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Science China(Technological Sciences) 2022年第4期65卷 956-965页

作者： wang Na XU LuYu XIE fei SHI yan wang YiXuan Engineering Training Center Beihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Department of Pulmonary and Critical Care Medicine Chinese PLA General HospitalBeijing 100191China

Pneumatic proportional control servo regulator is the core component of a pneumatic-loading experimental system,which is very important in solving the overcharging ***,previous research on control of pneumatic proportional regulator in a pneumatic-loading experimental system led to failure in analysis of the influence of opening error of the switch regulator because it did not analyze the regulator basic working principle and *** traditional control method cannot fully solve the overcharging problem nor ensure adequate control performance of the *** seriously studying the working principle and key mechanical parameters of the valve,a fuzzy parameter-adaptive controller is designed by introducing a linear mixture of the pressure and opening errors of the switch regulator to reduce pressure overshoot and optimize its control *** to the fuzzy-control strategy based on the working characteristics and mechanical parameters of the valve,the overshoot phenomenon of the pneumatic-loading system is solved,and the pressure overshoot is *** error of the output air pressure of the regulator is 1.24%,which is *** adjustable pressure range of the regulator is 0.2–0.6 *** maximum deviation is 0.012 *** linearity of the case is 1.34%F.S.

关键词： pneumatic proportional servo regulator pneumatic-loading experimental system mathematical model fuzzy parameter-adaptive controller opening error of the switch regulator

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

景区旅游厕所满意度的重要性和绩效性实证研究——以山东省4个5A级景区为例

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数学的实践与认识 2017年第5期47卷 72-82页

作者：郭安禧郭英之孙雪飞徐薛艳王纯阳复旦大学工商管理博士后流动站上海200433 上海商学院酒店管理学院上海201400 复旦大学旅游学系上海200433 五邑大学经济管理学院广东江门529020

长期以来,旅游厕所是我国旅游业最突出的薄弱环节.旅游厕所问题不仅关乎游客的切身利益,而且关乎目的地的长远发展.本研究以在趵突泉等4个旅游景区调查的575位游客为样本,利用IPA方法分析游客对旅游厕所30个评价指标的感知.结果表明:1)... 详细信息

长期以来,旅游厕所是我国旅游业最突出的薄弱环节.旅游厕所问题不仅关乎游客的切身利益,而且关乎目的地的长远发展.本研究以在趵突泉等4个旅游景区调查的575位游客为样本,利用IPA方法分析游客对旅游厕所30个评价指标的感知.结果表明:1)游客对反映旅游厕所"找得到"、"进得去"、"呆得下"的评价指标有最高的重要性感知.对旅游厕所的内饰、外观等方面的评价指标有最低的重要性感知;2)游客对旅游厕所在标识、免收费、开放时间等方面的表现有最高的绩效感知,对旅游厕所在辅助服务人性化、配套设备现代化等方面的表现满意度最低;3)如厕环境、服务残障人士等方面有高重要性但旅游厕所的实际表现不佳,是今后"厕所革命"的工作重心.研究结果有助于从游客需求的角度为我国目前正在推进的旅游厕所革命提供理论依据和实践指导.

关键词：旅游厕所重要性感知绩效感知 IPA方法厕所革命

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin wang Fangyuan Cheng Zhaoli Han Bo yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li yanqi Song Sujuan Qin Qiaoyan Wen fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

Adaptive saturated tracking control for solid launch vehicles in ascending based on differential inclusion stabilization

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Defence Technology（防务技术） 2023年第8期26卷 157-179页

作者： fei Liu Song-yan wang Tao Chao Ming yang Control and Simulation Center Harbin Institute of TechnologyHarbin150090China

The large-range uncertainties of specific impulse,mass flow per second,aerodynamic coefficients and atmospheric density during rapid turning in solid launch vehicles(SLVs) ascending leads to the deviation of the actual trajectory from the reference *** of the traditional trajectory tracking methods is to observe the uncertainties by Extended State Observer(ESO) and then modify the control ***,ESO cannot accurately estimate the uncertainties when the uncertainty ranges are large,which reduces the guidance *** paper introduces differential inclusion(DI) and designs a controller to solve the large-range parameter uncertainties *** above uncertainties have large ranges,it can be combined with the ascent dynamic equation and described as a DI system in the mathematical form of a *** the DI system is stabilized,all the subsets are *** from the traditional controllers,the parameters of the designed controller are calculated by the uncertain ***,the controller can solve the problem of large-range parameter uncertainties of in ***,the ascent deviation system is obtained by linearization along the reference *** trajectory tracking system with engine parameters and aerodynamic uncertainties is described as an ascent DI system with respect to state deviation,which is called DI system.A DI adaptive saturation tracking controller(DIAST) is proposed to stabilize the DI ***,an improved barrier Lyapunov function(named time-varying tangent-log barrier Lyapunov function) is proposed to constrain the state *** with traditional barrier Lyapunov function,it can dynamically adjust the boundary of deviation convergence,which improve the convergence rate and accuracy of altitude,velocity and LTIA *** addition,the correction amplitudes of angle of attack(AOA) and angle of sideslip(AOS) need to be limited in order to guarantee that the overload constraint is n

