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Clinical relevance of distolingual roots and periodontal status in mandibular first molars: a cross-sectional study employing CBCT analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 244-253页

作者： feifei mao Meng WANG Shuai ZHOU Yan ZHAO Jiaping HUANG Fengying YIN Haiping YANG Pei-hui DING Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310016China

Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of *** study aimed to assess the morphological features of PMFM-DLR and investigate the correlation between the morphological features of PMFM-DLR and periodontal status in patients with Eastern Chinese ethnic *** and methods:A total of 836 cone beam computed tomography(CBCT)images with 1497 mandibular first molars were analyzed to observe the prevalence of PMFM-DLR at the patients and tooth levels in Eastern *** them,complete periodontal charts were available for 69 Chinese patients with 103 *** and regression analyses were used to evaluate the correlation between the morphological features of DLR,bone loss,and periodontal clinical parameters,including clinical attachment loss(CAL),probing pocket depth(PPD),gingival recession(GR),and furcation involvement(FI).Results:The patient-level prevalence and tooth-level prevalence of DLR in mandibular first molars were 29.4%and 26.3%,*** linear regression analysis suggested that bone loss at the lingual site and CAL were negatively affected by the angle of separation between distolingual and mesial roots in the transverse section,while they were significantly influenced by age and the angle of separation between distobuccal and mesial roots in the coronal ***:The prevalence of PMFM-DLR in Eastern China was relatively high in our *** morphological features of DLR were correlated with the periodontal status of mandibular first *** study provides critical information on the morphological features of DLR for improved diagnosis and treatment options of mandibular molars with DLR.

关键词： Distolingual root Mandibular first molar Periodontal clinical parameter Clinical attachment loss Cone beam computed tomography(CBCT)

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A novel chemotherapy strategy for advanced hepatocellular carcinoma: a multicenter retrospective study

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Chinese Medical Journal 2022年第19期135卷 2338-2343页

作者： Juxian Sun Chang Liu Jie Shi Nanya Wang Dafeng Jiang feifei mao Jingwen Gu Liping Zhou Li Shen Wan Yee Lau Shuqun Cheng Department of Hepatic Surgery VI Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200433China Department of Integrative Oncology Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200433China Department of Outpatient Department Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200433China Department of Oncology First Hospital of Jlin UniversityChangchunJlin 1300China Department of Oncology Zhejiang Sian International Hospital JiaxingZhejang 314000China Tongji University Cancer Center Shanghai Tenth People's HospitaSchool of MedicineTongji UniversitShanghai 200040China Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinNew TerritoriesHong Kong SAR 999077China.

Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not *** study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall *** Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease ***:From July 2013 to July 2018,111 patients with HCC were included in this *** median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,***:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC.

关键词： Hepatocellular carcinoma ATRA plus FOLFOX4 Overall survival All-trans-retinoic acid Fluorouracil Leucovorin Oxaliplatin

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Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5096-5105页

作者： Juxian Sun feifei mao Chang Liu Fan Zhang Dafeng Jiang Weixing Guo Lei Huo Liping Zhou Wan Yee Lau Jie Shi Shuqun Cheng Department of Hepatic Surgery VI Third Affliated Hospital of Naval Medical UniversityShanghaiChina Tongji University Cancer Center Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghaiChina Department of General Surgery Fujian Cancer HospitalFujan Medical UniversityFuzhouChina Department of Oncology Zhejiang Sian International HospitalJiaxingChina Department of Radiology Third Affliated Hospital of Naval Medical UniversityShanghaiChina Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinNew TerritoriesHong Kong SARChina

The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced ***,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).Systemic chemotherapy,such as FOLFOX4(infusions of fluorouracil,leucovorin,and oxaliplatin),has been reported for treating advanced HCC with EHM,but its effectiveness is very poor.

关键词： FOLFOX4 metastasis chemotherapy

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Novel isostructural iron‐series‐MOF calcined derivatives as positive and negative electrodes: A new strategy to obtain matched electrodes in a supercapacitor device

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SmartMat 2023年第3期4卷 56-69页

作者： Yawen Dong Jiadi Liu Hui Zhang Qingqing Li feifei mao Aimin Lu Hua Wu Kuaibing Wang Cheng Zhang Qichun Zhang Jiangsu Key Laboratory of Pesticide Sciences Department of ChemistryCollege of SciencesNanjing Agricultural UniversityNanjingChina College of Resources and Environmental Sciences Nanjing Agricultural UniversityNanjingChina Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhouChina Department of Materials Science and Engineering City University of Hong KongHong Kong SARChina

