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益生菌的抗生素耐药性特征研究进展

实用预防医学 2024年第7期31卷 887-892页

作者：任飞鸿赵婷婷黄小丹兰州大学公共卫生学院甘肃兰州730000

目前,由于人类和动物抗生素使用的不断增加,微生物耐药问题已发展为全球主要的公共卫生问题之一。中国作为世界上最大的抗生素生产国和消费国之一,抗生素耐药基因传播状况更不容忽视。随着全球对益生菌的关注日益增加,在充分肯定益生菌... 详细信息

目前,由于人类和动物抗生素使用的不断增加,微生物耐药问题已发展为全球主要的公共卫生问题之一。中国作为世界上最大的抗生素生产国和消费国之一,抗生素耐药基因传播状况更不容忽视。随着全球对益生菌的关注日益增加,在充分肯定益生菌健康功效的同时,也应紧密关注其可能带来的抗生素耐药基因传播问题。研究指出,益生菌自身携带的耐药基因可通过基因水平转移的方式传递给人体肠道中的致病菌,导致耐药感染,亟待深入挖掘和探索益生菌耐药机制及耐药基因传播特征。因此,本研究总结了人体肠道耐药基因的组成和传播机制,在此基础上进一步综述了益生菌耐药机制以及在耐药基因驱动下益生菌耐药性的发展特征,并对益生菌耐药机制的研究瓶颈以及未来益生菌的安全性评估进行了总结和展望。

关键词：益生菌耐药基因耐药机制水平转移

黔东低海拔地区立体气候对水稻品种展示效果的影响

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安徽农学通报 2024年第19期30卷 1-8页

作者：张玉清任菲宏邓川王姣李甫荣付瑞滢铜仁市农业科学院贵州铜仁554300 铜仁市气象局贵州铜仁554300

为探寻不同水稻品种在黔东低海拔地区不同小气候条件下的种植表现,本试验选择川谷优1378等51个水稻品种在贵州铜仁西部塘头基地和东部坝黄基地开展了展示试验,并对各水稻品种的生育期、种植表现和产量等指标进行分析。结果表明,小气候... 详细信息

为探寻不同水稻品种在黔东低海拔地区不同小气候条件下的种植表现,本试验选择川谷优1378等51个水稻品种在贵州铜仁西部塘头基地和东部坝黄基地开展了展示试验,并对各水稻品种的生育期、种植表现和产量等指标进行分析。结果表明,小气候差异对水稻种植表现和产量均产生影响,生育期变化受种植区立体气候影响,且与品种适应性有关;各品种株高、穗长等种植表现存在差异,结实率均表现为西部基地低于东部基地;43个参展品种在西部基地的实测产量高于东部基地,增加了9.0~7047.0 kg/hm^(2);7个品种在西部基地种植的产量低于东部基地,降低了60.0~3979.5 kg/hm^(2)。综合各品种生育期、农艺性状及产量等表现,筛选出九优27占、宜香优800和中9优2号适合在黔东低海拔西部地区推广种植;晶两优1206、旌优312、玮两优钰占和澳富优287适合在黔东低海拔东部地区推广种植。

关键词：水稻立体气候生育期水稻产量

Frequent Gain and Loss of Resistance against Tobacco Mosaic Virus in Nicotiana Species

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Molecular Plant 2015年第12期8卷 1813-1815页

作者： Yuan, Xinjie Yan, Chenghuan Wu, Zhujun ren, feihong Zhang, Hui Baker, Barbara Chen, Jiongjiong Kuang, Hanhui Huazhong Agr Univ Key Lab Hort Plant Biol Minist EducMOAColl Hort & Forestry Sci Key Lab Hort Crop Biol & Genet Improvement Cent R Wuhan 430070 Peoples R China Univ Calif Berkeley Dept Plant & Microbial Biol Berkeley CA 94720 USA USDA ARS Ctr Plant Gene Express Albany CA 94710 USA

Dear Editor Resistance （R） genes represent one of the most divergent gene families in plants. Novel resistance function might arise through point mutations or sequence exchanges between paralogues （Kuang et al., 20... 详细信息

关键词： Tobacco mosaic virus Nicotiana Tobacco

Unstable Allotetraploid Tobacco Genome due to Frequent Homeologous Recombination, -. Segmental Deletion, and Chromosome Loss

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Molecular Plant 2018年第7期11卷 914-927页

作者： Shumin Chen feihong ren Lei Zhang Yong Liu Xuejun Chen Yuanmei Li Liang Zhang Bin Zhu Pan.Zeng Zaiyun Li Robert M. Larkin Hanhui Kuang Key Laboratory of Horticultural Plant Biology Ministry of Education Key Laboratory of Horticultural Crop Biology and Genetic Improvement (Central Region) MOA College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan 430070 People's Republic of China Yunan Academy of Tobacco Agricultural Science Kunming Yunnan Province People's Republic of China College of Plant Science Huazhong Agricultural University Wuhan 430070 People's Republic of China These authors contributed equally to this article.

