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Permanent Magnetic Properties of Melt-Spun YCo5Cx Ribbons

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Chinese Physics Letters 2010年第6期27卷 210-212页

作者： WANG fei yan Yu YUAN zhou BAI Xue DU Xiao-Bo WANG Wen-Quan SU Feng JIN Han-Min State key Laboratory for Superhard Materials and Department of Physics Jilin University Changchun 130012

Ribbons of nominal compositions YCo5 Cx （x = 0, 0.2, 0.4, 0.6） are prepared by melt spinning at surface velocities v = 5, 10, 15, 20, 25, 30 and 35 m/s. YCo5 ribbon is crystallized in a single YCo5 phase of hexagonal CaCu5 structure. A small quantity of YCoC2 phase appears in the ribbons with C addition besides the YCo5 phase. With the increase of x the lattice constant c increases and a along with the unit cell volume decreases. The largest values of iHc = 888 kA/m and （BH）max = 58.4 k Jim3 at present for the YCo5 ribbon system were obtained with x = 0.4 and v = 20 m/s. The improvement of the permanent magnetic properties is rooted in the refinement of the microstructure and the appearance of the YCoC2 phase which can act as domain wall pinning centers.

关键词： PERMANENT magnets MELT spinning COBALT compounds SURFACES (Technology) CRYSTALLIZATION ADDITION reactions CRYSTAL lattices MICROSTRUCTURE FLUX pinning

Mitofusin-2 mediated mitochondrial Ca2+ uptake 1/2 induced liver injury in rat remote ischemic perconditioning liver transplantation and alpha mouse liver-12 hypoxia cell line models

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World Journal of Gastroenterology 2017年第38期23卷 6995-7008页

作者： Ruo-Peng Liang Jun-Jun Jia Jian-Hui Li Ning He yan-fei zhou Li Jiang Tao Bai Hai-yang Xie Lin zhou Yu-Ling Sun Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University Institute of Hepatobiliary and Pancreatic Diseases Zhengzhou University Key Lab of Combined Multi-Organ Transplantation Ministry of Public Health Division of Hepatobiliary and Pancreatic Surgery Department of Surgery First Affiliated Hospital Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

AIM To investigate the protective mechanism of mitofusin-2 (Mfn2) in rat remote ischemic perconditioning (RIC) models and revalidate it in alpha mouse liver-12 (AML-12) hypoxia cell lines. METHODS Sprague-Dawley rats were divided into three groups (n = 6 each): sham, orthotopic liver transplantation and RIC. After operation, blood samples were collected to test alanine aminotransferase and aspartate aminotransferase. The liver lobes were harvested for histopathological examination, western blotting (WB) and quantitative real-time (qRT)-PCR. AML-12 cell lines were then subjected to normal culture, anoxic incubator tank culture (hypoxia) and anoxic incubator tank culture with Mfn2 knockdown (hypoxia + Si), and data of qRT-PCR, WB, mitochondrial membrane potential (Delta psi m), apoptosis, endoplasmic reticulum Ca2+ concentrations and mitochondrial Ca2+ concentrations were collected. RESULTS Both sham and normal culture groups showed no injury during the experiment. The RIC group showed amelioration of liver function compared with the orthotopic liver transplantation group (P < 0.05). qRTPCR and WB confirmed that Mfn2-mitochondrial Ca2+ uptake 1/2 (MICUs) axis was changed (P < 0.005). In AML-12 cell lines, compared with the hypoxia group, the hypoxia + Si group attenuated the collapse of..m and apoptosis (P < 0.005). The endoplasmic reticulum Ca2+ decrease and mitochondrial Ca2+ overloading observed in the hypoxia group were also attenuated in the hypoxia + Si group (P < 0.005). Finally, qRT-PCR and WB confirmed the Mfn2-MICUs axis change in all the groups (P < 0.005). CONCLUSION Mfn2 participates in liver injury in rat RIC models and AML-12 hypoxia cell lines by regulating the MICUs pathway.

