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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Variation of Out-of-Plane Constraint and Its Effects on Fracture

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上海交通大学学报 2004年第z2期38卷 212-216页

作者： fei xu Yulong Li Wanlin Guo Department of Mechanical Engineering Tokyo University of Science Noda2788510 Japan School of Aeronautics Northwestern Polytechnical University Xi''an710072 P. R. China School of Aeronautics Northwestern Polytechnical University Xi''an710072 P. R. China School of Aeronautics and Astronauts Nanjing University of Aeronautics and AstronautsNaniing210016 P.R.China

The limitations of using one-parameter to describe the crack-tip fields have prompted investigators to consider better descriptions of the crack tip fields. The two-parameter descriptions, such as J-Q theory, have been an important development in this field. But under the consideration of plane strain and three-dimensional problem, the effects of the out-of-plane stress can not be neglected In this paper, effects of the in-plane constraint as well as the out-of-plane constraint are studied by aid of the finite element method on the plane strain condition. It is obvious that both the in-plane constraint (Q factor) and the out-of-plane constraint (Tz = σzz/(σxx + σyy) ) affect the crack tip *** important features of the out-of-plane constraint are described out based on the simulation results. At the end of this paper, a three-parameter formulation is proposed, in which both the in-plane constraint and the out-of-plane constraint are considered. Comparing with the results of the FEM numerical simulation, the three-parameter description can provide a better prediction near the crack tip.

关键词： in-plane constraint out-of-plane constraint three-parameter formulation crack tip field elastic-plastic

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Synthesis and electrochemical properties of Li_2MnSiO_4/C nanoparticles via polyol process

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Rare Metals 2010年第5期29卷 511-514页

作者： LIU Wengang xu Yunhua YANG rong School of Material Science and Engineering Xi 'an University of Architecture and Technology Xi 'an 710055 China School of Science Xi 'an University of Technology Xi 'an 710048 China

Carbon-coated lithium manganese silicate （Li2MnSiO4/C） nanoparticles were synthesized by polyol process. X-ray diffraction （XRD） patterns of the obtained materials exhibit a good fit with that of the Li2MnSiO4 phase. Field emission scanning electron microscopy （FESEM） images of the obtained samples show that the particle size is only tens of nanometers. The high resolution transmission electron microscopy （HRTEM） analysis shows that the Li2MnSiO4 nanoparticles are surrounded by a very thin film of amorphous carbon. The composite prepared through polyol process shows good performance as cathode materials in lithium cells at room temperature. The charge capacity of the Li2MnSiO4/C samples is 219 mAh/g （about 1.3 Li^＋ per unit formula extracted）, and the discharge capacity is 132 mAh/g （about 0.8 Li^＋ per unit formula inserted） in the first cycle in the voltage range of 1.5-4.8 V. A good capacity cycling maintenance of 81.8% after 10 cycles was obtained.

关键词： lithium ion batteries cathode materials electrochemical properties polyol process silicates

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Cure of a New Type Composite on Noise Control and Effect of Filler Modification

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Journal of Materials Science & Technology 2003年第z1期19卷 135-136页

作者： Jun CAI fei xu Weimin CAI School of Municipal and Environment Englineering Harbin Institute of Technology Harbin150001china School of Environment Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China School of Environment Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

A new type composite of high efficiency sound attenuation was cured. The superfine tungsten powder, plasticizerand stabilizer are added into the PVC resin and blended in the mixing chamber of a HAAKE rheometer. The effect ofthe filler modification is considered in the composite cure. The properties of modified composite and unmodified oneare studied by SEM morphology viewing, acoustic and mechanical measurement. The test results indicate that thereason of the better soundproof and mechanical properties is the particle uniform dispersion and stronger adhesion.

关键词： Composite, Filler modification, Soundproof property, Mechanical property

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan Zou Zhijun Yang Lili Guo Ruxiang xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Precipitation Distribution of the Extended Global Spring-Autumn Monsoon and Its Possible Formation Mechanism

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Journal of Ocean University of China 2021年第5期20卷 1027-1036页

作者： QIN Ling HUANG fei xu Shibin Key Laboratory of Physical Oceanography Ocean University of ChinaQingdao 266100China Laboratory for Ocean and Climate Dynamics Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266100China Ningbo Collaborative Innovation Center of Nonlinear Hazard System of Ocean and Atmosphere Ningbo UniversityNingbo 315211China

The global monsoon(GM)comprises two major modes,namely,the solstitial mode and equinoctial asymmetric *** this paper,we extend the GM domain from the tropics to the global region and name it the global spring-autumn monsoon(GSAM),which mainly indicates a spring-autumn asymmetrical precipitation pattern exhibiting annual *** distribution and possible formation mechanisms are also *** GSAM domain is mainly distributed over oceans,located both in the midlatitude and tropical regions of the Pacific and *** the GSAM domains of both the Northern and Southern Hemispheres,more precipitation occurs in local autumn than in local *** formation mechanisms of GSAM precipitation vary according to the different *** precipitation in the tropical domain of the Eastern Hemisphere is influenced by the circulation differences between the onset and retreat periods of the Asian summer monsoon,while tropical cyclone activities cause precipitation over the South China Sea(SCS)and western North Pacific(WNP).GSAM precipitation in the tropical domain of the Western Hemisphere is influenced by the tropical asymmetrical circulation between the Northern and Southern Hemispheres and the variation in the intertropical convergence zone(ITCZ)driven by the intensity of the sea surface temperature cold tongues over the equatorial eastern Pacific and eastern *** precipitation in the midlatitude domain is influenced by the differences in water vapor transportation and convergence between spring and *** addition,GSAM precipitation is also affected by extratropical cyclone activities.

关键词： global monsoon equinoctial asymmetric mode monsoon precipitation mechanism

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Molecular dynamics study on surface formation and phase transformation in nanometric cutting of β-Sn

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Advances in Manufacturing 2022年第3期10卷 356-367页

作者： Zhi-Fu xue Min Lai fei-fei xu Feng-Zhou Fang State Key Laboratory of Precision Measuring Technology and Instruments Laboratory of Micro-Nano Manufacturing TechnologyTianjin UniversityTianjin 300072People's Republic of China

Atomic motion and surface formation in the nanometric cutting process ofβ-Sn are investigated using molecular dynamics(MD).A stagnation region is observed that changes the shape of the tool edge involved in nanometric cutting,resulting in a fluctuation in the cutting *** is found that single-crystal tin releases the high compressive stress generated under the tool pressure through slip and phase *** tin transformation proceeds from aβ-Sn structure to a bct-Sn *** effects of the cutting speed,undeformed chip thickness(UCT)and tool edge radius on material removal are also explored.A better surface is obtained through material embrittlement caused by a higher *** addition,a smaller UCT and sharper tool edge help reduce subsurface damage.

关键词： β-Sn Molecular dynamics(MD) Nanometric cutting Surface formation Phase transformation

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HTAP评测基准的评测能力综述

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软件学报 2025年第1期36卷 424-445页

作者：翁思扬俞融王清帅胡梓锐倪葎张蓉周烜周傲英徐泉清杨传辉刘维杨攀飞华东师范大学数据科学与工程学院蚂蚁集团OceanBase 工业和信息化部电子第五研究所

对数据库系统即时修改数据的高效实时分析需求推动了数据库系统向同时支持OLTP业务和OLAP业务两种场景的HTAP数据库系统的快速发展.面对众多的HTAP数据库系统,为了推动HTAP数据库系统的公平比较和健康发展,定义和实现相应的评测基准来评... 详细信息

对数据库系统即时修改数据的高效实时分析需求推动了数据库系统向同时支持OLTP业务和OLAP业务两种场景的HTAP数据库系统的快速发展.面对众多的HTAP数据库系统,为了推动HTAP数据库系统的公平比较和健康发展,定义和实现相应的评测基准来评估HTAP数据库系统的新特性至关重要.首先,分析HTAP数据库系统的关键特征并抽象总结HTAP数据库系统实现的关键技术.然后,提炼出HTAP数据库系统的设计难点和构建HTAP评测基准的挑战,并基于此提出HTAP评测基准应考虑的设计维度,包括数据生成、负载生成、评价指标和一致性模型支持性.对比现有HTAP评测基准在设计维度和实现技术上的差异,总结评测基准在不同设计维度上的优劣.此外,运行已公开的典型评测基准,展示并分析它们对HTAP数据库系统关键特征的评测能力以及对不同HTAP数据库系统的横向对比的支持能力.最后,总结对HTAP评测基准的能力需求和未来的一些研究方向,指出语义一致的负载控制和新鲜数据访问度量是HTAP数据库系统评测基准定义的关键问题.

关键词： HTAP评测基准 HTAP数据库系统性能分析新鲜度

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Minimal two-spheres with constant curvature in the quaternionic projective space

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Science China Mathematics 2020年第5期63卷 993-1006页

作者： Jie fei Chiakuei Peng Xiaowei xu Department of Mathematical Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Mathematics University of Science and Technology of ChinaHefei 230026China Wu Wen-Tsun Key Laboratory of Mathematics University of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China

In this paper we completely classify the homogeneous two-spheres,especially,the minimal homogeneous ones in the quaternionic projective space *** to our classification,more minimal constant curved two-spheres in HPnare obtained than what Ohnita conjectured in the paper"Homogeneous harmonic maps into complex projective *** J Math,1990,13:87–116".

关键词： minimal two-sphere Gauss curvature quaternionic projective space

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Influences of meridional flowpath on the performance of swept blade in an axial compressor stage

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航空动力学报 2015年第8期30卷 1875-1887页

作者： YU Xian-jun xu Peng-fei ZHANG Yi-fei LIU Bao-jie School of Energy and Power Engineering Beiiing University of Aeronautics and Astronautics Beijing 100191 China National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Energy and Power EngineeringBeijing University of Aeronautics and Astronautics Beijing 100191 China Collaborative Innovation Center for Advanced Aero-Engine Beijing 100191 China

A series of numerical simulations were conducted in both a 1.5stage axial compressor model and a simplified planar cascade *** cases with different blade sweep schemes in the cascade model were simulated with free-slip endwalls to minimize the influence of endwall 3-D(three-dimensional)*** results obtained in the cascade model were discussed at first for getting a clear insight into the effects of blade sweep without other *** then the simulation results of the 1.5stage compressor model were discussed *** discussions focused on the influences of different meridional flowpath designs,*** mid radius(CMR)design,constant outer radius(COR)design and constant inner radius(CIR)design,on the performance of the swept *** results showed that the most critical effect produced by blade sweep was attributed to the redistribution of local mass-flow-rate in blade spanwise *** change of meridional flowpath did not change the mass-flow-rate redistribution ***,the trends for local mass-flow-rate redistribution in compressor stage model showed some discrepancies compared with the results shown in the planar cascade model.

关键词：航空航空动力学航空发动机发动原理

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