检索结果-南通市图书馆

Magmatic Processes at the Oman Ophiolite Paleoridge–Perspectives on the Role of Water

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2020年第S1期94卷 21-22页

作者： Juergen KOEPKE Sandrin T.feig Leibniz University Hannover 30167 HannoverGermany University of Tasmania Hobart TAS 700Australia

The Oman ophiolite is regarded as best proxy for accreted oceanic crust from typical fast-spreading ridge systems on land. However, the Oman ophiolite is influenced by initial subduction zone initiation, and the nature of the details of the subduction zone setting is still under controversial debate. While a first magmatic phase shows features of magmatic accretion very similar to those known from the East Pacific Rise, except that the primary melts were slightly water-enriched, a second type of magmatism is characterized by an apparent subductionzone related imprint, producing rocks like FAB basalts and boninites in the upper crust, as well as cross-cutting gabbronorites and wehrlites in the deeper crust. In this paper, we apply diverse experimental studies in wet tholeiitic and peridotitic systems performed at lower pressures(100 to 500 MPa) in the experimental lab of the University Hannover, in order to constrain the details of the magmatic processes proceeded at the Oman ophiolite paleoridge during the Cretaceous, with special focus on the influence of water on the phase stabilities and phase relations. The experiments were performed in vertically oriented internally heated pressure vessels(IHPV)(see Berndt et al., 2002;Fig. 1). This facility uses as pressure medium mixtures of Ar and H2 in order to adjust the required fH2 in the vessel, enabling us to control the redox conditions. The fH2 prevailing in the IHPV at high P and T was measured with a Shaw-membrane made of platinum. The overall variation in fO2 in all experimental series was in the range between ~FMQ-1 and ~FMQ+3.2, thus covering the range of oxygen fugacities prevailing in natural MORB magmas(Bezos and Humler, 2005). For understanding the magmatic processes during the Oman ophiolite paleoridge accretion, transects through the lower(GT1) and middle(GT2) crust have been drilled in the frame of ICDP(International Continental Scientific Drilling Program). Drill sites have been selected in the Wadi Tayi

关键词： Oman ophiolite wet magmatism magmatic accretion fast-spreading ridge subduction zone initiation

在线全文

学校读者我要写书评

暂无评论

皮肤色度学:一种客观可靠的肤色测量技术

中华皮肤科杂志 2022年第2期55卷 185-186页

作者： Ly BCK Dyer EB feig JL Department of Dermatology John Hopkins University School of Medicine Baltimore Maryland L’Oréal Research and Innovation Aulnay-sous-Bois France

皮肤科需要具有良好的一致性和可重复性的肤色评价方法。研究人员和医生在评价药物干预、环境暴露和生理变化时经常需要描述皮肤的颜色,肤色参数(如色素沉着)与罹患皮肤癌的风险有关。此外,紫外线暴露引起的最小红斑量常被用于制定光疗... 详细信息

皮肤科需要具有良好的一致性和可重复性的肤色评价方法。研究人员和医生在评价药物干预、环境暴露和生理变化时经常需要描述皮肤的颜色,肤色参数(如色素沉着)与罹患皮肤癌的风险有关。此外,紫外线暴露引起的最小红斑量常被用于制定光疗计划。迄今为止,Fitzpatrick皮肤类型(FST)量表被广泛用于皮肤分型,肤色是其中重要的考量因素。

关键词：最小红斑量色素沉着环境暴露皮肤的颜色皮肤类型光疗色度学可重复性

Immortalized Sertoli cell lines sk11 and sk9 and binding of spermatids in vitro

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2007年第3期9卷 312-320页

作者： Katja M. Wolski Caroline feig Christiane Kirchhoff Don F. Cameron Department of Pathology and Cell Biology School of Basic Biomedical Sciences University of South Florida Collegeof Medicine Tampa Florida 33612 USA Department of Molecular Andrology University Clinics Eppendorf University of Hamburg Hamburg Germany

Aim： To determine the effectiveness of the ski 1, sk9 and ski 1 TNUA5 Sertoli cell lines in binding germ cells in vitro. Methods： The immortalized Sertoli cell lines sk9, ski 1 and ski 1 TNUA5 were used in co-culture experiments with germ cells in media with or without reproductive hormones and incubated for 44 h at 32℃. The number of germ cells bound to Sertoli cells was then determined and statistically analyzed. Western blot analysis and reverse transcriptasepolymerase chain reaction （RT-PCR） studies were employed to investigate the presence of cell adhesion proteins and follicle stimulating hormone （FSH） receptor, respectively. Results： No statistical difference between the number of bound step-8 spermatids and bound pre-step 8 spermatids on Sertoli cells from any of the cell lines existed. After the addition of germ cells, Sertoli ceils showed more lipid accumulation in their cytoplasm, indicating active phagocytosis. Western blot analysis in the ski I TNUA5 line indicated the expression of N-cadherin. FSH-only and testosterone-only treatments increased N-cadherin expression, regardless of germ cell addition. The addition of germ cells to the ski l TNUA5 Sertoli cells increased the expression of espin, as did the addition of FSH with germ cells. RT-PCR studies of the ski I TNUA5 cells indicated that the mRNA for FSH receptor decreased with successive passages. Conclusion： In vitro binding between isolated germ cells and sk9, skll or skll TNUA5 Sertoli cells is not feasible, and therefore these cell lines are not useful for the in vitro investigation of Sertoli-germ cell interactions and primary Sertoli cell isolates must still be used.

关键词： sk Sertoli cells immortalized Sertoli cells Sertoli-germ cell binding Sertoli-germ cell co-culture Sertoli-spermatid junctionalcomplex in vitro cell-cell binding

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SOA架构奠定电子商务成功的基础

电子商务 2006年第3期7卷 29-31页

作者： Ephraim feig Kinterra公司CTO

今天所谈的是．作为服务构建的软件。

关键词：电子商务 SOA 基础架构商业决策

在线全文

学校读者我要写书评

暂无评论

溶剂环境建模——在生物分子模拟中的应用

国外科技新书评介 2010年第10期 16-17页

作者： Michael feig 孙方敏不详中国科学院电子学研究所

目前人们普遍关注现实的宏观分子模型的发展，本书介绍了准确高效的溶剂环境建模方式的最新进展。自始至终，本书的重点都放在这种模型在生物工程模拟研究中的应用，其覆盖面相当广泛，且可以推广到其它的系统。

关键词：环境建模分子模拟应用生物溶剂分子模型建模方式工程模拟

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

腹腔镜下结肠癌切除术(英文)

腹腔镜下结肠癌切除术(英文)

襻利尿剂作用的细胞机制:与药物疗效和副作用的关系

中国医师协会内镜医师分会成立大会、中国第十四届内镜医学学术大会、《中国内镜杂志》创刊十周年学术讨论会、恩德思奖（Endoscopics Award）颁奖大会

作者： Barry W.feig Associate Professor Department of Surgical Oncology M.D.Anderson Cancer Center M.D.

关键词：结肠癌切除术 CCR LCR

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

国外医学.心血管疾病分册 1987年第1期 41-42页

作者： feig PU 钱肇美

Na-K-2Cl复合转运系统是细胞膜离子转运系统之一.1个钠离子,1个钾离子和2个氯离子的复合转运可双向进行,且不伴电荷转移.该系统存在于红细胞,Ehrlich腹水肿瘤细胞和取自下列组织和上皮的培养细胞——结肠、Sharks泌盐直肠腺、亨利氏襻... 详细信息

Na-K-2Cl复合转运系统是细胞膜离子转运系统之一.1个钠离子,1个钾离子和2个氯离子的复合转运可双向进行,且不伴电荷转移.该系统存在于红细胞,Ehrlich腹水肿瘤细胞和取自下列组织和上皮的培养细胞——结肠、Sharks泌盐直肠腺、亨利氏襻升支粗段.襻利尿剂可抑制Na-K-2Cl复合转运,如苯氧基乙酸衍生物利尿酸、氨磺酰苯甲酸衍生物速尿和布美他尼.

