中南林业科技大学食品科学与工程学院湖南长沙410004 中南林业科技大学稻谷及副产物深加工国家工程实验室湖南长沙410004

藤茶(vine tea)为葡萄科(Vitacea)蛇葡萄属(Ampelopsis michx.)显齿蛇葡萄(Ampelopsis grossedentata)植物的嫩茎叶经加工而成的茶制品。藤茶中含有丰富黄酮类物质,其中最主要成分为二氢杨梅素(dihydromyricetin,DMY)。科学研究发现,藤... 详细信息

藤茶(vine tea)为葡萄科(Vitacea)蛇葡萄属(Ampelopsis michx.)显齿蛇葡萄(Ampelopsis grossedentata)植物的嫩茎叶经加工而成的茶制品。藤茶中含有丰富黄酮类物质,其中最主要成分为二氢杨梅素(dihydromyricetin,DMY)。科学研究发现,藤茶及其主要活性成分具有抗癌、抗氧化、降脂、抗炎、抑菌和抗疲劳等作用,并且向一些重要基因和调控信号传导通路,参与不同的生物学功效,但其作用的分子机理尚不清楚。作者根据近年来国内外的最新研究进展,对藤茶及其主要活性成分的生物活性、调控的信号传导通路和作用的关键靶基因等进行了系统综述,以期为藤茶及其活性成分的深入研究提供理论参考,也有利于今后进一步对藤茶及其主要活性成分的开发利用。

关键词：藤茶黄酮二氢杨梅素生理功能作用机理