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Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： yan-li Jiang Juan li Peng-fei Zhang Feng-Xian Fan Jie Zou Pin yang Peng-fei Wang Shao-Yu Wang Jing Zhang Department of Magnetic Resonance Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance liver biopsy Significant fibrosis

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Combining prognostic value of serum carbohydrate antigen 19-9 and tumor size reduction ratio in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 798-809页

作者： Dong-Qin Xia Yong Zhou Shuang yang Fang-fei li li-Ya Tian yan-Hua li Hai-yan Xu Cai-Zhi Xiao Wei Wang Oncology Treatment Center of Traditional Chinese Medicine Chongqing University Cancer HospitalChongqing 400030China Department of Oncology Chongqing Weisiteng Biotech Translational Research InstituteChongqing 430039China Chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 430065China

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social *** To evaluate the significance of serum carbohydrate antigen 19-9(CA19-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer *** study specifically assessed CA19-9 levels and tumor size before and after *** A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this *** average age was 65.4±10.6 years and 72(46.2%)patients were *** survival analysis,we defined the post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level as the CA19-9 ratio(CR).The patients were divided into three groups:CR0.5 and*** regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR0.5 and*** on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)***-rank tests showed that both OS and DFS were significantly different among the groups according to CR and TR(P<0.05).CR and TR after NAT were associated with increased odds of achieving a complete or near-complete pathologic ***,CR(hazard ratio:1.721,95%CI:1.373-3.762;P=0.006),and TR(hazard ratio:1.435,95%CI:1.275-4.363;P=0.014)were identified as independent factors associated with *** This study demonstrated that post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgical resection.

关键词： Pancreatic ductal adenocarcinoma Carbohydrate antigen 19-9 Tumor size Pathologic response Biomarkers

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Overview of ectopic pancreas

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 284-288页

作者： Chang-fei li Qiu-Ru li Miao Bai Yuan-Shi Lv yan Jiao Patient Service Center The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Neurology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Fundus Disease The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Thyroid Head and Neck Surgery Jilin Cancer HospitalChangchun 130000Jilin ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

This editorial discusses the article written by Zheng et al that was published in the latest edition of the World Journal of Gastrointestinal *** primary focus is on the causes,location,diagnosis,histological classification,and therapy of ectopic *** pancreas refers to the presence of pancreatic tissue that is situated in a location outside its usual anatomical placement,and is not connected to the normal pancreas in terms of blood supply or anatomical ***,the embryological origin of ectopic pancreas remains *** most prevalent form of ectopic pancreatic is gastric ectopic *** ultrasonography examination can visualize the morphological charac-teristics of the ectopic pancreatic lesion and pinpoint its anatomical *** histological categorization of ectopic pancreas *** treatment has been widely advocated in ectopic pancreas.

关键词： Pancreas Gastric ectopic pancreas Diagnosis Treatment Anatomy

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Work-function-induced interfacial electron redistribution of MoO_(2)/WO_(2) heterostructures for high-efficiency electrocatalytic hydrogen evolution reaction

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Rare Metals 2024年第2期43卷 489-499页

作者： Tong-fei li Jing li Lu-Ping Zhang Jia-Wei Ke Meng-Xing Fan li-Fang Zhang Cheng-Wei Deng Yi Sun Tao Qian Cheng-lin yan School of Chemistry and Chemical Engineering Nantong UniversityNantong226019China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China Aerospace Hydrogen Energy Technology(Shanghai)Co.Ltd. Shanghai201800China Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou215006China light Industry Institute of Electrochemical Power Sources Suzhou215006China

