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Ellerman Bombs, Type Ⅱ White-light Flares and Magnetic Reconnection in the Solar Lower Atmosphere

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Chinese Journal of Astronomy and Astrophysics 2001年第2期1卷 176-184页

作者： Peng－feichen ChengFang 等 DepartmentofAstronomy NanjingUniversityNanjing210093 DepartmentofAstronomy NanjingUniversityNanjing

Ellerman bombs and Type Ⅱ white-light flares share many common features despite the large energy gap between them. Both are considered to result from local heating in the solar lower atmosphere. This paper presents numerical simulations of magnetic reconnection occurring in such a deep atmosphere, with the aim to account for the common features of the two phenomena. Our numerical results manifest the following two typical characteristics of the assumed reconnection process: (1) magnetic reconnection saturates in -600-900 s, which is just the lifetime of the two phenomena; (2) ionization in the upper chromosphere consumes quite a large part of the energy released through reconnection, making the heating effect most significant in the lower chromosphere. The application of the reconnection model to the two phenomena is discussed in detail.

关键词： Sun: atmosphere-Sun: flares- Sun: magnetic fields

Authenticating Tripartite Key Agreement Protocol with Pairings

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Journal of Computer Science & Technology 2004年第2期19卷 169-176页

作者： Sheng-LiLiu Fang-GuoZhang Ke-feichen DepartmentofComputerScienceandEngineering ShanghaiJiaoTongUniversityShanghai200030P.R.China SchoolofInformationScienceandTechnology ZhongshanUniversityGuangzhou510275P.R.China

In this paper, an authenticated tripartite key agreement protocol is proposed, which is an ID-based one with pairings. This protocol involves only one round. The authenticity of the protocol is assured by a special signature scheme, so that messages carrying the information of two ephemeral keys can be broadcasted authentically by an entity. Consequently, one instance of the protocol results in eight session keys for three entities. In other word, one instance of the protocol generates a session key, which is eight times longer than those obtained from traditional key agreement protocols. Security attributes of the protocol are presented, and the computational overhead and bandwidth of the broadcast messages are analyzed as well.

关键词： key agreement bilinear pairing identity-based cryptography

Two Sympathetic Homologous CMEs on 2002 May 22

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Chinese Journal of Astronomy and Astrophysics 2005年第3期5卷 265-272页

作者： Jian-XiaCheng ChengFang Peng-feichen Ming-DeDing DepartmentofAstronomy NanjingUniversityNanjing210093

Sympathetic coronal mass ejections (CMEs) usually occur in different active regions connected by interconnecting magnetic loops, while homologous CMEs occur within the same active region with an almost the same background magnetic field, and so are similar in shapes. Two sympathetic CMEs erupted within 3 hours on 2002 May 22, originating from the same active region, AR 9948. Their multi-wavelength data were collected and analyzed. It is suggested that emerging flux triggered the occurrence of the first CME and the corresponding flare, the reconnection inflow of which in turn triggered the eruption of the second CME. Based on the fact that the two sympathetic CMEs have many similarities, in their shapes, their low-lying dimming areas, etc., we tentatively propose, for the first time, the phenomenon of sympathetic homologous CMEs.

关键词： filament flares CMEs

BioBroker: Knowledge Discovery Framework for Heterogeneous Biomedical Ontologies and Data

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Journal of Intelligent Learning Systems and Applications 2018年第1期10卷 1-20页

作者： feichen Shen Yugyung Lee University of Missouri Kansas City MO USA

A large number of ontologies have been introduced by the biomedical community in recent years. Knowledge discovery for entity identification from ontology has become an important research area, and it is always interesting to discovery how associations are established to connect concepts in a single ontology or across multiple ontologies. However, due to the exponential growth of biomedical big data and their complicated associations, it becomes very challenging to detect key associations among entities in an inefficient dynamic manner. Therefore, there exists a gap between the increasing needs for association detection and large volume of biomedical ontologies. In this paper, to bridge this gap, we presented a knowledge discovery framework, the BioBroker, for grouping entities to facilitate the process of biomedical knowledge discovery in an intelligent way. Specifically, we developed an innovative knowledge discovery algorithm that combines a graph clustering method and an indexing technique to discovery knowledge patterns over a set of interlinked data sources in an efficient way. We have demonstrated capabilities of the BioBroker for query execution with a use case study on a subset of the Bio2RDF life science linked data.

