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A FULLY DISCRETE IMPLICIT-EXPLICIT FINITE ELEMENT METHOD FOR SOLVING THE FITZHUGH-NAGUMO MODEL

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Journal of Computational Mathematics 2020年第3期38卷 469-486页

作者： Li Cai Ye Sun feifei jing Yiqiang Li Xiaoqin Shen Yufeng Nie NPU-UoG International Cooperative Lab for Computation&Application in Cardiology Northwestern Polytechnical UniversityXi'an 710072China School of Science Xi'an University of TechnologyXi'an 710048China Research Center for Computational Science Northwestern Polytechnical UniversityXi'an 710072China

This work develops a fully discrete implicit-explicit finite element scheme for a parabolicordinary system with a nonlinear reaction term which is known as the FitzHugh-Nagumo model from *** first-order backward Euler discretization for the time derivative,and an implicit-explicit discretization for the nonlinear reaction term are employed for the model,with a simple linearization technique used to make the process of solving equations more *** stability and convergence of the fully discrete implicit-explicit finite element method are proved,which shows that the FitzHugh-Nagumo model is accurately solved and the trajectory of potential transmission is *** numerical results are also reported to verify the convergence results and the st ability of the proposed method.

关键词： Finite element method Nonlinear reaction term FitzHugh-Nagumo model Implicit-explicit scheme St ability and error estimates

Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder

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Neural Regeneration Research 2024年第7期19卷 1618-1624页

作者： Luyi Wang Man Xu Yan Wang feifei Wang jing Deng Xiaoya Wang Yu Zhao Ailing Liao Feng Yang Shali Wang Yingbo Li Institute of Neuroscience Department of PhysiologySchool of Basic Medical ScienceChongqing Medical UniversityChongqingChina Department of Pediatric Chongqing University Fuling HospitalChongqingChina Department of Neurosurgery Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Pathology Affiliated Hospital of North Sichuan Medical CollegeNanchongSichuan ProvinceChina NHC Key Laboratory of Birth Defects and Reproductive Health Chongqing Population and Family Planning Science and Technology Research InstituteChongqingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina

Autism spectrum disorders are a group of neurodevelopmental disorders involving more than 1100 genes,including Ctnnd2 as a candidate ***2knockout mice,serving as an animal model of autis m,have been demonstrated to exhibit decreased density of dendritic *** role of melatonin,as a neuro hormone capable of effectively alleviating social interaction deficits and regulating the development of dendritic spines,in Ctnnd2 deletion-induced nerve injury remains unclea *** the present study,we discove red that the deletion of exon 2 of the Ctnnd2 gene was linked to social interaction deficits,spine loss,impaired inhibitory neurons,and suppressed phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt) signal pathway in the prefrontal *** findings demonstrated that the long-term oral administration of melatonin for 28 days effectively alleviated the aforementioned abnormalities in Ctnnd2 gene-knockout ***,the administration of melatonin in the prefro ntal cortex was found to improve synaptic function and activate the PI3K/Akt signal pathway in this *** pharmacological blockade of the PI3K/Akt signal pathway with a PI3K/Akt inhibitor,wo rtmannin,and melatonin receptor antagonists,luzindole and 4-phenyl-2-propionamidotetralin,prevented the melatonin-induced enhancement of GABAergic synaptic *** findings suggest that melatonin treatment can ameliorate GABAe rgic synaptic function by activating the PI3K/Akt signal pathway,which may contribute to the improvement of dendritic spine abnormalities in autism spectrum disorders.

关键词： autism Ctnnd2 deletion GABAergic neurons melatonin PI3K/Akt signal pathway prefrontal cortex social behavior spine density synaptic-associated proteins

Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species

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Bio-Design and Manufacturing 2024年第1期7卷 14-30页

作者： Xinshuo Huang Baoming Liang Shantao Zheng feifei Wu Mengyi He Shuang Huang jingbo Yang Qiangqiang Ouyang Fanmao Liu jing Liu Hui-jiuan Chen Xi Xie State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-Sen UniversityGuangzhou 510006China School of Biomedical Engineering Sun Yat-Sen UniversityShenzhen 518107China Pazhou Lab Guangzhou 510330China The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510006China

Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in *** glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose *** technology is less invasive,yet microneedle adhesion with skin tissue is *** this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in *** microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle *** to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into *** MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation ***,the MASA was integrated into a monitoring system using custom *** work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