The engineering of the electronic configurations of active sites,together with the production of more accessible active sites through heterostructure design,has been established as a forceful methodology for boosting water electrolysis ***,a facile approach is developed to fabricate well-dispersed MoO_(2) and WO_(2) nanoparticles with abundant heterointerfaces entrapped in N,P-doped carbon nanofibers(referred to as MoO_(2)/WO_(2)@N,P-CNFs hereafter)as hydrogen evolution reaction(HER)electrocatalysts in alkaline and acidic *** spectroscopic analyses and theoretical findings manifest that the heterointerface formed by the work function modulation of MoO_(2)/WO_(2) triggers the spontaneous electron redistribution from MoO_(2)to WO_(2) and a built-in electric field,which is essential to promote water adsorption,optimize the H-intermediate adsorption energy,result in the enhanced charge transfer efficiency,and ultimately increase the intrinsic HER ***,the intimate confinement of MoO_(2)/WO_(2) heterostructures in the porous carbon substrate can restrain the active sites from unfavorable coarsening and detachment,thus ensuring facilitated HER kinetics and outstanding structural *** a result,MoO_(2)/WO_(2)@N,P-CNFs exhibit superior catalytic HER performance in acidic and basic solutions,requiring 118 and 95 mV overpotentials to achieve 10 mA·cm^(−2),respectively,surpassing a number of reported non-noble metal-based *** work provides guidelines for the rational design and construction of special metallic heterocomponents with optimized interfacial electronic structure for various electrochemical technologies.

关键词： Electrospinning MoO_(2)/WO_(2) heterostructure Work function Hydrogen evolution reaction

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Influence of Electroshocking Treatment on Microstructure and Mechanical Properties of Ti-6.5Al-3.5Mo-1.5Zr-0.3Si Thin-Wall Specimen Manufactured by Laser Melting Deposition

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 145-158页

作者： yan Wen Xuan Sun Jian Zhou Bingliang liu Haojie Guo Yuxin li fei Yin liqiang Wang Lechun Xie lin Hua Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan430070China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan430070China Hubei Longzhong Laboratory Xiangyang441000China Shanghai Aircraft Manufacturing Co. Ltd.Commercial Aircraft Corporation of ChinaLtd.Shanghai201324China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China

In order to improve the properties of titanium alloys manufactured by laser melting deposition(LMD),the electroshocking treatment(EST)was proposed in this *** effects of EST on microstructure and mechanical properties of LMD Ti-6.5Al-3.5Mo-1.5Zr-0.3Si were *** results showed that the width of the heat affected band decreased and disappeared under the thermal and athermal effects of EST,resulting in the uniform *** the microstructure,theαlaths became coarser gradually,and the quantity ofα/βinterface was *** reduction of the quantity ofα/βinterface leads to make less resistant to dislocation,resulting in the reduction in hardness and *** discontinuous grain boundaryαphase and nucleationαcolony near grain boundary inhibited the crack propagation and improved the ***,EST can manipulate the microstructure and improve the mechanical properties of LMD titanium alloys.

关键词： Electroshocking treatment(EST) Laser melting deposition(LMD) Titanium alloy Microstructure Mechanical properties

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Impacts of pancreatic exocrine insufficiency on gut microbiota

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 271-279页

作者： Yulin GUO Feng CAO fei li Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Acute Pancreatitis Clinical Center of Capital Medical University Beijing 100053China

Pancreatic exocrine insufficiency(PEI)can be induced by various kinds of diseases,including chronic pancreatitis,acute pancreatitis,and *** main pathogenetic mechanism of PEI involves the decline of trypsin synthesis,disorder of pancreatic fluid flow,and imbalance of secretion *** studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis,with the abundance of Lactobacillus and Bifidobacterium increasing the most,which could be partially reversed by pancreatic enzyme replacement *** studies have also confirmed the association between PEI and the dysbiosis of gut *** exocrine secretions and changes in duodenal p H as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut *** turn,the gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional *** forward,more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the gut microbiota.

关键词： Pancreatic exocrine insufficiency Gut microbiota Gut microbiome Pancreatic enzyme replacement therapy

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Growth of ablative Rayleigh-Taylor instability induced by time-varying heat-flux perturbation

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Matter and Radiation at Extremes 2024年第1期9卷 85-93页

作者： yang liu De-Hua Zhang Jing-fei Xin Yudong Pu Jun li Tao Tao Dejun Sun Rui yan Jian Zheng Department of Modern Mechanics University of Science and Technology of ChinaHefei 230026China Deep Space Exploration Laboratory Hefei 230026China Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Institute of Applied Physics and Computational Mathematics Beijing 100094China Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefeiAnhui 230026China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong UniversityShanghai 200240China CAS Center for Excellence in Ultra-intense Laser Science Shanghai 201800China

The evolution of ablative Rayleigh–Taylor instability(ARTI)induced by single-mode stationary and time-varying perturbations in heat flux is studied numerically in two *** with the stationary case,time-varying heat-flux perturbation mitigates ARTI growth because of the enhanced thermal smoothing induced by the wave-like traveling heat flux.A resonance is found to form when the phase velocity of the heat-flux perturbation matches the average sound speed in the ablation *** the resonant regime,the coherent density and temperature fluctuations enhance the electron thermal conduction in the ablation region and lead to larger ablation pressure and effective acceleration,which consequently yield higher linear growth rate and saturated bubble *** enhanced effective acceleration offers increased implosion velocity but can also compromise the integrity of inertial confinement fusion shells by causing faster ARTI growth.

关键词： perturbation stationary acceleration

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SAC-Based Computation Offloading for Reconfigurable Intelligent Surface-Aided Mobile Edge Networks

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China Communications 2024年第6期21卷 261-270页

作者： li Bin Qian Zhen fei Zesong School of Computer Science Nanjing University of Information Science&TechnologyNanjing 210044China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science&TechnologyNanjing 210044 School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

In this paper,we concentrate on a reconfigurable intelligent surface(RIS)-aided mobile edge computing(MEC)system to improve the offload efficiency with moving user equipments(UEs).We aim to minimize the energy consumption of all UEs by jointly optimizing the discrete phase shift of RIS,UEs’transmitting power,computing resources allocation,and the UEs’task offloading strategies for local computing and *** formulated problem is a sequential decision making across multiple coherent time ***,the mobility of UEs brings uncertainties into the decision-making *** cope with this challenging problem,the deep reinforcement learning-based Soft Actor-Critic(SAC)algorithm is first proposed to effectively optimize the discrete phase of RIS and the UEs’task offloading ***,the transmitting power and computing resource allocation can be determined based on the *** results demonstrate that the proposed algorithm can be trained more stably and perform approximately 14%lower than the deep deterministic policy gradient benchmark in terms of energy consumption.

关键词： MEC RIS soft actor-critic user mobility

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Boosting the performance of liNi_(0.90)Co_(0.06)Mn_(0.04)O_(2) electrode by uniform li_(3)PO_(4) coating via atomic layer deposition

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Chinese Chemical Letters 2024年第5期35卷 499-503页

作者： Mingjiao Lu Zhixing Wang Gui Luo Huajun Guo Xinhai li Guochun yan Qihou li Xianglin li Ding Wang Jiexi Wang School of Metallurgy and Environment Central South UniversityChangsha 410083China BASF ShanShan Battery Materials Co. Ltd.Changsha 410006China Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Nonferrous Value-Added Metallurgy Central South UniversityChangsha 410083China School of Physics and Chemistry Hunan First Normal UniversityChangsha 410205China National and Local Joint Engineering Laboratory for lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China

Ultra-high nickel material is considered to be a promising cathode ***,with the increase of nickel content,the interfacial side reactions between the cathode and electrolyte become increasingly ***,an atomically controllable ionic conductor li_(3)PO_(4)(LPO)coating is deposited on the liNi_(0.90)Co_(0.06)Mn_(0.04)O_(2)(NCM9064)based electrode by the atomic layer deposition *** results shows that the LPO coating is uniformly and densely covered on the surface of secondary particles of NCM9064,helping to prevent the direct contact between the electrolyte and cathode during the chargingdischarging *** addition,the coating layer is electrochemically *** a result,the interfacial side reactions during the long cycle are effectively suppressed,and the solid electrolyte interphase layer at the interface is *** electrode with 20 layers of LPO deposition(ALD-LPO-20)exhibits an excellent capacity retention of 81%after 200 cycles in 2.8-4.3 V at 25℃,which is 18%higher than the unmodified material(ALD-LPO-0).Besides,the moderate LPO coating improves the rate capability and high temperature cycling performance of *** study provides a method for the modification of ultra-high nickel cathode materials and corresponding electrodes.

关键词： Ultra-high nickel material liNi_(0.90)Co_(0.06)Mn_(0.04)O_(2) Atomic layer deposition li_(3)PO_(4) Ionic conductor

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun li Fang-Zhou Sun Chun-Xiao li Hong-Nan Mo yan-Tong Zhou Dan Lv Jing-Tong Zhai Hai-li Qian fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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