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硫代硫酸盐浸金工艺研究进展

湿法冶金 2020年第6期39卷 451-458页

作者：王玉詹伟泉贾菲菲宋少先武汉理工大学资源与环境工程学院湖北武汉430070

综述了铜氨硫代硫酸盐浸金机制,介绍了矿石预处理及体系中铜、氨、硫代硫酸盐等组分、体系pH、温度、氧气氛等条件对浸出的影响,以及提高金浸出率和浸出稳定性的强化方法、作用机制,指出硫代硫酸盐浸金体系存在的问题及改进方向。

关键词：硫代硫酸盐金浸出机制进展

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热处理辉钼矿光催化原位还原银离子的研究

硅酸盐通报 2020年第9期39卷 2987-2992页

作者：袁媛贾菲菲杨丙桥邢浩宋少先武汉理工大学资源与环境工程学院武汉430070 武汉工程大学兴发矿业学院武汉430073

二硫化钼作为一种典型的层状过渡金属硫化物(TMDs)材料,因具有较窄的能带间隙,可在光照条件下将贵金属离子原位还原成单质,从而利于贵金属的回收,然而由于天然辉钼矿大量暴露的基面催化活性低,使得还原效果较差。本文探究热处理对辉钼... 详细信息

二硫化钼作为一种典型的层状过渡金属硫化物(TMDs)材料,因具有较窄的能带间隙,可在光照条件下将贵金属离子原位还原成单质,从而利于贵金属的回收,然而由于天然辉钼矿大量暴露的基面催化活性低,使得还原效果较差。本文探究热处理对辉钼矿晶体结构与银离子原位还原性能的影响。研究结果表明:热处理可提高辉钼矿原位还原银离子性能,由原矿的17 mg/g提升到23 mg/g;当pH值为3.0、银离子初始浓度为50 mg/L时,热处理辉钼矿对银离子的原位还原效果最佳;银离子原位还原效果的提升可能源于热处理使得辉钼矿对可见光的吸收能力变强及活性位点变多。

关键词：辉钼矿热处理银离子原位还原

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海南岛十倍体油茶资源分布及评价

热带作物学报 2024年第8期45卷 1585-1595页

作者：张敬涛赖杭桂张诗慧王文泉胡海燕刘进平李欣窈赵欣宋家明吴文嫱黄东益王健黄小龙贾效成陈飞飞海南大学热带农林学院海南海口570228 海南省林业科学研究院/海南省红树林研究院海南海口571100 海南大学生命科学学院海南海口570228 中国热带农业科学院椰子研究所海南文昌571339

油茶(Camellia)作为海南岛的传统植物油料资源,在海南生长的大多为常绿中小型乔木,白花大果油茶在海南岛各地区均有广泛分布。本研究通过对海南全岛各市县分布有30龄以上油茶居群调查取样,采用流式细胞术及染色体制片技术进行倍性鉴定... 详细信息

油茶(Camellia)作为海南岛的传统植物油料资源,在海南生长的大多为常绿中小型乔木,白花大果油茶在海南岛各地区均有广泛分布。本研究通过对海南全岛各市县分布有30龄以上油茶居群调查取样,采用流式细胞术及染色体制片技术进行倍性鉴定。研究表明:在调查采样的23个居群中,鉴定十倍体16份,八倍体7份,涵盖海南16个市县,其中有12个县市(儋州、陵水、琼海、五指山、定安、澄迈、屯昌、临高、昌江、乐东、琼中、保亭)发现了十倍体的油茶居群,超100龄以上的油茶古树及热带雨林野生油茶居群鉴定均为十倍体,而八倍体居群普遍在60龄以下且可溯源为人工栽培,此次调查居群中未发现其他倍性油茶资源。由此可见,海南岛油茶资源分布主要为十倍体和八倍体,而十倍体是本岛原生油茶资源,八倍体树龄未超60年,为20世纪60—70年代从广东等地引种的越南油茶,两类油茶生长适应性均表现良好。鉴于山茶属油茶组在其他油茶分布区并未发现十倍体油茶树种,海南岛大范围十倍体油茶的分布及热带雨林十倍体野生油茶居群的发现,论证了十倍体油茶种应是海南岛区域性原生树种,由海南独特的热带岛屿季风性气候等生态因子演化形成。其资源分布范围为海南岛18°38′42″N~19°49′53″N,108°51′0″E~110°29′46″E,海拔4.17~1090 m。

关键词：海南油茶种质资源流式细胞术倍性

基于问题导向的中医学概论课程线上线下混合式金课的建设与实践

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广西中医药大学学报 2024年第2期27卷 78-81页

作者：吴元洁卜菲菲宋婷婷韩荣春贾学昭徐伟齐亚军兰崴王陈红安徽中医药大学安徽合肥230012

安徽中医药大学中医学概论课程为国家线上一流本科课程,该文针对课程教学内容繁多、学生前期基础知识积累不足、问题意识和高阶思维薄弱的现状,尝试在课程慕课建设的基础上,梳理金课指标,优化教学内容,改进教学方法,完善多元评价体系,... 详细信息

安徽中医药大学中医学概论课程为国家线上一流本科课程,该文针对课程教学内容繁多、学生前期基础知识积累不足、问题意识和高阶思维薄弱的现状,尝试在课程慕课建设的基础上,梳理金课指标,优化教学内容,改进教学方法,完善多元评价体系,并采用了以问题导向的线上线下混合式教学模式,即以生活问题、自主学习问题、思政问题为导向建设线上金课,以课堂问题、专业问题、实践问题为导向建设线下金课,以期提高课程教学效果,促进学生多维发展。

关键词：中医学概论问题导向混合式教学一流课程建设教学改革

Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1746-1755页

作者： Wei Deng Qi Lv Fengdi Li jiangning Liu Zhiqi song feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing jia Kai Gao jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases NHC Key Laboratory of Human Disease Comparative MedicineInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China National Center of Technology Innovation for Animal Model BeijingChina CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential *** booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type.

