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A Multitime-scale Deep Learning Model for Lithium-ion Battery Health Assessment Using Soft Parameter-sharing Mechanism

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Chinese Journal of Electrical Engineering 2024年第3期10卷 1-11页

作者： Lulu Wang Kun Zheng Yijing Li Zhipeng Yang feifan Zhou Jia Guo Jinhao Meng North China Electric Power Test and Research Institute of China Datang Group Science and Technology Research Institute Co. Ltd.Beijing 100040China School of Future Technology Xi'an Jiaotong UniversityXi'an 710049China National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology Xi'an Jiaotong UniversityXi'an 710049China School of Electrical Engineering Xi'an Jiaotong UniversityXi'an 710049China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Efficient assessment of battery degradation is important to effectively utilize and maintain battery management *** study introduces an innovative residual convolutional network(RCN)-gated recurrent unit(GRU)model to accurately assess health of lithium-ion batteries on multiple time *** model employs a soft parameter-sharing mechanism to identify both short-d dT and long-term degradation *** continuously looped(V),T(V),dQ/dV and dT/dV are extracted to form a four-channel image,dV dV from which the RCN can automatically extract the features and the GRU can capture the temporal *** designing a soft parameter-sharing mechanism,the model can seamlessly predict the capacity and remaining useful life(RUL)on a dual time *** proposed method is validated on a large MIT-Stanford dataset comprising 124 cells,showing a high accuracy in terms of mean absolute errors of 0.00477 for capacity and 83 for ***,studying the partial voltage fragment reveals the promising performance of the proposed method across various voltage ***,in the partial voltage segment of 2.8-3.2 V,root mean square errors of 0.0107 for capacity and 140 for RUL are achieved.

关键词： Residual convolutional network-gated recurrent unit capacity estimation soft parameter sharing remaining useful life prediction

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Determination of 20(S)-protopanaxadiol in human plasma by HPLC–MS/MS:application to a pharmacokinetic study

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Acta Pharmaceutica Sinica B 2013年第6期3卷 385-391页

作者： feifan Xie Sanwang Li Zeneng Cheng Xingling Liu Hong Zhang Peijiong Li Zhi Liu Xin Guo Peng Yu School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Hunan Tiger-Xiangya R&D Company Ltd. Changsha 410013China

A rapid,specific and sensitive HPLC-MS/MS method was developed and validated for the determination of 20(S)-protopanaxadiol(PPD)in human *** and the internal standard PD were extracted from plasma by liquid-liquid extraction with cyclohexane-methylene dichloride(2:1,v/v).The separation was performed on a HyPURIYTY C18 column using methanol-5 mM ammonium formate(90:10,v/v)as mobile phase at a flow rate of 0.35 mL/*** spectrometric detection was carried out by electrospray ionization(ESI)in the positive ion mode using multiple reaction monitoring(MRM).The monitored transitions were m/z 425.4-217.2 for PPD and at m/z 461.4-425.5 for *** method was linear over the range 0.512-100 ng/mL with a lower limit of quantification(LLOQ)of 0.512 ng/*** mean extraction recovery of PPD was greater than 78.2%and no significant matrix effect was *** intra-and inter-day precisions were less than 10%and the biases below 4%for *** validated method was applied to a three-level single-dose clinical pharmacokinetics study of 12 healthy Chinese volunteers and the main pharmacokinetic parameters of PPD were obtained.

关键词： 20(S)-Protopanaxadiol HPLC–MS/MS Human plasma Pharmacokinetics Liquid–liquid extraction

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Mid-infrared all-optical modulators based on an acetylene-filled hollow-core fiber

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Light(Advanced Manufacturing) 2022年第4期3卷 86-93页

作者： Kaiyuan Zheng Shoulin Jiang feifan Chen Yan Zhao Shoufei Gao Yingying Wang Hoi Lut Ho Wei Jin Department of Electrical Engineering and Photonics Research Institute The Hong Kong Polytechnic UniversityHong KongChina Photonics Research Center The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenChina Institute of Photonics Technology Jinan UniversityGuangzhouChina

We report all-optical mid-infrared phase and intensity modulators based on the photo-thermal effect in an acetylene-filled anti-resonant hollow-core *** absorption of the control beam promotes the gas molecules to a higher energy level,which induces localized heating through non-radiative relaxation and modulates the refractive index of the gas material and hence the accumulated phase of the signal beam propagating through the hollow-core *** modulating the intensity of the control beam,the phase of the signal beam is modulated *** use of a 1.53μm near-infrared control beam,all-optical phase modulation up to 2.2πrad is experimentally demonstrated at the signal wavelength of 3.35μ*** the phase modulator placed in one arm of a Mach-Zehnder interferometer,intensity modulation with on-off ratio of 25 dB is *** gas-filled hollow-core-fiber modulators could operate over an ultra-broad wavelength band from near-to mid-infrared and have promising application in mid-infrared photonic systems.