关键词： Solid launch vehicles Trajectory tracking Adaptive controller Differential inclusion

Preparation, Electrochemical Property and Application in Bulk-modified Electrode of Dawson-type Phospho-molybdate-doped Polypyrrole Composite Nanoparticles

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Chemical Research in Chinese Universities 2006年第5期22卷 556-559页

作者： wang Xiu-li ZHAO Hai-yan wang Yi-fei Faculty of Chemistry and Chemical Engineering Bohai University Jinzhou 121000 P. R. China

A kind of inorganic-organic hybrid semiconductor composite nanoparticles： Dawson-type phosphomolybdate- doped polypyrrole （P2Mo18-PPy） was designed and prepared using microemulsion oxidation-polymerization at room temperature and characterized by TEM and IR. The P2Mo18-PPy was used as a bulk-modifier to fabricate a chemically modified carbon paste electrode（CPE） by direct mixing, which represents the example of polyoxometalates（ POMs）- doped semiconductor polymer nanoparticles modified electrode. Both the advantage of POMs-doped polymer and the surface-renewal property of the CPE were fully utilized. The electrochemical behavior of the P2Mo18-PPY bulk-modified CPE（P2Mo18-PPy-CPE） was investigated with cyclic voltammetry. Three couples of reversible redox peaks were observed in the range from ＋ 800 to 0 mV, which corresponded to the reduction and oxidation through two-, four- and six-electron processes, respectively. The P2 Mo18-PPY-CPE showed a high electrocatalytic activity for the reduction of nitrite, which expanded the application of POMs-doped semiconductor polymer nanoparticles.

关键词： Dawson-type phosphomolybdate Polypyrrole Composite nanoparticles Bulk-modified Carbon paste electrode Electrocatalysis

Democratic organization of the thalamocortical neural ensembles in nociceptive signal processing

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生理学报 2008年第5期60卷 669-676页

作者： LUO fei wang Jin-yan Key Laboratary of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China

Acute pain is a warning protective sensation for any impending ***,chronic pain syndromes are often resistant diseases that may consume large amount of health care *** has been suggested by recent studies that pain perception may be formed in central neural networks via large-scale coding processes,which involves sensory,affective,and cognitive *** central areas are involved in these processes,including structures from the spinal cord,the brain stem,the limbic system,to the ***,chronic painful diseases may be the result of some abnormal coding within this network.A thorough investigation of coding mechanism of pain within the central neuromatrix will bring us great insight into the mechanisms responsible for the development of chronic pain,hence leading to novel therapeutic interventions for pain management.

关键词：神经系统疼痛处理方法临床分析

奈比洛尔对自发性高血压大鼠心肌连接蛋白43重构的影响

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中国药物与临床 2017年第3期17卷 323-326页

作者：魏泽卉李志东殷莎张飞王燕山西医科大学基础医学院药理教研室太原030001

目的探讨奈比洛尔对自发性高血压大鼠(SHR)心肌连接蛋白43(Cx43)重构的影响。方法动物随机分成:SHR组(等量蒸馏水,灌胃),奈比洛尔组(奈比洛尔8 mg·kg^(-1)·d^(-1),灌胃),WKY(Wistar-Kyoto)组(等量蒸馏水,灌胃)。给药8周,期间每周测定... 详细信息

目的探讨奈比洛尔对自发性高血压大鼠(SHR)心肌连接蛋白43(Cx43)重构的影响。方法动物随机分成:SHR组(等量蒸馏水,灌胃),奈比洛尔组(奈比洛尔8 mg·kg^(-1)·d^(-1),灌胃),WKY(Wistar-Kyoto)组(等量蒸馏水,灌胃)。给药8周,期间每周测定尾动脉收缩压。试验结束后,3%戊巴比妥钠(30 mg/kg)麻醉大鼠,分离心脏,利用免疫组织化学方法和蛋白质印迹技术观察心肌Cx43的分布和表达的影响。结果与WKY组相比,SHR收缩压持续上升,奈比洛尔则可显著降低收缩压。免疫组织化学与蛋白质印迹法结果显示,WKY组Cx43阳性表达规则分布于闰盘,SHR组Cx43阳性颗粒排列紊乱位于侧边或胞内,且蛋白表达水平明显降低。奈比洛尔可使Cx43规则分布于闰盘处,Cx43表达升高。结论奈比洛尔在显著降压的同时,可改善SHR心肌Cx43分布和表达。

关键词：心肌大鼠奈比洛尔 Cx43

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang Liangwei Cong Guoyu Qian Dong wang Laishi Li Yusheng Wu Zhi wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis