检索结果-南通市图书馆

Hypoxic tumor microenvironment:Destroyer of natural killer cell function

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第2期36卷 138-150页

作者： Yongfei Zhang feifei guo Yufeng Wang Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

In recent years, immunotherapy has made remarkable progress in treating certain tumors and hematological malignancies. However, the efficacy of natural killer(NK) cells, which are an important subset of innate lymphocytes used in anticancer immunotherapy, remains limited. Hypoxia, a critical characteristic of the tumor microenvironment(TME), is involved in tumor development and resistance to radiotherapy, chemotherapy, and immunotherapy. Moreover, hypoxia contributes to the impairment of NK cell function and may be a significant factor that limits their therapeutic effects. Targeted hypoxia therapy has emerged as a promising research area for enhancing the efficacy of NK cell therapy. Therefore, understanding how the hypoxic TME influences NK cell function is crucial for improving antitumor treatment outcomes.

关键词： Hypoxia immunotherapy NK cell tumor microenvironment

Immune evasion and therapeutic opportunities based on natural killer cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2023年第3期35卷 283-298页

作者： Jinjin Zhang feifei guo Lingyu Li Songling Zhang Yufeng Wang Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Department of Gynecology Obstetrics and Gynecology CenterThe First Hospital of Jilin UniversityChangchun 130021China Department of Gynecological Oncology Obstetrics and Gynecology CenterThe First Hospital of Jilin UniversityChangchun 130021China

Natural killer(NK)cells can elicit an immune response against malignantly transformed cells without recognizing antigens,and they also exhibit cytotoxic effects and immune surveillance functions in tumor *** several studies have shown the promising antitumor effects of NK cells in immunotherapy,their function is often limited in the tumor microenvironment because tumor cells can easily escape NK cell-induced ***,for efficient tumor immunotherapy,the mechanism by which tumor cells escape NK cell-induced cytotoxicity must be fully *** novel molecules and checkpoint receptors that mediate the disruption of NK cells in the tumor microenvironment have been *** this review,we analyze and detail the major activating and inhibitory receptors on the surface of NK cells to delineate the mechanism by which tumor cells suppress NKG2D ligand expression and increase tumor receptor and inhibitory receptor expression[NKG2A,programmed cell death1(PD-1),and T-cell immunoglobulin and immunoreceptor tyrosine inhibitory motif(TIGIT)]on the NK cell surface,and thus inhibit NK cell *** also reviewed the current status of treatments based on these surface *** comparing the therapeutic effects related to the treatment status and bypass mechanisms,we attempt to identify optimal single or combined treatments to suggest new treatment strategies for tumor immunotherapy.

关键词： Immune evasion natural killer cell NKG2D PD-1 combination therapy

TCMATHF:a bioinformatics platform to predict pharmacological action of drug and dynamic molecular changes against from myocardial infarction to heart failure

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2023年第S1期37卷 26-27页

作者： XI Yujie TANG Xuan guo feifei YANG Hongjun Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China China Academy of Chinese Medical Sciences Beijing 100700China

OBJECTIVE To investigate the characteristics and regulations of medication in different stages of disease by constructing a dynamic disease network and a cellular feature network spanning from myocardial infarction to heart *** Based on transcrip⁃tome and single-cell sequencing data from a mouse model of left anterior descending coro⁃nary artery ligation,a dynamic early-middle-late network and cellular feature network were con⁃structed by integrating differential gene expres⁃sion trends and biological *** robust⁃ness of the perturbation effect of traditional Chi⁃nese medicine(TCM)on the disease network was calculated based on multi-target TCM,and we acquired the foundational data by analyzing the results of *** predictive plat⁃form was scrutinized and assessed with regards to the functional attributes of FDA approveddrugs and compound prescriptions,in order to determine the primary stages of intervention and the drug patterns actions in the progression of heart *** In this study,we devel⁃oped a prediction and analysis platform for assessing the efficacy of drugs using a networkbased *** accuracy of the system was validated by FDA *** was found that blood-activating drugs,heat-clearing drugs,and phlegm-expelling drugs exhibited favorable intervention effects during the early to middle stages of the disease by investigating the effects of single herbs and TCM prescriptions on disease ***,phlegm-expelling drugs,spirit-nourishing drugs,and diuretic showed better intervention effects during the mid⁃dle to late *** findings were consis⁃tent with the clinical use of *** of the clustering heatmap results of TCM prescriptions revealed that the formulas aimed at qi stagnation and blood stasis had a strong effect in early stage,while the formulas for qi and yin deficiency and cardiorenal yang deficiency had a strong effect in the middle to late ***,analys