关键词： Remote ischemic per-conditioning Ischemia-reperfusion injury Ca2+ Mitofusin-2 Mitochondrial Ca2+ uniporter

Remote ischemic perconditioning prevents liver transplantation-induced ischemia/reperfusion injury in rats: Role of ROS/RNS and e NOS

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World Journal of Gastroenterology 2017年第5期23卷 830-841页

作者： Ning He Jun-Jun Jia Jian-Hui Li yan-fei zhou Bing-Yi Lin Yi-Fan Peng Jun-Jie Chen Tian-Chi Chen Rong-Liang Tong Li Jiang Hai-yang Xie Lin zhou Shu-Sen Zheng Key Lab of Combined Multi-Organ Transplantation Ministry of Public Health Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalZhejiang University School of Medicine

AIM To investigate the underlying mechanisms of the protective role of remote ischemic perconditioning (RIPerC) in rat liver transplantation. METHODS Sprague-Dawley rats were subjected to sham, orthotopic liver transplantation (OLT), ischemic postconditioning (IPostC) or RIPerC. After 3 h reperfusion, blood samples were taken for measurement of alanine aminotransferase, aspartate aminotransferase, creatinine (Cr) and creatinine kinase-myocardial band (CK-MB). The liver lobes were harvested for the following measurements: reactive oxygen species (ROS), H2O2, mitochondrial membrane potential (Delta psi m) and total nitric oxide (NO). These measurements were determined using an ROS/H2O2, JC1 and Total NOx Assay Kit, respectively. Endothelial NO synthase (eNOS) was analyzed by reverse transcription-polymerase chain reaction (RTPCR) and western blotting, and peroxynitrite was semiquantified by western blotting of 3-nitrotyrosine. RESULTS Compared with the OLT group, the grafts subjected to RIPerC showed significantly improved liver and remote organ functions (P < 0.05). ROS (P < 0.001) including H2O2 (P < 0.05) were largely elevated in the OLT group as compared with the sham group, and RIPerC (P < 0.05) reversed this trend. The collapse of Delta psi m induced by OLT ischemia/reperfusion (I/R) injury was significantly attenuated in the RIPerC group (P < 0.001). A marked increase of NO content and phosphoserine eNOS, both in protein and mRNA levels, was observed in liver graft of the RIPerC group as compared with the OLT group (P < 0.05). I/R-induced 3-nitrotyrosine content was significantly reduced in the RIPerC group as compared with the OLT group (P < 0.05). There were no significant differences between the RIPerC and IPostC groups for all the results except Cr. The Cr level was lower in the RIPerC group than in the IPostC group (P < 0.01). CONCLUSION Liver graft protection by RIPerC is similar to or better than that of IPostC, and involves inhibition of oxidative stres

关键词： Liver transplantation Ischemia/reperfusion injury Remote ischemic perconditioning Endothelial nitric oxide synthase Reactive oxygen species

Preparation and characterization of ferromagnetic fluids modified by carboxyl PEG

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Journal of Chinese Pharmaceutical Sciences 2012年第1期21卷 50-56页

作者： yan-fei zhou Ling-Ran Du Chao zhou Tian-Yuan Fan Department of Pharmaceutics School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

To prepare and characterize the ferromagnetic fluid of Fe304 modified by carboxyl PEG （FF/carboxyl PEG） for hyperthermia of tumor, the magnetic nanoparticles （NPs） of Fe304 were prepared by chemical co-precipitation method, and then modified with carboxyl PEG. The iron content of FFs was determined by spectrophotometric method using o-phenanthroline. The stability of FF/carboxyl PEG was assessed by the sedimentation method. FF/carboxyl PEG was characterized by X-ray diffraction （XRD）, transmission electron microscopy （TEM）, infrared spectrometry （IR） and vibrating sample magnetometer （VSM）. Heating effect of FF/carboxyl PEG was measured in an alternating magnetic field in vitro. The stability of FF/carboxyl PEG was much better than that of unmodified ferromagnetic fluid. FF/carboxyl PEG was proved to be composed of Fe304 by both XRD and IR. TEM showed that the ferromagnetic particles were well-dispersed. The average particle size was calculated as 5 nm by XRD. The saturation magnetization and residual magnetization of FF/carboxyl PEG were 47.01 and 3.41 emu/g, respectively. The coercive force was 6.70e. The specific absorption rate （SAR） of the FF/carboxyl PEG was 63.0 W/g[Fe]. The FF/carboxyl PEG shows the promise for hyperthermia of tumor.

