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Effect of bainite microstructure during two-step quenching and partitioning process on strength and toughness properties of a 0.3%C bainitic steel

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Journal of Iron and Steel Research International 2018年第2期25卷 235-242页

作者： Cheng-hui Su Qiang-guo Li xue-fei huang Wei-gang huang College of Materials Science and Engineering SichuanUniversity Chengdu 610065 Sichuan China

The effect of bainite transformation and microstructure on the mechanical properties in 0.3%C bainitic steel was investigated via the heat treatment process of quenching at higher initial temperature and partitioning below martensite-start temperature. The results show that bainite transformation takes place with the partitioning time increasing during partitioning below martensite-start temperature. The microstructure of samples treated by this two-step quenching and partitioning process consists of lath bainite, lath martensite and retained austenite. This kind of multiphase microstructure exhibits better strength of 1420 MPa, ductility of 21.8 % and the product of strength and elongation of 30.8 GPa%. Furthermore, the excellent impact toughness of 103 J is exhibited by partitioning at 280 ℃ for 3 h. In addition, the coalescence of bainite platelets was found in the sample treated by partitioning for 8 h, leading to the deterioration of toughness.

关键词： Quenching and partitioning Bainitic steel Impact toughness Coalesced bainite

Preparation of Al2O3–SiO2 composite aerogels and their Cu2+absorption properties

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International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 317-324页

作者： Xiao-guang Liu Qiu-shuo Mao Yue Jiang Yan Li Jia-lin Sun fei-xue huang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Fundamental Experimental Centre of Nature Science University of Science and Technology BeijingBeijing 100083China

In order to remediate heavy metal ions from waste water,Al2O3–SiO2 composite aerogels are prepared via a sol–gel and an organic solvent sublimation drying *** characterisation techniques have been employed including X-ray diffraction(XRD),Fourier transform infrared spectrometry(FTIR),scanning electron microscope(SEM),Energy-dispersion X-ray spectroscopy(EDX),Brunauer–Emmett–Teller(BET)N2 adsoprtion isotherm,and atomic absorption spectrometer(AAS).XRD and FTIR suggest that the aerogels are composed of mainly Al2O3 and minor *** have a high specific surface area(827.544 m^2/g)and high porosity(86.0%)with a pore diameter of~20 *** microstructures show that the distribution of Al,Si,and O is *** aerogels can remove~99%Cu^2+within~40 min and then reach the equilibrium uptake(~69 mg/g).Preliminary calculations show that the Cu2+uptake by the aerogels follows pseudo second-order kinetics where chemical sorption may take effect owing largely to the high surface area,high porosity,and abundant functional groups,such as Al–OH and Si–OH,in the aerogel *** prepared aerogels may serve as efficient absorbents for Cu^2+removal.

关键词： heavy metal ion aerogel absorption organic solvent sublimation drying specific surface area porosity

Effect of biliary drainage on inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats

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World Journal of Gastroenterology 2013年第15期19卷 2319-2330页

作者： Zi-Kai Wang Jian-Guo Xiao xue-fei huang Yi-Chun Gong Wen Li Department of Gastroenterology and Hepatology the General Hospital of the Chinese People's Liberation Army Critical Care Medicine the General Hospital of the Chinese People's Liberation Army Department of Cadre Health Care the Navy General Hospital of the Chinese People's Liberation Army Intensive Care Unit the 309th Hospital of the Chinese People's Liberation Army