关键词： Knowledge Discovery Ontology Linked Data

中晚期肝癌免疫治疗患者生活质量现状的调查研究

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中国癌症防治杂志 2024年第4期16卷 468-473页

作者：卢飞臣游雪梅赵凤娟李繁荣韦双双杨莉洁广西医科大学附属肿瘤医院护理部广西医科大学附属肿瘤医院肝胆外科区域性高发肿瘤早期防治研究教育部重点实验室(广西医科大学)南宁530021

目的分析中晚期肝癌免疫治疗患者生活质量现状及影响因素,为改善中晚期肝癌免疫治疗患者生活质量提供依据。方法选取2022年1月至2023年7月在广西医科大学附属肿瘤医院接受免疫治疗的211例中晚期肝癌患者为研究对象。采用一般资料调查表... 详细信息

目的分析中晚期肝癌免疫治疗患者生活质量现状及影响因素,为改善中晚期肝癌免疫治疗患者生活质量提供依据。方法选取2022年1月至2023年7月在广西医科大学附属肿瘤医院接受免疫治疗的211例中晚期肝癌患者为研究对象。采用一般资料调查表、医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)、肝胆肿瘤治疗功能评定量表(functional assessment of cancer therapy-hepatobiliary questionnaire,FACT-Hep)进行横断面调查。采用多重线性回归分析生活质量的影响因素。结果中晚期肝癌免疫治疗患者的生活质量总分为(130.04±15.28)分。多重线性回归分析结果显示,HADS-D>7分(β=-10.257,95%CI:-14.862~-5.653)、有既往肝切除手术(β=-8.484,95%CI:-12.765~-4.203)是总生活质量较差的影响因素;HADS-A>7分(β=-2.273,95%CI:-3.866~-0.681)、有既往肝切除手术(β=-2.500,95%CI:-3.825~-1.174)是身体状况维度得分较差的影响因素,文化程度为初中(β=2.574,95%CI:0.862~4.286)、TACE/HAIC(β=1.746,95%CI:0.010~3.482)是身体状况维度得分较好的影响因素;家庭月收入在4000~5999元(β=-2.357,95%CI:-4.429~-0.284)、HADS-D>7分(β=-1.182,95%CI:-1.992~-0.372)是社会/家庭状况维度得分较差的影响因素;HADS-D>7分(β=-3.422,95%CI:-4.276~-2.568)是心理状况维度得分较差的影响因素,肿瘤数目为多发(β=1.053,95%CI:0.131~1.975)是心理状况维度得分较好的影响因素;HADS-D>7分(β=-2.483,95%CI:-3.526~-1.440)是功能状况维度得分较差的影响因素;有既往肝切除手术(β=-4.255,95%CI:-6.560~-1.951)是肝胆特异性状况维度得分较差的影响因素,TACE/HAIC(β=3.555,95%CI:0.590~6.520)是肝胆特异性状况维度得分较好的影响因素。肝胆特异性状况维度得分较差的影响因素。结论中晚期肝癌免疫治疗患者总体健康状况不佳,应重视文化程度低、家庭月收入少、联合治疗、疾病及心理负担重的患者,制定和实施有效的个体化方案以改善其生活质量。

关键词：肝癌免疫治疗生活质量影响因素

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甲状腺癌患者生育指导的证据总结

中国计划生育和妇产科 2024年第2期16卷 71-76页

作者：杨莉洁韦双双李繁荣赵凤娟唐如冰卢飞臣游雪梅广西医科大学附属肿瘤医院头颈外科广西南宁530021 广西医科大学附属肿瘤医院护理部广西医科大学附属肿瘤医院医学影像中心区域性高发肿瘤早期防治研究教育部重点实验室

目的检索、评价并汇总国内外甲状腺癌患者生育指导的最佳证据,为临床医护人员开展甲状腺癌患者生育期的指导提供循证依据。方法依据证据资源的“6S模型”系统检索各指南网站、数据库及相关网站中有关甲状腺癌患者生育相关的临床决策、... 详细信息

目的检索、评价并汇总国内外甲状腺癌患者生育指导的最佳证据,为临床医护人员开展甲状腺癌患者生育期的指导提供循证依据。方法依据证据资源的“6S模型”系统检索各指南网站、数据库及相关网站中有关甲状腺癌患者生育相关的临床决策、指南、专家共识、证据总结、系统评价和Meta分析,检索时限为建库至2023年3月。由2名接受过系统循证护理培训的研究者独立完成文献的质量评价,并结合专业人士的意见,对符合质量标准的文献进行证据提取及汇总。结果共纳入12篇文献,其中1篇临床决策、7篇指南、3篇专家共识、1篇系统评价。汇总了包括生育安全、生育咨询、生育时机、妊娠期用药指导及监测、产后指导、健康教育6个方面的20条最佳证据。结论本研究的最佳证据制作过程科学、严谨,可为临床医护人员开展甲状腺癌患者生育指导提供参考。建议证据使用者在应用本证据开展生育指导时,应考虑临床实际,并结合患者的意愿和身体具体情况,为患者提供专业的、全面的生育咨询及妊娠期间用药指导,以帮助患者顺利完成生育计划。

关键词：甲状腺癌生育证据总结循证护理

Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO

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World Journal of Gastroenterology 2004年第15期10卷 2205-2208页

作者： TaoWang feichen ZheChen Yi-FengWut Xiao-LiXu ShuZheng XunHu CancerInstitute SecondHospitalofMedicineCollegeofZhejiangUniversityHangzhou310009ZhejiangProvinceChina LifeScienceCollegeofZhejiangUniversity Hangzhou310009.ZhejiangProvinceChina

