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Nomogram for predicting the risk of anxiety and depression in patients with non-mild burns

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World Journal of Psychiatry 2024年第8期14卷 1233-1243页

作者： Jie Chen Jian-fei zhang xia xiao Yu-Jun Tang He-Jin Huang Wen-Wen Xi Li-Na Liu Zheng-Zhou Shen Jian-Hua Tan Feng Yang Department of Burns and Plastic Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Beauty Surgery Nantong Shenmei Medical Beauty ClinicNantong 226001Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Post-burn anxiety and depression affect considerably the quality of life and recovery of patients;however,limited research has demonstrated risk factors associated with the development of these *** To predict the risk of developing post-burn anxiety and depression in patients with non-mild burns using a nomogram *** We enrolled 675 patients with burns who were admitted to The Second Affiliated Hospital,Hengyang Medical School,University of South China between January 2019 and January 2023 and met the inclusion *** patients were randomly divided into development(n=450)and validation(n=225)sets in a 2:1 *** and multivariate logistic regression analyses were conducted to identify the risk factors associated with post-burn anxiety and depression dia-gnoses,and a nomogram model was *** Female sex,age<33 years,unmarried status,burn area≥30%,and burns on the head,face,and neck were independent risk factors for developing post-burn anxiety and depression in patients with non-mild *** nomogram model demonstrated predictive accuracies of 0.937 and 0.984 for anxiety and 0.884 and 0.923 for depression in the development and validation sets,respectively,and good predictive *** and decision curve analyses confirmed the clinical utility of the *** The nomogram model predicted the risk of post-burn anxiety and depression in patients with non-mild burns,facilitating the early identification of high-risk patients for intervention and treatment.

关键词： Burn Post-burn anxiety Depression Risk prediction Nomogram model

考虑不确定性情况下的故障树重要度分析方法及应用

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系统工程与电子技术 2024年第3期46卷 935-941页

作者：李贵杰詹扬李大伟夏广庆大连理工大学航空航天学院辽宁大连116024 大连理工大学工业装备结构分析国家重点实验室辽宁大连116024 海军大连舰艇学院辽宁大连116018

为了度量底事件发生概率不确定性对顶事件的影响程度,在建立故障树概率组成函数的基础上,基于矩独立重要性测度提出了考虑底事件发生概率不确定性情况的故障树重要度分析方法。以某飞机结冰探测系统为例,利用所提出的重要度方法分析了... 详细信息

为了度量底事件发生概率不确定性对顶事件的影响程度,在建立故障树概率组成函数的基础上,基于矩独立重要性测度提出了考虑底事件发生概率不确定性情况的故障树重要度分析方法。以某飞机结冰探测系统为例,利用所提出的重要度方法分析了底事件发生概率不确定性对该系统故障的影响程度,设计者可根据重要度结果更有针对性地开展分析与设计,同时也验证了所提方法的合理性。

关键词：故障树分析不确定性系统可靠性重要性测度

Will the Globe Encounter the Warmest Winter after the Hottest Summer in 2023?

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Advances in Atmospheric Sciences 2024年第4期41卷 581-586页

作者： fei ZHENG Shuai HU Jiehua MA Lin WANG Kexin LI Bo WU Qing BAO Jingbei PENG Chaofan LI Haifeng ZONG Yao YAO Baoqiang TIAN Hong CHEN xianmei LANG Fangxing FAN xiao DONG Yanling zhan Tao ZHU Tianjun ZHOU Jiang ZHU International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nansen-Zhu International Research Centre(NZC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Monsoon System Research(CMSR) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China CAS Key Lab of Regional Climate-Environment for Temperate East Asia(RCE-TEA) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

In the boreal summer and autumn of 2023,the globe experienced an extremely hot period across both oceans and *** consecutive record-breaking mean surface temperature has caused many to speculate upon how the global temperature will evolve in the coming 2023/24 boreal *** this report,as shown in the multi-model ensemble mean(MME)prediction released by the Institute of Atmospheric Physics at the Chinese Academy of Sciences,a medium-to-strong eastern Pacific El Niño event will reach its mature phase in the following 2−3 months,which tends to excite an anomalous anticyclone over the western North Pacific and the Pacific-North American teleconnection,thus serving to modulate the winter climate in East Asia and North *** some uncertainty due to unpredictable internal atmospheric variability,the global mean surface temperature(GMST)in the 2023/24 winter will likely be the warmest in recorded history as a consequence of both the El Niño event and the long-term global warming ***,the middle and low latitudes of Eurasia are expected to experience an anomalously warm winter,and the surface air temperature anomaly in China will likely exceed 2.4 standard deviations above climatology and subsequently be recorded as the warmest winter since ***,the necessary early warnings are still reliable in the timely updated mediumterm numerical weather forecasts and sub-seasonal-to-seasonal prediction.