关键词： Optical phase modulator Mid-infrared Hollow-core fiber Mach-Zehnder interferometer Photothermal effect

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Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 390-397页

作者： Qiqi Zhang Hui Huang Aijun Sun Chunyan Liu Zhidong Wang feifan Shi Wei Duan Xueying Sun Qi Wang Ping Sun Chunwen Pu Yong Zhang Department of Biobank The Sixth Affiliated People’s Hospital of Dalian Medical UniversityDalianLiaoningChina Outpatient Department of Hepatitis The Sixth Affiliated People’s Hospital of Dalian Medical UniversityDalianLiaoningChina Department of Pathology The Sixth Affiliated People’s Hospital of Dalian Medical UniversityDalianLiaoningChina School of Pharmacy Shenyang Pharmaceutical UniversityShenyangLiaoningChina School of Medicine Deakin UniversityVictoriaAustralia

Background and Aims:The natural course of chronic hepatitis B virus(HBV)infection is widely studied;however,follow-up studies of the same patients are ***,we studied the dynamic changes of serum HBV RNA and cytokines in hepatitis B virus e antigen(HBeAg)-positive patients treated with entecavir(ETV)to explore the relationship between the HBV serum viral nucleic acids and host ***:Thirty-three chronic hepatitis B patients who are HBeAg-positive,with high virus load(HBV DNA>20,000 IU/mL),and received standard nucleos(t)ide analogue(NA)antiviral therapy(ETV)for more than 48 weeks were *** serum levels of HBV nucleic acids and selected cytokines were measured at 0,12,24,and 48 weeks ***:Serum HBV RNA could still be detected while serum HBV DNA had fallen below the detection limit in patients treated with *** was a strong positive correlation between HBV RNA and HBeAg,with a concomitant decrease in the secretion of cytokines from type 1 helper T(Th1)/type 2 helper T(Th2)/interleukin(IL)-17 producing T(Th17)***-4 and IL-10 were the main cytokines negatively associated with serum HBV ***:HBeAg can be used to reflect the load of HBV RNA indirectly,because serum HBV RNA has not been widely used in clinical ***,serum IL-4 and IL-10 might be explored in combination with HBV RNA in guiding future clinical antiviral therapy.

关键词： HBV RNA Cytokines HBeAg positive Entecavir Chronic hepatitis B

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Broadband all-fiber optical phase modulator based on photo-thermal effect in a gas-filled hollow-core fiber

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Opto-Electronic Advances 2023年第5期6卷 10-16页

作者： Shoulin Jiang feifan Chen Yan Zhao Shoufei Gao Yingying Wang Hoi Lut Ho Wei Jin Photonics Research Center the Hong Kong Polytechnic University Shenzhen Research InstituteShenzhen 518057China Department of Electrical Engineering and Photonics Research Institute the Hong Kong Polytechnic UniversityHong Kong 999077China Institute of Photonics Technology Jinan UniversityGuangzhou 510632China

We report broadband all-fiber optical phase modulation based on the photo-thermal effect in a gas-filled hollow-core *** phase modulation dynamics are studied by multi-physics simulation.A phase modulator is fabricated using a 5.6-cm-long anti-resonant hollow-core fiber with pure acetylene *** has a half-wave optical power of 289 mW at 100 kHz and an average insertion loss 0.6 dB over a broad wavelength range from 1450 to 1650 *** rise and fall time constants are 3.5 and 3.7μs,respectively,2–3 orders of magnitude better than the previously reported microfiber-based photo-thermal phase *** gas-filled hollow-core waveguide configuration is promising for optical phase modulation from ultraviolet to mid-infrared which is challenging to achieve with solid optical fibers.