The types of mutations and their corresponding frequencies are difficult to measure in complex genomes. In this study, a high-throughput method was developed to identify spontaneous loss-of-function alleles for the resistance gene N and the transgenic avirulence gene P50 in allotetraploid tobacco. A total of 2134 loss- of-function alleles of the N gene were identified after screening 14 million F1 hybrids. Analysis of these mutants revealed striking evolutionary patterns for genes in polyploids. Only 14 of the loss-of-function mutations were caused by spontaneous point mutations or indels, while the others were caused by home- ologous recombination （with a frequency of 1/12 000） or chromosome loss （1/15 000）. Loss of the chromosome with the PS0 insertion occurred at a similar frequency （1/13 000）, and the frequency of spon- taneous segmental deletion in this chromosome was 1/16 000. Both homeologous recombination and chromosome loss considerably decreased the viability of the mutants. Our data suggest that the high mutation rate in polyploids is probably due to the occurrence of homeologous recombination and the toler- ance of large mutations such as chromosome loss in polyploid genomes. Frequent mutations tend to drive polyploids to extinction unless a novel mutation helps the polyploid to effectively compete with diploids or find a new ecological niche.

关键词： polyploid genome evolution homeologous recombination chromosome loss spontaneous mutation

Intermittent energy restriction altered the fecal metabolites in Chinese and Pakistani individuals driven by shifts in diet and gut microbiota

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Intermittent energy restriction altered the fecal metabolite...

Template-Assisted Synthesis of 2D Perovskite Grating Single Crystal Films at Low Temperatures for UV Polarization-Sensitive Photodetectors

中国营养学会第十五届全国营养科学大会

作者： Siyu Chen Ikram Ali Tingyu Yang feihong ren Xiaodan Huang 兰州大学公共卫生学院

Intermittent energy restriction(IER) defined as periods of energy restriction interspersed with normal energy intake. As a common alternative form of intermittent energy restriction, Ramadan fasting is a religious practice where practitioners of the Muslim faith undergo a yearly ritual in which no food or beverages are consumed between sunrise to sunset for 29-30 days. Our previous finding has demonstrated that Ramadan fasting could leads to shifts in human gut microbiota structured by changing dietary composition. Together with gut microbiota, metabolites also jointly participate the gut function in nutritive, immunologic, and protective in host metabolism. However, limited human studies have been conducted to characterize whether diet-related behaviors, such as fasting(intermittent energy restriction) can influence fecal metabolites, given consideration of ethnic difference. In this study, we aim to study the changes of metabolites in fecal of two ethnic groups before and after fasting by metabolomics, search for potential biomarkers and related metabolic pathways, and thus figure out whether Ramadan fasting altered the metabolites in Chinese and Pakistani individuals with consideration of diet changes. The study will provide new ideas for potential influence of intermittent energy restriction on human health. Methods 34 healthy adult participants, living in the city of Lanzhou and distributed across two ethnic groups(16 Chinese and 18 Pakistani) were recruited in this study. B survey and fecal samples were collected from the two groups before and after Ramadan fasting. LC-MS metabolomics data analysis was used to detect the metabolites from fecal samples. Unsupervised principle component analysis and(orthogonal) partial least-squares-discriminant analysis were employed to identify differential metabolites between different groups. Software as Compound Discoverer3.1 and R were used to analysis metabolomics and metagenomic data before and after fasting in different

关键词： Ethnicity Ramadan fasting Dietary habit Fecal metabolomics LC-MS

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Template-Assisted Synthesis of 2D Perovskite Grating Single ...

第十一届新型太阳能材料科学与技术学术研讨会

作者： feihong Ye Pengbin Gui Xingang ren Anhui University

The 11 the layered structure of 2D perovskites hinders the interlayer carrier transport,which limits the improvement of device ***,nanoscale structures are normally used to enhance the light absorption ability,which is an effective strategy to improve the photocurrent in 2D perovskite-based ***,a template-assisted low-temperature method is proposed to fabricate 2D perovskite((C6H5C2H4NH3)2PbBr4,(PEA)2PbBr4) grating single crystal films(GSCFs).The crystallinity of the(PEA)2PbBr4 GSCFs is significantly improved due to the slow evaporation of the precursor solution under low *** on this high crystalline quality and extremely ordered microstructures,the metal–semiconductor–metal photodetectors are ***,the photocurrent of this photodetector varies as the angle of the incident polarized light,resulting in a high polarization ratio of 1.12.

关键词： 2D perovskite grating single crystal films UV Polarization-Sensitive Photodetectors

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改善颗粒物污染的道路绿地植被屏障研究进展

生态学报 2022年第13期42卷 5177-5186页

作者：任飞虹白骅邱兆文田顺长安大学建筑学院西安710061 长安大学汽车学院西安710064

减少道路环境的颗粒物污染对通勤者的健康至关重要。道路绿地在交通排放和邻近区域之间形成屏障,但这种植被屏障是否可以有效消减局部颗粒物污染仍然需要深入研究和探讨。结合现有研究成果,阐述了植被对颗粒物污染的影响途径;分析了街... 详细信息

减少道路环境的颗粒物污染对通勤者的健康至关重要。道路绿地在交通排放和邻近区域之间形成屏障,但这种植被屏障是否可以有效消减局部颗粒物污染仍然需要深入研究和探讨。结合现有研究成果,阐述了植被对颗粒物污染的影响途径;分析了街道峡谷和开放道路两种典型城市道路环境中,植被组成及群落结构设计的关键特征对颗粒物分布和扩散的影响;总结了有利于消减颗粒物浓度的植被单株性状和叶片微形态;探讨了影响颗粒物浓度的其他因子的耦合作用;针对不同道路环境提出了有效的植被屏障设计建议,并指出了植被群落设计和叶片微形态方面的研究趋势,以期优化道路植被规划,改善路域空气质量。

关键词：颗粒物污染开放道路街道峡谷植被屏障叶片微形态

Evolution of the Resistance against TMV in Nicotiana spp.

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Evolution of the Resistance against TMV in Nicotiana spp.

第十三届全国植物基因组学大会

作者： Shumin Chen,Jiongjiong Chen,feihong ren,Zhujun Wu,,Hui Zhang,Chenhuan Yan, Hanhui Kuang~* Dept of Vegetable Crops,Huazhong Agricultural University,Wuhan 430070,China

The resistance gene N against TMV is alternatively spliced and its two transcripts are required for its full *** alternative exon is provided by a miniature invertedrepeat transposable element(MITE).The insertion of the MITE in intron 3 was found only in the Ngene but not in any other N *** better understand the evolution of the N gene,its avirulence gene(p50) in TMV was transformed into a

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基于《脾胃论》思想论治特应性皮炎

中医杂志 2023年第11期64卷 1165-1170页

作者：金秋百任飞鸿李佳琦王若伊宋坪中国中医科学院广安门医院北京市100053 北京中医药大学

李杲在《脾胃论》中论及脾土、心火、肺金的关系时提出脾土不足既可招致心火来乘,亦可导致肺金不足,将李杲之相关论述概括为土虚火来乘、土虚金亦虚。脾虚是特应性皮炎形成的关键因素,而在本病发生发展中,病机常由单一脾虚演变为脾肺不... 详细信息

李杲在《脾胃论》中论及脾土、心火、肺金的关系时提出脾土不足既可招致心火来乘,亦可导致肺金不足,将李杲之相关论述概括为土虚火来乘、土虚金亦虚。脾虚是特应性皮炎形成的关键因素,而在本病发生发展中,病机常由单一脾虚演变为脾肺不足,表虚不固;土虚火乘,湿热为患。结合李杲对脾土、心火、肺金关系的认识及特应性皮炎的疾病特点,可采用甘温药如人参、甘草等,补土泻火,采用风药如柴胡、羌活等,升发阳气,宣畅气液,兼能胜湿,此为治本;采用性凉之药如黄连、黄芩等,以泻心火,若皮疹渗出或瘙痒明显,还可酌增凉药以折火势,此为治标。临证时需根据脾虚、肺虚、心火的轻重程度以斟酌甘温药、风药、寒凉药之比例。

关键词：特应性皮炎《脾胃论》脾虚李杲