The performance of asymmetric supercapacitors(ASCs)is strongly restricted by the capacity gap between the positive and negative *** address this issue,two new electrode materials deriving from Co‐and Fe‐based metal–organic frameworks(MOFs,Co‐TAMBA‐d,and Fe‐TAMBA‐d)through a single‐step sintering method have been developed by considering the superiorities of the derivatives of MOFs including large surface areas,sufficient metal‐atom‐doping content,and extreme surface wettability to the bath *** as‐prepared Co‐TAMBA‐d as a positive electrode delivers typical pseudocapacitive behavior with the improvement of capacity,which is better than those of pristine MOF materials,while Fe‐TAMBA‐d as negative electrodes displays better electrochemical behavior than those of activated *** based on these two electrodes exhibits excellent energy density and power density of 47Wh/kg and 1658 W/kg,respectively,where this device can maintain prominent cycling stability with capacity retention after 5000 cycles being about 75%.Furthermore,the capacity can feed a series of red light‐emitting diodes,which gives solid evidence of the potential *** results can afford the feasibility of isostructural MOF derivatives as promising electrodes in novel ASCs.

关键词： asymmetric supercapacitor Co‐and Fe‐based MOFs isostructural MOFs MOF derivatives

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Doped microspheres for whispering gallery mode microlasing

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Science Bulletin 2024年第13期69卷 2021-2024页

作者： Xiaoxuan Wang Chaoyang Huang Chuansheng Xia feifei Qin Gangyi Zhu Lingfeng mao Yi Ma Zengliang Shi Qiannan Cui Chunxiang Xu State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Electronic Science and Engineering Southeast UniversityNanjing 210096China Peter Grünberg Research Centre College of Telecommunications and Information EngineeringNanjing University of Posts and TelecommunicationsNanjing 210003China

Whispering gallery mode(WGM)optical microcavities,which are capable of light field confinement and manipulation in a relatively small volume,have gained considerable attention from fundamentals in enhanced light-matter interactions to laser applications[1].Undergoing decades of development,the improvement of lasing performance is always a significant issue,including low threshold and high quality(Q)factor[2].Increasing optical gain and reducing the losses are the key aspects towards the realization of a high-quality WGM laser.A perfect cavity structure and a smooth surface are the most crucial determinants to reduce optical losses and enhance light field confined abilities.

关键词： optical lasing mode

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Screening the Optimal Patterned Surfaces Consisting of Cell Morphology Mimicking Micro-pillars and Nanotube Arrays for the Design of Titanium Implants#br#

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Journal of Bionic Engineering 2021年第2期18卷 361-374页

作者： Ping Zhou Hongjiao Li feifei mao Hongxin Huang Siqi Long Fei He Jing Chen Shicheng Wei School and Hospital of Stomatology Lanzhou UniversityLanzhou 730000China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Institute of Microelectronics Peking UniversityBeijing 100871China

Micron/nano scale topographic modification has been a significant focus of interest in current titanium(Ti)surface ***,the influence of micron/nano structured surface on cell or bacterium behavior on the Ti implant has rarely been systematically ***,except for popular microgrooves,little work has been carried out on the reaction of cells to the bionic *** this study,several micro-pillars mimicking cell morphology were prepared on Ti surfaces by lithography and contact printing(ICP)method,and they were further decorated with nanotube arrays by anodization *** surface modifications remarkablly increased the surface roughness of pristine Ti surface from 91.17 nm±5.57 nm to be more than 1000 nm,and reduced their water contact angles from 68.3°±0.7°to be 16.9°±2.4°.Then,the effects of these hierarchical micron/nano scale patterns on the behaviors of MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and *** were studied,aiming to evaluate their performance in osseointegration,gingival epithelial sealing and antibacterial *** an innovative scoring strategy,our findings showed that square micro-pillars with 6μm width and 2μm height combined with 85 nm diameter nanotubes was suitable for implant neck design,while square micro-pillars with 3μm width and 3.6μm height combined with 55 nm diameter nanotubes was the best for implant body *** study reveals the synergistic effect of the hierarchical micron/nano scale patterns on MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and *** *** provides insight into the design of biomedical implant surfaces.