关键词： Microarrow sensor array Glucose sensing Reactive oxygen species sensing Integrated system Continuous monitoring

日本对胶济铁路利权的觊觎和攫夺——以中日关于运价和货捐交涉为中心(1914—1928)

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史学月刊 2020年第10期 50-61页

作者：景菲菲南开大学历史学院天津300350 日本爱知大学中国研究科

1914年日军占领青岛及胶济铁路后,日本政府对在胶济铁路运输的本国商品征收低于他国商品的运价,排挤他国商贸,把山东变为其势力范围。日本政府迫使北洋政府与之签订了一系列条约,将其对胶济铁路利权的攫夺"合法化"。在北洋政府的坚持下... 详细信息

1914年日军占领青岛及胶济铁路后,日本政府对在胶济铁路运输的本国商品征收低于他国商品的运价,排挤他国商贸,把山东变为其势力范围。日本政府迫使北洋政府与之签订了一系列条约,将其对胶济铁路利权的攫夺"合法化"。在北洋政府的坚持下,中日条约订明青岛为中国自开口岸,这为日后中国自主制定运价提供了一定的法律依据。1922年中日签订《解决山东悬案条约》后,中国收回胶济铁路管理权,自主制定运价,对铁路运输商品实行统一运价并按照运价征收货捐。日本反对征收货捐,不断提出交涉。但直到1928年北洋政府统治结束,日本的目的也未能实现。中日关于胶济铁路运价和货捐的交涉,其实质是中国反对日本侵夺中国铁路利权的斗争。

关键词：胶济铁路运价货捐山东问题

Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions

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Bio-Design and Manufacturing 2024年第1期7卷 88-103页

作者： Shuang Huang Shantao Zheng Mengyi He Chuanjie Yao Xinshuo Huang Zhengjie Liu Qiangqiang Ouyang jing Liu feifei Wu Hang Gao Xi Xie Hui-jiuan Chen State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-Sen UniversityShenzhen 518107China The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080China Pazhou Lab Guangzhou 510335China Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029China

Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical *** sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological *** semi-implantable devices are mainly based on single-parameter *** semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode *** study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)*** electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric *** MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above *** vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex *** work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

关键词： Multiplexed microfilament electrode cluster Physiological ion sensing Subcutaneous and brain experiment Wearable platform for multi-ion detection Continuous real-time monitoring system

“守信”与“维权”:中日围绕胶济铁路沿线城镇开埠的交涉(1914—1928)

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史林 2023年第5期 140-153,219页

作者：景菲菲中国海洋大学马克思主义学院暨中国社会史研究所 266100

民国北京政府为收回山东主权,宣言自择胶济铁路沿线适当城镇自开商埠。日本为了继续维持在山东的经贸优势地位,要求中国将胶济铁路沿线八处城镇实施开埠,这超出了中国之前的宣言。为约束日侨与维护国际信誉,外交部同意了日本要求,但山... 详细信息

民国北京政府为收回山东主权,宣言自择胶济铁路沿线适当城镇自开商埠。日本为了继续维持在山东的经贸优势地位,要求中国将胶济铁路沿线八处城镇实施开埠,这超出了中国之前的宣言。为约束日侨与维护国际信誉,外交部同意了日本要求,但山东各界却一再反对实施开埠。日本不断向中国提出交涉,张宗昌就任山东省长后才答应其将两处城镇自开商埠。中日关于胶济铁路沿线城镇开埠问题的交涉,充分体现了中国反对日本侵夺中国商埠权益的努力。

关键词：胶济铁路沿线城镇自开商埠山东问题

Diagnosis,Treatment,and Associated Factors Among Patients with HCV Infection—Jiangsu Province,China,2004–2020

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China CDC weekly 2024年第1期6卷 1-5,I0001-I0003页

作者： Dandan Yang jing Lu Zhi Zhang Chuanwu Sun Zhuping Xu Yao Qi XiaoXia Liu Huan Ding feifei Chai Zhengdong Zhang Baoli Zhu Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of Jiangsu ProvinceNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of XuzhouXuzhou CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of WuxiWuxi CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of YanchengYancheng CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of ZhenjiangZhenjiang CityJiangsu ProvinceChina.