关键词：苯氧基乙酸布美他尼直肠腺氯离子离子转运细胞机制转运系统利尿酸钾离子 Ehrlich

Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2017年第12期8卷 926-931页

作者： Hua Jiang Bo Song Peng Wang Bizhi Shi Qixiang Li Mingliang Fan Shengmeng di Jie Yang Zonghai Li State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200032 China. CARsgen Therapeutics Shanghai 200231 China. Crown Biosciences Inc. Science & Technology Innovation Park Taicang City 215400 China. Blood Engineering Laboratory Shanghai Blood Center Shanghai 200051 China. State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200032 China. Zonghaili@***. CARsgen Therapeutics Shanghai 200231 China. Zonghaili@***.

Dear Editor, Pancreatic cancer is a devastating disease ranked as the 4th leading cause of cancer-related deaths in the United States, and its incidence rate is increasing according to the latest statistics. The overall survival rates for patients with pan- creatic cancer have not significantly improved over the past thirty years （Siegel et al., 2012; Simard et al., 2012）. One of the reasons for the high mortality rates is the high resistance of pancreatic cancer to chemotherapy and radiation. Most patients are diagnosed at late stages of the disease. Approximately 15%-20% of patients diagnosed with pan- creatic cancer are eligible for surgical resection, and 85% of these patients eventually experience relapse and ultimately cancer-related death （Siegel et al., 2012）. In recent years, increasing evidence indicates that the fibro-inflammatory stroma is a source of cellular and molecular components contributing to tumor progression and metastasis （feig et al., 2012; Waghray et al., 2013）. Importantly, increased levels of stroma are positively related to a poor prognosis （Erkan et al., 2008）. Despite the broader understanding of pancre- atic cancer biology, gemcitabine, a chemotherapeutic approved for pancreatic cancer treatment approximately twenty years ago, still remains the standard of care （Burris et al., 1997）. Thus, the development of novel treatment strategies for this devastating disease is urgently needed.

关键词： Efficient growth suppression pancreatic cancer PDX model fully human anti-mesothelin CAR-T cells

在线全文

学校读者我要写书评

暂无评论

慢性心力衰竭患者胱抑素C的变化及意义

现代生物医学进展 2010年第7期10卷 1291-1293页

作者：张良周胜华方臻飞胡新群唐秋红中南大学湘雅二医院心内科湖南长沙410011

目的:观察慢性心力衰竭(Chronic Heart Failure,CHF)患者血清胱抑素C(Cystatin C)水平变化,探讨其与CHF之间的意义。方法:研究对象包括从2008年9月-2009年8月本院入选的CHF组70例,正常对照组30例,采用双抗夹心ELISA法检测血清Cystatin ... 详细信息

目的:观察慢性心力衰竭(Chronic Heart Failure,CHF)患者血清胱抑素C(Cystatin C)水平变化,探讨其与CHF之间的意义。方法:研究对象包括从2008年9月-2009年8月本院入选的CHF组70例,正常对照组30例,采用双抗夹心ELISA法检测血清Cystatin C含量,CHF患者心力衰竭程度按NYHA法分级,记录住院期间及出院6个月内全因病死率和因慢性心衰发作再入院率。结果:CHF组患者血清Cystatin C含量明显高于对照组,心功能Ⅳ级组血清Cystatin C浓度高于心功能Ⅱ、Ⅲ级组。根据慢性心衰患者血清中位数Cystatin C浓度,分为CystatinC>1.2mg/l组和CystatinC<1.2mg/l组。两组患者住院期间全因死亡率比较中未发现有明显差异;但高血清Cystatin C浓度组患者较低血清Cystatin C浓度组患者在住院期间死亡有增加的趋势。追踪随访6个月,高血清Cys C浓度组患者出院期间全因死亡率、因心衰再住院率有明显高于低浓度组,有统计学意义(P<0.05)。结论:Cystatin C与CHF的发生有密切关系,可以诊断CHF及反映CHF近中期预后一个很有前途的指标。

关键词：慢性心力衰竭胱抑素C 预后