AIM: To investigate the signal pathway of honokiol-induced apoptosis on human colorectal carcinoma RKO cells and to evaluate whether p53 and p53-related genes were involved in honokiol-treated RKO ***: Cell cycle distribution and subdiploid peak were analyzed with a flow cytometer and DNA fragment with electrophoresis on agarose gels. Transcriptional level of Bax, Bcl-2, Bid and Bcl-xl was accessed by *** blotting was used to measure p53 protein expression and other factors related to *** inhibition of two cell lines (RKO, SW480) with high expression of p53 and one cell line with p53 negative expression (LS180) was monitored by MTr ***: Honokiol induced RKO cell apoptosis in a dosedependent manner. The mRNA expression level and proteinlevel of Bid were up-regulated while that of Bcl-xl wasdown-regulated, but no changes in Bax and Bcl-2 were observed. Western blotting showed p53 expression had no remarkable changes in honokiol-induced RKO cell apoptosis. LS180 cells treated with honokiol exhibited apparent growth inhibition like RKO ceils and Sw480 ***: Honokiol can induce RKO cells apoptosis through activating caspase cascade by p53-indepenent pathway.

关键词：和厚朴酚引导作用细胞调亡 p53 结直肠细胞系统 RKO 基因表达肿瘤

Honokiol:A potent chemotherapy candidate for human colorectal carcinoma

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World Journal of Gastroenterology 2004年第23期10卷 3459-3463页

作者： feichen TaoWang Yi-FengWu YingGu Xiao-LiXu ShuZheng XunHu CancerInstitute SecondAffiliatedHospitalofZhejiangUniversityHangzhou310009ZhejiangProvinceChina LifeScienceCollege ZhejiangUniversityHangzhou310027ZhejiangProvinceChina

AIM: To investigate the anticancer activity of Honokiol on RKO,a human colorectal carcinoma cell line in vitro and in vivo,and to evaluate its possible use in ***: In vitro anticancer activity of honokiol was demonstrated by its induction of apoptosis in tumor *** analyzed cell proliferation with MTT assay, cell cycle with flow cytosmeter, DNA fragment with electrophoresis on agarose gels. To test the mechanism of honokiol-induced apoptosis, Westem blotting was used to investigate the factors involved in this process. The pharmacokinetics study of honokiol was tested by high phase liquid *** in vivo study, Balb/c nude mice were incubated with RKO cells. Honokiol was injected intraperitoneally every other day into tumor bearing Balb/c nude ***: Our results showed that honokiol induced apoptosis of RKO cells in a time- and dose-dependent manner. At 5-10 ug/mL for 48 h, honokiol induced apoptosis through activating Caspase cascades. Pharmacokinetics study demonstrated that, honokiol could be absorbed quickly by intraperitoneal injection, and maintained in plasma for more than 10 h. In nude mice bearing RKO-incubated tumor, honokiol displayed anticancer activity by inhibiting tumor growth and prolonging the lifespan of tumor bearing ***: With its few toxicity to normal cells and potent anticancer activity in vitroand in vivo, honokiol might be a potential chemotherapy candidate in treating human colorectal carcinoma.

关键词：和厚朴酚化学疗法候补物质结直肠癌肿瘤消化系统

Predicate Oriented Pattern Analysis for Biomedical Knowledge Discovery

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Intelligent Information Management 2016年第3期8卷 66-85页

作者： feichen Shen Hongfang Liu Sunghwan Sohn David W. Larson Yugyung Lee CSEE Department University of Missouri Kansas City MO USA Department of Health Sciences Research Mayo Clinic College of Medicine Rochester MN USA Department of Surgery Mayo Clinic College of Medicine Rochester MN USA

In the current biomedical data movement, numerous efforts have been made to convert and normalize a large number of traditional structured and unstructured data (e.g., EHRs, reports) to semi-structured data (e.g., RDF, OWL). With the increasing number of semi-structured data coming into the biomedical community, data integration and knowledge discovery from heterogeneous domains become important research problem. In the application level, detection of related concepts among medical ontologies is an important goal of life science research. It is more crucial to figure out how different concepts are related within a single ontology or across multiple ontologies by analysing predicates in different knowledge bases. However, the world today is one of information explosion, and it is extremely difficult for biomedical researchers to find existing or potential predicates to perform linking among cross domain concepts without any support from schema pattern analysis. Therefore, there is a need for a mechanism to do predicate oriented pattern analysis to partition heterogeneous ontologies into closer small topics and do query generation to discover cross domain knowledge from each topic. In this paper, we present such a model that predicates oriented pattern analysis based on their close relationship and generates a similarity matrix. Based on this similarity matrix, we apply an innovated unsupervised learning algorithm to partition large data sets into smaller and closer topics and generate meaningful queries to fully discover knowledge over a set of interlinked data sources. We have implemented a prototype system named BmQGen and evaluate the proposed model with colorectal surgical cohort from the Mayo Clinic.

关键词： Biomedical Knowledge Discovery Pattern Analysis Predicate Query Generation