关键词： winter climate El Niño seasonal forecast GMST

A retrospective analysis of mature T-and NK-cell lymphomas

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Cancer Biology & Medicine 2024年第3期21卷 223-229页

作者： Junlei Jia xiaohui Wang Zheng Song Shen Meng Yue fei Jingwei Yu xia Liu Xue Han Lanfang Li Lihua Qiu Zhengzi Qian Shiyong Zhou Wenchen Gong Bin Meng Xiubao Ren xianhuo Wang Huilai zhang National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine and Department of LymphomaTianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinThe Sino-US Center for Lymphoma and Leukemia ResearchTianjin 300060China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China Department of Pathology Department of Immunology/Biotherapy Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin 300060China

Mature T-and natural killer(NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T-and NK-cell lymphomas is 2.1 per 100,000 people, according... 详细信息

关键词： lymphoma neoplasms killer

Thoracic giant cell tumor after two total en bloc spondylectomies including one emergency surgery:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2894-2903页

作者： Hai-Feng Liang Hao Xu Meng-Na zhan Jian xiao Juan Li Qin-Ming fei Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Orthopaedic Surgery Shanghai Geriatric Medical CenterShanghai 201104China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Orthopaedic Surgery Zhongshan Hospital Wusong BranchFudan UniversityShanghai 200940China

BACKGROUND For patients with acute paraplegia caused by spinal giant cell tumor(GCT)who require emergency decompressive surgery,there is still a lack of relevant reports on surgical *** study is the first to present the case of an acute paraplegic patient with a thoracic spinal GCT who underwent an emergency total en bloc spondylectomy(TES).Despite tumor recurrence,three-level TES was repeated after denosumab *** SUMMARY A 27-year-old female patient who underwent single-level TES in an emergency presented with sudden severe back pain and acute paraplegia due to a thoracic spinal *** emergency TES,the patient's spinal cord function recovered,and permanent paralysis was *** postoperative histopathological examination revealed that the excised neoplasm was a rare ***,the tumor recurred 9 months after the first *** 12 months of denosumab therapy,the tumor size was reduced,and tumor *** prevent recurrent tumor progression and provide a possible cure,a three-level TES was performed *** patient returned to an active lifestyle 1 month after the second surgery,and no recurrence of GCT was found at the last *** This patient with acute paraplegia underwent TES twice,including once in an emergency,and achieved good therapeutic *** in emergency surgery is feasible and safe when conditions permit;however,it may increase the risk of tumor recurrence.

关键词： Giant cell tumor Thoracic spine Emergency treatment Total en bloc spondylectomy Denosumab therapy Case report

高光谱结合深度学习的桑椹采后TSS含量无损检测

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光谱学与光谱分析 2024年第6期44卷 1724-1730页

作者：王子轩杨良黄凌霞何勇赵丽华占鹏飞河海大学商学院江苏南京210024 浙江省蚕蜂资源利用与创新研究重点实验室浙江杭州310058 湖州市农业科学研究院蚕桑所浙江湖州313002 农业农村部光谱检测重点实验室浙江杭州310058

桑椹起源于中国,是我国最具历史的“药食同源”水果之一。但桑椹采后快速变质和皮薄易腐败的特点制约了其产业化发展。总可溶性固形物(TSS)是决定桑椹风味和品质的重要成分,是其商业化的最基本品质特性之一。借助于近红外高光谱成像技... 详细信息