关键词： myocardial infarction heart failure dynamic network single cell drug perturbation

Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2022年第4期20卷 780-794页

作者： Zhongyang Liu Honglei Li Zhaoyu Jin Yang Li feifei guo Yangzhige He Xinyue Liu Yaning Qi Liying Yuan Fuchu He Dong Li State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China School of Basic Medical Sciences Anhui Medical UniversityHefei 230032China College of Chemistry and Environmental Science Hebei UniversityBaoding 071002China Suzhou Geneworks Technology Co. Ltd.Suzhou 215028China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China College of Life Sciences Hebei UniversityBaoding 071002China

After decades of development,protein and peptide drugs have now grown into a major drug class in the *** identification and validation are crucial for the discovery of protein and peptide drugs,and bioinformatics prediction of targets based on the characteristics of known target proteins will help improve the efficiency and success rate of target ***,owing to the developmental history in the pharmaceutical industry,previous systematic exploration of the target spaces has mainly focused on traditional small-molecule drugs,while studies related to protein and peptide drugs are ***,we systematically explore the target spaces in the human genome specifically for protein and peptide *** with other proteins,both successful protein and peptide drug targets have many special characteristics,and are also significantly different from those of small-molecule drugs in many *** on these features,we develop separate effective genome-wide target prediction models for protein and peptide ***,a user-friendly web server,Predictor Of Protein and Pept Ide drugs’therapeutic Targets(POPPIT)(http://***/),is established,which provides not only target prediction specifically for protein and peptide drugs but also abundant annotations for predicted targets.

关键词： Protein drug Peptide drug Target analysis Target prediction Web server

Integration of single-cell RNA sequencing and network disturbance to elucidate crosstalk between multi-components drug and trigeminal ganglia cells in migraine

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2023年第S1期37卷 38-39页

作者： ZHANG Bo XI Yujie HUANG Ying ZHANG Yi guo feifei YANG Hongjun Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Pre-vention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijingChina China Academy of Chinese Medical Sciences Beijing 100700China

OBJECTIVE To clarify the mecha⁃nism of Tou Tong Ning capsule(TTNC)and elu⁃cidate crosstalk between multi-components drug and trigeminal ganglia cells in ***⁃ODS We integrated single-cell RNA sequencing data and a quantitative evaluation algorithm of the disturbance of multi-target drugs on the dis⁃ease network to explore the specific pathology of TTNC for *** smooth muscle spasmolytic activity experiment was car⁃ried out to verify the results of bioinformatics *** TTNC can effectively regu⁃late the functions of synaptic signaling,inflamma⁃tion and immune response,and cerebrovascular smooth *** different cell subtypes of tri⁃geminal ganglia,TTNC can significantly disturb the robustness on neuronal cell networks and non-neural networks(fibroblast and vascular cells),indicating TTNC vasodilation activity of brain vessels and neural regulation activities of various neuro *** of cerebrovas⁃cular smooth muscle of mouse ex vivo confirmed the vasodilation activity of TTNC and active com⁃pounds(Emodin,Luteolin and Levistilide A).And literature mining confirmed the vasospasmolytic activity and neuroprotective effect activity of *** Integrating single-cell data and network disturbance tools provides a new strategy for the MoA of multi-components drug through cell subtyping.

