检索结果-南通市图书馆

Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao Yuguang Zhu Hua Tao Xiying Chen Feng Yin Yingyi Zhang Jianfeng Qin Yongyin Huang Bikun Cai Yonghao Lin Jiaxiang wu Yu Zhang Lu Liang Ao Shen Xi-Yong Yu The Fifth Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited therapeutic options *** this study,we reported the enhanced expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and endothelial cells,and confirmed MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we identified Ailanthone(AIL)from a natural compound library as the first small molecule capable of directly targeting and suppressing *** demonstrated the ability to inhibit both the activation of fibroblasts and endothelial-to-mesenchymal transition of endothelial cells when challenged by transforming growth factor-b1(TGF-b1).In an animal model of bleomycin-induced pulmonary fibrosis,AIL effectively mitigated the fibrotic process and restored respiratory ***,AIL acted as a suppressor of MEOX1 by disrupting the interaction between the transcription factor JUN and the promoter of MEOX1,thereby inhibiting MEOX1 expression and *** summary,our findings pinpointed MEOX1 as a cell-specific and clinically translatable target in ***,we demonstrated the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-dependent MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural product

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电动装载机电液复合制动协同控制策略研究

农业机械学报 2024年第6期55卷 442-450页

作者：叶月影吴瑕林添良集美大学诚毅学院厦门361021 福建省移动机械绿色智能驱动与传动重点实验室厦门361021 华侨大学机电及自动化学院厦门361021

针对电动装载机的电液复合制动系统,为满足多工况制动需求以及保障制动安全性,本文提出了一种基于再生制动自由行程液压制动阀的电动装载机液压制动系统。结合电动装载机的理想前后轮制动力分配曲线以及制动意图识别得到的制动强度,制... 详细信息

针对电动装载机的电液复合制动系统,为满足多工况制动需求以及保障制动安全性,本文提出了一种基于再生制动自由行程液压制动阀的电动装载机液压制动系统。结合电动装载机的理想前后轮制动力分配曲线以及制动意图识别得到的制动强度,制定了制动强度与整车制动力矩需求的分配曲线;为进一步提高再生制动力与液压制动力分配的协调性,同时兼顾制动能量回收效率,提出了一种基于行走再生制动和液压制动的电液复合制动协同控制策略,降低了整车总制动力矩波动,保证了制动模式切换的平顺性。最后,搭建了基于AMESim-Matlab/Simulink联合仿真模型,并搭建试验样机,验证了电动装载机复合制动协同控制策略的可行性,结果表明,该系统能量回收效率可达71.6%,制动回收率可达44.5%,一个工作循环实现节能7.6%,说明本文提出的控制策略具有良好的制动性能和能量回收效率。

关键词：电动装载机复合制动液压制动能量回收协同控制

维普期刊数据库博看期刊

Soil Organic Carbon and Its Fractions Across Vegetation Types:Effects of Soil Mineral Surface Area and Microaggregates

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2009年第2期19卷 258-264页

作者： wu Qing-Biao WANG Xiao-Ke OUYANG Zhi-yun Forestry College of Guangxi University Nanning 530004 China Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Soil organic carbon(SOC)can act as a sink or source of atmospheric carbon dioxide;therefore,it is important to understand the amount and composition of SOC in terrestrial ecosystems,the spatial variation in SOC,and the underlying mechanisms that stabilize *** this study,density fractionation and acid hydrolysis were used to assess the spatial variation in SOC,the heavy fraction of organic carbon(HFOC),and the resistant organic carbon(ROC)in soils of the southern Hulun Buir region,northeastern China,and to identify the major factors that contribute to this *** results showed that as the contents of clay and silt particles(0–50μm)increased,both methylene blue(MB)adsorption by soil minerals and microaggregate contents increased in the 0–20 and 20–40 cm soil layers(P<0.05).Although varying with vegetation types,SOC,HFOC,and ROC contents increased significantly with the content of clay and silt particles, MB adsorption by soil minerals,and microaggregate content(P<0.05),suggesting that soil texture,the MB adsorption by soil minerals,and microaggregate abundance might be important factors influencing the spatial heterogeneity of carbon contents in soils of the southern Hulun Buir region.