关键词： optical modulators photo-thermal effects hollow-core fibers

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Identification of candidate genes controlling fiber quality traits in upland cotton through integration of meta-QTL,significant SNP and transcriptomic data

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Journal of Cotton Research 2020年第4期3卷 324-335页

作者： XU Shudi PAN Zhenyuan YIN feifan YANG Qingyong LIN Zhongxu WEN Tianwang ZHU Longfu ZHANG Dawei NIE Xinhui Key Laboratory of Oasis Ecology Agricultural of Xinjiang Production and Construction Coprs Agricultural CollegeShihezi UniversityShihezi 832000XinjiangChina Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan 430070HubeiChina National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Research Institute of Economic Crops Xinjiang Academy of Agricultural SciencesUrumqi 830091China

Background:Meta-analysis of quantitative trait locus(QTL)is a computational technique to identify consensus QTL and refine QTL positions on the consensus map from multiple mapping *** combination of meta-QTL intervals,significant SNPs and transcriptome analysis has been widely used to identify candidate genes in various ***:In our study,884 QTLs associated with cotton fiber quality traits from 12 studies were used for meta-QTL analysis based on reference genome TM-1,as a result,74 meta-QTLs were identified,including 19 meta-QTLs for fiber length;18 meta-QTLs for fiber strength;11 meta-QTLs for fiber uniformity;11 meta-QTLs for fiber elongation;and 15 meta-QTLs for *** with 8589 significant single nucleotide polymorphisms associated with fiber quality traits collected from 15 studies,297 candidate genes were identified in the meta-QTL intervals,20 of which showed high expression levels specifically in the developing *** to the function annotations,some of the 20 key candidate genes are associated with the fiber ***:This study provides not only stable QTLs used for marker-assisted selection,but also candidate genes to uncover the molecular mechanisms for cotton fiber development.

关键词： Fiber quality traits Meta-QTL Significant SNPs Candidate genes Transcriptomic data

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基于Petri网和UML的工作流模型设计

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南京航空航天大学学报 2006年第1期38卷 121-125页

作者：柯飞帆宁宣熙南京航空航天大学经济管理学院南京210016

介绍了工作流的概念及发展过程,讨论工作流建模的基本方法。重点分析Petri网和UM L在工作流模型设计过程中的应用,结合Petri网语义定义工具和图形化界面以及UM L的面向对象特点,形成基于Petri网和UM L的工作流建模方法。工作流模型的语... 详细信息

介绍了工作流的概念及发展过程,讨论工作流建模的基本方法。重点分析Petri网和UM L在工作流模型设计过程中的应用,结合Petri网语义定义工具和图形化界面以及UM L的面向对象特点,形成基于Petri网和UM L的工作流建模方法。工作流模型的语义定义采用Petri网表达,给出工作流网的形式化描述。工作流系统的设计模型采用UM L进行定义,对于业务逻辑、执行过程、数据结构分别采用用户实例图、顺序图、类图进行描述。在工作流的实现上,采用软组件实现工作流服务组件的分布布置,并通过接口定义语言对功能组件中的服务进行发布。最后给出工作流的发展趋势,并计划开展工作流仿真和优化方面的研究。

关键词：工作流工作流建模 Petri网统一建模语言

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Investigation and Analysis of Catheter-Associated Skin Impairment in PICC’s Patients in Jingzhou City

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Journal of Biosciences and Medicines 2020年第10期8卷 38-46页

作者： Qianwen Li Hong Wang feifan Liu Yiqing He Yangtze University Jingzhou China Jingzhou Central Hospital Jingzhou China

Objective: To understand the status quo of PICC Catheter-associated Skin Impairment (CASI) in some hospitals at all levels in Jingzhou city, and to explore the risk factors for PICC Catheter-associated Skin Impairment. Methods: From June 2019 to July 2020, a self-made questionnaire for CASI status was used to facilitate the extraction of CASI patients in PICC in some hospitals at all levels in Jingzhou city. Local skin lesions were collected and classified during PICC maintenance, and the damage types, occurrence frequency and related influencing factors of CASI were counted to identify independent risk factors. Results: In this study, there were 173 cases of CASI in PICC’s patients including local infection 56.1% (97/173), exudation at the puncture site 16.8% (29/173), irritant dermatitis 21.4% (37/173), allergic dermatitis 4.6% (8/173), and tension injury 1.2% (2/173). After univariate analysis, there were statistically significant differences between CASI occurrence type and duration of catheter wear, age, underlying disease, skin moisture and hyperhidrosis, PICC maintenance as required, hospital grade maintenance and intermittent chemotherapy (P < 0.05). Then, disordered multiple Logistic regression analysis was performed, and exudation at the puncture site was used as the reference group. The results showed that patients with PICC were more likely to have CASI if they were aged, long catheter time, had diabetes, had moist and sweaty skin, and were in the intermittent stage of chemotherapy. Conclusion: The incidence of CASI is high in patients aged 70 - 79 years, and local infection is the most common. PICC’s patients with diabetes are at high risk of CASI. PICC’s patients with excessive sweating are more likely to have CASI. The intermittent stage of chemotherapy is the excessive CASI;time with tube affects CASI occurrence.