关键词： Ferromagnetic fluid Fe304 Carboxyl PEG Heating effect Hyperthermia

Influence of perfusate on liver viability during hypothermic machine perfusion

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World Journal of Gastroenterology 2015年第29期21卷 8848-8857页

作者： Jun-Jun Jia Jing Zhang Jian-Hui Li Xu-Dong Chen Li Jiang yan-fei zhou Ning He Hai-yang Xie Lin zhou Shu-Sen Zheng Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Combined Multiorgan Transplantation Ministry of Public Health Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Department of Vascular Surgery First Affiliated Hospital Zhejiang University School of Medicine

AIM: To optimize the perfusates used for hypothermicmachine perfusion(HMP).METHODS: Sprague-Dawley rats were assigned randomly to three groups(n = 12 per group) that received either saline, University of Wisconsin coldstorage solution(UW) or histidine-tryptophan-ketoglutarate solution(HTK) as the perfusate. Each group was divided into two subgroups: static cold storage(SCS) and HMP(n = 6 per subgroup). The liver graft was retrieved according to the method described by Kamada. For the SCS group, the graft was directly placed into cold perfusate(0-4?℃) for 6 h after liver isolation while the portal vein of the graft was connected to the perfusion machine for the HMP group. Then the perfusates were collected at different time points for analysis of aspartate aminotransferase(AST), alanine transaminase(ALT) and lactate dehydrogenase(LDH) levels. Liver tissues were obtained for evaluation of histology, dry/wet weight(D/W) ratio, and malondialdehyde(MDA) and adenosine-triphosphate(ATP) levels. The portal vein pressure and velocity were monitored in real time in all HMP ***: Comparison of HMP and SCS: Regardless of the perfusate, HMP improved the architecture of donor graft in reducing the congestion around sinusoids and central vein and maintaining sinusoid lining in morphology; HMP improved liver function in terms of ALT, AST and LDH, especially during the 3-6 h period(SCS vs HMP using saline: ALT3, 225.00 ± 105.62 vs 49.50 ± 18.50, P = 0.047; LDH3, 1362.17 ± 563.30 vs 325.75 ± 147.43, P = 0.041; UW: LDH6, 2880.14 ± 948.46 vs 2135.00 ± 174.27, P = 0.049; HTK, AST6, 307.50 ± 52.95 vs 185.20 ± 20.46, P = 0.041); HMP decreased MDA level(saline, 2.79 ± 0.30 vs 1.09 ± 0.09, P = 0.008; UW, 3.01 ± 0.77 vs 1.23 ± 0.68, P = 0.005; HTK, 3.30 ± 0.52 vs 1.56 ± 0.22, P = 0.006). Comparison among HMP subgroups: HTK showed less portal vein resistance than UW and saline(vs saline, 3.41 ± 0.49 vs 5.00 ± 0.38, P < 0.001; vs UW, 3.41 ± 0.49 vs 4.52 ± 0.63, P = 0.007); UW redu

关键词： Hypothermic machine perfusion Staticcold storage Liver viability Wisconsin cold-storagesolution Histidine-tryptophan-ketoglutarate solution

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： fei-Da Wu Hai-Feng zhou Wei yang Di Zhu Bi-fei Wu Hai-Bin Shi Sheng Liu Wei-Zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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悬索桥重力式锚碇结构-地基联合承载机制

交通运输工程学报 2017年第2期17卷 1-11页

作者：尹小涛严飞周磊王东英邓琴中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 云南省交通规划设计研究院陆地交通气象灾害防治技术国家工程实验室云南昆明650041 中国科学院大学工程科学学院北京100049

