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Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu peng Zhao feifei Lv Jie Sun Hongjun Li Zhen Gu Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

The superhydrophobic sponge decorated with Ni-Co double layered oxides with thiol modification for continuous oil/water separation

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Chinese Journal of Chemical Engineering 2023年第2期54卷 296-305页

作者： Xiaodong Yang Na Yang Ziqiang Gong feifei peng Bin Jiang Yongli Sun Luhong Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

In this paper, the superhydrophobic polyurethane sponge(SS-PU) was facilely fabricated by etching with Jones reagent to bind the nanoparticles of Ni-Co double layered oxides(LDOs) on the surface, and following modification with n-dodecyl mercaptan(DDT). This method provides a new strategy to fabricate superhydrophobic PU sponge with a water contact angle of 157° for absorbing oil with low cost and in large scale. It exhibits the strong absorption capacity and highly selective characteristic for various kinds of oils which can be recycled by simple squeezing. Besides, the as-prepared sponge can deal with the floating and underwater oils, indicating its application value in handling oil spills and domestic oily wastewater. The good self-cleaning ability shows the potential to clear the pollutants due to the ultralow adhesion to water. Especially, the most important point is that the superhydrophobic sponge can continuously and effectively separate the oil/water mixture against the condition of turbulent disturbance by using our designed device system, which exhibit its good superhydrophobicity, strong stability.Furthermore, the SS-PU still maintained stable absorption performance after 150 cycle tests without losing capacity obviously, showing excellent durability in long-term operation and significant potential as an efficient absorbent in large-scale dispose of oily water.

关键词： Superhydrophobic sponge Ni-Co double layered oxides Thiol modification Oil absorption Oil/water separation

Efficient and stable organic solar cells enabled by a poly(carbazole phosphonic acid)hole transporter

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Science China Chemistry 2024年第6期67卷 1941-1945页

作者： Zhijun Ren Siwei Luo Xiaoyu Shi Yunjie Dou Tianxiao Liu Lingyuan Wang Kwok Kiu Tsang feifei Wang Yu Zhao Yangyang Liu Xiaodong Hu Xiaoxiao peng Wei Liu He Yan Shangshang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Department of Chemistry Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsEnergy Institute and Hong Kong Branch of Chinese NationalEngineering Research Center for Tissue Restoration and ReconstructionHong Kong University of Science and TechnologyHong Kong999077China

Conventional self-assembled monolayer(SAM)hole transporters in organic solar cells(OSCs)generally suffer from poor uniformity and limited thickness tolerance,hindering their large-scale production.To overcome these limitations,we introduce a novel polymeric hole transporter synthesized by polymerizing carbazole phosphonic acid(PACz).The resultant Poly-2PACz material exhibits exceptional conductivity,high tolerance for variations in layer thickness,and improved film uniformity compared with conventional SAMs.Consequently,the OSCs utilizing Poly-2PACz achieve a remarkable power conversion efficiency of 19.1%and a high fill factor of 81.2%,surpassing the devices based on 2PACz.Moreover,Poly-2PACz-based OSCs demonstrate excellent operational stability,retaining over 80%of their initial efficiency after 1,400 h of continuous light exposure in ambient conditions.This work presents a novel strategy for designing hole transporters,paving the way for more efficient and stable OSCs.

关键词： organic solar cells hole transporters poly(carbazole phosphonic acid) stability

Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects

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Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 311-325页

作者： Ruirui Li feifei peng Jia Cai Dandan Yang peng Zhang School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Cancer is a big challenge that has plagued the human beings for ages and one of the most effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide clinical application of chemotherapy. The microenvironment plays a critical role in many aspects of tumor genesis. It generates the tumor vasculature and it is highly implicated in the progression to metastasis. To maintain a suitable environment for tumor progression, there are special microenvironment in tumor cell, such as low pH, high level of glutathione(GSH) and reactive oxygen species(ROS), and more special enzymes, which is different to normal cell. Microenvironment-targeted therapy strategy could create new opportunities for therapeutic targeting. Compared to other targeting strategies, microenvironment-targeted therapy strategy will control the drug release into tumor cells more accurately. Redox responsive drug delivery systems(DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower. In order to control the release of drugs more accurately and reduce side effects, other drug release stimuli have been introduced to redox responsive DDSs. Under the synergistic reaction of two stimuli, redox dual-stimuli responsive DDSs will control the release of drugs more accurately and quickly and even increase the accumulation. This review summarizes strategies of redox dual-stimuli responsive DDSs such as pH, light, enzyme, ROS, and magnetic guide to delivery chemotherapeutic agents more accurately, aiming at providing new ideas for further promoting the drug release,enhancing tumor-targeting and improving anticancer effects. To better illustrate the redox dual-stimuli responsive DDS, preparations of carriers are also briefly described in the review.