AIM: To investigate the effect of biliary drainage on inducible nitric oxide synthase (iNOS), CD14 and TGR5 expression in rats with obstructive jaundice (OJ). METHODS: Male adult Sprague-Dawley rats were randomly assigned to four groups: OJ, sham operation (SH), internal biliary drainage (ID) and external biliary drainage (ED). Rat models were successfully established by two operations and succumbed for extraction of Kupffer cells (KCs) and liver tissue collection on the 8 th and 15 th day. KCs were isolated by in situ hepatic perfusion and digested with collagen Ⅳ, density gradient centrifuged by percoll reagent and purified by cell culture attachment. The isolated KCs were cultured with the endotoxin lipopolysaccharide (LPS) with and without the addition of ursodeoxycholic acid (UDCA). The expression of iNOS, CD14 and bile acid receptor-TGR5 protein in rat liver tissues was determined by immunohistochemistry. The expression of iNOS and CD14 messenger RNA (mRNA) on the isolated KCs was detected by reverse transcription polymerase chain reaction (PCR) and the TGR5 mRNA level in KCs was measured by real-time quantitative PCR. RESULTS: The iNOS protein was markedly expressed in the liver of OJ rats, but rare expressed in SH rats. After relief of OJ, the iNOS expression was decidedly suppressed in the ID group (ID vs OJ, P < 0.01), but obviously increased in rats of ED (ED vs OJ, P=0.004). When interfered only with LPS, the expression of iNOS mRNA by KCs was increased in the OJ group compared with the SH group (P=0.004). After relief of biliary obstruction, the iNOS mRNA expression showed slight changes in the ED group (ED vs OJ, P=0.71), but dropped in the ID group (ID vs OJ, P=0.001). Compared with the simple intervention with LPS, the expressions of iNOS mRNA were significantly inhibited in all four groups after interfered with both LPS and UDCA (P < 0.01, respectively). After bile duct ligation, the CD14 protein expression in rat liver was significantly strengthene

关键词： Obstructive jaundice Biliary drainage Kupffer cells CD14 TGR5 Ursodeoxycholic acid

Herbal medicine Yin Zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole

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Acta Pharmacologica Sinica 2007年第10期28卷 1685-1692页

作者： Lan FAN,Guo WANG,Lian-sheng WANG,Yao CHEN,Wei ZHANG,Yuan-fei huang,Rui-xue huang,Dong-li HU,DanWANG,Hong-hao ZHOU~2Pharmacogenetics Research Institute,Institute of Clinical Pharmacology,Central South University,Hu-nan 410078,China cogenetics Research Institute Institute of Clinical Pharmacology Central South University Hu-nan 410078 China. hhzhou2003@***.

Aim:To explore the potential interactions between Yin Zhi huang (YZH) andomeprazole,a substrate of CYP3A4 and ***:Eighteen healthyvolunteers,including 6 CYP2C19~*1/~*1,6 CYP2C19~*1/~*2 or ~*3 and 6 CYP2C19~*2/~*2 were enrolled in a 2-phase,randomized,crossover clinical *** each phase,the volunteers received either placebo or 10 mL YZH oral liquid,3 times daily for *** all the patients took a 20 mg omeprazole capsule *** sampleswere collected up to 12 h after omeprazole *** concentrationsof omeprazole and its metabolites were quantified by HPLC with UV ***:After 14 d of treatment of YZH,plasma omeprazole significantlydecreased and those of omeprazole sulfone and 5-hydroxyomeprazole signifi-cantly *** ratios of the area under the plasma concentration-timecurves from time 0 to infinity (AUC0-∞of omeprazole to 5-hydroxyomprazole andthose of omeprazole to omeprazole sulfone decreased by 64.80%±12.51% (P=0.001) and 63.31%±18.45% (P=0.004) in CYP2C 19~*1/~*1,57.98%±14.80% (P=0.002)and 54.87%±18.42% (P=0.003) in CYP2C19~*1/~*2 or ~*3,and 37.74%±16.07% (P=0.004) and 45.16%±15.54% (P=0.003) in CYP2C19~*2/~*2,*** of the AUC0-∞ratio of omeprazole to 5-hydroxyomprazole in CYP2C19~*1/~*1and CYP2C19~*1/~*2 or ~*3 was greater than those in CYP2C19~*2/~*2 (P=0.047and P=0.009).Conclusion:YZH induces both CYP3A4-catalyzed sulfoxidationand CYP2C 19-dependent hydroxylation of omeprazole leading to decreases inplasma omeprazole concentrations.