关键词： hierarchical micron/nano design cell-like patterns nanotube arrays titanium implants implant osseointegration

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公安机关先期处置家暴警情问题研究

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警学研究 2022年第4期 110-118页

作者：毛飞飞陈晓洁江苏警官学院侦查系江苏南京210031 江苏省苏州市公安局相城分局江苏苏州215000

当前家暴问题仍然是难以有效解决的社会治安问题。从公安机关先期处置的角度出发,针对家庭暴力具有行为隐蔽性、对象特定性、后果反复性的特点,深入分析当前公安机关先期处置家暴警情存在固定证据难度大、调查干预机制滞后、二次处置效... 详细信息

当前家暴问题仍然是难以有效解决的社会治安问题。从公安机关先期处置的角度出发,针对家庭暴力具有行为隐蔽性、对象特定性、后果反复性的特点,深入分析当前公安机关先期处置家暴警情存在固定证据难度大、调查干预机制滞后、二次处置效果难以落实等难点问题,公安机关应该重视固定保护证据、建立家暴警情预警防控机制、严格规范处警流程等一系列环节,从而有效地将家暴警情化解在第一道防线。

关键词：家庭暴力先期处置对策

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肠道菌群代谢产物氧化三甲胺调控奶牛肝脏脂质沉积的可能机制

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动物营养学报 2024年第7期36卷 4156-4162页

作者：毛永霞王菲菲李晨雷郭延生宁夏大学动物科技学院银川750021

氧化三甲胺(Tmao)是一种具有生物活性的肠道菌群代谢产物。饲粮中胆碱、肉碱和甜菜碱经肠道菌群代谢生成三甲胺(TMA),大部分TMA在肝脏进一步被肝黄素依赖性单加氧酶(FMO)氧化为Tmao。近年来,众多研究发现血浆Tmao浓度与心血管疾病、慢... 详细信息

氧化三甲胺(Tmao)是一种具有生物活性的肠道菌群代谢产物。饲粮中胆碱、肉碱和甜菜碱经肠道菌群代谢生成三甲胺(TMA),大部分TMA在肝脏进一步被肝黄素依赖性单加氧酶(FMO)氧化为Tmao。近年来,众多研究发现血浆Tmao浓度与心血管疾病、慢性肾病、糖尿病、结直肠癌和非酒精性脂肪肝等疾病呈正相关关系,Tmao在畜禽脂肪沉积中的作用也被证实。本文综述了Tmao的代谢过程、生理功能及其在奶牛脂肪肝发生发展中的潜在作用,以期为高产奶牛脂肪肝发病机制、营养调控和防治研究提供新的方向与思路。

关键词：氧化三甲胺肠道菌群脂质代谢奶牛脂肪肝

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获得性免疫缺陷综合征合并隐球菌性脑膜炎的眼部病变特征分析

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中华眼科杂志 2015年第5期51卷 364-368页

作者：毛菲菲孙挥宇李丹首都医科大学附属北京地坛医院眼科 100015

目的探讨获得性免疫缺陷综合征（AIDS）合并隐球菌性脑膜炎患者眼部表现。方法回顾性研究。观察40例AIDS合并隐球菌性脑膜炎患者眼部病变特点，其中男性32例，女性8例，男女比例4：1，年龄11—67岁，平均年龄（38±12）岁，对所有患者... 详细信息

目的探讨获得性免疫缺陷综合征（AIDS）合并隐球菌性脑膜炎患者眼部表现。方法回顾性研究。观察40例AIDS合并隐球菌性脑膜炎患者眼部病变特点，其中男性32例，女性8例，男女比例4：1，年龄11—67岁，平均年龄（38±12）岁，对所有患者均行视力、眼球运动、眼压、裂隙灯显微镜、散瞳间接检眼镜眼底检查及眼底彩色照相。所有患者进行CD4＋T淋巴细胞的检测，行腰椎穿刺脑脊液检查。18例患者随访2周至4年5个月，4例患者住院期间死亡，18例患者至外地后失访。结果3例患者出现双眼复视，为双眼或单眼外展神经麻痹。视乳头水肿共19例（37只眼），1人单眼发病，其中伴视乳头周围出血者为12例（24只眼），不伴出血者为7例（13只眼）；出现视神经萎缩者为6例（12只眼），脉络膜病灶为2例（4只眼），眼底正常或仅伴有巨细胞病毒性视网膜炎（CMVR）者为14例（27只眼）。结论AIDS合并隐球菌性脑膜炎患者可伴随多种眼部并发症，其中最常见的为视乳头水肿。

关键词：脑膜炎隐球菌性获得性免疫缺陷综合征视乳头水肿视神经萎缩巨细胞病毒视网膜炎

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Identification Technology of Green Algae along the Coast of Qingdao

Identification Technology of Green Algae along the Coast of ...

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中国藻类学会第八次会员大会暨第十六次学术讨论会

作者： Wu feifei,ffang Jian,mao YunXiang*,KONG FanNa College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China

＜正＞The green tides caused by a proliferation of chlorophytes in recent years have been concerned by many algae researchers and environmentalists.A better ecological understanding of bloom dynamics including the ori...

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