关键词： carbon fractions microaggregates soil mineral surface area soil organic carbon vegetation

On the Koszul Modules of Exterior Algebras

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2007年第11期23卷 1967-1984页

作者： Jin yun GUO Quan Hong WAN Qiu Xian wu Department of Mathematics Xiangtan University Xiangtan 411105 P. R. China Department of Mathematics Hu'nan Normal University Changsha 410081 P. R. China

We prove that the Koszul modules over an exterior algebra can be filtered by the cyclic Koszul modules. We also introduce the cyclic dimension vector as invariants for studying the Koszul modules over an exterior alge... 详细信息

关键词： exterior algebra Koszul module cyclic dimension vector

Soliton, Positon and Negaton Solutions of Extended KdV Equation

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2008年第3期49卷 529-534页

作者： wu Hong-Xia ZENG yun-Bo FAN Tian-You Department of Mathematics Jimei University Xiamen 361021 China Department of Mathematics Beijing Institute of Technology Beijing 100081 China Department of Mathematical Sciences Tsinghua University Beijing 100084 China

Darboux transformation （DT） provides us with a comprehensive approach to construct the exact and explicit solutions to the negative extended KdV （eKdV） equation, by which some new solutions such as singular soliton, negaton, and positon solutions are computed for the eKdV equation. We rediscover the soliton solution with finiteamplitude in [A.V. Slyunyaev and E.N. Pelinovskii, J. Exp. Theor. Phys. 89 （1999） 173] and discuss the difference between this soliton and the singular soliton. We clarify the relationship between the exact solutions of the eKdV equation and the spectral parameter. Moreover, the interactions of singular two solitons, positon and negaton, positon and soliton, and two positons are studied in detail.

关键词： the extended KdV equation singular soliton positon negaton Darboux transformation

在线全文

学校读者我要写书评

暂无评论

基于应变的应变硬化指数演化行为研究

塑性工程学报 2024年第8期31卷 164-170页

作者：崔学习关铂镔周兵营吴向东万敏韩非北京航天试验技术研究所北京100074 中国运载火箭技术研究院空间物理重点实验室北京100076 北京航空航天大学机械工程及自动化学院北京100191 宝山钢铁股份有限公司中央研究院上海201900

为准确描述变形过程中双相高强钢板的应力应变关系,针对3种双相高强钢板应变硬化指数的演化行为进行了试验研究与理论模型预测。借助单向拉伸试验机和自主研发的DIC应变测量系统,获得了3种材料的真实应力-真实应变曲线,基于经典的Hollo... 详细信息

为准确描述变形过程中双相高强钢板的应力应变关系,针对3种双相高强钢板应变硬化指数的演化行为进行了试验研究与理论模型预测。借助单向拉伸试验机和自主研发的DIC应变测量系统,获得了3种材料的真实应力-真实应变曲线,基于经典的Hollomon流动应力模型,得到了其应变硬化指数的演化历程,发现3种材料应变硬化指数与真实应变呈非线性变化关系。为了更好地预测应变硬化指数的演化行为,提出了可以描述其值变化的非线性数学模型,并结合经典的Hollomon流动应力模型,提出了基于n值变化的修正的Hollomon-n流动应力模型,最后通过3种材料的真实应力-真实应变曲线验证了所提出模型的有效性。

关键词：双相高强钢板应变硬化指数数字图像相关法应变演化流动应力模型

Visual knowledge guided intelligent generation of Chinese seal carving

在线全文

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2022年第10期23卷 1479-1493页

作者： Kejun ZHANG Rui ZHANG Yehang YIN Yifei LI Wenqi wu Lingyun SUN fei wu Huanghuang DENG yunhe PAN College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China Alibaba-Zhejiang University Joint Institute of Frontier Technologies Hangzhou 310027China School of Software Technology Zhejiang UniversityHangzhou 310027China

We digitally reproduce the process of resource collaboration,design creation,and visual presentation of Chinese seal-carving *** develop an intelligent seal-carving art-generation system(Zhejiang University Intelligent Seal-Carving System,http://***/seal/;the website of the seal-carving search and layout system is http://***/seal/search_app/)to deal with the difficulty in using a visual knowledge guided computational art *** knowledge base in this study is the Qiushi Seal-Carving Database,which consists of open datasets of images of seal characters and seal *** propose a seal character generation method based on visual knowledge,guided by the database and ***,to create the layout of the seal,we propose a deformation algorithm to adjust the seal characters and calculate layout parameters from the database and knowledge to achieve an intelligent *** results show that this method and system can effectively deal with the difficulties in the generation of seal *** work provides theoretical and applied references for the rebirth and innovation of seal-carving art.