关键词： Chemotherapy Drug delivery system Redox responsive Dual-stimuli responsive Tumor-targeting

非编码RNA调控结核分枝杆菌感染巨噬细胞自噬的研究进展

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华中科技大学学报（医学版） 2024年第1期53卷 117-122页

作者：彭祥琳浦飞飞冯晶夏平华中科技大学同济医学院附属武汉市中西医结合医院骨科武汉430022 武汉市第四医院骨科武汉430033

结核病(tuberculosis, TB)是由结核分枝杆菌(Mycobacterium tuberculosis,MTB)引起的传染病,巨噬细胞自噬对于清除MTB具有重要作用,但MTB可以通过多种机制干扰宿主自噬,逃避巨噬细胞对其“灭杀”从而在宿主细胞内长期存活繁殖。在MTB感... 详细信息

结核病(tuberculosis, TB)是由结核分枝杆菌(Mycobacterium tuberculosis,MTB)引起的传染病,巨噬细胞自噬对于清除MTB具有重要作用,但MTB可以通过多种机制干扰宿主自噬,逃避巨噬细胞对其“灭杀”从而在宿主细胞内长期存活繁殖。在MTB感染的巨噬细胞中存在多种差异表达的非编码RNA(non-coding RNA,ncRNAs),这些ncRNAs通过调控自噬相关基因表达在自噬的多个环节影响巨噬细胞清除MTB。因此,阐明这些调控网络对开发新的抗结核药物具有重要意义。该文综述了现阶段研究中ncRNAs调控MTB感染巨噬细胞自噬的相关机制,介绍了细胞自噬的发生过程以及ncRNAs的调控作用,以期为阐明TB的发病机制以及研发抗结核药物提供新的思路。

关键词：结核病结核分枝杆菌非编码RNA 巨噬细胞细胞自噬

新疆奇台绿洲不同耕作年限荒漠灰钙土无机碳变化及其影响因素

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农业环境科学学报 2024年第1期43卷 91-101页

作者：彭康张飞飞邵志东张芳新疆大学地理与遥感科学学院乌鲁木齐830046 新疆大学新疆绿洲生态重点实验室乌鲁木齐830046

荒漠灰钙土是天山北麓地带性土壤,富含碳酸盐和硫酸钙,是优质土地后备资源。本研究采用野外调查取样与室内实验相结合的方法,对新疆奇台绿洲不同耕作年限(40 a)荒漠灰钙土无机碳变化及其影响因素进行分析,探讨了土壤无机碳与土壤理化参... 详细信息

荒漠灰钙土是天山北麓地带性土壤,富含碳酸盐和硫酸钙,是优质土地后备资源。本研究采用野外调查取样与室内实验相结合的方法,对新疆奇台绿洲不同耕作年限(40 a)荒漠灰钙土无机碳变化及其影响因素进行分析,探讨了土壤无机碳与土壤理化参数间的关系,特别是石膏对土壤无机碳的增汇作用。结果表明:①耕作层和犁底层的无机碳,对人类活动十分敏感。土壤无机碳随耕作年限先降低后升高,在耕作后的前10 a迅速下降表现为碳源,而后逐渐上升超过初始含量重新转为碳汇,耕作>40 a后土壤无机碳含量较耕作<3 a增加超过10 g·kg^(-1);②土壤无机碳的稳定性同位素δ^(13)C随着耕作年限的增加持续负向偏移,表现出具有截存现代大气CO_(2)的潜力;③荒漠灰钙土中含有极易风化且储量可观的石膏,为次生碳酸盐淀积提供了大量的钙源,这些Ca2+含量决定了研究区土壤无机碳库最终的储量大小。综上说明,富含石膏的荒漠灰钙土耕作后,具有较强的土壤无机碳增汇潜力,重视和准确估算这部分碳增汇潜力有助于我国“双碳”目标的实现。

关键词：荒漠灰钙土土壤无机碳耕作年限次生碳酸盐碳汇潜力

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面向留守儿童的App界面设计探究

玩具世界 2024年第3期 164-166页

作者：彭菲菲中原工学院艺术设计学院

随着社会的快速发展和城市化进程的推进，留守儿童问题日益凸显。留守儿童是指父母一方或双方外出务工或等原因而被迫留在家乡的儿童，他们在教育、心理、生活等多方面面临挑战，通过优化其日常使用的App可以使他们和父母得到有效的沟... 详细信息