桑椹起源于中国,是我国最具历史的“药食同源”水果之一。但桑椹采后快速变质和皮薄易腐败的特点制约了其产业化发展。总可溶性固形物(TSS)是决定桑椹风味和品质的重要成分,是其商业化的最基本品质特性之一。借助于近红外高光谱成像技术和深度学习方法优化桑椹采后TSS含量的预测模型,同时评估采后常见储运温度条件对定量模型的影响,为桑椹采后品质快速评价提供依据。选用具有一致商业成熟度的桑椹分别在常温(25℃)和低温(4℃)储藏,然后在不同储藏阶段对样本进行光谱数据采集和TSS含量测定直至桑椹腐败不适宜食用。基于校正后的高光谱图像提供的空间信息提取感兴趣区域以获得无背景的代表性光谱,然后将标准正态变换(SNV)、多元散射校正(MSC)、Savizkg-Golag(SG)平滑用于光谱的预处理,以提升光谱信噪比。利用深度学习方法实现了桑椹采后TSS含量的预测。对于常温和低温桑椹样本,最优CNN模型剩余预测偏差(RPD)值分别达到5.828和5.449,预测均方根误差(RMSEP)值分别为1.082和1.099°Brix,可见低温条件储藏降低了CNN模型的预测性能。为进一步验证CNN模型的效果,建立了基于传统经典机器学习方法偏最小二乘(PLS)和最小二乘支持向量机(LS-SVM)的TSS含量预测模型。结果表明,非线性模型LS-SVM更适合桑椹的TSS含量预测。对于两个不同储藏温度,最优LS-SVM模型RPD值分别为4.221和4.423,表明CNN优于经典机器学习方法。综上所述,高光谱成像结合深度学习CNN的桑椹采后TSS预测具有较大潜力,这为桑椹品质快速检测提供了技术支撑。

关键词：桑椹采后总可溶性固形物高光谱成像深度学习卷积神经网络

人力资源服务业高质量发展与新质生产力培育——逻辑机理、实施路径和关键举措

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中国劳动 2024年第1期 64-75页

作者：战梦霞高雨菲中国劳动和社会保障科学研究院北京100029 武汉大学弘毅学堂武汉430072

新质生产力作为引领新时代经济发展的新范式,是实现中国式现代化的重要手段。为了加快培育新质生产力,必须以产业创新为内生动力来推动构建现代化产业体系。其中,人力资源服务业作为典型的现代服务业,不仅是实施创新驱动发展战略、就业... 详细信息

新质生产力作为引领新时代经济发展的新范式,是实现中国式现代化的重要手段。为了加快培育新质生产力,必须以产业创新为内生动力来推动构建现代化产业体系。其中,人力资源服务业作为典型的现代服务业,不仅是实施创新驱动发展战略、就业优先战略和人才强国战略的重要抓手,而且还能与战略性新兴产业、未来产业实现融合发展来共同构建现代化产业体系。然而,当前人力资源服务业与高质量发展的要求相比还存在一定差距,需要立足产业内部“质的提升”以及与其他产业“量的加成”来共同推进产业创新,并通过采取加大改革力度,深化与实体经济协同发展,建立高标准服务市场体系,推进“多链”深度融合,优化人力资源市场配置,以及开展“数字双创”活动等措施来满足高质量发展的要求,才能为新质生产力培育提供有力支撑。

关键词：人力资源服务业新质生产力高质量发展创新现代化产业体系

The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan Luo Han Li Wenjuan Ma Jiaxin Cao Qun Chen feiteng Lu Miaozhen Qiu Penghui Zhou Zengfei xia Kangmei Zeng Jianhua zhan Ting Zhou Qiuyun Luo Wentao Pan Lin zhang Chaozhuo Lin Yan Huang Li zhang Dajun Yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2 inhibitor APG-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RNA sequencing,we found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APG-2575 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APG-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD206 expression on ***,these data provide evidence that further study on APG-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2575 ICIs Macrophages NLRP3

一类时间分数阶反应扩散方程弱解的全局有界性

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四川大学学报（自然科学版） 2024年第3期61卷 75-80页

作者：占慧高飞武汉理工大学数学系和数学科学中心武汉430070

时间分数阶反应扩散方程是经典非局部反应扩散方程的推广.本文研究了一类时间分数阶反应扩散方程弱解的全局有界性.利用Alikhanov不等式和局部能量估计,本文构造了分数阶微分不等式,结合Mittag-Leffler函数的渐近性质证明了方程解的局... 详细信息

时间分数阶反应扩散方程是经典非局部反应扩散方程的推广.本文研究了一类时间分数阶反应扩散方程弱解的全局有界性.利用Alikhanov不等式和局部能量估计,本文构造了分数阶微分不等式,结合Mittag-Leffler函数的渐近性质证明了方程解的局部有界性,然后运用分数阶Duhamel公式及其性质对方程求解和放缩,从而将解的局部有界性扩展到全局有界性.本研究克服了已有Duhamel公式的计算量问题,为方程解的全局性的研究提供了新思路.

关键词： Caputo分数阶导数反应扩散方程全局有界性非局部