关键词： PICC CASI Status Survey Multifactor Analysis

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Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons

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Life Metabolism 2023年第1期2卷 33-46页

作者： Feixiang Yuan Shangming Wu Ziheng Zhou Fuxin Jiao Hanrui Yin Yuguo Niu Haizhou Jiang Shanghai Chen feifan Guo Zhongshan Hospital State Key Laboratory of Medical NeurobiologyInstitute for Translational Brain ResearchMOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Chinese Academy of Sciences(CAS)Key Laboratory of Nutrition Metabolism and Food SafetyInnovation Center for Intervention of Chronic Disease and Promotion of HealthShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

Essential amino acids(EAAs)are crucial nutrients,whose levels change in rodents and patients with ***,how the levels of a single EAA affects depressive behaviors remains ***,we demonstrate that although deprivation of the EAA leucine has no effect in unstressed mice,it remarkably reverses the depression-like behaviors induced by chronic restraint stress(CRS).This beneficial effect is independent of feeding and is applicable to the dietary deficiency of other ***,the effect of leucine deprivation is suppressed by central injection of leucine or mimicked by central injection of ***,hypothalamic agouti-related peptide(AgRP)neural activity changes during CRS and leucine deprivation,and chemogenetically inhibiting AgRP neurons eliminates the antidepressant effects of leucine ***,the leucine deprivation-regulated behavioral effects are mediated by amino acid sensor general control non-derepressible 2(GCN2)in AgRP *** together,our results suggest a new drug target and/or dietary intervention for the reduction of depressive symptoms.

关键词： leucine deprivation depression AgRP neurons GCN2 amino acid sensing

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Construction and evaluation of a novel prognostic risk model of aging-related genes in bladder cancer

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Current Urology 2023年第4期17卷 236-245页

作者： Delin Wang Hao Ning Haihu Wu Yufeng Song Yaru Chu feifan Liu Zhenlin Zhao Fei Wu Jiaju Lyu Department of Urology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China Shandong First Medical University and Shandong Academy of Medical Sciences JinanChina Department of Urology Shandong Provincial Hospital Affiliated to Shandong UniversityJinanChina Department of Urology The Second Hospital of Shandong UniversityJinanChina

Background:Bladder cancer(BLCA)is the most common malignancy of the urinary ***-invasive bladder cancer(MIBC),which constitutes approximately 25%of all BLCA cases,is characterized by frequent recurrence and early onset of *** cancer most commonly occurs in elderly patients and is significantly associated with ***,the prognostic value of age-related genes in BLCA,especially in MIBC,remains *** and methods:Training and testing sets were obtained from The Cancer Genome Atlas BLCA *** expressed genes between BLCA and normal samples intersected with human aging-related *** Cox regression and least absolute shrinkage and selection operator regression analyses were used to identify prognostic aging-related signatures,followed by the construction of a risk score model and ***-Meier and receiver operating characteristic analyses were conducted to assess the predictive *** independent BLCA cohort of 165 samples was included for external *** CIBERSORT algorithm was used to explore the characteristics of the immune ***:Seven genes(IGF1,NGF,GCLM,PYCR1,EFEMP1,APOC3,and IFNB1)were identified by Cox and least absolute shrinkage and selection operator *** combining the gene signature with the clinical parameters of patients with BLCA,a risk-prognosis model and nomogram were constructed and validated with the testing *** cancer cases with high 7-gene signature scores(high-risk group)and low scores(low-risk group)showed distinct ***,7 types of immune cells were significantly altered between the low-and high-risk ***:Collectively,our data provide a 7-gene signature that serves as a potential biomarker for BLCA,especially ***,this 7-gene signature highlights the role of the tumor immune microenvironment in prognosis and thus might be related to the response to anti-programmed cell death protein 1-b

关键词： Bladder cancer Prognosis Aging-related genes Biomarker Immune microenvironment Overall survival

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