What is already known on this topic?The global efforts to address the hepatitis C virus(HCV)are progressing,but there are still significant gaps in the diagnosis and treatment of HCV,leading to an increasing number of deaths related to *** is added by this report?An extensive investigation was conducted to assess HCV RNA diagnosis,treatment uptake,and associated factors among individuals infected with HCV within Jiangsu *** study encompassed a large geographical area and utilized a substantial sample *** are the implications for public health practice?Implementing focused interventions to improve the timely diagnosis of HCV RNA and increase the uptake of HCV treatment could effectively reduce the future burden of HCV-related health problems,deaths,and healthcare *** is essential for achieving the global target of eliminating hepatitis C.

关键词： diagnosis utilized Jiangsu

Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling

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Protein & Cell 2024年第6期15卷 441-459页

作者： feifei Liu Yi Lu Xuebao Wang Shuhui Sun Huize Pan Min Wang Zehua Wang Weiqi Zhang Shuai Ma Guoqiang Sun Qun Chu Si Wang jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Sports Medicine Department Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China

The synovium,a thin layer of tissue that is adjacent to the joints and secretes synovial fluid,undergoes changes in aging that contribute to intense shoulder pain and other joint ***,the mechanism underlying human synovial aging remains poorly ***,we generated a comprehensive transcriptomic profile of synovial cells present in the subacromial synovium from young and aged *** delineating aging-related transcriptomic changes across different cell types and their associated regulatory networks,we identified two subsets of mesenchymal stromal cells(MSCs)in human synovium,which are lining and sublining MSCs,and found that angiogenesis and fibrosis-associated genes were upregulated whereas genes associated with cell adhesion and cartilage development were downregulated in aged ***,the specific cell-cell communications in aged synovium mirrors that of aging-related inflammation and tissue remodeling,including vascular hyperplasia and tissue *** particular,we identified forkhead box O1(FOXO1)as one of the major regulons for aging differentially expressed genes(DEGs)in synovial MSCs,and validated its downregulation in both lining and sublining MSC populations of the aged *** human FOXO1-depleted MSCs derived from human embryonic stem cells,we recapitulated the senescent phenotype observed in the subacromial synovium of aged *** data indicate an important role of FOXO1 in the regulation of human synovial ***,our study improves our understanding of synovial aging during joint degeneration,thereby informing the development of novel intervention strategies aimed at rejuvenating the aged joint.

关键词： FOXO1 degeneration inflammation

模具角度对CP-Zr室温ECAP变形组织与性能的影响

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稀有金属 2018年第4期42卷 367-372页

作者：杨西荣井菲菲刘晓燕罗雷西安建筑科技大学冶金工程学院陕西西安710055 陕西省冶金工程技术研究中心陕西西安710055

在等径弯曲通道变形（ECAP）中,模具角度是影响材料组织与性能的重要因素。本文分别采用通道夹角Φ=90°、外圆角Ψ=20°和通道夹角Φ=105°、外圆角Ψ=20°的模具,来探究模具角度对工业纯锆室温ECAP变形组织与性能的影响。通过金相显... 详细信息

在等径弯曲通道变形（ECAP）中,模具角度是影响材料组织与性能的重要因素。本文分别采用通道夹角Φ=90°、外圆角Ψ=20°和通道夹角Φ=105°、外圆角Ψ=20°的模具,来探究模具角度对工业纯锆室温ECAP变形组织与性能的影响。通过金相显微镜（OM）、透射电镜（TEM）、拉伸测试、扫描电镜（SEM）和X射线衍射（XRD）等手段,分析在不同模具角度下,工业纯锆单道次ECAP变形组织与性能。实验结果表明：通道夹角Φ=90°和Φ=105°的金相组织对比,Φ=90°的晶粒破碎更为明显。同时,对比两者TEM结果,通道夹角Φ=90°的板条破碎明显,存在大量位错和位错缠结并伴有孪晶发生,故ECAP变形过程中通道夹角Φ=90°的变形大于通道夹角Φ=105°,细化效率高。拉伸和SEM结果表明缩小通道夹角,会提高材料的抗拉强度和硬度。XRD结果表明,模具角度对织构类型具有一定影响,在通道夹角Φ=90°的单道次ECAP变形中主要形成的是B织构和C1织构,而在通道夹角Φ=105°的单道次ECAP变形中形成的是主要B织构和C2织构,同时,两种变形条件下,织构极点扩展方向不同。

关键词： ECAP变形模具角度工业纯锆组织性能织构