关键词： Yin Zhi huang induction CYP3A4 CYP2C19 omeprazole

Enactment of Default Point in KMV Risk Model on CMBC,SPDB,CMB,HUAXIA BANK and SDB

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Enactment of Default Point in KMV Risk Model on CMBC,SPDB,CM...

第五届（2010）中国管理学年会——管理科学与工程分会场

作者： fei xue huang Faculty of Management and Economics Dalian University of Technology Dalian 116024,China Jing qin Su Faculty of Management and Economics Dalian University of Technology Dalian116024,China

This study’s objective was to solve the problem that probing default point of KMV in listed bank of China.A new model of default point is constructed,because Chinese listed banks on owing to the existence of nontradable *** using of listed banks in China: CMBC,CMB,SDB,SPDB,HUA XIA BANK in the second half of 2004 to 2007 per annum related stocks and financial *** model of DPT equal to current liabilities (STD) plus 0.25 Long-term debt (LTD) for CMB,SPDB ,CMBC,HUA XIA BANK;The model of DPT equal to current liabilities (STD) plus 0.75 Long-term debt (LTD) for *** the same time,these models have been tested,the results will pass the *** new model is feasible for probing default point of KMV in listed bank of China.

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间充质干细胞治疗急性放射性损伤的研究

中华细胞与干细胞杂志（电子版） 2018年第2期8卷 120-124页

作者：薛飞黄平平中国医学科学院北京协和医学院血液学研究所天津300020

急性放射性损伤是组织损伤的一种重要类型,目前未有较理想的治疗方案。间充质干细胞(MSCs)能够多向分化、自我更新,且具有分泌多种细胞因子、抗炎、免疫调节等生物活性。其在促进组织修复的优势显而易见,而移植的时机、剂量长期以来莫... 详细信息

急性放射性损伤是组织损伤的一种重要类型,目前未有较理想的治疗方案。间充质干细胞(MSCs)能够多向分化、自我更新,且具有分泌多种细胞因子、抗炎、免疫调节等生物活性。其在促进组织修复的优势显而易见,而移植的时机、剂量长期以来莫衷一是。致瘤性等安全问题制约其临床研究的进一步开展。近年来,MSCs趋向于无细胞化移植取得了明显成效。这一研究新进展势必迎来急性放射性损伤治疗的新格局,本文对此研究现状及进展进行综述。

关键词：间充质干细胞放射损伤细胞治疗

Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期 308-316页

作者： Sili Wang Jiancheng huang Yanan Du Wei huang Yufeng xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying Bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi Xu Tianyi huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Synthesis and Optical Properties of ZnO Nanoparticles in Submicron PS Hollow Reactors

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Chinese Journal of Chemical Physics 2012年第6期25卷 719-724,I0004页

作者： xue-feng huang fei-fei Ju Mo-zhen Wang xue-wu Ge CAS Key Laboratory of Soft Matter Chemisry Department of Polymer Science and EngineeringUniversity of Science and Technology of China Hefei 230026 China

ZnO nanoparticles were first encapsulated in submicron PS hollow microspheres through two-step swelling process of core-shell structured PMMA/PS （PMMA： polymethyl methao- rylate） microspheres in acid-alkali solution, and the ZnO precursors, i.e. the ethanol solu- tions of （CHaCOO）2Zn and LiOH. The transmission electron microscope, X-ray diffraction, and thermogravimetric analysis results show that the feeding order of ethanol solutions of （CH3COO）2Zn and LiOH in the second swelling step has great influence on the loading efficiency and the size of ZnO nanoparticles, but little on their crystal form. The photolumi- nescence and UV-Vis absorption behavior of ZnO/PS microspheres show that the PS shell can effectively avoid the fluorescence quenching effect.

关键词： ZnO/PS hybrid material Core-shell polymer Swelling PS hollow microsphere Optical property