随着社会的快速发展和城市化进程的推进，留守儿童问题日益凸显。留守儿童是指父母一方或双方外出务工或等原因而被迫留在家乡的儿童，他们在教育、心理、生活等多方面面临挑战，通过优化其日常使用的App可以使他们和父母得到有效的沟通、获得更多学习资源。文章首先提出了面向留守儿童的App界面设计原则，其中包括直观简洁性、教育性、安全可控性、趣味互动性、疗愈性等。在此基础上，文章进一步分析了相关案例，展示优秀界面设计的优点与留守儿童及家长在使用后产生的效果与影响。最后，文章探讨了面向留守儿童的App界面设计策略，以期为后续的相关设计提供有效借鉴，也希望通过对这一问题的深入研究，为留守儿童提供更好的线上平台，助力他们更好地学习和发展。

关键词：留守儿童 App界面设计用户体验优化策略

基于IRC法和局部放电法的车载高压电缆绝缘状态评估

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高压电器 2024年第1期60卷 118-127,135页

作者：宋微贾步超张鹏张鹏鹏李飞霏辛东立中国铁路济南局集团有限公司济南250001 中车青岛四方机车车辆股份有限公司山东青岛266111 西南交通大学电气工程学院成都610031

为准确评估乙丙橡胶(EPDM)车载电缆的绝缘老化状态,引用了等温松弛电流(IRC)法和局部放电(PD)法,分别讨论了老化因子、局部放电特征信息与电缆老化状态之间的映射关系,结果表明:随着车载电缆运行里程的增加,老化因子、局部放电量、放电... 详细信息

为准确评估乙丙橡胶(EPDM)车载电缆的绝缘老化状态,引用了等温松弛电流(IRC)法和局部放电(PD)法,分别讨论了老化因子、局部放电特征信息与电缆老化状态之间的映射关系,结果表明:随着车载电缆运行里程的增加,老化因子、局部放电量、放电次数和放电电流均呈现规律性增长趋势,多种老化应力协同作用是造成车载电缆绝缘劣化的主要原因,绝缘材料内部陷阱的增多和加深是车载电缆老化的微观表现。协同等温松弛电流法和局部放电法对车载电缆绝缘状态的评估具有有效性和可行性,通过建立微观陷阱分布特性与宏观局部放电特性之间的联系,分析可得:深陷阱捕获电荷的能力较强,电荷极易集聚,局部放电容易发生,因此基于IRC法和局部放电法对车载电缆绝缘状态进行评估具有一定的价值意义,可指导高速动车组电网规划及电缆检修工作。

关键词：等温松弛电流老化因子局部放电陷阱绝缘状态

上海市低年级小学生近视进展与睡眠特征的关系

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中国学校卫生 2024年第5期45卷 727-731页

作者：彭慧史慧静朱鸿飞杨飞飞白慧莹薛俊磊张颜菲马飞飞彭谦王颖上海市嘉定区疾病预防控制中心学校卫生与眼病防治科 201899 复旦大学公共卫生学院复旦大学国家卫生健康委员会卫生技术评估重点实验室

目的探究睡眠特征对低年级小学生近视发生发展的影响,为近视防控工作提供参考依据。方法于2022年10月,采取整群随机抽样方法选取上海市嘉定区2所学校一、二年级小学生636名进行问卷调查与眼科检查,采用儿童睡眠习惯量表(CSHQ)评估睡眠质... 详细信息

目的探究睡眠特征对低年级小学生近视发生发展的影响,为近视防控工作提供参考依据。方法于2022年10月,采取整群随机抽样方法选取上海市嘉定区2所学校一、二年级小学生636名进行问卷调查与眼科检查,采用儿童睡眠习惯量表(CSHQ)评估睡眠质量;2023年10月进行视力检查随访(479名),期间针对学生学习、屏幕与户外活动时间等开展2次且每次持续2周监测。使用广义估计方程的多变量Logistic回归或线性回归模型来检验睡眠相关因素和近视之间的关联及其强度。结果基线调查上海市低年级小学生近视率为18.58%,随访新发近视率为17.18%。CSHQ总分平均值为(51.58±4.44)分,自然日平均睡眠持续时间为(9.43±4.84)h/d,其中仅11.6%儿童睡眠充足。调整混杂因素后,多变量Logistic回归分析结果显示,小学生睡眠不足与新发近视(OR=1.64,95%CI=1.05~2.56)存在正相关,卧床休息时间与新发近视(OR=0.74,95%CI=0.63~0.91)的关联有统计学意义(P值均<0.05)。卧床休息时间不一致与新发近视呈正相关(OR=1.07,P<0.05),卧床休息时间一致性、苏醒时间一致性与等效球镜之间的关联有统计学意义,睡眠时间、卧床休息时间及苏醒时间的一致性与眼轴长度之间的关联有统计学意义(P值均<0.05)。结论睡眠时间不足、卧床时间与近视发生发展存在一定关联。应保证儿童的充足睡眠时长,规律睡眠作息,减少小学生近视的发生。

关键词：近视睡眠患病率回归分析学生