关键词： neutral harbor Omi

Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

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Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Bin...

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Zhizhang Wang Weijie Yin Lizhen Zhu jia Li Yikun Yao feifei Chen Mengmeng Sun jiayuan Zhang Nan Shen Yan song Xing Chang Shanghai Institute of Nutrition and Health Chinese Academy of Sciences Department of Cellular and Molecular Medicine University of California at San Diego

Iron deposition is frequently observed in human autoinflammatory diseases,but its functional significance is largely *** we showed that iron promoted proinflammatory cytokine expression in T cells,including GM-CSF and IL-2,via regulating the stability of an RNA-binding protein *** depletion or Pcbp1 deficiency in T cells inhibited GMCSF production by attenuating Csf2 30 untranslated region(UTR) activity and messenger RNA ***1 deficiency or iron uptake blockade in autoreactive T cells abolished their capacity to induce experimental autoimmune encephalomyelitis,an animal model for multiple ***,intracellular iron protected PCBP1 protein from caspase-mediated proteolysis,and PCBP1 promoted messenger RNA stability of Csf2 and Il2 by recognizing UC-rich elements in the 30 *** study suggests that iron accumulation can precipitate autoimmune diseases by promoting proinflammatory cytokine ***-binding protein-mediated iron sensing may represent a simple yet effective means to adjust the inflammatory response to tissue homeostatic alterations.

关键词： Autoimmune disease Iron GM-CSF PCBP1 Post-transcriptional regulation

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养老机构护理员对老年人态度的研究进展

护理研究 2020年第23期34卷 4191-4194页

作者：贾锟季红于洁宋菲菲山东中医药大学护理学院山东250014 山东省千佛山医院

综述养老机构护理员对老年人态度的测量工具、影响因素和干预方式,总结改善养老机构护理员对老年人态度的建议,规范养老机构护理员服务行为,为我国养老机构护理员对老年人态度的相关研究提供依据。

关键词：养老机构护理员老年人态度影响因素测量工具老年护理综述

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2384-2391页

作者： Zhijian Xu Danrong Shi jian-Bao Han Yun Ling Xiangrui jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang song Xiao-Li Feng Ren-Rong Tian jia Ji Miaojin Zhu Nanping Wu Chunhui Wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang feifei Du Junliang Wu Peipei Wang Jingshan Shen jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Drug Discovery and Design Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesFirst Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650107China Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China Jinan Microecological Biomedicine Shandong Laboratory Jinan250117China

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by *** we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is effective against SARS-CoV-2 and *** of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC50=8.26μM),while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93μM(EC50).In comparison with vehicle-treated animals,rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the *** necropsy,nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude.A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center,which were randomized(1:1)to nelfinavir and control groups,showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs.14.5 days,P=0.055)and the duration of fever time by 3.8 days(2.8 vs.6.6 days,P=0.014)in mild/moderate COVID-19 *** antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients,together with its well-established good safety profile in almost all ages and during pregnancy,indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19.

关键词： drugs infected treatment

Integrated histopathological,lipidomic,and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

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Signal Transduction and Targeted Therapy 2022年第2期7卷 560-572页

作者： Zhiqi song Linlin Bao Wei Deng jiangning Liu Erjun Ren Qi Lv Mingya Liu feifei Qi Ting Chen Ran Deng Fengdi Li Yunpeng Liu Qiang Wei Hong Gao Pin Yu Yunlin Han Wenjie Zhao Junjun Zheng Xujian Liang Fuhe Yang Chuan Qin NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Shi jia Zhuang Academy Of Agricultural And Forestry Sciences ShijiazhuangChina Institute of Special Animal and Plant Sciences of CAAS ChangchunChina Chinese Academy of Agricultural Sciences(CAAS) BeijingChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted on mink farms between minks and humans in many ***,the systemic pathological features of SARS-CoV-2-infected minks are mostly ***,we demonstrated that minks were largely permissive to SARS-CoV-2,characterized by severe and diffuse alveolar damage,and lasted at least 14 days post inoculation(dpi).We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular,hepatobiliary,urinary,endocrine,digestive,and immune *** viral protein partially co-localized with activated Mac-2+macrophages throughout the ***,we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks,especially at 6 dpi,and were similar to that of patients with severe and fatal ***,altered metabolic pathways,abnormal digestion,and absorption of vitamins,lipids,cholesterol,steroids,amino acids,and proteins,consistent with hepatic dysfunction,highlight metabolic and immune *** kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage ***,which has significant anti-inflammatory and immunomodulating effects,was significantly downregulated at 6 dpi and displayed potential as a targeted *** data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients,delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies,vaccine research,and potential biomarkers.

关键词： patients alterations vitamin