关键词： Seal-carving Intelligent generation Deep learning Parametric modeling Computational art

包含有界切换增益的空间惯性传感器输出调节积分模型参考自适应控制

在线全文

学校读者我要写书评

暂无评论

中国科学：技术科学 2024年第3期54卷 490-500页

作者：孙笑云吴树范沈强上海交通大学航空航天学院上海200240 上海市引力波探测前沿科学研究基地上海200240

基于输出调节的多变量模型参考自适应控制(model reference adaptive control,MRAC)用于解决系统状态不可直接获取时,多变量系统向参考系统的稳定输出跟踪问题.在空间引力波探测航天器内部惯性传感器静电悬浮控制中,考虑到其作为航天器... 详细信息

基于输出调节的多变量模型参考自适应控制(model reference adaptive control,MRAC)用于解决系统状态不可直接获取时,多变量系统向参考系统的稳定输出跟踪问题.在空间引力波探测航天器内部惯性传感器静电悬浮控制中,考虑到其作为航天器平台惯性基准的稳定需求,双质量块动力学中存在的不连续干扰影响,以及应对不同工作模式的瞬态切换,提出一种基于积分输出调节MRAC的静电悬浮控制方案,引入有界的切换自适应校正增益及自适应积分修正项,用于系统不连续情况下的抗输入饱和、瞬态抑制及惯性传感器非敏感轴各自由度向参考状态的稳定逼近.基于Filippov集与广义梯度的Lyapunov分析验证该方案下,不连续系统中各闭环信号的收敛性,数值仿真验证样例空间引力波探测航天器中,作为关键载荷的双质量块空间惯性传感器各非敏感轴自由度针对位移噪声及残余加速度及切换瞬态的良好抑制效果.

关键词：静电悬浮控制空间引力波探测惯性传感器模型参考自适应控制不连续系统有界切换增益

Local and regional flood frequency analysis based on hierarchical Bayesian model in Dongting Lake Basin,China

在线全文

学校读者我要写书评

暂无评论

Water Science and Engineering 2019年第4期12卷 253-262页

作者： yun-biao wu Lian-qing Xue Yuan-hong Liu College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Department of Fundamental Education Wanjiang University of TechnologyMaanshan 243031China College of Water and Architectural Engineering Shihezi UniversityShihezi 832003China

This study developed a hierarchical Bayesian(HB)model for local and regional flood frequency analysis in the Dongting Lake Basin,in *** annual maximum daily flows from 15 streamflow-gauged sites in the study area were analyzed with the HB *** generalized extreme value(GEV)distribution was selected as the extreme flood distribution,and the GEV distribution location and scale parameters were spatially modeled through a regression approach with the drainage area as a *** Markov chain Monte Carlo(MCMC)method with Gibbs sampling was employed to calculate the posterior distribution in the HB *** results showed that the proposed HB model provided satisfactory Bayesian credible intervals for flood quantiles,while the traditional delta method could not provide reliable uncertainty estimations for large flood quantiles,due to the fact that the lower confidence bounds tended to decrease as the return periods ***,the HB model for regional analysis allowed for a reduction in the value of some restrictive assumptions in the traditional index flood method,such as the homogeneity region assumption and the scale invariance *** HB model can also provide an uncertainty band of flood quantile prediction at a poorly gauged or ungauged site,but the index flood method with L-moments does not demonstrate this uncertainty ***,the HB model is an effective method of implementing the flexible local and regional frequency analysis scheme,and of quantifying the associated predictive uncertainty.

关键词： Flood frequency analysis Hierarchical Bayesian model Index flood method Generalized extreme value distribution Dongting Lake Basin