关键词： Tou Tong Ning capsule(TTNC) migraine ScRNA-sq network disturbance vascular cell

The Evolution of the Central Plain Civilization in China (Ⅱ)

在线全文

学校读者我要写书评

暂无评论

China & The World Cultural Exchange 2012年第12期78卷 36-39页

作者： guo feifei Niu Aihong

Ancient Chinese had little knowledge of or influence on the mysterious and awe-inspiring *** assumed themselves to be incarnations of animals or plants, which gradually turned into their totems. As ancient Chinese developed, they started taming animals for domestic uses： dogs for hunting and home security, cattle for sowing and harvesting, horses for drawing carts, and cattle, sheep, and pigs for sacrifice.

关键词：中国文明中原演变古代动物植物狩猎

The Evolution of the Central Plain Civilization in China(Ⅰ)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China & The World Cultural Exchange 2012年第11期78卷 30-33页

作者： guo feifei and Niu Aihong

正China's Henan province, brief as Yu, got its name from the Yu state, which was one of the nine states in ancient China. The place with geographical advantage possesses superiority of radiating to the whole nation, and vibrant cultures, thus leading to its prosperity. The Xia, Shang and Zhou dynasties in ancient China set capitals in Luoyang of Henan province,

关键词： The Evolution of the Central Plain Civilization in China

南襄盆地南阳凹陷古近系核桃园组三段储层流体包裹体特征与成藏期次

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

天然气地球科学 2022年第7期33卷 1049-1059页

作者：郭飞飞攀枝花学院四川攀枝花617000

为厘清南襄盆地南阳凹陷古近系核桃园组三段(简称“核三段”)油气成藏期次,基于流体包裹体测试资料,利用包裹体岩相学、荧光观测及显微测温技术,对流体包裹体特征进行研究,并结合烃源岩热史、生烃史模拟,综合分析核三段油气成藏期次及... 详细信息

为厘清南襄盆地南阳凹陷古近系核桃园组三段(简称“核三段”)油气成藏期次,基于流体包裹体测试资料,利用包裹体岩相学、荧光观测及显微测温技术,对流体包裹体特征进行研究,并结合烃源岩热史、生烃史模拟,综合分析核三段油气成藏期次及时间。结果表明:①核三段储层发育2期油气包裹体:第Ⅰ期丰度较高,主要分布于石英颗粒微裂隙、次生加大边中,以灰褐色、淡黄色液烃包裹体为主,发黄色、黄绿色荧光,其伴生盐水包裹体均一温度峰值区间为75~100℃,反映低成熟—成熟油(0.5%1%)充注。②核三段烃源岩存在2个主力生烃期:第一期为核一段沉积早期—廖庄组沉积末期,因地层持续沉降烃源岩进入低成熟—成熟阶段并不断生烃,在廖庄组沉积末期因地层抬升剥蚀,生烃作用减缓;第二期为新近纪抬升剥蚀后地层再度沉降期,烃源岩进入高成熟阶段并再度生烃,第二期生烃量低于第一期。③核三段储层经历了2期油气充注:第一期形成于核一段沉积中期—廖庄组沉积末期(29.1~23 Ma),为低成熟—成熟油充注,该期是核三段储层主成藏期;第二期形成于新近纪中期—现今(10~0 Ma),为高成熟油充注。④应用Basinmod软件对成藏关键时刻(23 Ma)核三段顶界油气运移路径进行模拟,显示南阳凹陷核三段存在6个有利勘探目标区,其中Ⅰ—Ⅲ号为现有勘探区;Ⅳ—Ⅵ号是潜力勘探区。

关键词：流体包裹体成藏期次均一温度核桃园组南阳凹陷

Effects of siRNA Targeting Tie2 Gene Combinding With Carboplatin in A Nude Mouse Model of Endometrial Carcinoma

在线全文

学校读者我要写书评

暂无评论

Effects of siRNA Targeting Tie2 Gene Combinding With Carbopl...