基于普宣高速公路宣威岸重力式锚碇工程,设计了不回填无预应力、不回填有预应力和回填有预应力3种计算工况,利用数值仿真试验分析了重力式锚碇和地基的力学机制和破坏模式。承载机制表明:8倍设计荷载之前没有塑性变形,为弹性工作状态,... 详细信息

基于普宣高速公路宣威岸重力式锚碇工程,设计了不回填无预应力、不回填有预应力和回填有预应力3种计算工况,利用数值仿真试验分析了重力式锚碇和地基的力学机制和破坏模式。承载机制表明:8倍设计荷载之前没有塑性变形,为弹性工作状态,最大变形在锚岩界面,摩擦效应居主导,基底拉应力区可控,锚碇结构抗滑移和抗倾覆性均处于稳定可控状态;12倍设计荷载之后塑性区逐步扩展,达到20倍设计荷载时全部贯通,基底塑性变形明显,锚碇结构变形显著,基底夹持岩体剪切破坏,夹持效应居主导,基底拉应力区不可控,锚碇结构抗滑移和抗倾覆性均处于不可控状态;锚碇施加的预应力只在结构-岩基协调变形之前起作用,之后影响不大;回填可以极大地改善基底应力状态与结构扭转变形、抗滑移和抗倾覆稳定性,可在容许变形范围内适当考虑增强效应。可见,重力式锚碇结构-地基协调变形与联合承载机制,表现为摩擦效应、夹持效应和回填效应的综合作用。监测结果显示:通过基底拉应力和压应力监控结构与地基接触面安全性,监测值小于地基容许承载力3MPa;通过基底变位和地基深部水平位移监控结构抗滑移稳定性,实际工程监测值小于1mm;通过角点不均匀沉降监控锚碇抗倾覆稳定性,倾斜值小于0.006;通过大体积混凝土温控监测可知,内部最高温度小于60℃,进出水温差小于15℃,内表温差小于20℃,峰后降温速率小于3℃·d^(-1);锚束锁固荷载监测变化幅值不超过设计值的5%。

关键词：悬索桥重力式锚碇变形机制破坏模式联合承载机制

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重力式锚碇水平极限承载力估值公式探讨

铁道工程学报 2017年第1期34卷 41-46页

作者：尹小涛严飞周磊王东英邓琴中国科学院武汉岩土力学研究所岩土力学与工程国家重点试验室武汉430071 云南省交通规划设计研究院陆地交通气象灾害防治技术国家工程实验室昆明650041

研究目的:当前基于摩擦设计的重力式锚碇的水平极限承载力估值偏保守,没有考虑锚碇结构与地基协同作用,联合承载的估值结果与实际偏差较大。本文利用平硐岩基摩擦试验、重力式锚碇基底深部位移监测和数值仿真试验等手段,探讨重力式锚碇... 详细信息

研究目的:当前基于摩擦设计的重力式锚碇的水平极限承载力估值偏保守,没有考虑锚碇结构与地基协同作用,联合承载的估值结果与实际偏差较大。本文利用平硐岩基摩擦试验、重力式锚碇基底深部位移监测和数值仿真试验等手段,探讨重力式锚碇与岩基的协同作用和联合承载机制。研究结论:(1)极限试验破坏形态揭示了重力式锚碇不是单纯的摩擦承载,而是锚-岩联合承载;(2)锚碇-岩基联合极限承载分为两个阶段和三个效应,初期为基底摩擦极限承载,摩擦效应;之后,前部齿坎夹持岩体剪切破坏极限承载,锚岩系统联合承载性能达到极限,夹持效应;基底上覆土重量对上述两部分都有提高,回填效应;(3)提出了考虑上述效应和联合承载机制的重力式锚碇水平极限承载力估算公式,经工程案例检验,公式极限估值9.6P与数值仿真确定的极限值8.0P接近,说明公式精度有保证,符合实际破坏模式;(4)该研究成果可用于新型重力式锚碇的设计和安全监控领域。

关键词：重力式锚碇协同作用联合承载机制水平极限承载力估算公式

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan zhou Fuling yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress